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The map label for this gene is lldD

Identifier: 50083398

GI number: 50083398

Start: 108189

End: 109343

Strand: Direct

Name: lldD

Synonym: ACIAD0108

Alternate gene names: 50083398

Gene position: 108189-109343 (Clockwise)

Preceding gene: 50083397

Following gene: 50083399

Centisome position: 3.01

GC content: 47.45

Gene sequence:

>1155_bases
ATGATTATTTCTTCTTCAAATGATTATCGCGAAGCAGCAAAGCGCCGCTTGCCACCATTTCTGTTTCACTATATCGATGG
TGGGGCGTATGCAGAATATACGCTTAAGCGAAATGTTGAAGATTTATCGCAAATTGCGTTACGCCAGCGTGTACTCAATG
ACATGTCTAGCTTGAGTTTGGAAACAAAACTGTTTAACGAAACACTTTCGATGCCCGTTGCTTTATCACCTGTAGGCTTA
ACTGGGATGTATGCGCGTCGTGGCGAAGTGCAGGCCGCTGTCGCCGCCGATAAAAAGGGTATTCCCTTTACCATGTCGAC
AGTTTCGGTATGCCCAATTGAAGAAGTGACACCTGCGATCAAGCGTCCAATGTGGTTTCAGCTTTACGTATTGCGTGATC
GTGGCTTTATGAAAAATGCGCTGGAACGTGCCAAAGCTGCGGGTTGCTCAACACTGGTGTTTACCGTAGATATGCCTGTT
CCTGGCGCGCGCTATCGTGATGCACATTCGGGAATGAGTGGGCCAAATGCGGCGATGCGTCGTTATTTACAGTCTATGAT
GCACCCGCAATGGGCTTGGGATGTCGGATTGTTGGGTCGTCCTCACGATTTGGGGAATATTTCAAAATATTTGGGTAAAA
CCACAGGACTTGAAGATTATATTAGCTGGTTGGGCTCCAATTTTGACCCATCCATTTCATGGAAAGATTTGGAGTGGATT
CGTGAGTTTTGGGATGGCCCAATGGTGATTAAAGGCATTCTAGATCCTGAAGATGCCAAAGATGCTGTGCGTTTTGGGGC
AGATGGAATTGTGGTGTCTAATCATGGGGGGCGTCAGCTTGATGGTGTGATGTCTTCAGCGCGAGCGATGCCAGCGATTG
CAGAAGCAGTGAAAGGTGACCTGACCATTCTGGCCGATTCGGGCATTCGTAATGGTCTGGATGTCGTGCGTATGCTCGCC
TTGGGTGCAGACAGCGTAATGTTAGGTCGTGCCTTTATCTATGCATTGGCTGCACAGGGCGGGCAAGGTGTATCCAACTT
GCTTGATCTGATTGATAAAGAAATGCGCGTTGCCATGACCTTGACGGGTGCAAAAACCATTGCCGATATCAATGAAAGTT
GTCTGGTCGAAATGAATAAACTCATACAATCCTAA

Upstream 100 bases:

>100_bases
TATGTGGGCATATTGAATTTGTTATCGATCATGTGCGTTCTCTGGATGAAGATGAAGCTCGCCAGAAACGCGCCACACGT
TTACATAGGATTGATCAAAC

Downstream 100 bases:

>100_bases
AAGGTGGATTTGATGACACAACAGTCCGTTACAGCCTCTCAGCTATTAAACCAGCTTAAAAAGATTGTTGGCCCATCCTA
TGTCTTGACGGATGATCAGC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MIISSSNDYREAAKRRLPPFLFHYIDGGAYAEYTLKRNVEDLSQIALRQRVLNDMSSLSLETKLFNETLSMPVALSPVGL
TGMYARRGEVQAAVAADKKGIPFTMSTVSVCPIEEVTPAIKRPMWFQLYVLRDRGFMKNALERAKAAGCSTLVFTVDMPV
PGARYRDAHSGMSGPNAAMRRYLQSMMHPQWAWDVGLLGRPHDLGNISKYLGKTTGLEDYISWLGSNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARAMPAIAEAVKGDLTILADSGIRNGLDVVRMLA
LGADSVMLGRAFIYALAAQGGQGVSNLLDLIDKEMRVAMTLTGAKTIADINESCLVEMNKLIQS

Sequences:

>Translated_384_residues
MIISSSNDYREAAKRRLPPFLFHYIDGGAYAEYTLKRNVEDLSQIALRQRVLNDMSSLSLETKLFNETLSMPVALSPVGL
TGMYARRGEVQAAVAADKKGIPFTMSTVSVCPIEEVTPAIKRPMWFQLYVLRDRGFMKNALERAKAAGCSTLVFTVDMPV
PGARYRDAHSGMSGPNAAMRRYLQSMMHPQWAWDVGLLGRPHDLGNISKYLGKTTGLEDYISWLGSNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARAMPAIAEAVKGDLTILADSGIRNGLDVVRMLA
LGADSVMLGRAFIYALAAQGGQGVSNLLDLIDKEMRVAMTLTGAKTIADINESCLVEMNKLIQS
>Mature_384_residues
MIISSSNDYREAAKRRLPPFLFHYIDGGAYAEYTLKRNVEDLSQIALRQRVLNDMSSLSLETKLFNETLSMPVALSPVGL
TGMYARRGEVQAAVAADKKGIPFTMSTVSVCPIEEVTPAIKRPMWFQLYVLRDRGFMKNALERAKAAGCSTLVFTVDMPV
PGARYRDAHSGMSGPNAAMRRYLQSMMHPQWAWDVGLLGRPHDLGNISKYLGKTTGLEDYISWLGSNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARAMPAIAEAVKGDLTILADSGIRNGLDVVRMLA
LGADSVMLGRAFIYALAAQGGQGVSNLLDLIDKEMRVAMTLTGAKTIADINESCLVEMNKLIQS

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=382, Percent_Identity=34.0314136125654, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI54234014, Length=384, Percent_Identity=33.0729166666667, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI7705393, Length=384, Percent_Identity=33.0729166666667, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=83.8196286472149, Blast_Score=672, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=381, Percent_Identity=31.2335958005249, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=30.6338028169014, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=28.4960422163588, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281363140, Length=381, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI78707190, Length=381, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI78707188, Length=381, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_ACIAD (Q6FFS1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_044908.1
- ProteinModelPortal:   Q6FFS1
- SMR:   Q6FFS1
- STRING:   Q6FFS1
- GeneID:   2881112
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0108
- NMPDR:   fig|62977.3.peg.23
- eggNOG:   COG1304
- HOGENOM:   HBG517781
- OMA:   WIREFWE
- PhylomeDB:   Q6FFS1
- ProtClustDB:   PRK11197
- BioCyc:   ASP62977:ACIAD0108-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 42131; Mature: 42131

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSSNDYREAAKRRLPPFLFHYIDGGAYAEYTLKRNVEDLSQIALRQRVLNDMSSLSL
CEECCCCHHHHHHHHCCCHHHHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ETKLFNETLSMPVALSPVGLTGMYARRGEVQAAVAADKKGIPFTMSTVSVCPIEEVTPAI
HHHHHHHHHCCCEEECCCCCCHHHHCCCCHHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMKNALERAKAAGCSTLVFTVDMPVPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYLQSMMHPQWAWDVGLLGRPHDLGNISKYLGKTTGLEDYISWLGSNFDPSISWKDLEWI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARAMPAIAEAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LTILADSGIRNGLDVVRMLALGADSVMLGRAFIYALAAQGGQGVSNLLDLIDKEMRVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEE
LTGAKTIADINESCLVEMNKLIQS
ECCCHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIISSSNDYREAAKRRLPPFLFHYIDGGAYAEYTLKRNVEDLSQIALRQRVLNDMSSLSL
CEECCCCHHHHHHHHCCCHHHHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ETKLFNETLSMPVALSPVGLTGMYARRGEVQAAVAADKKGIPFTMSTVSVCPIEEVTPAI
HHHHHHHHHCCCEEECCCCCCHHHHCCCCHHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMKNALERAKAAGCSTLVFTVDMPVPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYLQSMMHPQWAWDVGLLGRPHDLGNISKYLGKTTGLEDYISWLGSNFDPSISWKDLEWI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARAMPAIAEAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LTILADSGIRNGLDVVRMLALGADSVMLGRAFIYALAAQGGQGVSNLLDLIDKEMRVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEE
LTGAKTIADINESCLVEMNKLIQS
ECCCHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA