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The map label for this gene is vanR [H]

Identifier: 49478884

GI number: 49478884

Start: 4852151

End: 4852855

Strand: Reverse

Name: vanR [H]

Synonym: BT9727_4801

Alternate gene names: 49478884

Gene position: 4852855-4852151 (Counterclockwise)

Preceding gene: 49478886

Following gene: 49478883

Centisome position: 92.65

GC content: 35.18

Gene sequence:

>705_bases
ATGAGTAAAGAAACAATCATGGTAGTGGATGATGAGAAGGAGATTCGAGAACTCATCGCCATCTATTTAAAAAATGAGGG
CTATAGGGTCTTGCAAGCTGAAAATGGAGAAGAAGGGTTAGAACTACTAAAGAAAAACGAAGTGCACTTAATTGTCCTTG
ATATTATGATGCCCAAAATTGATGGTATCCACATGTGTATGAAGGTGCGAGAAATAGCAGAAATGCCTATTATTATGTTA
TCTGCAAAAACGCAAGATATGGATAAAATTTTAGGGCTAACAACGGGTGCAGATGACTATGTTACAAAGCCTTTTAATCC
ATTAGAACTCATTGCTCGAATTAAGTCACAGCTTAGAAGATACATGAAAATGAATGGTGGAATAAGTGCACAAAATGAAA
ATGAAGTTGAAATTGGAGATATGAAAATCAATGTAACCACACATAAAGTAACTATCGCTGATCAAGAAGTAAAATTAACT
CCGAGGGAGTTTGCTATTTTAGAATTGCTTGCTCGCAATCAAGGGATGGTAATGAGTGCAGAACAAATTTATGAAAGAGT
GTGGAAAGAGGAAGCTTTTCAATCTGATAATACCGTGATGGTACATATTCGGAAAATACGTGAAAAAATTGAAGAAAACC
CGAGAAAACCTCGGTACGTTAAAACTGTTTGGGGAGTAGGATATAAAATTGAAAAAGATATTTAA

Upstream 100 bases:

>100_bases
TCGTTGCTTGTATTTGGTATGTATGTATACAAAAACGAAGTACTACGGTAAGTAAATAGAGAAAAGCATAAGTTTTGGAA
ATTACATCGGAGGAGATTTT

Downstream 100 bases:

>100_bases
ATTATTTCATCCTTTGAATAATAAAATTAAAAGGATGTATAAAAAATTGCAATGTTATATTTTAAAAAGTATTAGAATAC
AGCTCATTACAACCTTTTTT

Product: response regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSKETIMVVDDEKEIRELIAIYLKNEGYRVLQAENGEEGLELLKKNEVHLIVLDIMMPKIDGIHMCMKVREIAEMPIIML
SAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGGISAQNENEVEIGDMKINVTTHKVTIADQEVKLT
PREFAILELLARNQGMVMSAEQIYERVWKEEAFQSDNTVMVHIRKIREKIEENPRKPRYVKTVWGVGYKIEKDI

Sequences:

>Translated_234_residues
MSKETIMVVDDEKEIRELIAIYLKNEGYRVLQAENGEEGLELLKKNEVHLIVLDIMMPKIDGIHMCMKVREIAEMPIIML
SAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGGISAQNENEVEIGDMKINVTTHKVTIADQEVKLT
PREFAILELLARNQGMVMSAEQIYERVWKEEAFQSDNTVMVHIRKIREKIEENPRKPRYVKTVWGVGYKIEKDI
>Mature_233_residues
SKETIMVVDDEKEIRELIAIYLKNEGYRVLQAENGEEGLELLKKNEVHLIVLDIMMPKIDGIHMCMKVREIAEMPIIMLS
AKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRRYMKMNGGISAQNENEVEIGDMKINVTTHKVTIADQEVKLTP
REFAILELLARNQGMVMSAEQIYERVWKEEAFQSDNTVMVHIRKIREKIEENPRKPRYVKTVWGVGYKIEKDI

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=38.4279475982533, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.8888888888889, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=34.6491228070175, Blast_Score=148, Evalue=2e-37,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=32.4561403508772, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=35.0877192982456, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=32.7433628318584, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=32.1888412017167, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=31.9327731092437, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.4978165938865, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=31.858407079646, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=31.5789473684211, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=28.9473684210526, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=29.5652173913043, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=30.5676855895196, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=32.0754716981132, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=30.8943089430894, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=31.3725490196078, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=32, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27094; Mature: 26963

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKETIMVVDDEKEIRELIAIYLKNEGYRVLQAENGEEGLELLKKNEVHLIVLDIMMPKI
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCEEEEEEEEECCCC
DGIHMCMKVREIAEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRR
CHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YMKMNGGISAQNENEVEIGDMKINVTTHKVTIADQEVKLTPREFAILELLARNQGMVMSA
HHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEEECCCEEECHHHHHHHHHHHCCCCCEECH
EQIYERVWKEEAFQSDNTVMVHIRKIREKIEENPRKPRYVKTVWGVGYKIEKDI
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCEEEHHHCCCEEEECCC
>Mature Secondary Structure 
SKETIMVVDDEKEIRELIAIYLKNEGYRVLQAENGEEGLELLKKNEVHLIVLDIMMPKI
CCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCEEEEEEEEECCCC
DGIHMCMKVREIAEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELIARIKSQLRR
CHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YMKMNGGISAQNENEVEIGDMKINVTTHKVTIADQEVKLTPREFAILELLARNQGMVMSA
HHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEEECCCEEECHHHHHHHHHHHCCCCCEECH
EQIYERVWKEEAFQSDNTVMVHIRKIREKIEENPRKPRYVKTVWGVGYKIEKDI
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCEEEHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]