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The map label for this gene is dld [H]

Identifier: 50083399

GI number: 50083399

Start: 109347

End: 111065

Strand: Direct

Name: dld [H]

Synonym: ACIAD0109

Alternate gene names: 50083399

Gene position: 109347-111065 (Clockwise)

Preceding gene: 50083398

Following gene: 50083400

Centisome position: 3.04

GC content: 44.56

Gene sequence:

>1719_bases
GTGGATTTGATGACACAACAGTCCGTTACAGCCTCTCAGCTATTAAACCAGCTTAAAAAGATTGTTGGCCCATCCTATGT
CTTGACGGATGATCAGCAAACCCGCCAATACCGTCAGGGTCGACGCTTTGGTGAGGGGCATGTGCTGGCGGTGGTGTGTC
CTGCTACGCTCCTTGAGCAATGGCATGTTTTACAGGCGGCAATCGCAGCTGATTGTATTGTGATTATGCAGGCAGCAAAT
ACAGGGCTAACGGGAGGTTCTACTCCCTATGGCCAGGATTATGATCGACCTGTACTGGTGATGAGCACGCGCCGCTTAAA
AGGAATTCAGGTCATCCATGAGGGTAAACAAGTGGTGTGTTTACCGGGTGCGACGCTGGATCATCTTGAGCAACTGTTAA
AAAGCTATAATCGAGAACCACATTCAGTGATTGGCTCTTCCTGTATTGGCGCATCAGTGTTGGGGGGAGTATGTAATAAT
TCGGGTGGAGCACTGGTACGCCGTGGTCCTGCCTATACCGAGCTGGCTTTGTACGCACAGGTAGACCAACAAGGACAGTT
GCATCTGGTGAATCACCTTGGCATTGATCTTGGACAGACACCCGAAGAAATTTTGACGCGACTGGAATCACAGCAGTATC
AGGCCAGTGATATTCTGGATGATACGCGTCAGGCCTCTGATCGTCGTTATGCCGATGACGTGACACAAGTTGATGCAGAT
AGTCCAGCACGTTTTAATGCAGATCCTTCCCGTTTGTTTGAGGCTTCGGGTTCAGCGGGTAAAGTCTGTGTATTTGCGGT
ACGCTTAGATACCTATGAAAAAGTTGAAAGTGATGTGTTTTATGTTGGCAGTAATGATGCAGATGATCTCACGGCAATCC
GTCGCTATCTGCTGACCTCCTTGCCGAGCTTACCGATTGCGGGTGAATATATTCATCGTGATGCCTATCAGATTGGGGAA
AAATACGGTAAAGATACCTTTTTATTTATTGAAAAATTTGGGACTGCCAACGTACCCAAAGCCTTTGCCATGAAAGACAA
AATCGATGGTGTTCTGGAAAAATTGAAGATAAAAGGGCTTACGGATCATTTATTACAAGCTCTGACTTTTTGCTTACCTA
GCCATCTACCAAAACGCATGACCGAGTTTCGCGATCTATACCAGCATCATCTGATTTTAAGAATTGAGAAAAACAGTAAA
GCACTGACCGAACAGTTTTTAACAGAATATTTTGCGCTCCATTCTACGGGTGCTTATTTTTTATGTGATCAAGATGAAGG
TCGTAAAGCCTTTTTACATCGTTTTGCGATAGCAGGTGCAGCCATTCGTTATCGGGATACACATCGTAATGAAGTAGAGG
ATATTGTGGCACTGGATATTGCCTTGCGCCGTAATGATCGGCAGTGGGTTGAGCAACTGCCAGAGGAAATGGAAAAAAAG
ATTTTACATAAGCTGTATTATGGTCATTTTTTCTGTCATGTGTTTCATCAGGACTATATTATTCAAAAAGGCGTTAATCC
GCTTGAGATGGAACATGAGATGTGGAAATTACTGGATGCACGACGTGCAGAGTATCCCGCAGAACATAATGTTGGACATT
TATATATTGCCAAACCTGCGCTAGCAAATTTTTATCAAAGGCTTGATCCAACCAATCGTTTTAATGTGGGTATTGGGCAC
ACCTCAAAGCTAAAGTACTGGGGAAAATCGACACAATAA

Upstream 100 bases:

>100_bases
AGAAATGCGCGTTGCCATGACCTTGACGGGTGCAAAAACCATTGCCGATATCAATGAAAGTTGTCTGGTCGAAATGAATA
AACTCATACAATCCTAAAAG

Downstream 100 bases:

>100_bases
CAGACCAAAACATAATACAAAAATACATAGCGCGGGCTTCTTACATTTCAGTTGGTTTTAAGGTTGCAAAAGCAAAAGAA
AGAAACTAAGGTGAACGGGA

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MDLMTQQSVTASQLLNQLKKIVGPSYVLTDDQQTRQYRQGRRFGEGHVLAVVCPATLLEQWHVLQAAIAADCIVIMQAAN
TGLTGGSTPYGQDYDRPVLVMSTRRLKGIQVIHEGKQVVCLPGATLDHLEQLLKSYNREPHSVIGSSCIGASVLGGVCNN
SGGALVRRGPAYTELALYAQVDQQGQLHLVNHLGIDLGQTPEEILTRLESQQYQASDILDDTRQASDRRYADDVTQVDAD
SPARFNADPSRLFEASGSAGKVCVFAVRLDTYEKVESDVFYVGSNDADDLTAIRRYLLTSLPSLPIAGEYIHRDAYQIGE
KYGKDTFLFIEKFGTANVPKAFAMKDKIDGVLEKLKIKGLTDHLLQALTFCLPSHLPKRMTEFRDLYQHHLILRIEKNSK
ALTEQFLTEYFALHSTGAYFLCDQDEGRKAFLHRFAIAGAAIRYRDTHRNEVEDIVALDIALRRNDRQWVEQLPEEMEKK
ILHKLYYGHFFCHVFHQDYIIQKGVNPLEMEHEMWKLLDARRAEYPAEHNVGHLYIAKPALANFYQRLDPTNRFNVGIGH
TSKLKYWGKSTQ

Sequences:

>Translated_572_residues
MDLMTQQSVTASQLLNQLKKIVGPSYVLTDDQQTRQYRQGRRFGEGHVLAVVCPATLLEQWHVLQAAIAADCIVIMQAAN
TGLTGGSTPYGQDYDRPVLVMSTRRLKGIQVIHEGKQVVCLPGATLDHLEQLLKSYNREPHSVIGSSCIGASVLGGVCNN
SGGALVRRGPAYTELALYAQVDQQGQLHLVNHLGIDLGQTPEEILTRLESQQYQASDILDDTRQASDRRYADDVTQVDAD
SPARFNADPSRLFEASGSAGKVCVFAVRLDTYEKVESDVFYVGSNDADDLTAIRRYLLTSLPSLPIAGEYIHRDAYQIGE
KYGKDTFLFIEKFGTANVPKAFAMKDKIDGVLEKLKIKGLTDHLLQALTFCLPSHLPKRMTEFRDLYQHHLILRIEKNSK
ALTEQFLTEYFALHSTGAYFLCDQDEGRKAFLHRFAIAGAAIRYRDTHRNEVEDIVALDIALRRNDRQWVEQLPEEMEKK
ILHKLYYGHFFCHVFHQDYIIQKGVNPLEMEHEMWKLLDARRAEYPAEHNVGHLYIAKPALANFYQRLDPTNRFNVGIGH
TSKLKYWGKSTQ
>Mature_572_residues
MDLMTQQSVTASQLLNQLKKIVGPSYVLTDDQQTRQYRQGRRFGEGHVLAVVCPATLLEQWHVLQAAIAADCIVIMQAAN
TGLTGGSTPYGQDYDRPVLVMSTRRLKGIQVIHEGKQVVCLPGATLDHLEQLLKSYNREPHSVIGSSCIGASVLGGVCNN
SGGALVRRGPAYTELALYAQVDQQGQLHLVNHLGIDLGQTPEEILTRLESQQYQASDILDDTRQASDRRYADDVTQVDAD
SPARFNADPSRLFEASGSAGKVCVFAVRLDTYEKVESDVFYVGSNDADDLTAIRRYLLTSLPSLPIAGEYIHRDAYQIGE
KYGKDTFLFIEKFGTANVPKAFAMKDKIDGVLEKLKIKGLTDHLLQALTFCLPSHLPKRMTEFRDLYQHHLILRIEKNSK
ALTEQFLTEYFALHSTGAYFLCDQDEGRKAFLHRFAIAGAAIRYRDTHRNEVEDIVALDIALRRNDRQWVEQLPEEMEKK
ILHKLYYGHFFCHVFHQDYIIQKGVNPLEMEHEMWKLLDARRAEYPAEHNVGHLYIAKPALANFYQRLDPTNRFNVGIGH
TSKLKYWGKSTQ

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=568, Percent_Identity=54.7535211267606, Blast_Score=644, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 64657; Mature: 64657

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLMTQQSVTASQLLNQLKKIVGPSYVLTDDQQTRQYRQGRRFGEGHVLAVVCPATLLEQ
CCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCEEEEECHHHHHHH
WHVLQAAIAADCIVIMQAANTGLTGGSTPYGQDYDRPVLVMSTRRLKGIQVIHEGKQVVC
HHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHEECCCEEEE
LPGATLDHLEQLLKSYNREPHSVIGSSCIGASVLGGVCNNSGGALVRRGPAYTELALYAQ
ECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHEEEEEE
VDQQGQLHLVNHLGIDLGQTPEEILTRLESQQYQASDILDDTRQASDRRYADDVTQVDAD
CCCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
SPARFNADPSRLFEASGSAGKVCVFAVRLDTYEKVESDVFYVGSNDADDLTAIRRYLLTS
CCCCCCCCHHHHHHCCCCCCCEEEEEEECCHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
LPSLPIAGEYIHRDAYQIGEKYGKDTFLFIEKFGTANVPKAFAMKDKIDGVLEKLKIKGL
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCH
TDHLLQALTFCLPSHLPKRMTEFRDLYQHHLILRIEKNSKALTEQFLTEYFALHSTGAYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEE
LCDQDEGRKAFLHRFAIAGAAIRYRDTHRNEVEDIVALDIALRRNDRQWVEQLPEEMEKK
EECCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ILHKLYYGHFFCHVFHQDYIIQKGVNPLEMEHEMWKLLDARRAEYPAEHNVGHLYIAKPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHH
LANFYQRLDPTNRFNVGIGHTSKLKYWGKSTQ
HHHHHHHCCCCCCEEECCCCCCCEECCCCCCC
>Mature Secondary Structure
MDLMTQQSVTASQLLNQLKKIVGPSYVLTDDQQTRQYRQGRRFGEGHVLAVVCPATLLEQ
CCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCEEEEECHHHHHHH
WHVLQAAIAADCIVIMQAANTGLTGGSTPYGQDYDRPVLVMSTRRLKGIQVIHEGKQVVC
HHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHEECCCEEEE
LPGATLDHLEQLLKSYNREPHSVIGSSCIGASVLGGVCNNSGGALVRRGPAYTELALYAQ
ECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHEEEEEE
VDQQGQLHLVNHLGIDLGQTPEEILTRLESQQYQASDILDDTRQASDRRYADDVTQVDAD
CCCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
SPARFNADPSRLFEASGSAGKVCVFAVRLDTYEKVESDVFYVGSNDADDLTAIRRYLLTS
CCCCCCCCHHHHHHCCCCCCCEEEEEEECCHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
LPSLPIAGEYIHRDAYQIGEKYGKDTFLFIEKFGTANVPKAFAMKDKIDGVLEKLKIKGL
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCH
TDHLLQALTFCLPSHLPKRMTEFRDLYQHHLILRIEKNSKALTEQFLTEYFALHSTGAYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEE
LCDQDEGRKAFLHRFAIAGAAIRYRDTHRNEVEDIVALDIALRRNDRQWVEQLPEEMEKK
EECCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ILHKLYYGHFFCHVFHQDYIIQKGVNPLEMEHEMWKLLDARRAEYPAEHNVGHLYIAKPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHH
LANFYQRLDPTNRFNVGIGHTSKLKYWGKSTQ
HHHHHHHCCCCCCEEECCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]