Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 50083356

GI number: 50083356

Start: 59258

End: 60127

Strand: Reverse

Name: nadC [H]

Synonym: ACIAD0062

Alternate gene names: 50083356

Gene position: 60127-59258 (Counterclockwise)

Preceding gene: 50083359

Following gene: 50083341

Centisome position: 1.67

GC content: 44.6

Gene sequence:

>870_bases
CTGGATTACATCTTGGACGTAATTATGAGCATCCCTCAATCCCTGCTTGAGCAATCGATTCAAATCAATATCCAACAGGC
ATTACAGGAAGATATTGGTGATGGTGACATTACTGCGATGCTGACACCAGAAGATGAACAGGCCACCGCAACCATTATTA
CACGTGAAAACATGATATTGGCTGGTCGTCCGTGGGTAGATGCCTTGATTACCCGTTACGATGCCTCGGTTCAAATTGAA
TGGCTGAAACAGGAAGGTGAACAGGTTGCTGCTGGTGAAGCGTTTTTAAAGCTCGCAGGTTCGGCACGTAGTTTATTGAC
GGTTGAACGTCCTGCACTCAATTTTGTTCAAACATTATCTGCGGTTGCAACCAAAGCTGCATTTTATGTACAGCAACTTG
AAGGATTACACACCAAGCTGCTCGATACCCGTAAAACCTTACCTGGTTTGCGTATTGCACAAAAATATGCGGTCGCACTG
GGAGGTGGTCAAAATCACCGTTTAGGTTTATTTGATGCATTTTTGATTAAAGAAAATCATATTATGGCGGCTGGCGGTAT
TGCTCAAGCCATTGAAAAAGCCCATCAGATCGCACCTGGCAAACCTGTGGAAGTCGAGGTTGAAACCTGGGATGAACTTG
ACCAAGCTTTACAGGCAGGCGCCGATATTGTGATGCTGGATAACTTTAGTCAGCAGCAAATGATTGAGGCCGTAAAATAT
GTGGCAGGTCGTTGTAAACTCGAAGCCTCAGGCAATATCACACTGGATAATTTACGCGAAGTTGCCAGCACTGGTGTTGA
TTATATTTCGATGGGTGTACTCACCAAAGATGTGACCGCGATTGATCTGTCGATGCGTTTTAATGCTTAA

Upstream 100 bases:

>100_bases
ACATATCATTTGAACAGCAGCATTGCATCTGCTTTTGTGGATTATTGTGCCAATAATACTTATTTTTTAAAACGACAATG
CTAATATATCGCTCAATTTT

Downstream 100 bases:

>100_bases
CCCTCCTCACGGTTTGTTTGAGTTAAATTAAGATGAGTCTGATCTTTTGATGTATTTTTGGCTGTTTGGGTGGTTTTTTG
CCATGCCGAAACAGCCTGAT

Product: nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MDYILDVIMSIPQSLLEQSIQINIQQALQEDIGDGDITAMLTPEDEQATATIITRENMILAGRPWVDALITRYDASVQIE
WLKQEGEQVAAGEAFLKLAGSARSLLTVERPALNFVQTLSAVATKAAFYVQQLEGLHTKLLDTRKTLPGLRIAQKYAVAL
GGGQNHRLGLFDAFLIKENHIMAAGGIAQAIEKAHQIAPGKPVEVEVETWDELDQALQAGADIVMLDNFSQQQMIEAVKY
VAGRCKLEASGNITLDNLREVASTGVDYISMGVLTKDVTAIDLSMRFNA

Sequences:

>Translated_289_residues
MDYILDVIMSIPQSLLEQSIQINIQQALQEDIGDGDITAMLTPEDEQATATIITRENMILAGRPWVDALITRYDASVQIE
WLKQEGEQVAAGEAFLKLAGSARSLLTVERPALNFVQTLSAVATKAAFYVQQLEGLHTKLLDTRKTLPGLRIAQKYAVAL
GGGQNHRLGLFDAFLIKENHIMAAGGIAQAIEKAHQIAPGKPVEVEVETWDELDQALQAGADIVMLDNFSQQQMIEAVKY
VAGRCKLEASGNITLDNLREVASTGVDYISMGVLTKDVTAIDLSMRFNA
>Mature_289_residues
MDYILDVIMSIPQSLLEQSIQINIQQALQEDIGDGDITAMLTPEDEQATATIITRENMILAGRPWVDALITRYDASVQIE
WLKQEGEQVAAGEAFLKLAGSARSLLTVERPALNFVQTLSAVATKAAFYVQQLEGLHTKLLDTRKTLPGLRIAQKYAVAL
GGGQNHRLGLFDAFLIKENHIMAAGGIAQAIEKAHQIAPGKPVEVEVETWDELDQALQAGADIVMLDNFSQQQMIEAVKY
VAGRCKLEASGNITLDNLREVASTGVDYISMGVLTKDVTAIDLSMRFNA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=268, Percent_Identity=34.7014925373134, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=57.4074074074074, Blast_Score=281, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=29.5373665480427, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31539; Mature: 31539

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYILDVIMSIPQSLLEQSIQINIQQALQEDIGDGDITAMLTPEDEQATATIITRENMIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCEEE
AGRPWVDALITRYDASVQIEWLKQEGEQVAAGEAFLKLAGSARSLLTVERPALNFVQTLS
ECCCHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHH
AVATKAAFYVQQLEGLHTKLLDTRKTLPGLRIAQKYAVALGGGQNHRLGLFDAFLIKENH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCEEHHHHEEEECCC
IMAAGGIAQAIEKAHQIAPGKPVEVEVETWDELDQALQAGADIVMLDNFSQQQMIEAVKY
EEEECHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
VAGRCKLEASGNITLDNLREVASTGVDYISMGVLTKDVTAIDLSMRFNA
HHHHEEEECCCCEEHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECC
>Mature Secondary Structure
MDYILDVIMSIPQSLLEQSIQINIQQALQEDIGDGDITAMLTPEDEQATATIITRENMIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCEEE
AGRPWVDALITRYDASVQIEWLKQEGEQVAAGEAFLKLAGSARSLLTVERPALNFVQTLS
ECCCHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHH
AVATKAAFYVQQLEGLHTKLLDTRKTLPGLRIAQKYAVALGGGQNHRLGLFDAFLIKENH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCEEHHHHEEEECCC
IMAAGGIAQAIEKAHQIAPGKPVEVEVETWDELDQALQAGADIVMLDNFSQQQMIEAVKY
EEEECHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
VAGRCKLEASGNITLDNLREVASTGVDYISMGVLTKDVTAIDLSMRFNA
HHHHEEEECCCCEEHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]