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The map label for this gene is atoB

Identifier: 49481745

GI number: 49481745

Start: 5078164

End: 5079345

Strand: Reverse

Name: atoB

Synonym: BT9727_5028

Alternate gene names: 49481745

Gene position: 5079345-5078164 (Counterclockwise)

Preceding gene: 49480424

Following gene: 49480423

Centisome position: 96.98

GC content: 44.75

Gene sequence:

>1182_bases
ATGAGTAAAACAGTTATTTTAAGTGCTGCAAGAACACCGGTTGGAAAATTTGGAGGATCTTTAAAAGATGTAAAAGCAAC
AGAACTTGGAGGAATCGCAATTAAAGCAGCGCTTGAAAGAGCGAATGTTTCAGCTAGTGATGTTGAGGAAGTTATATTCG
GAACGGTTATTCAAGGTGGGCAGGGACAAATTCCATCGCGCCAAGCGGCACGGGCTGCTGGAATCCCTTGGGAAGTGCAG
ACGGAAACAGTCAATAAAGTTTGTGCATCAGGGCTTCGTGCGGTTACTTTAGCGGATCAAATTATTCGTACTGGCGACCA
ATCACTAATTGTAGCTGGCGGTATGGAGTCGATGAGTAACAGTCCTTACATTTTACGAGGAGCAAGATGGGGATACAGAA
TGGGTAACAACGAAGTCATTGATTTAAACGTTGCTGACGGTTTAACATGTGCATTTTCAGGTATACACATGGGTGTTTAT
GGCGGAGAAGTTGCGAAGGAGGATGGAATTTCTCGCGAAGCGCAAGATGAATGGGCATATCGTAGCCATCAGCGTGCGGT
TTCAGCACATAAAGAAGGACGTTTTGAAGAGGAAATCGTGCCAGTAACGATTCCACAAAGAAAAGGGGATCCTATTGTCG
TTGCAAAGGATGAGGCGCCGCGTGAAGATACAACAATTGAAAAGCTAGCAAAATTAAAACCTGTATTTGATAAGACAGCG
ACGGTAACAGCTGGTAATGCACCAGGGCTAAACGATGGTGGCGCTGCACTTGTATTAATGAGCGAAGAGAGAGCGAAGCA
AGAAGGAAGAAAGCCGTTAGCGACAATTTTGGCACATACAGCAATTGCAGTGGAGTCTAAAGATTTCCCGAGAACGCCAG
GTTATGCAATTAACGCATTGCTTGAAAAAACAGGCAAGACAATTGAAGACATTGATTTATTCGAGATTAATGAAGCATTT
GCAGCGGTAGCAATTGCAAGTACAGAAATCGCAGGAATTGACCCAGAAAAATTGAATGTAAATGGCGGCGCAGTGGCGAT
GGGACATCCGATTGGAGCAAGCGGAGCGCGCATTATCGTTACATTAATCCATGCACTTAAGCAACGCGGCGGTGGAATTG
GAATTGCTTCGATTTGTAGTGGTGGCGGTCAAGGCGATGCAGTGATGATTGAAGTTCACTAA

Upstream 100 bases:

>100_bases
GAATACAACTTTAGAGAGAGGTGCAATCATTGCACCTCTTCTCAGCGTAACAATGCCGAGCGAGCGCTCGGTGCTAAAAA
AAGAAATGGGGGAAAGAAAC

Downstream 100 bases:

>100_bases
TTAAGATTAGAAGATATATAGTTTATTAAAAATTAAGGGGGAAGAAGAAATGGGTGTACAAAAAATTGTTGTAATTGGTG
CAGGACAAATGGGGTCAGGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSASDVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQ
TETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILRGARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVY
GGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQRKGDPIVVAKDEAPREDTTIEKLAKLKPVFDKTA
TVTAGNAPGLNDGGAALVLMSEERAKQEGRKPLATILAHTAIAVESKDFPRTPGYAINALLEKTGKTIEDIDLFEINEAF
AAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHALKQRGGGIGIASICSGGGQGDAVMIEVH

Sequences:

>Translated_393_residues
MSKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSASDVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQ
TETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILRGARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVY
GGEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQRKGDPIVVAKDEAPREDTTIEKLAKLKPVFDKTA
TVTAGNAPGLNDGGAALVLMSEERAKQEGRKPLATILAHTAIAVESKDFPRTPGYAINALLEKTGKTIEDIDLFEINEAF
AAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHALKQRGGGIGIASICSGGGQGDAVMIEVH
>Mature_392_residues
SKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSASDVEEVIFGTVIQGGQGQIPSRQAARAAGIPWEVQT
ETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSNSPYILRGARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVYG
GEVAKEDGISREAQDEWAYRSHQRAVSAHKEGRFEEEIVPVTIPQRKGDPIVVAKDEAPREDTTIEKLAKLKPVFDKTAT
VTAGNAPGLNDGGAALVLMSEERAKQEGRKPLATILAHTAIAVESKDFPRTPGYAINALLEKTGKTIEDIDLFEINEAFA
AVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIVTLIHALKQRGGGIGIASICSGGGQGDAVMIEVH

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=47.4489795918367, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=48.0719794344473, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=39.1304347826087, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=38.1679389312977, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=33.2558139534884, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.4347826086957, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=50.2551020408163, Blast_Score=350, Evalue=7e-98,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=45.5242966751918, Blast_Score=337, Evalue=6e-94,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=37.75, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=35.8395989974937, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=31.219512195122, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=44.559585492228, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI133906874, Length=387, Percent_Identity=43.1524547803618, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=40.4580152671756, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=34.7319347319347, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=35.8585858585859, Blast_Score=207, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=45.5919395465995, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=35.929648241206, Blast_Score=206, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=47.3145780051151, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=45.4081632653061, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=39.9484536082474, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=31.4553990610329, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41151; Mature: 41020

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSASDVEEVIFGTVIQGG
CCCEEEEEECCCCHHHHCCCCCCCCHHHCCCCHHEEHHHHCCCCHHHHHHHHHHHHCCCC
QGQIPSRQAARAAGIPWEVQTETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSN
CCCCCCHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHCCC
SPYILRGARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAY
CCEEEEECCCCEECCCCCEEEEECCCCCEEEECCEEEEECCCCHHHHCCCCCHHHHHHHH
RSHQRAVSAHKEGRFEEEIVPVTIPQRKGDPIVVAKDEAPREDTTIEKLAKLKPVFDKTA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCHHHCCCE
TVTAGNAPGLNDGGAALVLMSEERAKQEGRKPLATILAHTAIAVESKDFPRTPGYAINAL
EEECCCCCCCCCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHH
LEKTGKTIEDIDLFEINEAFAAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIV
HHHHCCCCCCCCEEEHHHHHHEEEEECCEECCCCCCEEECCCCEEEECCCCCCCCHHHHH
TLIHALKQRGGGIGIASICSGGGQGDAVMIEVH
HHHHHHHHCCCCEEEHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
SKTVILSAARTPVGKFGGSLKDVKATELGGIAIKAALERANVSASDVEEVIFGTVIQGG
CCEEEEEECCCCHHHHCCCCCCCCHHHCCCCHHEEHHHHCCCCHHHHHHHHHHHHCCCC
QGQIPSRQAARAAGIPWEVQTETVNKVCASGLRAVTLADQIIRTGDQSLIVAGGMESMSN
CCCCCCHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHCCC
SPYILRGARWGYRMGNNEVIDLNVADGLTCAFSGIHMGVYGGEVAKEDGISREAQDEWAY
CCEEEEECCCCEECCCCCEEEEECCCCCEEEECCEEEEECCCCHHHHCCCCCHHHHHHHH
RSHQRAVSAHKEGRFEEEIVPVTIPQRKGDPIVVAKDEAPREDTTIEKLAKLKPVFDKTA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCHHHCCCE
TVTAGNAPGLNDGGAALVLMSEERAKQEGRKPLATILAHTAIAVESKDFPRTPGYAINAL
EEECCCCCCCCCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHH
LEKTGKTIEDIDLFEINEAFAAVAIASTEIAGIDPEKLNVNGGAVAMGHPIGASGARIIV
HHHHCCCCCCCCEEEHHHHHHEEEEECCEECCCCCCEEECCCCEEEECCCCCCCCHHHHH
TLIHALKQRGGGIGIASICSGGGQGDAVMIEVH
HHHHHHHHCCCCEEEHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]