Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 161349957

GI number: 161349957

Start: 3309498

End: 3310091

Strand: Direct

Name: hisB

Synonym: ACIAD3395

Alternate gene names: 161349957

Gene position: 3309498-3310091 (Clockwise)

Preceding gene: 50086365

Following gene: 50086370

Centisome position: 91.97

GC content: 43.94

Gene sequence:

>594_bases
ATGACAGAACGTATCATTGAAGTGGTAAGAAATACCAATGAGACCAAGATTCGAGTTCGTTTAAACCTCGATGGGTCTGG
TCAGGGTACACTGAACACTGGAGTTCCATTTTTAGACCATATGATTGATCAAATCAAGCGACATGGCCTATTTGATATCG
ATATTCACTGTGATGGTGATTTGGAAATTGACGATCACCATACCGTGGAAGACTGTGGCATCACCCTCGGACAAGCTTTT
GCGCAGGCACTGGGTGATAAAAAAGGGTTACGCCGTTATGGACATTTTTATGCACCATTGGATGAATCACTATCGCGCGT
AGTCGTAGATCTGTCTGGTCGTCCAGGTTTATTTATGGATATTCCATTTACTCGCGCGCGTATCGGCAGCTTTGATGTGG
ATCTGTTCTCTGAATTTTTTCAGGGTTTTGTCAATCACGCATTGATGACGTTGCATATCGATAATCTTAAAGGCAAAAAC
AGCCATCACCAAATTGAAAGCGTGTTTAAAGCATTTGCACGTGCCTTACGTATGGCGTGTGAAATTGATCCTCGCGCGGC
TGGCAGCATTGCTTCAACCAAAGGGAGCCTGTAA

Upstream 100 bases:

>100_bases
TGATTAACCCTCCTGAGCAATCTATGATGCTGTCACTTTTTCGTCACAGCGAATTGATCTTTATATTCATCATTTTTGAC
GTTTTTTGAGGAACGTGTCC

Downstream 100 bases:

>100_bases
TAATGACCCGCATTGCCCTTCTTGATTATGGTATGGGAAATTTACACTCTGCTGCTAAAGCACTTGAGCATGTCGGGGCA
ACCGTAGATGTCACCAATGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTERIIEVVRNTNETKIRVRLNLDGSGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAF
AQALGDKKGLRRYGHFYAPLDESLSRVVVDLSGRPGLFMDIPFTRARIGSFDVDLFSEFFQGFVNHALMTLHIDNLKGKN
SHHQIESVFKAFARALRMACEIDPRAAGSIASTKGSL

Sequences:

>Translated_197_residues
MTERIIEVVRNTNETKIRVRLNLDGSGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAF
AQALGDKKGLRRYGHFYAPLDESLSRVVVDLSGRPGLFMDIPFTRARIGSFDVDLFSEFFQGFVNHALMTLHIDNLKGKN
SHHQIESVFKAFARALRMACEIDPRAAGSIASTKGSL
>Mature_196_residues
TERIIEVVRNTNETKIRVRLNLDGSGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAFA
QALGDKKGLRRYGHFYAPLDESLSRVVVDLSGRPGLFMDIPFTRARIGSFDVDLFSEFFQGFVNHALMTLHIDNLKGKNS
HHQIESVFKAFARALRMACEIDPRAAGSIASTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=47.6923076923077, Blast_Score=177, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=42.5339366515837, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_ACIAD (Q6F7A8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047879.2
- ProteinModelPortal:   Q6F7A8
- SMR:   Q6F7A8
- STRING:   Q6F7A8
- GeneID:   2878924
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3395
- NMPDR:   fig|62977.3.peg.3072
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q6F7A8
- ProtClustDB:   PRK00951
- BioCyc:   ASP62977:ACIAD3395-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21951; Mature: 21820

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERIIEVVRNTNETKIRVRLNLDGSGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGD
CHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
LEIDDHHTVEDCGITLGQAFAQALGDKKGLRRYGHFYAPLDESLSRVVVDLSGRPGLFMD
CEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEECCCCCCEEEE
IPFTRARIGSFDVDLFSEFFQGFVNHALMTLHIDNLKGKNSHHQIESVFKAFARALRMAC
CCHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
EIDPRAAGSIASTKGSL
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TERIIEVVRNTNETKIRVRLNLDGSGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGD
HHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
LEIDDHHTVEDCGITLGQAFAQALGDKKGLRRYGHFYAPLDESLSRVVVDLSGRPGLFMD
CEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEECCCCCCEEEE
IPFTRARIGSFDVDLFSEFFQGFVNHALMTLHIDNLKGKNSHHQIESVFKAFARALRMAC
CCHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
EIDPRAAGSIASTKGSL
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA