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The map label for this gene is ATPA [H]

Identifier: 49476189

GI number: 49476189

Start: 1765435

End: 1766970

Strand: Reverse

Name: ATPA [H]

Synonym: BH15340

Alternate gene names: 49476189

Gene position: 1766970-1765435 (Counterclockwise)

Preceding gene: 49476190

Following gene: 49476188

Centisome position: 91.5

GC content: 44.14

Gene sequence:

>1536_bases
ATGGATATTAGACCATCTGAAATTTCAAAAATTCTAAAAGAACAAATCAAAAACTTTGACCAAAAGGCTGAAGTTTCAGA
AATTGGTTGGGTTTTGTCTGTGGGTGATGGTATCGCTCGCGTTTATGGTTTGGATAATGTCCAAGCAGGGGAGATGGTCT
CCTTTTCAAACGGTGTGCGTGGTATGGCACTCAATTTGGAAATCGATAATGTCGGGGTGGTCATTTTCGGATCAGATCGT
GATATCCGTGAGGGCGATTGTGTTAAACGACTCGGTGCTATTGTCGAGGTGCCTGTCGGTCCAGCTTTGCTAGGGCGTGT
TGTCGATGCACTGGGAAACCCTATAGATGGTAAGGGACCTCTTAAGGCAACAGAATATCGTCGTGTCGATGTGAAAGCTC
CAGGCATTATTCCACGTCAGTCCGTGCATGAGCCAATGTCCACAGGATTGAAGGCTATCGATGCACTCATCCCCATTGGA
CGTGGACAACGTGAATTGGTGATCGGTGATCGCCAAACAGGAAAAACAGCAATTTTGCTCGATGCATTCTTAAACCAAAA
ACCCTTCCATGAAAAAGATGCGGGGAATGAGAAGGATAAAGTCTATTGTATTTATGTTGCTATCGGTCAAAAACGTTCAA
CCGTGGCGCAATTTGTTAAAGTTTTAGAAGAGCGTGGAGCACTTGAGTATTCCATTATCGTAGCAGCTACAGCTTCTGAT
CCCGCGCCCATGCAATTTATCGCACCTCTTGCTGGTTGTGCAATGGGAGAATATTTCCGTGATAATGGCCAACATGCTTT
GATCGGTTATGATGATCTTTCAAAACAAGCCGTCGCTTATCGCCAAATGTCCCTTTTGCTTCGTCGTCCGCCTGGTCGTG
AAGCCTATCCTGGTGATGTTTTCTATCTTCATTCACGCCTTTTAGAGCGCGCTGCAAAACTTAATGCTGAAAATGGTTCC
GGGTCTTTGACCGCTTTGCCTGTCATTGAAACACAGGCCAATGACGTTTCTGCCTATATTCCCACAAACGTGATTTCCAT
CACCGATGGGCAAATTTTTCTAGAAACGAATTTATTTTATCAAGGAATTCGTCCTGCTGTTAATGTTGGTCTTTCTGTGT
CGCGTGTTGGCTCTGCTGCACAAATTAAGGCGATGAAGCAGGTTGCTGGTTCCATTAAAGGAGAATTAGCACAATATCGT
GAAATGGCTGCCTTCGCACAGTTTGGTTCCGATTTGGATGCCTCAACACAGCGTCTTTTAAATCGTGGTGCCCGTTTAAC
AGAGCTTTTAAAACAACCACAATTTTCTCCACTGAAAACAGAAGAACAGGTTGTTGTTATCTTTGCCGGTGTCAATGGTT
ATCTTGATGCTTTGGCTGTGGCTGATGTCGGTCGATTCGAACAGGGACTTTTGACACTTCTGCGCAGTGATCACTCAGAT
CTTTTGCAGGCAATTGCTGATCAAAAACAGCTAACCGATGACATCAAGGATAAGTTGATCGTTGTTCTTAATACTTACGC
AAAGAATTTTTCGTAA

Upstream 100 bases:

>100_bases
CTTGGTGGGTTGATCATTCGTCTGGGATCATCACAGATCGATACGTCCCTTATGGCGAAGTTGTCTTCGCTTAAGATTGC
ATTGAAAAAGAGGTCAGCTG

Downstream 100 bases:

>100_bases
TGAGTTGATGGAATGCTTCAATGGCGTCGTTAAAGGATCTTAGAGACCGTATCGCCTCGGTTAAGGCAACACAAAAAATT
ACCAAAGCAATGCAAATGGT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MDIRPSEISKILKEQIKNFDQKAEVSEIGWVLSVGDGIARVYGLDNVQAGEMVSFSNGVRGMALNLEIDNVGVVIFGSDR
DIREGDCVKRLGAIVEVPVGPALLGRVVDALGNPIDGKGPLKATEYRRVDVKAPGIIPRQSVHEPMSTGLKAIDALIPIG
RGQRELVIGDRQTGKTAILLDAFLNQKPFHEKDAGNEKDKVYCIYVAIGQKRSTVAQFVKVLEERGALEYSIIVAATASD
PAPMQFIAPLAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNAENGS
GSLTALPVIETQANDVSAYIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYR
EMAAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVVVIFAGVNGYLDALAVADVGRFEQGLLTLLRSDHSD
LLQAIADQKQLTDDIKDKLIVVLNTYAKNFS

Sequences:

>Translated_511_residues
MDIRPSEISKILKEQIKNFDQKAEVSEIGWVLSVGDGIARVYGLDNVQAGEMVSFSNGVRGMALNLEIDNVGVVIFGSDR
DIREGDCVKRLGAIVEVPVGPALLGRVVDALGNPIDGKGPLKATEYRRVDVKAPGIIPRQSVHEPMSTGLKAIDALIPIG
RGQRELVIGDRQTGKTAILLDAFLNQKPFHEKDAGNEKDKVYCIYVAIGQKRSTVAQFVKVLEERGALEYSIIVAATASD
PAPMQFIAPLAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNAENGS
GSLTALPVIETQANDVSAYIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYR
EMAAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVVVIFAGVNGYLDALAVADVGRFEQGLLTLLRSDHSD
LLQAIADQKQLTDDIKDKLIVVLNTYAKNFS
>Mature_511_residues
MDIRPSEISKILKEQIKNFDQKAEVSEIGWVLSVGDGIARVYGLDNVQAGEMVSFSNGVRGMALNLEIDNVGVVIFGSDR
DIREGDCVKRLGAIVEVPVGPALLGRVVDALGNPIDGKGPLKATEYRRVDVKAPGIIPRQSVHEPMSTGLKAIDALIPIG
RGQRELVIGDRQTGKTAILLDAFLNQKPFHEKDAGNEKDKVYCIYVAIGQKRSTVAQFVKVLEERGALEYSIIVAATASD
PAPMQFIAPLAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNAENGS
GSLTALPVIETQANDVSAYIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYR
EMAAFAQFGSDLDASTQRLLNRGARLTELLKQPQFSPLKTEEQVVVIFAGVNGYLDALAVADVGRFEQGLLTLLRSDHSD
LLQAIADQKQLTDDIKDKLIVVLNTYAKNFS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=68.9108910891089, Blast_Score=707, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=68.9108910891089, Blast_Score=707, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=308, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI19913426, Length=319, Percent_Identity=27.8996865203762, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI32189394, Length=384, Percent_Identity=25, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1790172, Length=517, Percent_Identity=56.2862669245648, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI1790170, Length=421, Percent_Identity=25.6532066508314, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788251, Length=305, Percent_Identity=28.8524590163934, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=505, Percent_Identity=70.4950495049505, Blast_Score=719, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=505, Percent_Identity=70.4950495049505, Blast_Score=717, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=505, Percent_Identity=65.1485148514851, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=292, Percent_Identity=27.7397260273973, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=292, Percent_Identity=27.7397260273973, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71988068, Length=75, Percent_Identity=60, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25144756, Length=402, Percent_Identity=23.8805970149254, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=64, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319370, Length=507, Percent_Identity=67.258382642998, Blast_Score=710, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=350, Percent_Identity=29.1428571428571, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=380, Percent_Identity=25, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24658560, Length=507, Percent_Identity=68.6390532544379, Blast_Score=702, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=27.8688524590164, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=27.8688524590164, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=27.8688524590164, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574560, Length=421, Percent_Identity=25.1781472684086, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24638766, Length=381, Percent_Identity=24.4094488188976, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55512; Mature: 55512

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRPSEISKILKEQIKNFDQKAEVSEIGWVLSVGDGIARVYGLDNVQAGEMVSFSNGVR
CCCCHHHHHHHHHHHHHCCCHHCCHHHHCEEEECCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLEIDNVGVVIFGSDRDIREGDCVKRLGAIVEVPVGPALLGRVVDALGNPIDGKGP
EEEEEEEECCEEEEEECCCCCCCCCHHHHHHCCEEECCCCHHHHHHHHHHHCCCCCCCCC
LKATEYRRVDVKAPGIIPRQSVHEPMSTGLKAIDALIPIGRGQRELVIGDRQTGKTAILL
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DAFLNQKPFHEKDAGNEKDKVYCIYVAIGQKRSTVAQFVKVLEERGALEYSIIVAATASD
EHHHCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCC
PAPMQFIAPLAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERAAKLNAENGSGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETNLFY
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECHHH
QGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDASTQRLL
HCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
NRGARLTELLKQPQFSPLKTEEQVVVIFAGVNGYLDALAVADVGRFEQGLLTLLRSDHSD
HCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLQAIADQKQLTDDIKDKLIVVLNTYAKNFS
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCC
>Mature Secondary Structure
MDIRPSEISKILKEQIKNFDQKAEVSEIGWVLSVGDGIARVYGLDNVQAGEMVSFSNGVR
CCCCHHHHHHHHHHHHHCCCHHCCHHHHCEEEECCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLEIDNVGVVIFGSDRDIREGDCVKRLGAIVEVPVGPALLGRVVDALGNPIDGKGP
EEEEEEEECCEEEEEECCCCCCCCCHHHHHHCCEEECCCCHHHHHHHHHHHCCCCCCCCC
LKATEYRRVDVKAPGIIPRQSVHEPMSTGLKAIDALIPIGRGQRELVIGDRQTGKTAILL
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DAFLNQKPFHEKDAGNEKDKVYCIYVAIGQKRSTVAQFVKVLEERGALEYSIIVAATASD
EHHHCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCC
PAPMQFIAPLAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERAAKLNAENGSGSLTALPVIETQANDVSAYIPTNVISITDGQIFLETNLFY
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECHHH
QGIRPAVNVGLSVSRVGSAAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDASTQRLL
HCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
NRGARLTELLKQPQFSPLKTEEQVVVIFAGVNGYLDALAVADVGRFEQGLLTLLRSDHSD
HCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLQAIADQKQLTDDIKDKLIVVLNTYAKNFS
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA