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The map label for this gene is hssS [H]

Identifier: 49480108

GI number: 49480108

Start: 3094961

End: 3096337

Strand: Reverse

Name: hssS [H]

Synonym: BT9727_3012

Alternate gene names: 49480108

Gene position: 3096337-3094961 (Counterclockwise)

Preceding gene: 49478095

Following gene: 49478092

Centisome position: 59.12

GC content: 35.88

Gene sequence:

>1377_bases
ATGAAATCATTATATTCTAGATTTGTATTTATGACAGTCGGTATTATGCTACTTAGTAGTATTATCGGCTTTTTATTAAC
GAACGTATATTATCAAATGAAGTTAAAACCGTATAACAGCGAAAAGATTTTAAAGTATGCGGAAGAAGTTAAATCGTTAT
ATGAAAAGCAAAGCGAAGAAAATCAAGAGGCGTACTTACAATCTATTGCGAAGTTAGGGTATGAAATTTATATTGTAGAT
GATCAAAAGAATGGAAAGCGTATCGGCAATGCGTTTCGTAAGACGACGATAAGTGATGATACAATCCGTAAAGTGTTGAA
TGGCGAAACGTTTAATGGTGTTTCCACATATCCAACTCGTCTCTTTATTACCGGTTTTTTCGATAATGAATTAATAAATA
GTGTCGGTGTACCACTAAAGCACGGTGATAAACAGTACGCATTATTTATTCGCCCTGACATTCAAAACCAATTCGGCGAG
ATGCGAATTTTCTTAGCGGTATTACTTGGGTTTATCGTACTATTAAGTATTATTTTTATAGCGATTGCAGCAGGATATAT
CGTTCGTCCCATTCGTAAATTTACGAACGCGACGCAAAAAATTGCGAGTGGGGAATATGAAATTGAATTAGACGTAAAAC
GAAAAGATGAAATTGGTACGTTATCTACAAGCTTCCAAAAGATGACGAAAAGTATAAAAGAACTAGATGAAATGAGACAA
GAATTCGTTTCGAACGTTTCACATGAATTCCAGTCACCGCTTTCTTCTATACAAGGTTTTTCGAAGACATTACAAACAGA
AAAGATGAGCATGGAAGAAAGAAACCATTACTTACAAATTATTGAGGGCGAAAGTAAGCGAATGTCTAGTTTATGTAAAC
AGTTACTTACGCTAGCTTCATTAGATAAAGAAGAGAAAGTGTTGCAAATAAAAGAATTCAATTTGCAGAAGCAAATTAAA
GACGTCATTTTTATGCTCGAATGGAAATGGCGCGAGAAAGATATCGCTGTTGAATTTGATGTACCGGACATAACAATTCA
AGGTGATGAAAACTTACTTCATCAAGTATGGAGTAACATTTTCACGAATAGCATCAAGTTTTCAAATGAGGGTGGGACCA
TTGAGTTTTTTGTCGAAGAGTTAGAGTCTAGCGTTATAATCTCTATATCCGATAACGGAATCGGTATGGAAAAAGAAGAA
ATGGAACGTATTTTTGATCGCTTTTATAAGGTGGATACAGCAAGGGCAAGAAACGTAGAAGGCAGCGGTTTAGGATTATC
GATTGTGCAGAAGATTGTTGAACTGCATAACGGAAACGTTTCGGTATATAGCACGAAAGGGGAAGGGACTACTGTTCGGG
TGGAGCTTCCGAAATAG

Upstream 100 bases:

>100_bases
GTTCATGTGAAAAGGCTCCGAGATCGTTTCTCAAAACGAACGGATGATTTTCAAATTACGACAGTACGCGGACTCGGGTA
TAAGTTGGAGCTGAAATAAA

Downstream 100 bases:

>100_bases
ATGGAAGAGGCTGTTTGGGAACGGCCTCTTCTTTTTGTCGTTTTTTGTCGGTAAGTCGATATAATCGAAAAATCGCTGAT
ATAATTCGAGTTACGCCGAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQMKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVD
DQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTRLFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGE
MRIFLAVLLGFIVLLSIIFIAIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSMEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIK
DVIFMLEWKWREKDIAVEFDVPDITIQGDENLLHQVWSNIFTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEE
MERIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELPK

Sequences:

>Translated_458_residues
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQMKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVD
DQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTRLFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGE
MRIFLAVLLGFIVLLSIIFIAIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSMEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIK
DVIFMLEWKWREKDIAVEFDVPDITIQGDENLLHQVWSNIFTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEE
MERIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELPK
>Mature_458_residues
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQMKLKPYNSEKILKYAEEVKSLYEKQSEENQEAYLQSIAKLGYEIYIVD
DQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTRLFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGE
MRIFLAVLLGFIVLLSIIFIAIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSMEERNHYLQIIEGESKRMSSLCKQLLTLASLDKEEKVLQIKEFNLQKQIK
DVIFMLEWKWREKDIAVEFDVPDITIQGDENLLHQVWSNIFTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEE
MERIFDRFYKVDTARARNVEGSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELPK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=25.5474452554745, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786783, Length=338, Percent_Identity=27.5147928994083, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786600, Length=262, Percent_Identity=29.3893129770992, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=31.4655172413793, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=28.1512605042017, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=26.8382352941176, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790436, Length=339, Percent_Identity=25.9587020648968, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=25, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=25.5972696245734, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=20.7612456747405, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=25.6637168141593, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787894, Length=289, Percent_Identity=22.4913494809689, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789808, Length=292, Percent_Identity=23.2876712328767, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=28.1818181818182, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787374, Length=269, Percent_Identity=23.4200743494424, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=445, Percent_Identity=21.7977528089888, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789403, Length=285, Percent_Identity=25.2631578947368, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786912, Length=468, Percent_Identity=21.7948717948718, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=216, Percent_Identity=23.1481481481481, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=25.6944444444444, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52573; Mature: 52573

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQMKLKPYNSEKILKYAEEVKSLYEKQSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
NQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTR
HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCE
LFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI
EEEEECCCHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSMEERNHYLQIIEGESKRMSSLCKQLLTLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHH
LDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKDIAVEFDVPDITIQGDENLLHQVWSNI
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCEEEEECCHHHHHHHHHHH
FTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEEMERIFDRFYKVDTARARNVE
HHCCEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELPK
CCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MKSLYSRFVFMTVGIMLLSSIIGFLLTNVYYQMKLKPYNSEKILKYAEEVKSLYEKQSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
NQEAYLQSIAKLGYEIYIVDDQKNGKRIGNAFRKTTISDDTIRKVLNGETFNGVSTYPTR
HHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCE
LFITGFFDNELINSVGVPLKHGDKQYALFIRPDIQNQFGEMRIFLAVLLGFIVLLSIIFI
EEEEECCCHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAAGYIVRPIRKFTNATQKIASGEYEIELDVKRKDEIGTLSTSFQKMTKSIKELDEMRQ
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFVSNVSHEFQSPLSSIQGFSKTLQTEKMSMEERNHYLQIIEGESKRMSSLCKQLLTLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHH
LDKEEKVLQIKEFNLQKQIKDVIFMLEWKWREKDIAVEFDVPDITIQGDENLLHQVWSNI
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCEEEEECCHHHHHHHHHHH
FTNSIKFSNEGGTIEFFVEELESSVIISISDNGIGMEKEEMERIFDRFYKVDTARARNVE
HHCCEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GSGLGLSIVQKIVELHNGNVSVYSTKGEGTTVRVELPK
CCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA