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The map label for this gene is murC

Identifier: 49481451

GI number: 49481451

Start: 4476822

End: 4478132

Strand: Reverse

Name: murC

Synonym: BT9727_4420

Alternate gene names: 49481451

Gene position: 4478132-4476822 (Counterclockwise)

Preceding gene: 49481452

Following gene: 49481444

Centisome position: 85.5

GC content: 37.91

Gene sequence:

>1311_bases
ATGACAGTTTACCATTTTGTAGGAATTAAAGGAACAGGAATGAGTTCATTAGCGCAAATTCTTCATGACATGAAGCATAC
TGTTCAAGGGTCTGATTATGAAAAGCGTTTCTTTACACAAACAGCGTTGGAAAAGCGTAGTATCTCGATTCTTCCTTTTG
ATAAAAGTAATGTAAAAGAAGGACAAGTGATTATTGCAGGAAATGCATTCCCTGATACGCATGAAGAAATCGTAGCAGCA
AAAGAATTAAACATCCCAGTACATCGTTACCATCACTTCTTAGGTGACCTTATGAACCAATACACAAGTGTTGCTGTAAC
TGGTGCGCATGGAAAAACATCAACAACTGGTTTGTTAGCCCATGTAATGCAAGGTGCACACCCTACATCTTACCTTATTG
GAGATGGAACAGGGCATGGGGTAGAAAATAGTAAGTATTTTGTATTTGAAGCTTGTGAGTATCGTCGTCATTTCTTGTCT
TACAATCCAGACTATGCAATTATGACAAACATTGATTTTGATCATCCAGATTATTTCACAGATATCAATGATGTATTCAG
TGCATTCCAAGAGATGGCATTGCAAGTGAAAAAAGGCATTATTGCATGTGGAGATGATGAAGAACTTCAAAAAATTCAAG
CGAAAGTACCTGTTATTTTCTATGGATTTGGAGAAGATAATGATTTCCAAGCACGTAACATTCAAAAGAGAACTGACGGT
ACTATTTTCGATGTATTCGTTCGTAATACGTACTATGACACGTTCAAAATTACAGGCTACGGCAACCACAGCGTATTAAA
TGCATTAGCAGTAATCGCACTTTGCCATTATGAAAACGTTGATGTAGAAGCAGTTAAGCATCAGTTAACAACTTTTGAAG
GTGTAAAACGTCGCTTTAATGAAAAGCCAATGGGAGAGCAAGTTATTATTGATGACTACGCACACCATCCGACAGAAATT
AATGCAACGATTGAAGCAGCTCGTCAAAAACATCCAGAGCGTGAAATTGTCGCTGTATTCCAGCCGCACACATTCTCACG
TACAGAAAAATTCTTAGATGAGTTCGCTGAAAGCCTAAGCAAAGCTGACCAAGTATACTTATGTGATATTTTCGGATCAG
CGCGCGAAAACAAAGGTGAATTAACAATTGAAGATCTACAAAAGCGTATTGACGGTGCAGAACTAATTACAGATACAACA
ACGGATGTATTAAAGAAACATAAAAACGGCGTTCTCATTTTCATGGGCGCAGGAGACATCCAAAAATTCGAAGCAGCTTA
CGTAAAAGAAGTTCAAGTTGCAGAGAAGTAA

Upstream 100 bases:

>100_bases
ACATCAAAAATGTATGATGATTACCAAAATAAGAAAAGATTCATATACTGTCTTATAGATAGGCCGTTGTATTAGTTCGA
AATGTTGGAGGTTCTTTAAG

Downstream 100 bases:

>100_bases
TAAAAAAGACGCATAGCGGTGGCTGTGCGTCTTTTTTGTTGTGTTCGATACGTTTAAAAAGCATCGATAGGTTGGTATTG
TTTATTCTTTTTGTAGAGTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRSISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAA
KELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLS
YNPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEI
NATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTT
TDVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK

Sequences:

>Translated_436_residues
MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRSISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAA
KELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLS
YNPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEI
NATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTT
TDVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK
>Mature_435_residues
TVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRSISILPFDKSNVKEGQVIIAGNAFPDTHEEIVAAK
ELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLAHVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSY
NPDYAIMTNIDFDHPDYFTDINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDGT
IFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFNEKPMGEQVIIDDYAHHPTEIN
ATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLSKADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTT
DVLKKHKNGVLIFMGAGDIQKFEAAYVKEVQVAEK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=470, Percent_Identity=29.3617021276596, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790680, Length=385, Percent_Identity=29.8701298701299, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49230; Mature: 49099

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRSISILPFDKSNVKE
CEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
GQVIIAGNAFPDTHEEIVAAKELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLA
CEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHH
HVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSYNPDYAIMTNIDFDHPDYFT
HHHHCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHC
DINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
CHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHCCC
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFN
CEEEEEEECCEECEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
EKPMGEQVIIDDYAHHPTEINATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLS
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTTDVLKKHKNGVLIFMGAGDI
CCCEEEEEEECCCCCCCCCCEEHHHHHHHCCCHHHHHCCHHHHHHHCCCCEEEEEECCCH
QKFEAAYVKEVQVAEK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVYHFVGIKGTGMSSLAQILHDMKHTVQGSDYEKRFFTQTALEKRSISILPFDKSNVKE
EEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
GQVIIAGNAFPDTHEEIVAAKELNIPVHRYHHFLGDLMNQYTSVAVTGAHGKTSTTGLLA
CEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHH
HVMQGAHPTSYLIGDGTGHGVENSKYFVFEACEYRRHFLSYNPDYAIMTNIDFDHPDYFT
HHHHCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHC
DINDVFSAFQEMALQVKKGIIACGDDEELQKIQAKVPVIFYGFGEDNDFQARNIQKRTDG
CHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHCCC
TIFDVFVRNTYYDTFKITGYGNHSVLNALAVIALCHYENVDVEAVKHQLTTFEGVKRRFN
CEEEEEEECCEECEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
EKPMGEQVIIDDYAHHPTEINATIEAARQKHPEREIVAVFQPHTFSRTEKFLDEFAESLS
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KADQVYLCDIFGSARENKGELTIEDLQKRIDGAELITDTTTDVLKKHKNGVLIFMGAGDI
CCCEEEEEEECCCCCCCCCCEEHHHHHHHCCCHHHHHCCHHHHHHHCCCCEEEEEECCCH
QKFEAAYVKEVQVAEK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA