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The map label for this gene is fkpA [H]

Identifier: 50083360

GI number: 50083360

Start: 63404

End: 64111

Strand: Reverse

Name: fkpA [H]

Synonym: ACIAD0066

Alternate gene names: 50083360

Gene position: 64111-63404 (Counterclockwise)

Preceding gene: 50083361

Following gene: 50083359

Centisome position: 1.78

GC content: 43.5

Gene sequence:

>708_bases
ATGAGTAAAGCCTTACCCATTGCTGTCGCTGTAATTTTAGGCGGTGCTGCACTTATCCCTGTTTATTACGCCTCTCAGCA
TCCTGCGACAGATGTAGGTAGCAAGGCAGATAAAAATGCGACTCCAGTACAAAAAATCAGTTATGCACTGGGCTACGAAG
TAGCAAACCAGACGCCTGCCGAGCTCGATGTTAATACATTTGTGCAAGGTATTCGTGATGGTCATGCACATGCTCCTGCC
GCTTATACCGAAGAACAGTTACAAGCAGCTTATAAAGAATATCAGCAGGAAATGCAGAAAAAACAGCTTGATCAAACTCA
TCAGTCTGCCTCAAGCAGCAACAATTTTCTTGCAGAAAATGCCAAAAAAGAAGGCGTTAAAACCACTGCTTCTGGTTTGC
AGTACAAAATTATTACCGAAGGTACAGGTAAACGTCCAAGCGCTTCATCTGTGGTAAAGGTCAATTATAAAGGTCAATTG
ACTGATGGTAAGGTATTTGACAGCTCTTACGAGCGTGGTCAACCTGTCGAGTTCCCATTAAATCAAGTGATTCCAGGCTG
GACTGAAGGCTTACAGCTTCTCAAGGAAGGTGGTAAAGCGACCTTGTATATCCCAGCCAAACTGGGCTATGGTGAGCAAG
GTGTTCCTGGCATGATCCCACCAAACAGTACTTTAATTTTTGATGTAGAACTGTTAGAAGTGAAATAG

Upstream 100 bases:

>100_bases
CCACTCGTTTTTTTCTGCAAACATTATATGCTTTGCAGATGCGTGCTAAGATCACATGCATGAACAACATGATCAAATAA
ACATCTTTTTGGAACCTTGT

Downstream 100 bases:

>100_bases
TGAAAAAGGAGAGTGCGATACTCTCCTTATTTTTTTGGAAATATCATGATGAAAAAAATAGGTTTGGCTCTGATCGCCTC
AAGTATGACAGTGACTGCTT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSKALPIAVAVILGGAALIPVYYASQHPATDVGSKADKNATPVQKISYALGYEVANQTPAELDVNTFVQGIRDGHAHAPA
AYTEEQLQAAYKEYQQEMQKKQLDQTHQSASSSNNFLAENAKKEGVKTTASGLQYKIITEGTGKRPSASSVVKVNYKGQL
TDGKVFDSSYERGQPVEFPLNQVIPGWTEGLQLLKEGGKATLYIPAKLGYGEQGVPGMIPPNSTLIFDVELLEVK

Sequences:

>Translated_235_residues
MSKALPIAVAVILGGAALIPVYYASQHPATDVGSKADKNATPVQKISYALGYEVANQTPAELDVNTFVQGIRDGHAHAPA
AYTEEQLQAAYKEYQQEMQKKQLDQTHQSASSSNNFLAENAKKEGVKTTASGLQYKIITEGTGKRPSASSVVKVNYKGQL
TDGKVFDSSYERGQPVEFPLNQVIPGWTEGLQLLKEGGKATLYIPAKLGYGEQGVPGMIPPNSTLIFDVELLEVK
>Mature_234_residues
SKALPIAVAVILGGAALIPVYYASQHPATDVGSKADKNATPVQKISYALGYEVANQTPAELDVNTFVQGIRDGHAHAPAA
YTEEQLQAAYKEYQQEMQKKQLDQTHQSASSSNNFLAENAKKEGVKTTASGLQYKIITEGTGKRPSASSVVKVNYKGQLT
DGKVFDSSYERGQPVEFPLNQVIPGWTEGLQLLKEGGKATLYIPAKLGYGEQGVPGMIPPNSTLIFDVELLEVK

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=43.9252336448598, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=43.9252336448598, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=49.4252873563218, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=49.4252873563218, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=49.4252873563218, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=41.1214953271028, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI224809329, Length=92, Percent_Identity=41.304347826087, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI224809327, Length=92, Percent_Identity=41.304347826087, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4758384, Length=92, Percent_Identity=41.304347826087, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI8923659, Length=97, Percent_Identity=40.2061855670103, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI224809331, Length=92, Percent_Identity=41.304347826087, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4503729, Length=102, Percent_Identity=40.1960784313725, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33469985, Length=103, Percent_Identity=34.9514563106796, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=41.3793103448276, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI87082390, Length=192, Percent_Identity=42.1875, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1789745, Length=205, Percent_Identity=42.4390243902439, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=42.4528301886792, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=47.0588235294118, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=43, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=87, Percent_Identity=54.0229885057471, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=48.9130434782609, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323482, Length=109, Percent_Identity=44.0366972477064, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=119, Percent_Identity=36.9747899159664, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363946, Length=110, Percent_Identity=42.7272727272727, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17352457, Length=110, Percent_Identity=42.7272727272727, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=39.4230769230769, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356629, Length=100, Percent_Identity=44, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647110, Length=111, Percent_Identity=37.8378378378378, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25300; Mature: 25169

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKALPIAVAVILGGAALIPVYYASQHPATDVGSKADKNATPVQKISYALGYEVANQTPA
CCCCHHHHHHHHHCCHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
ELDVNTFVQGIRDGHAHAPAAYTEEQLQAAYKEYQQEMQKKQLDQTHQSASSSNNFLAEN
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AKKEGVKTTASGLQYKIITEGTGKRPSASSVVKVNYKGQLTDGKVFDSSYERGQPVEFPL
HHHCCCEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCH
NQVIPGWTEGLQLLKEGGKATLYIPAKLGYGEQGVPGMIPPNSTLIFDVELLEVK
HHCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure 
SKALPIAVAVILGGAALIPVYYASQHPATDVGSKADKNATPVQKISYALGYEVANQTPA
CCCHHHHHHHHHCCHHHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
ELDVNTFVQGIRDGHAHAPAAYTEEQLQAAYKEYQQEMQKKQLDQTHQSASSSNNFLAEN
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AKKEGVKTTASGLQYKIITEGTGKRPSASSVVKVNYKGQLTDGKVFDSSYERGQPVEFPL
HHHCCCEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCCH
NQVIPGWTEGLQLLKEGGKATLYIPAKLGYGEQGVPGMIPPNSTLIFDVELLEVK
HHCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]