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The map label for this gene is hemC

Identifier: 50083560

GI number: 50083560

Start: 284746

End: 285681

Strand: Direct

Name: hemC

Synonym: ACIAD0286

Alternate gene names: 50083560

Gene position: 284746-285681 (Clockwise)

Preceding gene: 50083559

Following gene: 50083561

Centisome position: 7.91

GC content: 44.12

Gene sequence:

>936_bases
TTGATCTCAATCCTTATGCAAACCTTAAAGATTGCTACACGACAAAGCCCGCTTGCGTTATGGCAGGCAGAACATATTCG
TGATCGGTTACAGGCACTTTATCCTGAGCTTAAGGTTGAATTAGTCAAGTTTGTTACACAGGGTGATAAAATACTGGATA
CACCTTTAGCTAAAATTGGTGGTAAAGGTTTGTTCGTTAAAGAGCTTGAAGCAGCGCTATTGGATGGACGCGCAGATTTG
GCAGTACATTCCATGAAAGATGTCCCAATGCATTTGCCAGAGGGTTTAAGCCTTGCGGTCATTTGTGAGCGTGAAGATCC
ATTGGATGCTTTTGTGTCTAATCATGTGATGAGTTTTGATCAATTGCCTTTGGGGGCGCGTGTGGGGACGTCAAGCTTAC
GCCGTAAATGTCAAATTCTTAAACAACGTCCAGATCTTGAAATTATAGACTTACGTGGCAATGTGGGGACCCGTTTGGCA
AAGCTTGATGATGGACAATATGATGCCATTGTTCTGGCAAGTGCAGGATTAAAGCGTCTAGGACTAATATCACGTATTCG
TCATAGCATAAATGCTGAAATTAGTTTACCTGCTGTAGGCCAAGGGGCTTTAGGGCTTGAATGTCGAGCAAATGATAAAA
AGATTCTTGATCTAATTGCACCGCTTGCACATCAGCCAACCTCTGCTTGCGTTAGGGCTGAACGTGCGTTTAATGCGTAT
TTGGAAGGTGGATGTCAGGTTCCGATTGCTGGTTTTGCTACACTGACACAGGAGTGTCTGACTTTGGAAGGCCGTGTAGG
AAGTGTAGATGGTAAAACCTTACTTAAGGATCATGTAGAAGGTCATGCAGATCAGGCTGAGGTGCTTGGTGTGCAATTGG
CGAAGCAGTTACTTGCACAGGGTGCAGGCGAATTGCTGCGTGATTTATATCAATAA

Upstream 100 bases:

>100_bases
AATGTAAATTAAGTCGCACATTCATCGTACTAAGGGTGTGAAAGAACATATTTTACTTGCATTTTTAAGCAATCGGGTTA
AGTTTAGAGTCTGTTTTTTA

Downstream 100 bases:

>100_bases
ACTACCATGCTGCTGATTAATACACGACCCGCAGATCGTGCAGATGAACTGACACAGGCTGTATCTGCACAGGGTTATCG
TGTAGAAAATCTTCCTTTAT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MISILMQTLKIATRQSPLALWQAEHIRDRLQALYPELKVELVKFVTQGDKILDTPLAKIGGKGLFVKELEAALLDGRADL
AVHSMKDVPMHLPEGLSLAVICEREDPLDAFVSNHVMSFDQLPLGARVGTSSLRRKCQILKQRPDLEIIDLRGNVGTRLA
KLDDGQYDAIVLASAGLKRLGLISRIRHSINAEISLPAVGQGALGLECRANDKKILDLIAPLAHQPTSACVRAERAFNAY
LEGGCQVPIAGFATLTQECLTLEGRVGSVDGKTLLKDHVEGHADQAEVLGVQLAKQLLAQGAGELLRDLYQ

Sequences:

>Translated_311_residues
MISILMQTLKIATRQSPLALWQAEHIRDRLQALYPELKVELVKFVTQGDKILDTPLAKIGGKGLFVKELEAALLDGRADL
AVHSMKDVPMHLPEGLSLAVICEREDPLDAFVSNHVMSFDQLPLGARVGTSSLRRKCQILKQRPDLEIIDLRGNVGTRLA
KLDDGQYDAIVLASAGLKRLGLISRIRHSINAEISLPAVGQGALGLECRANDKKILDLIAPLAHQPTSACVRAERAFNAY
LEGGCQVPIAGFATLTQECLTLEGRVGSVDGKTLLKDHVEGHADQAEVLGVQLAKQLLAQGAGELLRDLYQ
>Mature_311_residues
MISILMQTLKIATRQSPLALWQAEHIRDRLQALYPELKVELVKFVTQGDKILDTPLAKIGGKGLFVKELEAALLDGRADL
AVHSMKDVPMHLPEGLSLAVICEREDPLDAFVSNHVMSFDQLPLGARVGTSSLRRKCQILKQRPDLEIIDLRGNVGTRLA
KLDDGQYDAIVLASAGLKRLGLISRIRHSINAEISLPAVGQGALGLECRANDKKILDLIAPLAHQPTSACVRAERAFNAY
LEGGCQVPIAGFATLTQECLTLEGRVGSVDGKTLLKDHVEGHADQAEVLGVQLAKQLLAQGAGELLRDLYQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=336, Percent_Identity=41.9642857142857, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI66933009, Length=336, Percent_Identity=41.9642857142857, Blast_Score=228, Evalue=8e-60,
Organism=Escherichia coli, GI48994974, Length=308, Percent_Identity=60.3896103896104, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=38.3647798742138, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20130425, Length=294, Percent_Identity=42.5170068027211, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_ACIAD (Q6FFA9)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045070.1
- ProteinModelPortal:   Q6FFA9
- SMR:   Q6FFA9
- STRING:   Q6FFA9
- GeneID:   2878315
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0286
- NMPDR:   fig|62977.3.peg.624
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   Q6FFA9
- ProtClustDB:   PRK00072
- BioCyc:   ASP62977:ACIAD0286-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33765; Mature: 33765

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISILMQTLKIATRQSPLALWQAEHIRDRLQALYPELKVELVKFVTQGDKILDTPLAKIG
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHC
GKGLFVKELEAALLDGRADLAVHSMKDVPMHLPEGLSLAVICEREDPLDAFVSNHVMSFD
CCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
QLPLGARVGTSSLRRKCQILKQRPDLEIIDLRGNVGTRLAKLDDGQYDAIVLASAGLKRL
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCEEEEECCCHHHH
GLISRIRHSINAEISLPAVGQGALGLECRANDKKILDLIAPLAHQPTSACVRAERAFNAY
HHHHHHHHHCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LEGGCQVPIAGFATLTQECLTLEGRVGSVDGKTLLKDHVEGHADQAEVLGVQLAKQLLAQ
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GAGELLRDLYQ
CHHHHHHHHCC
>Mature Secondary Structure
MISILMQTLKIATRQSPLALWQAEHIRDRLQALYPELKVELVKFVTQGDKILDTPLAKIG
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHC
GKGLFVKELEAALLDGRADLAVHSMKDVPMHLPEGLSLAVICEREDPLDAFVSNHVMSFD
CCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
QLPLGARVGTSSLRRKCQILKQRPDLEIIDLRGNVGTRLAKLDDGQYDAIVLASAGLKRL
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCEEEEECCCHHHH
GLISRIRHSINAEISLPAVGQGALGLECRANDKKILDLIAPLAHQPTSACVRAERAFNAY
HHHHHHHHHCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LEGGCQVPIAGFATLTQECLTLEGRVGSVDGKTLLKDHVEGHADQAEVLGVQLAKQLLAQ
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GAGELLRDLYQ
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA