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The map label for this gene is aspP [H]

Identifier: 50083552

GI number: 50083552

Start: 275197

End: 275817

Strand: Reverse

Name: aspP [H]

Synonym: ACIAD0275

Alternate gene names: 50083552

Gene position: 275817-275197 (Counterclockwise)

Preceding gene: 50083553

Following gene: 50083551

Centisome position: 7.66

GC content: 43.96

Gene sequence:

>621_bases
ATGACCATATTAGAACAGGCGAGTTATTCGCATCACGATGTCGAAATTGAAAAACGTGAATCACTTTATCAAGGCTTCAC
TCGACTTGAAAAAGTCAGCTTTCGACATCGCCTGTTTAATCAGCAAGAATACACCCCCGTGATTCAGCGTGAATTGATCA
CAAGGAAGCAAGCGGCGGGTGTGTTGCTGTATAGTCATCCGCAACGAAAATTTGCATTGATCGAACAATTTCGGATTGGT
GCAATTGAAGATACATCATCACCTTGGCAACTTGAAATTATTGCAGGGGTACTCGATGGAGATGAGTCGCCAGAAACCTG
TATCAGACGCGAATGCCTAGAAGAATCTGGCTGTGAAATTCAGGCAGCTCAACATCTGTTTAGCTTTTACCCTTCAGCAG
GTGCCTGTTCAGAGTTATTCCATCTTTATACTGCTCAAACGACGCTACCTGAATATGGCGGTGTTTTTGGACTTGCAGAA
GAAGGTGAAAACATCAAACTTCATCTTTTTGACTATGATCAACTCACCACATTGCTGTCACAGGGTCGTTTGCGTAATGC
ACCTGTGATTATGGCACTACAATGGCTTGCTCAGCAGATTCGTCAGCAGGACGCGACATAA

Upstream 100 bases:

>100_bases
ACTGTATCAAAAAGTCTAAAACGCTAAAAAAAGCGTTTGTCTTTAATTTGAACTCAGTTAGGATGAAATACAGACATGTA
TTTCATCCTTTTTAAATTTT

Downstream 100 bases:

>100_bases
TCATGTTTAAGATTACGCCCTTTTCGACTCAACAACATGTGATTATCCAAATTACAGACACCCATTTGCTGGAAGACCCA
CAACAGGAATTTGTTGGCAT

Product: adenosine diphosphate sugar pyrophosphatase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTILEQASYSHHDVEIEKRESLYQGFTRLEKVSFRHRLFNQQEYTPVIQRELITRKQAAGVLLYSHPQRKFALIEQFRIG
AIEDTSSPWQLEIIAGVLDGDESPETCIRRECLEESGCEIQAAQHLFSFYPSAGACSELFHLYTAQTTLPEYGGVFGLAE
EGENIKLHLFDYDQLTTLLSQGRLRNAPVIMALQWLAQQIRQQDAT

Sequences:

>Translated_206_residues
MTILEQASYSHHDVEIEKRESLYQGFTRLEKVSFRHRLFNQQEYTPVIQRELITRKQAAGVLLYSHPQRKFALIEQFRIG
AIEDTSSPWQLEIIAGVLDGDESPETCIRRECLEESGCEIQAAQHLFSFYPSAGACSELFHLYTAQTTLPEYGGVFGLAE
EGENIKLHLFDYDQLTTLLSQGRLRNAPVIMALQWLAQQIRQQDAT
>Mature_205_residues
TILEQASYSHHDVEIEKRESLYQGFTRLEKVSFRHRLFNQQEYTPVIQRELITRKQAAGVLLYSHPQRKFALIEQFRIGA
IEDTSSPWQLEIIAGVLDGDESPETCIRRECLEESGCEIQAAQHLFSFYPSAGACSELFHLYTAQTTLPEYGGVFGLAEE
GENIKLHLFDYDQLTTLLSQGRLRNAPVIMALQWLAQQIRQQDAT

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789412, Length=189, Percent_Identity=37.037037037037, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788810, Length=149, Percent_Identity=32.8859060402685, Blast_Score=91, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 23609; Mature: 23478

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILEQASYSHHDVEIEKRESLYQGFTRLEKVSFRHRLFNQQEYTPVIQRELITRKQAAG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
VLLYSHPQRKFALIEQFRIGAIEDTSSPWQLEIIAGVLDGDESPETCIRRECLEESGCEI
EEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCH
QAAQHLFSFYPSAGACSELFHLYTAQTTLPEYGGVFGLAEEGENIKLHLFDYDQLTTLLS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECHHHHHHHHH
QGRLRNAPVIMALQWLAQQIRQQDAT
CCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TILEQASYSHHDVEIEKRESLYQGFTRLEKVSFRHRLFNQQEYTPVIQRELITRKQAAG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
VLLYSHPQRKFALIEQFRIGAIEDTSSPWQLEIIAGVLDGDESPETCIRRECLEESGCEI
EEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCH
QAAQHLFSFYPSAGACSELFHLYTAQTTLPEYGGVFGLAEEGENIKLHLFDYDQLTTLLS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECHHHHHHHHH
QGRLRNAPVIMALQWLAQQIRQQDAT
CCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]