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The map label for this gene is hisD

Identifier: 50083892

GI number: 50083892

Start: 656263

End: 657555

Strand: Direct

Name: hisD

Synonym: ACIAD0663

Alternate gene names: 50083892

Gene position: 656263-657555 (Clockwise)

Preceding gene: 50083891

Following gene: 50083893

Centisome position: 18.24

GC content: 44.55

Gene sequence:

>1293_bases
TTGATGCGACGTTTATCGACTCAAGATCAAAGCTTTAAACAGGTTTTTGCAGATCTGTTAGCGTTTGAAACTGTAAATGA
TCCTGAACTTTTAAAAACAGTAGACCAAATCATTGCTGATGTACGTCAGTATGGTGATGAACATGTTCTTAAGCTCACTC
AGCAGTTTGATCGACATCCAGCGCATCAATTTTCAGATTTGGAACTGACCCAAGAGCAACTTAAAACTGCATTTGAGGCC
TTAACGGCTGAAATACGTGAAGCCCTTGAATTGGCTGCGGAGCGTATTCGCAGTTTTCACCAAGCTCAAAAGCAAGAAGG
TTGGAGCTATGTGGATGCATTGGGAAATACCTTGGGTCAAAAAGTGACACCTTTAGATCGTGTCGGTATTTATGTCCCTG
GTGGTTTGGCATCTTATCCGTCTTCGGTACTTATGAATGCAATTCCAGCACATGTGGCTGGTGTACCAGAAATTATCATG
GTCGTGCCAGCACCAAATGGTGAGTTGAATTCTCTGGTTTTGGCTGCGGCATATTTGGCTGGAGTAAGCCGTATTTTTAC
GATAGGTGGAGCGCAGGCTGTTGCCGCTTTGGCTTATGGCACCCAGACTATTCCAGCAGTAGATAAAATTACTGGACCTG
GTAACAGATTTGTTGCGGCCGCTAAGCGCGCTGTTTTCGGTCAGGTCGGAATTGACATGATCGCCGGTCCATCTGAAATT
CTGGTATATGCAGAAGGTCAGAATAATGCTAAATGGTTGGCAATGGATCTTTTGTCACAAGCGGAACACGATACCGTTGC
ACAAGCCATTTTTATTACACCAGATGAAGCATTACTTGATGAAGTCGCTCAAGCGATTGAAGAACATTTAGCTGCATTAC
CTAAAGCTGATATTGCGCGGACTTCAATTGCAAATCGTGGAGCACTGGTTCTGGTTAAGGATCGTGATGAGGCCATTGAA
TTAATTAATCAGGTGGCCCCTGAACATTTAGAGCTGTGTCTGGATGAATCAGAAGCGATGAGTCAGAAGATTCGTCATGC
AGGTGCAATCTTTATGGGACGCTATACACCAGAAGCGATTGGCGATTACTGTGCAGGTCCGAATCATGTATTACCAACAT
CGGGTACCGCACGTTTTTCATCGCCTCTTGGGGTGTATGACTTTCAAAAACGTTCAAGTTTGATCATGTGTTCGCAAGAA
GGCGTGAAAAGCTTGGCAAAGGCGGCAGACGTATTGGCTCAACAGGAAAATCTGGATGCACATGCACGTTCTGCACGTTA
TCGTTATCAGTAA

Upstream 100 bases:

>100_bases
TCAATGAAACAATGCAAGATTGTTGATGGTTGATTACCCACAGAAGCCATGAAAAAGAGTACACTAAGATCTTATTTTCA
CTTAGCACCTTGTAGGTAAA

Downstream 100 bases:

>100_bases
GTATTAATATTTTAGCAAGATCAGAGCTTAGTAACTGCTCTACGGGGCTGATTTTCAGCCCTTTTTTGAGAATAGAAAGA
TGAATGTCACTAATGAAAAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHPAHQFSDLELTQEQLKTAFEA
LTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIM
VVPAPNGELNSLVLAAAYLAGVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQVGIDMIAGPSEI
LVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKADIARTSIANRGALVLVKDRDEAIE
LINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQE
GVKSLAKAADVLAQQENLDAHARSARYRYQ

Sequences:

>Translated_430_residues
MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHPAHQFSDLELTQEQLKTAFEA
LTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIM
VVPAPNGELNSLVLAAAYLAGVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQVGIDMIAGPSEI
LVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKADIARTSIANRGALVLVKDRDEAIE
LINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQE
GVKSLAKAADVLAQQENLDAHARSARYRYQ
>Mature_430_residues
MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHPAHQFSDLELTQEQLKTAFEA
LTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIM
VVPAPNGELNSLVLAAAYLAGVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQVGIDMIAGPSEI
LVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKADIARTSIANRGALVLVKDRDEAIE
LINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQE
GVKSLAKAADVLAQQENLDAHARSARYRYQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=402, Percent_Identity=40.0497512437811, Blast_Score=290, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=409, Percent_Identity=39.6088019559902, Blast_Score=272, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_ACIAD (Q6FEC8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045402.1
- ProteinModelPortal:   Q6FEC8
- SMR:   Q6FEC8
- STRING:   Q6FEC8
- GeneID:   2878926
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0663
- NMPDR:   fig|62977.3.peg.361
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q6FEC8
- ProtClustDB:   PRK00877
- BioCyc:   ASP62977:ACIAD0663-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46672; Mature: 46672

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 328-328 ACT_SITE 329-329 BINDING 131-131 BINDING 192-192 BINDING 215-215 BINDING 238-238 BINDING 260-260 BINDING 263-263 BINDING 329-329 BINDING 362-362 BINDING 416-416 BINDING 421-421

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHP
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
AHQFSDLELTQEQLKTAFEALTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
KVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIMVVPAPNGELNSLVLAAAYLA
CCCCHHHCCEEECCCHHHCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
GVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQVGIDMIAGPSEI
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCEE
LVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKADIAR
EEEEECCCCCHHHHHHHHHHCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHH
TSIANRGALVLVKDRDEAIELINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAI
HHHCCCCCEEEEECCHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHCCCEEECCCHHHH
GDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQEGVKSLAKAADVLAQQENLDA
HHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCH
HARSARYRYQ
HHHCCCCCCC
>Mature Secondary Structure
MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHP
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
AHQFSDLELTQEQLKTAFEALTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
KVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIMVVPAPNGELNSLVLAAAYLA
CCCCHHHCCEEECCCHHHCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
GVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQVGIDMIAGPSEI
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCEE
LVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKADIAR
EEEEECCCCCHHHHHHHHHHCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHH
TSIANRGALVLVKDRDEAIELINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAI
HHHCCCCCEEEEECCHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHCCCEEECCCHHHH
GDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQEGVKSLAKAADVLAQQENLDA
HHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCH
HARSARYRYQ
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA