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The map label for this gene is hssR [H]

Identifier: 49478095

GI number: 49478095

Start: 3096339

End: 3097016

Strand: Reverse

Name: hssR [H]

Synonym: BT9727_3013

Alternate gene names: 49478095

Gene position: 3097016-3096339 (Counterclockwise)

Preceding gene: 49478096

Following gene: 49480108

Centisome position: 59.13

GC content: 36.14

Gene sequence:

>678_bases
ATGAAGATGATACATATTTTATTAGCTGATGACGATAAACATATTAGAGAGTTGTTACATTACCATTTACAAAAAGAGGG
GTTTAAAGTTTTTGAGGCAGAAGATGGAAAGGTAGCGCAAGAAGTATTAGAGAAAGGAAATATTCATCTTGCGATCGTAG
ACATTATGATGCCGTTCGTTGATGGCTATACGTTATGTGAAGAAATTCGTAAATATCATGATATTCCTGTTATTTTATTA
ACGGCGAAAGATCAGTTAGTGGATAAAGAGAAAGGATTCATTTCTGGTACAGATGATTATATTGTGAAACCATTTGAACC
AGCTGAAGTCATTTTTCGTATGAAAGCTTTATTGCGCCGTTATCAAATGCTGAGTGCAGACATAATTACACTTCACGGGA
CAACAATTGATCGTAAAGGTGTTGAAGTAAAGTGTAATGGGCAGACGATTTTGCTTCCATTAAAGGAATTTGAGTTATTA
TCACAACTTGCTAGCTATCCTGGAAGAACATTTTCAAGAGAAGAGTTAATTGAACTAGTATGGGGAATGGATTTTGAAGG
GGATGAACGAACAGTTGATGTTCATGTGAAAAGGCTCCGAGATCGTTTCTCAAAACGAACGGATGATTTTCAAATTACGA
CAGTACGCGGACTCGGGTATAAGTTGGAGCTGAAATAA

Upstream 100 bases:

>100_bases
TATTTTGAATCATCTGTTTTCAAAATAGATTCTTTTTCTTGCAAAAAATCCAATTGTTTCTTAATGTAGTGATGTAGAAG
GATGAACAAGAGAGGGTTTA

Downstream 100 bases:

>100_bases
AATGAAATCATTATATTCTAGATTTGTATTTATGACAGTCGGTATTATGCTACTTAGTAGTATTATCGGCTTTTTATTAA
CGAACGTATATTATCAAATG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKMIHILLADDDKHIRELLHYHLQKEGFKVFEAEDGKVAQEVLEKGNIHLAIVDIMMPFVDGYTLCEEIRKYHDIPVILL
TAKDQLVDKEKGFISGTDDYIVKPFEPAEVIFRMKALLRRYQMLSADIITLHGTTIDRKGVEVKCNGQTILLPLKEFELL
SQLASYPGRTFSREELIELVWGMDFEGDERTVDVHVKRLRDRFSKRTDDFQITTVRGLGYKLELK

Sequences:

>Translated_225_residues
MKMIHILLADDDKHIRELLHYHLQKEGFKVFEAEDGKVAQEVLEKGNIHLAIVDIMMPFVDGYTLCEEIRKYHDIPVILL
TAKDQLVDKEKGFISGTDDYIVKPFEPAEVIFRMKALLRRYQMLSADIITLHGTTIDRKGVEVKCNGQTILLPLKEFELL
SQLASYPGRTFSREELIELVWGMDFEGDERTVDVHVKRLRDRFSKRTDDFQITTVRGLGYKLELK
>Mature_225_residues
MKMIHILLADDDKHIRELLHYHLQKEGFKVFEAEDGKVAQEVLEKGNIHLAIVDIMMPFVDGYTLCEEIRKYHDIPVILL
TAKDQLVDKEKGFISGTDDYIVKPFEPAEVIFRMKALLRRYQMLSADIITLHGTTIDRKGVEVKCNGQTILLPLKEFELL
SQLASYPGRTFSREELIELVWGMDFEGDERTVDVHVKRLRDRFSKRTDDFQITTVRGLGYKLELK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=34.375, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=33.7899543378995, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=33.1896551724138, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=34.070796460177, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.0357142857143, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=34.8623853211009, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.4978165938865, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.7433628318584, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.2869955156951, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=35.2422907488987, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=34.841628959276, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=28.3185840707965, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=27.9475982532751, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=29.8507462686567, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26139; Mature: 26139

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMIHILLADDDKHIRELLHYHLQKEGFKVFEAEDGKVAQEVLEKGNIHLAIVDIMMPFV
CCEEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCEEEEHHHHHHHHH
DGYTLCEEIRKYHDIPVILLTAKDQLVDKEKGFISGTDDYIVKPFEPAEVIFRMKALLRR
CHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
YQMLSADIITLHGTTIDRKGVEVKCNGQTILLPLKEFELLSQLASYPGRTFSREELIELV
HHHHHCCEEEEECCEECCCCCEEEECCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
WGMDFEGDERTVDVHVKRLRDRFSKRTDDFQITTVRGLGYKLELK
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEC
>Mature Secondary Structure
MKMIHILLADDDKHIRELLHYHLQKEGFKVFEAEDGKVAQEVLEKGNIHLAIVDIMMPFV
CCEEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCEEEEHHHHHHHHH
DGYTLCEEIRKYHDIPVILLTAKDQLVDKEKGFISGTDDYIVKPFEPAEVIFRMKALLRR
CHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
YQMLSADIITLHGTTIDRKGVEVKCNGQTILLPLKEFELLSQLASYPGRTFSREELIELV
HHHHHCCEEEEECCEECCCCCEEEECCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
WGMDFEGDERTVDVHVKRLRDRFSKRTDDFQITTVRGLGYKLELK
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA