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The map label for this gene is mutS2 [H]

Identifier: 49478686

GI number: 49478686

Start: 4349921

End: 4352281

Strand: Reverse

Name: mutS2 [H]

Synonym: BT9727_4285

Alternate gene names: 49478686

Gene position: 4352281-4349921 (Counterclockwise)

Preceding gene: 49478687

Following gene: 49478685

Centisome position: 83.1

GC content: 38.92

Gene sequence:

>2361_bases
ATGTTAGAAAGAACGTTGCGTGTATTAGAATATAATAAAGTAAAAGAACAATTACTTGAACATACAGCATCTTCACTTGG
TCGTGACAAAGTGAAGAACTTAGTGCCGAGCACTGATTTTGAAGAAATTGTAGAGATGCAAGATACAACGGATGAAGCAG
CGAAAGTCATTCGTTTAAAAGGTAGTGCACCGTTAGGTGGTATTACAGATATTCGCTCAAATGTGAAGCGTGCAAAGATT
GGAAGTATGCTAAGTCCAAATGAACTACTTGATATTGCGAATACGATGTATGGTAGTCGCAATATGAAACGTTTCATTGA
AGATATGGTTGATAATGGTGTCGAGCTTCCCATTTTAGAAACTCATGTCGCCCAAATTGTATCTTTATATGATTTAGAAA
AGAAAATTACAAATTGCATCGGTGACGGCGGTGAAGTAGTCGATAGCGCAAGTGATAAACTGCGCGGTATTCGTACTCAA
ATTCGTACTGCAGAAAGCCGTATTCGTGAAAAGTTAGAAAACATGACGCGTTCTTCAAACTCGCAAAAGATGCTGTCTGA
CTCGATTGTAACGATTCGTAACGAACGTTACGTAATCCCAGTAAAACAAGAATACCGCGGTGTATATGGCGGTATTGTTC
ACGATCAATCGGCTTCTGGACAAACATTATTTATTGAACCACAAGTCATTGTAGAATTAAATAACGCGCTTCAAGAAGCA
CGTGTGAAAGAAAAACAAGAAATCGAACGCATCTTATTAATGTTAACAGAAGAAGTGGCAGTAGAAGCGGATATCGTTTT
ATCAAACGTAGAAGTAGTTGCAAATCTTGATTTCATCTTTGCGAAAGCTTTTTATGCGAAGCGTATTAAAGCAACCAAGC
CAATCGTAAATAACGAGCGTTATATGGATTTAAGACAGGCACGTCATCCGCTTATTGATCCAGAAGTTATCGTGCCAAAT
AACATTATGTTAGGTAAAGATTTCACGACAATTGTTATTACAGGACCGAATACAGGTGGTAAAACAGTTACGCTGAAAAC
AGTTGGTATTTGTGTATTAATGGCGCAATCTGGTCTTCACATTCCAGTAATGGATGAGTCAGAGATTTGTGTATTTAAAA
ATATATTTGCTGATATCGGTGATGAGCAATCGATTGAACAAAGTTTAAGTACGTTCTCCTCACATATGGTGAACATTGTT
GATATTTTAGAAAAAGCTGATTTTGAAAGCTTAGTTTTATTCGATGAATTAGGTGCTGGAACAGACCCGCAAGAAGGGGC
TGCACTTGCCATTTCAATTTTAGATGAAGTATGTAATCGCGGTGCTCGCGTTGTTGCTACGACGCATTACCCAGAATTAA
AAGCATACGGATATAACCGTGAGCAAGTTATTAATGCGAGTGTTGAGTTCGATGTAAATACATTAAGCCCAACGTATAAA
TTATTAATCGGTGTACCAGGACGTAGTAATGCCTTTGAAATTTCGAAACGTCTTGGATTATCTGATCGCGTCATTGATCA
AGCTCGTAACCACATTAGTACAGATACAAATAAAATTGAAAATATGATTGCGAAGTTAGAAGAAAGTCAAAAAAATGCAG
AGCGTGACTGGAACGAAGCAGAAGCACTTCGCAAGCAATCTGAAAAACTGCACCGCGAATTACAACGTCAAATCATTGAA
TTTAACGAAGAGCGTGATGAACGATTATTAAAAGCGCAAAAAGAAGGGGAAGAAAAAGTCGAAGCTGCAAAGAAAGAAGC
AGAAGGCATTATTCAAGAACTTCGTCAATTGCGTAAAGCACAGCTTGCAAACGTGAAAGATCACGAGCTAATTGAAGCGA
AGAGCCGTCTAGAAGGCGCAGCACCAGAGCTTGTGAAGAAACAAAAAGTAAACGTGAAAAATACTGCGCCGAAACAACAG
TTACGCGCAGGTGATGAAGTAAAAGTATTAACGTTCGGTCAAAAAGGTCAATTGCTTGAAAAAGTAAGTGATACAGAGTG
GAGCGTACAAATTGGTATTCTGAAGATGAAAGTAAAAGAATCTAATATGGAATACATTAATACACCGAAACAAACAGAGA
AAAAAGCAGTTGCAACAGTAAAAGGTAGAGACTATCATGTTTCGCTAGAGCTTGATCTTCGTGGTGAACGATTTGAAAAT
GCAATGGCGCGCGTTGAGAAATACTTAGACGATGCCCAGCTTGCAAGCTATCCTCGTGTATCAATCATTCACGGTAAAGG
AACAGGAGCACTTCGCCAAGGTGTTCAAGATTACTTGAAGAAGCACCGCGGTGTAAAAACATTCCGTTACGGTGACATGG
GCGAGGGAGGCCTAGGCGTAACAGTTGTCGAATTAAAATAG

Upstream 100 bases:

>100_bases
AAGGGTTGGATTCAAAAAGATAACGTAATTAACACGTGGGATATTGAACGTTTATTAGACTATATTAAACGTAATAAGTA
ACACAAGGGGGACCTGCAAC

Downstream 100 bases:

>100_bases
AAAACAACGAAACAAAGGGGAAACCATTATATGTTTATGGACAAACTTGCAAAAGTATTGTTAGCTTGTTGTGGAATATT
TTTGGTGATTGGGGTTATTT

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKNLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKI
GSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQ
IRTAESRIREKLENMTRSSNSQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPN
NIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTYK
LLIGVPGRSNAFEISKRLGLSDRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQ
LRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK

Sequences:

>Translated_786_residues
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKNLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKI
GSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQ
IRTAESRIREKLENMTRSSNSQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPN
NIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTYK
LLIGVPGRSNAFEISKRLGLSDRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQ
LRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK
>Mature_786_residues
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKNLVPSTDFEEIVEMQDTTDEAAKVIRLKGSAPLGGITDIRSNVKRAKI
GSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILETHVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQ
IRTAESRIREKLENMTRSSNSQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNERYMDLRQARHPLIDPEVIVPN
NIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTYK
LLIGVPGRSNAFEISKRLGLSDRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEAEALRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQ
LRAGDEVKVLTFGQKGQLLEKVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGVTVVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=591, Percent_Identity=25.5499153976311, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4504191, Length=309, Percent_Identity=27.1844660194175, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4557761, Length=250, Percent_Identity=29.2, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI36949366, Length=227, Percent_Identity=28.1938325991189, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI26638666, Length=290, Percent_Identity=28.2758620689655, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI4505253, Length=290, Percent_Identity=28.2758620689655, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI26638664, Length=294, Percent_Identity=28.2312925170068, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI262231786, Length=218, Percent_Identity=30.2752293577982, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1789089, Length=333, Percent_Identity=27.027027027027, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=363, Percent_Identity=26.1707988980716, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17534743, Length=341, Percent_Identity=26.099706744868, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17539736, Length=271, Percent_Identity=25.4612546125461, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=278, Percent_Identity=25.8992805755396, Blast_Score=76, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=299, Percent_Identity=27.4247491638796, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=248, Percent_Identity=29.0322580645161, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321912, Length=319, Percent_Identity=25.3918495297806, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321109, Length=268, Percent_Identity=29.4776119402985, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=268, Percent_Identity=26.865671641791, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320047, Length=260, Percent_Identity=25.3846153846154, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664545, Length=270, Percent_Identity=29.6296296296296, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24584320, Length=280, Percent_Identity=27.8571428571429, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88210; Mature: 88210

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKNLVPSTDFEEIVEMQDTTDEAAKVIRLK
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHCCHHHHHHEEEEE
GSAPLGGITDIRSNVKRAKIGSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILE
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
THVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQIRTAESRIREKLENMTRSSN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
CHHHHHCCCEEEECCEEEEECHHHHCCHHCCEEECCCCCCCEEEECCHHEEHHHHHHHHH
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNER
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
YMDLRQARHPLIDPEVIVPNNIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLH
HHHHHHHCCCCCCCCEECCCCEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCE
IPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAG
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCC
TDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTYK
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCHHHEEEEEEEEEECCCCCEEE
LLIGVPGRSNAFEISKRLGLSDRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEA
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
EALRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
QLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQLRAGDEVKVLTFGQKGQLLE
HHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCCHHHH
KVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
HHCCCCEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHEEECCCEEEEEEEEECCCHHHHH
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGV
HHHHHHHHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCE
TVVELK
EEEEEC
>Mature Secondary Structure
MLERTLRVLEYNKVKEQLLEHTASSLGRDKVKNLVPSTDFEEIVEMQDTTDEAAKVIRLK
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHCCHHHHHHEEEEE
GSAPLGGITDIRSNVKRAKIGSMLSPNELLDIANTMYGSRNMKRFIEDMVDNGVELPILE
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
THVAQIVSLYDLEKKITNCIGDGGEVVDSASDKLRGIRTQIRTAESRIREKLENMTRSSN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SQKMLSDSIVTIRNERYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
CHHHHHCCCEEEECCEEEEECHHHHCCHHCCEEECCCCCCCEEEECCHHEEHHHHHHHHH
RVKEKQEIERILLMLTEEVAVEADIVLSNVEVVANLDFIFAKAFYAKRIKATKPIVNNER
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
YMDLRQARHPLIDPEVIVPNNIMLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLH
HHHHHHHCCCCCCCCEECCCCEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCE
IPVMDESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAG
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCC
TDPQEGAALAISILDEVCNRGARVVATTHYPELKAYGYNREQVINASVEFDVNTLSPTYK
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCHHHEEEEEEEEEECCCCCEEE
LLIGVPGRSNAFEISKRLGLSDRVIDQARNHISTDTNKIENMIAKLEESQKNAERDWNEA
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
EALRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEGIIQELRQLRKA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
QLANVKDHELIEAKSRLEGAAPELVKKQKVNVKNTAPKQQLRAGDEVKVLTFGQKGQLLE
HHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCCHHHH
KVSDTEWSVQIGILKMKVKESNMEYINTPKQTEKKAVATVKGRDYHVSLELDLRGERFEN
HHCCCCEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHEEECCCEEEEEEEEECCCHHHHH
AMARVEKYLDDAQLASYPRVSIIHGKGTGALRQGVQDYLKKHRGVKTFRYGDMGEGGLGV
HHHHHHHHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCE
TVVELK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA