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The map label for this gene is hisG

Identifier: 50083891

GI number: 50083891

Start: 655293

End: 655979

Strand: Direct

Name: hisG

Synonym: ACIAD0661

Alternate gene names: 50083891

Gene position: 655293-655979 (Clockwise)

Preceding gene: 50083890

Following gene: 50083892

Centisome position: 18.21

GC content: 40.47

Gene sequence:

>687_bases
TTGATGAATGATATGAGAAACGATGATCCAAACTTTAACGTAATGGGGAATTTTGATCATGGTTTAACATTGGCGCTTAG
TAAGGGGCGTATTTTAAAAGAGACTTTACCTTTGCTGGAGGCAGCAGGTATTAATTTACTTGAAGACCCAGAAAAATCCC
GTAAATTAATTTTTCCTACCACACATCAAAAAGTCCGTATTTTGATTTTACGTGCATCTGATGTGCCAACTTATGTAGAA
AATGGTGCTGCGGACTTTGGGGTAGCGGGTAAAGATGTCTTGATGGAACATGGTGCACAGCATGTTTATGAGTTACTTGA
TCTTAAAATTGCAAATTGCAAATTGATGACCGCTGGTAAAGTCGGAATGCAACACCCCAAAGGCCGTTTAAAGATTGCTA
CTAAATATGTAAATTTAACGCGTCAATACTATGCAAGCCTTGGTGAGCAGGTGGATGTGATCAAACTTTACGGCTCAATG
GAGCTGGCACCTTTGGTGGGTTTAGGTGACTACATTGTGGATGTAGTTGATACTGGAAATACCTTGCGGGCAAATGGTTT
GGAGCCTTTAGAGGAGATCATGAAAGTGTCATCTCGTCTGATTGTGAATAAGGCCAGCTTTAAGCGTAAACAAGCTTTAT
TAGATCCGATTCTTGCTCAAGTGGAAGAGGCTGTGAATCAGCGTTAA

Upstream 100 bases:

>100_bases
AAGGAGATACTTTGATTGACCGTATTTATCACATTGATCGTGGTTATGAAAATATTGAAGCTAAATTACAAAGTTTAGGC
GCTAAGATTAAGCGAGTAAG

Downstream 100 bases:

>100_bases
CCTTAACATCAGCAAGTTGCGTATTTTATTCAAGAACCGCCATATTCTGGCGGTTTTTTGTCATTGGAACAGGTAACTAT
TGTTGTTTGATTAAGATATA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MMNDMRNDDPNFNVMGNFDHGLTLALSKGRILKETLPLLEAAGINLLEDPEKSRKLIFPTTHQKVRILILRASDVPTYVE
NGAADFGVAGKDVLMEHGAQHVYELLDLKIANCKLMTAGKVGMQHPKGRLKIATKYVNLTRQYYASLGEQVDVIKLYGSM
ELAPLVGLGDYIVDVVDTGNTLRANGLEPLEEIMKVSSRLIVNKASFKRKQALLDPILAQVEEAVNQR

Sequences:

>Translated_228_residues
MMNDMRNDDPNFNVMGNFDHGLTLALSKGRILKETLPLLEAAGINLLEDPEKSRKLIFPTTHQKVRILILRASDVPTYVE
NGAADFGVAGKDVLMEHGAQHVYELLDLKIANCKLMTAGKVGMQHPKGRLKIATKYVNLTRQYYASLGEQVDVIKLYGSM
ELAPLVGLGDYIVDVVDTGNTLRANGLEPLEEIMKVSSRLIVNKASFKRKQALLDPILAQVEEAVNQR
>Mature_228_residues
MMNDMRNDDPNFNVMGNFDHGLTLALSKGRILKETLPLLEAAGINLLEDPEKSRKLIFPTTHQKVRILILRASDVPTYVE
NGAADFGVAGKDVLMEHGAQHVYELLDLKIANCKLMTAGKVGMQHPKGRLKIATKYVNLTRQYYASLGEQVDVIKLYGSM
ELAPLVGLGDYIVDVVDTGNTLRANGLEPLEEIMKVSSRLIVNKASFKRKQALLDPILAQVEEAVNQR

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=222, Percent_Identity=31.981981981982, Blast_Score=85, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=207, Percent_Identity=31.8840579710145, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ACIAD (Q6FEC9)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045401.1
- ProteinModelPortal:   Q6FEC9
- SMR:   Q6FEC9
- STRING:   Q6FEC9
- GeneID:   2878928
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0661
- NMPDR:   fig|62977.3.peg.360
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q6FEC9
- ProtClustDB:   PRK01686
- BioCyc:   ASP62977:ACIAD0661-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 25271; Mature: 25271

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNDMRNDDPNFNVMGNFDHGLTLALSKGRILKETLPLLEAAGINLLEDPEKSRKLIFPT
CCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCC
THQKVRILILRASDVPTYVENGAADFGVAGKDVLMEHGAQHVYELLDLKIANCKLMTAGK
CCCEEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCEECCEEEEECCC
VGMQHPKGRLKIATKYVNLTRQYYASLGEQVDVIKLYGSMELAPLVGLGDYIVDVVDTGN
CCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCHHHHEEECCCC
TLRANGLEPLEEIMKVSSRLIVNKASFKRKQALLDPILAQVEEAVNQR
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNDMRNDDPNFNVMGNFDHGLTLALSKGRILKETLPLLEAAGINLLEDPEKSRKLIFPT
CCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCC
THQKVRILILRASDVPTYVENGAADFGVAGKDVLMEHGAQHVYELLDLKIANCKLMTAGK
CCCEEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCEECCEEEEECCC
VGMQHPKGRLKIATKYVNLTRQYYASLGEQVDVIKLYGSMELAPLVGLGDYIVDVVDTGN
CCCCCCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCHHHHEEECCCC
TLRANGLEPLEEIMKVSSRLIVNKASFKRKQALLDPILAQVEEAVNQR
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA