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The map label for this gene is ugd [H]

Identifier: 50083364

GI number: 50083364

Start: 68507

End: 69670

Strand: Direct

Name: ugd [H]

Synonym: ACIAD0072

Alternate gene names: 50083364

Gene position: 68507-69670 (Clockwise)

Preceding gene: 50083358

Following gene: 50083365

Centisome position: 1.9

GC content: 37.97

Gene sequence:

>1164_bases
GTGAATATTACAATTGTAGGTACAGGCTATGTAGGTTTGTCCAATGCTATGTTGTTTGCACAGCAGCATCAGGTGATTGC
ATTGGATATCGATCCAGCTCGTGTAGACTTGCTCAATCATAAAACTTCTCCCATACACGATACTGAAATTAGTCAGTATT
TACAAAAAGAGATTAATTTTCAAGCAACACTTGATTCAACAGTTGCTTATGCCAATGCCGAAGTCATTATTATTGCAACC
CCGACCAATTATGATGAGCAAACCAATTACTTTGACACAAGTTCGATTGAACAGGTTTTGAGTGACCTAAGTAACCAAAG
CAGTCAGGCAATTATTGTCATTAAATCTACAATTCCTGTGGGTTTTACTCAAAAAATGCAACTGCAATATCCAAGTTTAA
AGATTGTATTTTCACCCGAGTTTTTACGTGAAGGAAAAGCACTGTTAGATAATCTTTATCCCTCACGCATTGTGGTGGGT
GATACATCCGAAATAGGCCAAAAGATAGGTGCACTTTTTAAAGCGGGCAGTTTAAAAGAAGACGTCGATGTACTTTTAAT
GGATGCTACTGAAGCAGAAGCGGTTAAATTATTTTCAAATACGTATTTGGCTATGCGAGTTGCATATTTTAATGAGCTAG
ATACCTATTGCGCTTCACGAGGGTTAAACAGTAAAGATATCATTAGCGCTGTAGGTAAAGACCCGCGTATAGGTACACAT
TACAACAATCCATCTTTTGGCTATGGTGGTTATTGCCTTCCAAAAGATACCAAGCAGTTACTTGCAAATTATCAGGATGT
ACCACAAACCCTGATTTCTGCAATTATTCAATCCAATACGACACGTAAAGATTTTATTGCAGAGCAAATTGTCAAGAAAG
CACCTGAAACAGTAGGCATTTACCGACTGGTGATGAAAGCGGGCAGTGATAATTTTAGACAGTCTGCGATACAAGGCATT
ATGAAGCGCCTTAAAGCAAAGGGTATTCGTGTAGTGGTATATGAACCCGTGCTTCAAGAATCCTCTTTCTTTGGCTCAGA
CGTCGTAAATGACTTAGTAGAGTTCAAACAACAAAGCGATATCATTATTGCAAACCGAATTGTATCTGATTTAGATGATG
TACTTGAGAAAGTTTTTACACGTGATCTGTTTGGTGACAATTAA

Upstream 100 bases:

>100_bases
TACATCATCTCGAACCATGTCTCTTAATTTTGTCATTTAGATATCGTGTTAAAGTTTTATTTTATAAATTTTTTATATGA
AAGTTTTTGAGGGAAAGTGT

Downstream 100 bases:

>100_bases
TTCATACAATTTTGAGATATGGATACGATTATGAAAACAATTGCCATGGTAGTGATATTGTATGGAAAGCGTTTTGAAGA
ATCTAAAACGTTACAAAGTT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNITIVGTGYVGLSNAMLFAQQHQVIALDIDPARVDLLNHKTSPIHDTEISQYLQKEINFQATLDSTVAYANAEVIIIAT
PTNYDEQTNYFDTSSIEQVLSDLSNQSSQAIIVIKSTIPVGFTQKMQLQYPSLKIVFSPEFLREGKALLDNLYPSRIVVG
DTSEIGQKIGALFKAGSLKEDVDVLLMDATEAEAVKLFSNTYLAMRVAYFNELDTYCASRGLNSKDIISAVGKDPRIGTH
YNNPSFGYGGYCLPKDTKQLLANYQDVPQTLISAIIQSNTTRKDFIAEQIVKKAPETVGIYRLVMKAGSDNFRQSAIQGI
MKRLKAKGIRVVVYEPVLQESSFFGSDVVNDLVEFKQQSDIIIANRIVSDLDDVLEKVFTRDLFGDN

Sequences:

>Translated_387_residues
MNITIVGTGYVGLSNAMLFAQQHQVIALDIDPARVDLLNHKTSPIHDTEISQYLQKEINFQATLDSTVAYANAEVIIIAT
PTNYDEQTNYFDTSSIEQVLSDLSNQSSQAIIVIKSTIPVGFTQKMQLQYPSLKIVFSPEFLREGKALLDNLYPSRIVVG
DTSEIGQKIGALFKAGSLKEDVDVLLMDATEAEAVKLFSNTYLAMRVAYFNELDTYCASRGLNSKDIISAVGKDPRIGTH
YNNPSFGYGGYCLPKDTKQLLANYQDVPQTLISAIIQSNTTRKDFIAEQIVKKAPETVGIYRLVMKAGSDNFRQSAIQGI
MKRLKAKGIRVVVYEPVLQESSFFGSDVVNDLVEFKQQSDIIIANRIVSDLDDVLEKVFTRDLFGDN
>Mature_387_residues
MNITIVGTGYVGLSNAMLFAQQHQVIALDIDPARVDLLNHKTSPIHDTEISQYLQKEINFQATLDSTVAYANAEVIIIAT
PTNYDEQTNYFDTSSIEQVLSDLSNQSSQAIIVIKSTIPVGFTQKMQLQYPSLKIVFSPEFLREGKALLDNLYPSRIVVG
DTSEIGQKIGALFKAGSLKEDVDVLLMDATEAEAVKLFSNTYLAMRVAYFNELDTYCASRGLNSKDIISAVGKDPRIGTH
YNNPSFGYGGYCLPKDTKQLLANYQDVPQTLISAIIQSNTTRKDFIAEQIVKKAPETVGIYRLVMKAGSDNFRQSAIQGI
MKRLKAKGIRVVVYEPVLQESSFFGSDVVNDLVEFKQQSDIIIANRIVSDLDDVLEKVFTRDLFGDN

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=365, Percent_Identity=25.4794520547945, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI296040438, Length=255, Percent_Identity=26.2745098039216, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI296040443, Length=355, Percent_Identity=23.3802816901408, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=62.8865979381443, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI48994968, Length=347, Percent_Identity=24.4956772334294, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17560350, Length=393, Percent_Identity=24.9363867684478, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136908, Length=370, Percent_Identity=25.4054054054054, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 42956; Mature: 42956

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITIVGTGYVGLSNAMLFAQQHQVIALDIDPARVDLLNHKTSPIHDTEISQYLQKEINF
CEEEEEECCCCCHHHHHEEEECCCEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
QATLDSTVAYANAEVIIIATPTNYDEQTNYFDTSSIEQVLSDLSNQSSQAIIVIKSTIPV
EEECCCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
GFTQKMQLQYPSLKIVFSPEFLREGKALLDNLYPSRIVVGDTSEIGQKIGALFKAGSLKE
CCCCCEEEECCCEEEEECHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCC
DVDVLLMDATEAEAVKLFSNTYLAMRVAYFNELDTYCASRGLNSKDIISAVGKDPRIGTH
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
YNNPSFGYGGYCLPKDTKQLLANYQDVPQTLISAIIQSNTTRKDFIAEQIVKKAPETVGI
CCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHH
YRLVMKAGSDNFRQSAIQGIMKRLKAKGIRVVVYEPVLQESSFFGSDVVNDLVEFKQQSD
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHCCC
IIIANRIVSDLDDVLEKVFTRDLFGDN
EEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNITIVGTGYVGLSNAMLFAQQHQVIALDIDPARVDLLNHKTSPIHDTEISQYLQKEINF
CEEEEEECCCCCHHHHHEEEECCCEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
QATLDSTVAYANAEVIIIATPTNYDEQTNYFDTSSIEQVLSDLSNQSSQAIIVIKSTIPV
EEECCCCEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCC
GFTQKMQLQYPSLKIVFSPEFLREGKALLDNLYPSRIVVGDTSEIGQKIGALFKAGSLKE
CCCCCEEEECCCEEEEECHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCC
DVDVLLMDATEAEAVKLFSNTYLAMRVAYFNELDTYCASRGLNSKDIISAVGKDPRIGTH
CCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
YNNPSFGYGGYCLPKDTKQLLANYQDVPQTLISAIIQSNTTRKDFIAEQIVKKAPETVGI
CCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHH
YRLVMKAGSDNFRQSAIQGIMKRLKAKGIRVVVYEPVLQESSFFGSDVVNDLVEFKQQSD
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHCCC
IIIANRIVSDLDDVLEKVFTRDLFGDN
EEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]