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The map label for this gene is hbd

Identifier: 49480423

GI number: 49480423

Start: 5077263

End: 5078114

Strand: Reverse

Name: hbd

Synonym: BT9727_5027

Alternate gene names: 49480423

Gene position: 5078114-5077263 (Counterclockwise)

Preceding gene: 49481745

Following gene: 49481208

Centisome position: 96.95

GC content: 38.85

Gene sequence:

>852_bases
ATGGGTGTACAAAAAATTGTTGTAATTGGTGCAGGACAAATGGGGTCAGGAATTGCGCAAGTATGTGCAATGGCAGGATA
TGACGTGAAGGTACAAGATTTACAACAAGAGCAATTAGATAGAGGATTGGCTATCATTACGAAAAACTTAGCGCGCCAAG
TAGAAAAAGGACGCATGAAGGAAGAAGAGAAAGAAGCAACTTTAAATCGTCTTACAGTAACGCTTGATCTAGGTTGTGTG
AAGGAAGCGGATCTTATTATTGAAGCAGCTGTTGAGAAAATGGATATTAAAAAGAAAATCTTTGCAAATCTAGATGAAAT
TGCTCCAGAACACGCGATTTTAGCGACGAATACGTCATCCCTGCCAATTACAGAAATTGCCGCAGTAACGAAGCGCCCGG
AAAAAGTAATCGGTATGCACTTTATGAATCCCGTTCCGGTTATGAAACTTGTTGAAATTATTCGTGGTTTGGCTACAGAT
GATACGGTATACGAAACAATTGAAGATATTACGAAGAAGATTGGGAAAGTACCAGTTGAAGTGAATGATTTCCCAGGATT
TGTATCGAACCGTATTTTATTACCGATGATTAACGAAGCAATCTATACGTTATATGAAGGTGTAGCGACGAAAGAAGCGA
TTGATGAAGTAATGAAACTTGGTATGAATCACCCGATGGGCCCTTTAACACTCGCTGATTTTATCGGTTTAGATACATGT
TTATACATTATGGAAGTGTTACATGAAGGTTTAGGTGATAGTAAATATCGCCCATGTCCATTACTACGTAAGTACGTAAA
TGCAGGATGGTTAGGACGTAAAACAGGTCGTGGTTTCTACGTTTACGAATAA

Upstream 100 bases:

>100_bases
ATTTGTAGTGGTGGCGGTCAAGGCGATGCAGTGATGATTGAAGTTCACTAATTAAGATTAGAAGATATATAGTTTATTAA
AAATTAAGGGGGAAGAAGAA

Downstream 100 bases:

>100_bases
ATCCCCCTTTGTTACAAAATAGTGGTCTTACCAAATTGTTAAAAGGATATATAGCAAATGGAGGCGGAGTATATGAACTT
TCGTTTTAATGAAGAGCAAC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MGVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLQQEQLDRGLAIITKNLARQVEKGRMKEEEKEATLNRLTVTLDLGCV
KEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSSLPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATD
DTVYETIEDITKKIGKVPVEVNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKTGRGFYVYE

Sequences:

>Translated_283_residues
MGVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLQQEQLDRGLAIITKNLARQVEKGRMKEEEKEATLNRLTVTLDLGCV
KEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSSLPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATD
DTVYETIEDITKKIGKVPVEVNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKTGRGFYVYE
>Mature_282_residues
GVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLQQEQLDRGLAIITKNLARQVEKGRMKEEEKEATLNRLTVTLDLGCVK
EADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSSLPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATDD
TVYETIEDITKKIGKVPVEVNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTCL
YIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKTGRGFYVYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.9065743944637, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.3680781758958, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=39.3617021276596, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI68989263, Length=297, Percent_Identity=35.6902356902357, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI261878539, Length=297, Percent_Identity=35.6902356902357, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI115430219, Length=239, Percent_Identity=31.7991631799163, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=42.0494699646643, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=37.984496124031, Blast_Score=173, Evalue=9e-45,
Organism=Escherichia coli, GI1790281, Length=265, Percent_Identity=33.9622641509434, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=40.418118466899, Blast_Score=224, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.2777777777778, Blast_Score=220, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=40, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=39.1459074733096, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=39.1459074733096, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=39.1459074733096, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=38.0782918149466, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI71985923, Length=288, Percent_Identity=34.375, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=32.3843416370107, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=194, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=194, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=40.8450704225352, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=40.8450704225352, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=40.8450704225352, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI20129993, Length=228, Percent_Identity=29.3859649122807, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45549573, Length=245, Percent_Identity=26.530612244898, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31310; Mature: 31179

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLQQEQLDRGLAIITKNLARQVEKGRMK
CCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
EEEKEATLNRLTVTLDLGCVKEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSS
HHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEECCCC
LPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATDDTVYETIEDITKKIGKVPVE
CCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCE
VNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
ECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKTGRGFYVYE
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
GVQKIVVIGAGQMGSGIAQVCAMAGYDVKVQDLQQEQLDRGLAIITKNLARQVEKGRMK
CCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
EEEKEATLNRLTVTLDLGCVKEADLIIEAAVEKMDIKKKIFANLDEIAPEHAILATNTSS
HHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEECCCC
LPITEIAAVTKRPEKVIGMHFMNPVPVMKLVEIIRGLATDDTVYETIEDITKKIGKVPVE
CCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCE
VNDFPGFVSNRILLPMINEAIYTLYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
ECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMEVLHEGLGDSKYRPCPLLRKYVNAGWLGRKTGRGFYVYE
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]