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The map label for this gene is nodT [H]

Identifier: 49476203

GI number: 49476203

Start: 1793364

End: 1794848

Strand: Reverse

Name: nodT [H]

Synonym: BH15480

Alternate gene names: 49476203

Gene position: 1794848-1793364 (Counterclockwise)

Preceding gene: 49476204

Following gene: 49476202

Centisome position: 92.95

GC content: 43.77

Gene sequence:

>1485_bases
ATGCATATCAGAGATCTTAAAAGGAGTACTTCTAACAGACTGCTTTATAGTGTTTTGTTTTGTTTTTTTATATTCTCAGG
ATGTATGGTTGGTCCTAATTATCAGAAGACATCTTTTCGTGTTCCAGCAGTTTGGGGAGAACAGTCTGAAAAGACATCTG
GGCGTATGGTTACACTTGCAGGATGGTGGCGGCATTTGAATGATCCTGTTTTGAATGCGCTCATGAATGATGCAATTTCT
GGAAATAATAATGTTGCTGTTGCTAAAGCACGTGTGCGTGAGGCACGCGCTGGTTTAGGCCAAACTGTTGGATCTCTTTT
GCCAAGTGTGTCAAGTTCAATTTCAGGAACCCGTAATGGTTCTGAGCAATCTGATGCGTCTTTAAGCCAATATCGTAGTG
GTTTTGATGCAAGTTGGGAACTTGATTTTTTTGGTGGGCATAAGCGAGCAGTTGAAGCTGCACATTATGGTCTTGAAGCC
GCTGTGGAAGATATGCGTGCTACCATGGTGACGCTGCTTGGAGATGTGGCAACAAATTATGTGCAAGTGCGCGGTTGGCA
ACAAAAATTGTTGATTGTGCGGCAAATCGCTGCATCACAGCGTAAAACATATGAATTGATGCGTGCTAAATTAACGGCGG
GTGATGCTTCGGAACTTGATATTTCAAATGCACAAGCACAAGTGGCTAATACAGAAGCAGATATAGCACAGATGGAAGCA
AATTTAGCAATGAGCATTCATCGTCTTTCTGTTTTAACCGGTCATGTGCCTACGGCTTTGAGAGATCTTTTACAAAAAAA
TGCAAAACAAGCAAAGATTCCGCAACCGCACTGGCCGATACCAGCAGGAATTCCTGCTGATATTTTGTTAACACGCCCAG
ATTTACGACGGGCAGAACGCCAATACGCGCAAGCGACAGCTCGGATTGGTCAGCGTGAGGCAGAGCGTTATCCATCACTT
ACTTTAACCGGTAGTATTTCGACAGCAGCAACGGCAATTGATCAATTATGGAAAAATTCAACGATTGGGTGGTCTTTTGG
GCCTGGTCTTCGTTTTCCTTTTTTTAATGGAGGGCAGATTGTTGCGTCTGTTGCGGTGGCGCGCGCGCAGCGCGATCAGG
CTTTTATTACCTATCGGGCTGCTGTATTGGGAGCTTTAGAAGATGTGGAAAATGCGCTTGTAAGATTGACTAAAGAACAT
CAGCGCTTAGAAAAGCTTATCATTGCTAATAAAGCTTTTCAGCGTTCTTTGCAACTTTCACGGAGCCTTTTTGAAAATGG
AAATACCAGTTTTCTTGAATTGTTAAATGCTGATCGCTCTTATTATTCTGCGCAAATGGCGCTTAAAGATAGCCGTATCT
CTTTGGTGACCCAATATATTGCGTTGATGAAAGCATTAGGTGGTGGTTGGGATGGTGTTGTTGATGTGTCACGTCCGGAA
GTTGTTGATGGTGTACGCCGTTCGCGTGCAAAGGTAGGGCAATGA

Upstream 100 bases:

>100_bases
TCACGTTCCTGTGCAAACTGTATTTGATTTTTCAGGTTAATTTTGAAATAAGAAGTAAATAAAATATTAATAGTTGATTC
TGGGAAATGCGGGAGACTAG

Downstream 100 bases:

>100_bases
AAAAAAATTTTATTAAAAATTTTATTAAAAAACGTAAAAAACTTTCCTTTTTATTAATTGCTATATTCCTTATCATCTTG
TTTTTATGGTTGCGTTCTGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MHIRDLKRSTSNRLLYSVLFCFFIFSGCMVGPNYQKTSFRVPAVWGEQSEKTSGRMVTLAGWWRHLNDPVLNALMNDAIS
GNNNVAVAKARVREARAGLGQTVGSLLPSVSSSISGTRNGSEQSDASLSQYRSGFDASWELDFFGGHKRAVEAAHYGLEA
AVEDMRATMVTLLGDVATNYVQVRGWQQKLLIVRQIAASQRKTYELMRAKLTAGDASELDISNAQAQVANTEADIAQMEA
NLAMSIHRLSVLTGHVPTALRDLLQKNAKQAKIPQPHWPIPAGIPADILLTRPDLRRAERQYAQATARIGQREAERYPSL
TLTGSISTAATAIDQLWKNSTIGWSFGPGLRFPFFNGGQIVASVAVARAQRDQAFITYRAAVLGALEDVENALVRLTKEH
QRLEKLIIANKAFQRSLQLSRSLFENGNTSFLELLNADRSYYSAQMALKDSRISLVTQYIALMKALGGGWDGVVDVSRPE
VVDGVRRSRAKVGQ

Sequences:

>Translated_494_residues
MHIRDLKRSTSNRLLYSVLFCFFIFSGCMVGPNYQKTSFRVPAVWGEQSEKTSGRMVTLAGWWRHLNDPVLNALMNDAIS
GNNNVAVAKARVREARAGLGQTVGSLLPSVSSSISGTRNGSEQSDASLSQYRSGFDASWELDFFGGHKRAVEAAHYGLEA
AVEDMRATMVTLLGDVATNYVQVRGWQQKLLIVRQIAASQRKTYELMRAKLTAGDASELDISNAQAQVANTEADIAQMEA
NLAMSIHRLSVLTGHVPTALRDLLQKNAKQAKIPQPHWPIPAGIPADILLTRPDLRRAERQYAQATARIGQREAERYPSL
TLTGSISTAATAIDQLWKNSTIGWSFGPGLRFPFFNGGQIVASVAVARAQRDQAFITYRAAVLGALEDVENALVRLTKEH
QRLEKLIIANKAFQRSLQLSRSLFENGNTSFLELLNADRSYYSAQMALKDSRISLVTQYIALMKALGGGWDGVVDVSRPE
VVDGVRRSRAKVGQ
>Mature_494_residues
MHIRDLKRSTSNRLLYSVLFCFFIFSGCMVGPNYQKTSFRVPAVWGEQSEKTSGRMVTLAGWWRHLNDPVLNALMNDAIS
GNNNVAVAKARVREARAGLGQTVGSLLPSVSSSISGTRNGSEQSDASLSQYRSGFDASWELDFFGGHKRAVEAAHYGLEA
AVEDMRATMVTLLGDVATNYVQVRGWQQKLLIVRQIAASQRKTYELMRAKLTAGDASELDISNAQAQVANTEADIAQMEA
NLAMSIHRLSVLTGHVPTALRDLLQKNAKQAKIPQPHWPIPAGIPADILLTRPDLRRAERQYAQATARIGQREAERYPSL
TLTGSISTAATAIDQLWKNSTIGWSFGPGLRFPFFNGGQIVASVAVARAQRDQAFITYRAAVLGALEDVENALVRLTKEH
QRLEKLIIANKAFQRSLQLSRSLFENGNTSFLELLNADRSYYSAQMALKDSRISLVTQYIALMKALGGGWDGVVDVSRPE
VVDGVRRSRAKVGQ

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=471, Percent_Identity=28.6624203821656, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI2367348, Length=497, Percent_Identity=26.7605633802817, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 54340; Mature: 54340

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIRDLKRSTSNRLLYSVLFCFFIFSGCMVGPNYQKTSFRVPAVWGEQSEKTSGRMVTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEECCCCCCCCCCCEEEEE
GWWRHLNDPVLNALMNDAISGNNNVAVAKARVREARAGLGQTVGSLLPSVSSSISGTRNG
HHHHHCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SEQSDASLSQYRSGFDASWELDFFGGHKRAVEAAHYGLEAAVEDMRATMVTLLGDVATNY
CCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQVRGWQQKLLIVRQIAASQRKTYELMRAKLTAGDASELDISNAQAQVANTEADIAQMEA
HEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHHHH
NLAMSIHRLSVLTGHVPTALRDLLQKNAKQAKIPQPHWPIPAGIPADILLTRPDLRRAER
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHH
QYAQATARIGQREAERYPSLTLTGSISTAATAIDQLWKNSTIGWSFGPGLRFPFFNGGQI
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
VASVAVARAQRDQAFITYRAAVLGALEDVENALVRLTKEHQRLEKLIIANKAFQRSLQLS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLFENGNTSFLELLNADRSYYSAQMALKDSRISLVTQYIALMKALGGGWDGVVDVSRPE
HHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCH
VVDGVRRSRAKVGQ
HHHHHHHHHHHCCC
>Mature Secondary Structure
MHIRDLKRSTSNRLLYSVLFCFFIFSGCMVGPNYQKTSFRVPAVWGEQSEKTSGRMVTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEECCCCCCCCCCCEEEEE
GWWRHLNDPVLNALMNDAISGNNNVAVAKARVREARAGLGQTVGSLLPSVSSSISGTRNG
HHHHHCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SEQSDASLSQYRSGFDASWELDFFGGHKRAVEAAHYGLEAAVEDMRATMVTLLGDVATNY
CCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQVRGWQQKLLIVRQIAASQRKTYELMRAKLTAGDASELDISNAQAQVANTEADIAQMEA
HEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHHHH
NLAMSIHRLSVLTGHVPTALRDLLQKNAKQAKIPQPHWPIPAGIPADILLTRPDLRRAER
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHH
QYAQATARIGQREAERYPSLTLTGSISTAATAIDQLWKNSTIGWSFGPGLRFPFFNGGQI
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
VASVAVARAQRDQAFITYRAAVLGALEDVENALVRLTKEHQRLEKLIIANKAFQRSLQLS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLFENGNTSFLELLNADRSYYSAQMALKDSRISLVTQYIALMKALGGGWDGVVDVSRPE
HHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCH
VVDGVRRSRAKVGQ
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]