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The map label for this gene is ffh [H]

Identifier: 49476256

GI number: 49476256

Start: 1847424

End: 1848995

Strand: Reverse

Name: ffh [H]

Synonym: BH16040

Alternate gene names: 49476256

Gene position: 1848995-1847424 (Counterclockwise)

Preceding gene: 49476257

Following gene: 49476255

Centisome position: 95.75

GC content: 44.15

Gene sequence:

>1572_bases
ATGTTTGAATCCTTACAAGAACGCCTTGGCTTCATCCTGTCTCATTTAACAGGGCGTGGTGCTTTGTCGGATCAGGATGT
CGCAGCGGCACTGCGAGAAATTCGTCGCGCTTTGTTAGAGGCCGATGTTGCACTTGATGTCGCACGTTCTTTTACTGATA
GGGTTCGTGAAAAAGCTGTTGGGTCTGCAATTGTTAAATCAATTAAACCTGGTCAGATGGTTGTTAAGATCGTTCATGAC
GAGCTGGTTCATGTGCTTGGAAATGAAGGCGTTCTGAGTGATCTAAACGCACCAGCACCTGTTGTTATCATGATGATTGG
TTTACAGGGTTCTGGAAAAACAACAACAACAGCAAAGTTGGCAAAGCGTTTAACCCATAAGCACAATAAAAAAGTTCTCA
TGGCCTCGTTAGATACACGTCGTCCTGCAGCACAGGAACAACTGCGTCAATTAGGAGAACAGGCAAAGCTTGCAAGCTTG
CCCATTATTGCAGGACAGTCCCCCGTCGATATCGCAACACGTGCGGTACAGGCAGCTAAACTTAGCGGTTATGATGTCCT
GCTTCTTGATACGGCAGGGCGTAATCATATTGATGAAGCTTTGATGCTTGAATTAGTTGAAATTAAAGCTTGTTGCCGTC
CTCATGAAATTATGTTGGTTGCTGATAGCCTGACTGGTCAGGATGCTGTCCATCTAGCACGTTCTTTTGATGAGCGTGTG
GGAATTACAGGAATTATTTTAACACGTATGGATAGTGATGGACGCGGTGGAGCCGCCCTTTCAATGCGTGCTGTAACGGG
AAAGCCGATAAAAGCAATCGGAATTGGGGAAAAAATAGACGATTTGGAAGAATTTCATCCTACTCGTATTGCTGATCGTA
TTCTCGGAATGGGTGATATTGTTTCTTTGGTGGAAAAAGCTGCTGAAACAATGGATCATGAGAAGGCAGCTGCTTTTGCA
AAAAAGATGCAAGCCGGAAAATTTGATCTTAATGATCTAGCAGATCAGTTGCAAAAAATGAAAAAACTTGGCGGGATGGG
GGGCATTATGGGAATGTTGCCCGGTTTGGGAAAGGTAAAAGATCAAATTGCTGCTGCCGGTCTTGATGATAGTTTGTTTA
ATCGTCAATTGGCTATTATTTCGTCAATGACGCCTTTAGAACGCGCCAATCCGGAATTGTTGAAACATAGCCGTAAACAA
CGAATCGCTAAGGGCTCTGGAACAAGTGCTGCTGATATTAATAAGCTTTTAAAAATGCATCGCCAAATGGCGGATATGGT
GAAAGCCATAGGAGGTAAAGGGAAAAGCAGTTTAATGGGAAAAATGTTTGGAGCACTTGGATCTAAAATGGGCCTTGGGG
GAATGGGAGCTTTGGGAAAAGATCCTGGAGCTCTGCCTGATTTATCGGAGTTTGATCCAAAGCAACTTTCAAAACTTCAA
AAGCAGATAGAAAGTGGTCATGGGGGGAATGTATTACCCGGTCTTCCGGGGCGTGGGCCTACATTTCCTGGTTTTTCCAA
TGGTCCTGCCGATAGAGGGGTAAATTTTCCTCAGCATCTCAAGAAAAAATAA

Upstream 100 bases:

>100_bases
TAATAAGGGTATAAAGAGATCTCAGAGGTCAACATCCGACGGCGCGGTGCGTTCTCGGATGCTGCTTTGGTTGGTTTGTT
ATGCAGCAATGAGGTAAATG

Downstream 100 bases:

>100_bases
GATGCAAAGAGGGAAGGAAGTATGATGCAGGAAAAAATATTGAGTGAATTGGCGTATTTACGACAATCTATTGATAATTT
TGATATCACGTTAATTCATA

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MFESLQERLGFILSHLTGRGALSDQDVAAALREIRRALLEADVALDVARSFTDRVREKAVGSAIVKSIKPGQMVVKIVHD
ELVHVLGNEGVLSDLNAPAPVVIMMIGLQGSGKTTTTAKLAKRLTHKHNKKVLMASLDTRRPAAQEQLRQLGEQAKLASL
PIIAGQSPVDIATRAVQAAKLSGYDVLLLDTAGRNHIDEALMLELVEIKACCRPHEIMLVADSLTGQDAVHLARSFDERV
GITGIILTRMDSDGRGGAALSMRAVTGKPIKAIGIGEKIDDLEEFHPTRIADRILGMGDIVSLVEKAAETMDHEKAAAFA
KKMQAGKFDLNDLADQLQKMKKLGGMGGIMGMLPGLGKVKDQIAAAGLDDSLFNRQLAIISSMTPLERANPELLKHSRKQ
RIAKGSGTSAADINKLLKMHRQMADMVKAIGGKGKSSLMGKMFGALGSKMGLGGMGALGKDPGALPDLSEFDPKQLSKLQ
KQIESGHGGNVLPGLPGRGPTFPGFSNGPADRGVNFPQHLKKK

Sequences:

>Translated_523_residues
MFESLQERLGFILSHLTGRGALSDQDVAAALREIRRALLEADVALDVARSFTDRVREKAVGSAIVKSIKPGQMVVKIVHD
ELVHVLGNEGVLSDLNAPAPVVIMMIGLQGSGKTTTTAKLAKRLTHKHNKKVLMASLDTRRPAAQEQLRQLGEQAKLASL
PIIAGQSPVDIATRAVQAAKLSGYDVLLLDTAGRNHIDEALMLELVEIKACCRPHEIMLVADSLTGQDAVHLARSFDERV
GITGIILTRMDSDGRGGAALSMRAVTGKPIKAIGIGEKIDDLEEFHPTRIADRILGMGDIVSLVEKAAETMDHEKAAAFA
KKMQAGKFDLNDLADQLQKMKKLGGMGGIMGMLPGLGKVKDQIAAAGLDDSLFNRQLAIISSMTPLERANPELLKHSRKQ
RIAKGSGTSAADINKLLKMHRQMADMVKAIGGKGKSSLMGKMFGALGSKMGLGGMGALGKDPGALPDLSEFDPKQLSKLQ
KQIESGHGGNVLPGLPGRGPTFPGFSNGPADRGVNFPQHLKKK
>Mature_523_residues
MFESLQERLGFILSHLTGRGALSDQDVAAALREIRRALLEADVALDVARSFTDRVREKAVGSAIVKSIKPGQMVVKIVHD
ELVHVLGNEGVLSDLNAPAPVVIMMIGLQGSGKTTTTAKLAKRLTHKHNKKVLMASLDTRRPAAQEQLRQLGEQAKLASL
PIIAGQSPVDIATRAVQAAKLSGYDVLLLDTAGRNHIDEALMLELVEIKACCRPHEIMLVADSLTGQDAVHLARSFDERV
GITGIILTRMDSDGRGGAALSMRAVTGKPIKAIGIGEKIDDLEEFHPTRIADRILGMGDIVSLVEKAAETMDHEKAAAFA
KKMQAGKFDLNDLADQLQKMKKLGGMGGIMGMLPGLGKVKDQIAAAGLDDSLFNRQLAIISSMTPLERANPELLKHSRKQ
RIAKGSGTSAADINKLLKMHRQMADMVKAIGGKGKSSLMGKMFGALGSKMGLGGMGALGKDPGALPDLSEFDPKQLSKLQ
KQIESGHGGNVLPGLPGRGPTFPGFSNGPADRGVNFPQHLKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=432, Percent_Identity=32.4074074074074, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI226371618, Length=338, Percent_Identity=34.9112426035503, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI23308697, Length=306, Percent_Identity=28.7581699346405, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI295424842, Length=306, Percent_Identity=28.7581699346405, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=35.9154929577465, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=51.1792452830189, Blast_Score=424, Evalue=1e-119,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=37.4015748031496, Blast_Score=145, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=414, Percent_Identity=31.8840579710145, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=31.986531986532, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=481, Percent_Identity=31.1850311850312, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=317, Percent_Identity=27.1293375394322, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17647949, Length=429, Percent_Identity=31.4685314685315, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24641198, Length=321, Percent_Identity=28.0373831775701, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 55772; Mature: 55772

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLQERLGFILSHLTGRGALSDQDVAAALREIRRALLEADVALDVARSFTDRVREKAV
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSAIVKSIKPGQMVVKIVHDELVHVLGNEGVLSDLNAPAPVVIMMIGLQGSGKTTTTAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEEEECCCCCCCHHHHHH
AKRLTHKHNKKVLMASLDTRRPAAQEQLRQLGEQAKLASLPIIAGQSPVDIATRAVQAAK
HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHH
LSGYDVLLLDTAGRNHIDEALMLELVEIKACCRPHEIMLVADSLTGQDAVHLARSFDERV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHC
GITGIILTRMDSDGRGGAALSMRAVTGKPIKAIGIGEKIDDLEEFHPTRIADRILGMGDI
CCEEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCHHHHHHHHHCHHHH
VSLVEKAAETMDHEKAAAFAKKMQAGKFDLNDLADQLQKMKKLGGMGGIMGMLPGLGKVK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHH
DQIAAAGLDDSLFNRQLAIISSMTPLERANPELLKHSRKQRIAKGSGTSAADINKLLKMH
HHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RQMADMVKAIGGKGKSSLMGKMFGALGSKMGLGGMGALGKDPGALPDLSEFDPKQLSKLQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
KQIESGHGGNVLPGLPGRGPTFPGFSNGPADRGVNFPQHLKKK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MFESLQERLGFILSHLTGRGALSDQDVAAALREIRRALLEADVALDVARSFTDRVREKAV
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSAIVKSIKPGQMVVKIVHDELVHVLGNEGVLSDLNAPAPVVIMMIGLQGSGKTTTTAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEEEECCCCCCCHHHHHH
AKRLTHKHNKKVLMASLDTRRPAAQEQLRQLGEQAKLASLPIIAGQSPVDIATRAVQAAK
HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHH
LSGYDVLLLDTAGRNHIDEALMLELVEIKACCRPHEIMLVADSLTGQDAVHLARSFDERV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHC
GITGIILTRMDSDGRGGAALSMRAVTGKPIKAIGIGEKIDDLEEFHPTRIADRILGMGDI
CCEEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCHHHHHHHHHCHHHH
VSLVEKAAETMDHEKAAAFAKKMQAGKFDLNDLADQLQKMKKLGGMGGIMGMLPGLGKVK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHH
DQIAAAGLDDSLFNRQLAIISSMTPLERANPELLKHSRKQRIAKGSGTSAADINKLLKMH
HHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RQMADMVKAIGGKGKSSLMGKMFGALGSKMGLGGMGALGKDPGALPDLSEFDPKQLSKLQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
KQIESGHGGNVLPGLPGRGPTFPGFSNGPADRGVNFPQHLKKK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA