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The map label for this gene is sdhA [H]

Identifier: 49476233

GI number: 49476233

Start: 1820683

End: 1822527

Strand: Reverse

Name: sdhA [H]

Synonym: BH15780

Alternate gene names: 49476233

Gene position: 1822527-1820683 (Counterclockwise)

Preceding gene: 49476234

Following gene: 49476232

Centisome position: 94.38

GC content: 46.12

Gene sequence:

>1845_bases
ATGGTGAGCACAGGATCATCTCTGGGCGCTAGAGCAGGCAATGCCCCTTATCGCACTGTAGATCATAAGTTTGATGTTGT
TGTTGTTGGGGCAGGCGGTGCTGGTTTGCGTGCTACGCTTGGTATGGCGGAGCAGGGATTAAAAACAGCCTGCATCACGA
AGGTTTTTCCAACCAGATCGCATACGGTTGCTGCACAAGGTGGTATTGCTGCGTCACTTTCCAATATGGGGCCTGACAAT
TGGCAATGGCATTTGTATGATACGGTAAAGGGATCTGATTGGTTAGGTGATACCGATGCAATGGAATATTTGGTGCGTAA
TGCACCAGCTGCTGTCTACGAATTAGAACATTATGGGGTTCCTTTTTCACGGACACAAGAAGGAAAAATTTATCAACGTC
CCTTTGGTGGACATACGACACAGTTTGGTGAAGGCCCACCTGTACAGCGGACTTGTGCAGCGGCTGATCGCACCGGGCAT
GCCATCTTGCATACGCTTTATGGACAGAGTTTAAAGCATAATGCGCAGTTCTTTATTGAATATTTTGCGCTTGATTTGAT
TATGACCGATGGTGTGTGTACGGGGGTTGTCGCTTGGAATCTTGATGATGGTGTTATCCACCGTTTTGCGGCTAAGATGG
TTGTTCTCGCCACTGGTGGCTATGGGCGTGCTTATTTTTCAGCAACATCAGCGCATACCTGTACGGGCGATGGTGGGGGA
ATGATCGCTCGTGCTGGATTGCCTCTACAGGATATGGAATTTGTTCAATTCCATCCTACAGGGATTTATGGTTCTGGCTG
CTTAATTACAGAAGGAGCCCGTGGTGAAGGCGGCTATTTGATCAATTCTGAGGGTGAACGCTTTATGGAGCGCTATGCGC
CTTCCTTTAAGGATTTGGCTTCACGTGATTTAGTTTCACGTTGTATAACCCTTGAAATTCGTGAAGGGCGTGGCGTTGGT
CCAAGAAAGGATCATATTCATTTGGTTCTCAATCATATTGACCCTGCTATATTGCATGAGCGCTTACCAGGAATTTCCGA
ATCCGCACGGATTTTTGCAGGGGTTGATGTGACCAAAGAACCTATCCCCATCCTGCCAACGGTTCATTATAACATGGGCG
GTATTCCCACAAATTACTACGGAGAAGTTCTTAATCCAACACCTGATTCACCTGATCGTGTTCAACCAGGTTTGATGGCA
GTGGGAGAAGCTGGCTGTGCTTCTGTTCATGGTGCTAACCGTTTGGGGTCAAATTCATTGATTGATCTTGTCGTATTTGG
TCGTGCCGCTGCAATTCGTGCCGGTGAAGTGATTGATCGAAATGCGGAAATTCCACCTCTTAATGAGGTGGCTATTGACG
AAATTATGACACGTTTTGATCGTTTGCGCTTTGCGCAAGGGGCAATACCAACTGCCGTATTGCGTGAGAAAATGCAACGT
ACTATGCAGGAAGATGCTGCTGTCTTCCGTACAGAAGATTCTTTGCAACAAGGATGCCAGCGGATAAGTCAAATCTGGGG
TGAATTGGCTGATCTCAAAGTCACAGATCGCTCTCTGATATGGAATTCTGATTTGGTCGAAACATTAGAACTTGAGAATT
TGATGGCCAATGCAATCACCACTGTTTATTCTGCAGAAGCGCGTTTAGAAAGTCGAGGCGCGCATGCACGTGAAGATTAT
CCAGAGCGTGATGACAAAAATTGGCGTAAACATACGCTTTCACATTTGTCAAAAGATGGTAAGGTGACTTTGTCCTATCG
ACCTGTCCATATTGATCCCTTAACATCTGAAGCAGATGGGGGTATCGACTTAAAACGTATTGCACCTAAAAAACGTGTTT
ACTAA

Upstream 100 bases:

>100_bases
TTACGGATAATTTTTTTGGTCTTAAATATTTTGTTTTGTTTTGTTTTGGGAGGGATCATCGTTTTTGCTCTTTTGAAAAT
TGCAATAGGGGGTTAAAAAT

Downstream 100 bases:

>100_bases
GGGGAGAATGAATTATGGTACAAATTAAGCTTCCCAAAAATTCGCAAGTAAAACCGGGAAAAGTTTGGCCTAAGCCTAAA
GATGCTAAGCAACTTACCGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MVSTGSSLGARAGNAPYRTVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLSNMGPDN
WQWHLYDTVKGSDWLGDTDAMEYLVRNAPAAVYELEHYGVPFSRTQEGKIYQRPFGGHTTQFGEGPPVQRTCAAADRTGH
AILHTLYGQSLKHNAQFFIEYFALDLIMTDGVCTGVVAWNLDDGVIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGG
MIARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLINSEGERFMERYAPSFKDLASRDLVSRCITLEIREGRGVG
PRKDHIHLVLNHIDPAILHERLPGISESARIFAGVDVTKEPIPILPTVHYNMGGIPTNYYGEVLNPTPDSPDRVQPGLMA
VGEAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGEVIDRNAEIPPLNEVAIDEIMTRFDRLRFAQGAIPTAVLREKMQR
TMQEDAAVFRTEDSLQQGCQRISQIWGELADLKVTDRSLIWNSDLVETLELENLMANAITTVYSAEARLESRGAHAREDY
PERDDKNWRKHTLSHLSKDGKVTLSYRPVHIDPLTSEADGGIDLKRIAPKKRVY

Sequences:

>Translated_614_residues
MVSTGSSLGARAGNAPYRTVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLSNMGPDN
WQWHLYDTVKGSDWLGDTDAMEYLVRNAPAAVYELEHYGVPFSRTQEGKIYQRPFGGHTTQFGEGPPVQRTCAAADRTGH
AILHTLYGQSLKHNAQFFIEYFALDLIMTDGVCTGVVAWNLDDGVIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGG
MIARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLINSEGERFMERYAPSFKDLASRDLVSRCITLEIREGRGVG
PRKDHIHLVLNHIDPAILHERLPGISESARIFAGVDVTKEPIPILPTVHYNMGGIPTNYYGEVLNPTPDSPDRVQPGLMA
VGEAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGEVIDRNAEIPPLNEVAIDEIMTRFDRLRFAQGAIPTAVLREKMQR
TMQEDAAVFRTEDSLQQGCQRISQIWGELADLKVTDRSLIWNSDLVETLELENLMANAITTVYSAEARLESRGAHAREDY
PERDDKNWRKHTLSHLSKDGKVTLSYRPVHIDPLTSEADGGIDLKRIAPKKRVY
>Mature_614_residues
MVSTGSSLGARAGNAPYRTVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLSNMGPDN
WQWHLYDTVKGSDWLGDTDAMEYLVRNAPAAVYELEHYGVPFSRTQEGKIYQRPFGGHTTQFGEGPPVQRTCAAADRTGH
AILHTLYGQSLKHNAQFFIEYFALDLIMTDGVCTGVVAWNLDDGVIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGG
MIARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLINSEGERFMERYAPSFKDLASRDLVSRCITLEIREGRGVG
PRKDHIHLVLNHIDPAILHERLPGISESARIFAGVDVTKEPIPILPTVHYNMGGIPTNYYGEVLNPTPDSPDRVQPGLMA
VGEAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGEVIDRNAEIPPLNEVAIDEIMTRFDRLRFAQGAIPTAVLREKMQR
TMQEDAAVFRTEDSLQQGCQRISQIWGELADLKVTDRSLIWNSDLVETLELENLMANAITTVYSAEARLESRGAHAREDY
PERDDKNWRKHTLSHLSKDGKVTLSYRPVHIDPLTSEADGGIDLKRIAPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=604, Percent_Identity=63.7417218543046, Blast_Score=761, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=598, Percent_Identity=51.1705685618729, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1790597, Length=586, Percent_Identity=41.296928327645, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788928, Length=570, Percent_Identity=31.7543859649123, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=622, Percent_Identity=60.7717041800643, Blast_Score=741, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=620, Percent_Identity=59.1935483870968, Blast_Score=710, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=608, Percent_Identity=62.828947368421, Blast_Score=769, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=577, Percent_Identity=63.9514731369151, Blast_Score=755, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=599, Percent_Identity=63.2721202003339, Blast_Score=757, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=599, Percent_Identity=63.2721202003339, Blast_Score=757, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=599, Percent_Identity=63.2721202003339, Blast_Score=757, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=593, Percent_Identity=56.4924114671164, Blast_Score=697, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66974; Mature: 66974

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTGSSLGARAGNAPYRTVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRS
CCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCC
HTVAAQGGIAASLSNMGPDNWQWHLYDTVKGSDWLGDTDAMEYLVRNAPAAVYELEHYGV
CEEEECCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHEEEHHHCCC
PFSRTQEGKIYQRPFGGHTTQFGEGPPVQRTCAAADRTGHAILHTLYGQSLKHNAQFFIE
CCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH
YFALDLIMTDGVCTGVVAWNLDDGVIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGG
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHEEEEEEECCCCEEEEECCCCCEEECCCCC
MIARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLINSEGERFMERYAPSFKDLA
EEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHH
SRDLVSRCITLEIREGRGVGPRKDHIHLVLNHIDPAILHERLPGISESARIFAGVDVTKE
HHHHHHHEEEEEEECCCCCCCCCCCEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCC
PIPILPTVHYNMGGIPTNYYGEVLNPTPDSPDRVQPGLMAVGEAGCASVHGANRLGSNSL
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCE
IDLVVFGRAAAIRAGEVIDRNAEIPPLNEVAIDEIMTRFDRLRFAQGAIPTAVLREKMQR
EEEEEECCHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TMQEDAAVFRTEDSLQQGCQRISQIWGELADLKVTDRSLIWNSDLVETLELENLMANAIT
HHHHHHHHEECHHHHHHHHHHHHHHHHHHHCCEEECCEEEECCHHHHHHHHHHHHHHHHH
TVYSAEARLESRGAHAREDYPERDDKNWRKHTLSHLSKDGKVTLSYRPVHIDPLTSEADG
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECEEECCCCCCCCC
GIDLKRIAPKKRVY
CEEHHHCCCHHCCC
>Mature Secondary Structure
MVSTGSSLGARAGNAPYRTVDHKFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRS
CCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCC
HTVAAQGGIAASLSNMGPDNWQWHLYDTVKGSDWLGDTDAMEYLVRNAPAAVYELEHYGV
CEEEECCCCHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHEEEHHHCCC
PFSRTQEGKIYQRPFGGHTTQFGEGPPVQRTCAAADRTGHAILHTLYGQSLKHNAQFFIE
CCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH
YFALDLIMTDGVCTGVVAWNLDDGVIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGG
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHEEEEEEECCCCEEEEECCCCCEEECCCCC
MIARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLINSEGERFMERYAPSFKDLA
EEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHH
SRDLVSRCITLEIREGRGVGPRKDHIHLVLNHIDPAILHERLPGISESARIFAGVDVTKE
HHHHHHHEEEEEEECCCCCCCCCCCEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCC
PIPILPTVHYNMGGIPTNYYGEVLNPTPDSPDRVQPGLMAVGEAGCASVHGANRLGSNSL
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCE
IDLVVFGRAAAIRAGEVIDRNAEIPPLNEVAIDEIMTRFDRLRFAQGAIPTAVLREKMQR
EEEEEECCHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TMQEDAAVFRTEDSLQQGCQRISQIWGELADLKVTDRSLIWNSDLVETLELENLMANAIT
HHHHHHHHEECHHHHHHHHHHHHHHHHHHHCCEEECCEEEECCHHHHHHHHHHHHHHHHH
TVYSAEARLESRGAHAREDYPERDDKNWRKHTLSHLSKDGKVTLSYRPVHIDPLTSEADG
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECEEECCCCCCCCC
GIDLKRIAPKKRVY
CEEHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA