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The map label for this gene is pgm [H]

Identifier: 49476038

GI number: 49476038

Start: 1554011

End: 1555639

Strand: Reverse

Name: pgm [H]

Synonym: BH13570

Alternate gene names: 49476038

Gene position: 1555639-1554011 (Counterclockwise)

Preceding gene: 49476040

Following gene: 49476037

Centisome position: 80.56

GC content: 43.03

Gene sequence:

>1629_bases
ATGACTCTCATGACAGTTTTGACTAAGGCTTTTGATGATCAAAAACTTGGAACGTTTGGTTTGCGCAAAAAAGTGTCGGT
TTTCCAACAGCCCCATTATGTTGAAAATTTTATTCAATCTCTTTTTAACAGCATTGGGTCTGTTGAGGGAAAACTGTTTA
TTCTTGGAGGAGATGGACGCTATTTTAACCGCAACCTTCTTCAAATTGTGTTGAAAATGGCCGCTGCTCATGGTGTTGCT
TGTGTTAAAGTCGGAAAAGAGGGACTGCTCTCCACGCCAGCTGTCTCACATCTTATTCGTAAATATCATGCTTATGGTGG
TATTATTCTCTCAGCAAGTCACAATCCTGGGGGAAGAGAGGGAGATTGTGGCATCAAGTACAATATTGCCAATGGTGGTC
CTGCTCCCGCTTCTTTATGTGATGCTGTTTTTGCAGCATCTAAGCGTCTTTCTTCTTATCGGATTATGGAGGTACCAGAT
ATTGATTTAGAAAGAGAAGGTACAACTTTTTTAGGACCCATGCAGATTGATATAATTGATCCTGTCGCCGATTATGTCGC
TTTGATGCAGGAGATTTTTGATTTTGATTGTATTGCCAAGGCTGTTGCAGAAGGGCTCACTTTGCGTTTTGATGCATTGC
ATGCGGTAACAGGGCCTTATGCGCATGAAATTTTTGAAAAATGCTTAGGGTTTTCTGAAGGAACGGTGGTCAATGGCGTT
CCTTTGCCAGATTTTGGAGGGAAGCCACCAGATCCCAATTTGCTTCATGCTAAGGCTCTTTATGATTTAGTGATGTCGGA
TCAAGGACCTGATCTTGGTGCTGCCTCTGATGGGGATGGAGATCGTAATCTCATTATGGGGCGTGGGCAATTTGTTACAC
CTTCTGATTCTCTTGCGATTATGGTTGATCATGCCCATCTGATTAAGGGGTATCGGCAGGGGATTGTGGGGATTGCTCGC
TCCATGCCAACAGGGCGTGCGGCTGATTTGGTTGCTGAAAAAAAAGGATTAAACTTTTTTGAAACACCAACCGGGTGGAA
GTTTTTTGGAACGCTTTTGGATGCTGGCTACGTGACCTTTTGTGGTGAAGAAAGCTTTGGTACAGGTTCTAATCATATCC
GCGAAAAAGATGGTTTATGGGCTGTGTTATTTTGGTTGAATCTTTTAGCGGTGACAGGAAAAACTGTGGCACAAATTGTG
CAGCAGCATTGGCGCACTTATGGGCGCTTTTACACTTTACGGTATGATTATGAAGAAGTAGAAACATGTAAAGCTTCCGC
AATCATCAATGCATTACGTGCATATTTACCAAAACCAGGAAGCGAAATTGCGGGACTCTCTGTCGAAAAAGCAGACGATT
TTACTTATCATGATCCTGTTGATCAAAGCATCAGTACTGGGCAGGGTGTGCGTATTTTTTTTAAAAATGGAGCACGACTC
GTGGTACGCTTATCGGGGACAGGAACAGTAGGCGCTACCTTACGCCTTTATTTTGAGCAGTTTGAGGGCGATCCCCGTAA
ACATAATCAAGATCCACAAAAAGTGCTTCAGCCTGTACAACAGGCAGCCTTTCAATTATTAAACATAAAACAACATTTGA
GGCGCACACAGCCTGATGTTATCACATAG

Upstream 100 bases:

>100_bases
CAAGTTTGCAAATATTTCACTGCCGCGTCAAGTAGAATTAATAGTCGACTTTGGTGGAACTTCACTCTAAAATCGAGCAA
AACATTATGAAGGTGCTTCC

Downstream 100 bases:

>100_bases
AGAACGGTTTCACATTGTCTCTTTCTGGTAAAAAACATTAGTTTATAATGATAAATCATCATTTTTCAACTTTAATCAGA
ATTTCGAATACAGTAAGCTT

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MTLMTVLTKAFDDQKLGTFGLRKKVSVFQQPHYVENFIQSLFNSIGSVEGKLFILGGDGRYFNRNLLQIVLKMAAAHGVA
CVKVGKEGLLSTPAVSHLIRKYHAYGGIILSASHNPGGREGDCGIKYNIANGGPAPASLCDAVFAASKRLSSYRIMEVPD
IDLEREGTTFLGPMQIDIIDPVADYVALMQEIFDFDCIAKAVAEGLTLRFDALHAVTGPYAHEIFEKCLGFSEGTVVNGV
PLPDFGGKPPDPNLLHAKALYDLVMSDQGPDLGAASDGDGDRNLIMGRGQFVTPSDSLAIMVDHAHLIKGYRQGIVGIAR
SMPTGRAADLVAEKKGLNFFETPTGWKFFGTLLDAGYVTFCGEESFGTGSNHIREKDGLWAVLFWLNLLAVTGKTVAQIV
QQHWRTYGRFYTLRYDYEEVETCKASAIINALRAYLPKPGSEIAGLSVEKADDFTYHDPVDQSISTGQGVRIFFKNGARL
VVRLSGTGTVGATLRLYFEQFEGDPRKHNQDPQKVLQPVQQAAFQLLNIKQHLRRTQPDVIT

Sequences:

>Translated_542_residues
MTLMTVLTKAFDDQKLGTFGLRKKVSVFQQPHYVENFIQSLFNSIGSVEGKLFILGGDGRYFNRNLLQIVLKMAAAHGVA
CVKVGKEGLLSTPAVSHLIRKYHAYGGIILSASHNPGGREGDCGIKYNIANGGPAPASLCDAVFAASKRLSSYRIMEVPD
IDLEREGTTFLGPMQIDIIDPVADYVALMQEIFDFDCIAKAVAEGLTLRFDALHAVTGPYAHEIFEKCLGFSEGTVVNGV
PLPDFGGKPPDPNLLHAKALYDLVMSDQGPDLGAASDGDGDRNLIMGRGQFVTPSDSLAIMVDHAHLIKGYRQGIVGIAR
SMPTGRAADLVAEKKGLNFFETPTGWKFFGTLLDAGYVTFCGEESFGTGSNHIREKDGLWAVLFWLNLLAVTGKTVAQIV
QQHWRTYGRFYTLRYDYEEVETCKASAIINALRAYLPKPGSEIAGLSVEKADDFTYHDPVDQSISTGQGVRIFFKNGARL
VVRLSGTGTVGATLRLYFEQFEGDPRKHNQDPQKVLQPVQQAAFQLLNIKQHLRRTQPDVIT
>Mature_541_residues
TLMTVLTKAFDDQKLGTFGLRKKVSVFQQPHYVENFIQSLFNSIGSVEGKLFILGGDGRYFNRNLLQIVLKMAAAHGVAC
VKVGKEGLLSTPAVSHLIRKYHAYGGIILSASHNPGGREGDCGIKYNIANGGPAPASLCDAVFAASKRLSSYRIMEVPDI
DLEREGTTFLGPMQIDIIDPVADYVALMQEIFDFDCIAKAVAEGLTLRFDALHAVTGPYAHEIFEKCLGFSEGTVVNGVP
LPDFGGKPPDPNLLHAKALYDLVMSDQGPDLGAASDGDGDRNLIMGRGQFVTPSDSLAIMVDHAHLIKGYRQGIVGIARS
MPTGRAADLVAEKKGLNFFETPTGWKFFGTLLDAGYVTFCGEESFGTGSNHIREKDGLWAVLFWLNLLAVTGKTVAQIVQ
QHWRTYGRFYTLRYDYEEVETCKASAIINALRAYLPKPGSEIAGLSVEKADDFTYHDPVDQSISTGQGVRIFFKNGARLV
VRLSGTGTVGATLRLYFEQFEGDPRKHNQDPQKVLQPVQQAAFQLLNIKQHLRRTQPDVIT

Specific function: This enzyme participates in both the breakdown and synthesis of glucose. Required for the synthesis of capsular polysaccharide and normal lipopolysaccharide [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI290463102, Length=568, Percent_Identity=47.3591549295775, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI21361621, Length=568, Percent_Identity=46.4788732394366, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI133922562, Length=566, Percent_Identity=44.1696113074205, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI290463104, Length=366, Percent_Identity=48.3606557377049, Blast_Score=340, Evalue=3e-93,
Organism=Homo sapiens, GI239743670, Length=114, Percent_Identity=48.2456140350877, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI239741729, Length=114, Percent_Identity=47.3684210526316, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1786904, Length=535, Percent_Identity=25.981308411215, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17535441, Length=560, Percent_Identity=46.0714285714286, Blast_Score=472, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6323752, Length=568, Percent_Identity=47.1830985915493, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322722, Length=572, Percent_Identity=46.6783216783217, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17864244, Length=566, Percent_Identity=46.643109540636, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59344; Mature: 59212

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLMTVLTKAFDDQKLGTFGLRKKVSVFQQPHYVENFIQSLFNSIGSVEGKLFILGGDGR
CHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
YFNRNLLQIVLKMAAAHGVACVKVGKEGLLSTPAVSHLIRKYHAYGGIILSASHNPGGRE
CHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
GDCGIKYNIANGGPAPASLCDAVFAASKRLSSYRIMEVPDIDLEREGTTFLGPMQIDIID
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEECCEEEEEEH
PVADYVALMQEIFDFDCIAKAVAEGLTLRFDALHAVTGPYAHEIFEKCLGFSEGTVVNGV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHHCCCCCCCEECCC
PLPDFGGKPPDPNLLHAKALYDLVMSDQGPDLGAASDGDGDRNLIMGRGQFVTPSDSLAI
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCEEE
MVDHAHLIKGYRQGIVGIARSMPTGRAADLVAEKKGLNFFETPTGWKFFGTLLDAGYVTF
EECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEE
CGEESFGTGSNHIREKDGLWAVLFWLNLLAVTGKTVAQIVQQHWRTYGRFYTLRYDYEEV
ECCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEECHHHH
ETCKASAIINALRAYLPKPGSEIAGLSVEKADDFTYHDPVDQSISTGQGVRIFFKNGARL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEE
VVRLSGTGTVGATLRLYFEQFEGDPRKHNQDPQKVLQPVQQAAFQLLNIKQHLRRTQPDV
EEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IT
CC
>Mature Secondary Structure 
TLMTVLTKAFDDQKLGTFGLRKKVSVFQQPHYVENFIQSLFNSIGSVEGKLFILGGDGR
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
YFNRNLLQIVLKMAAAHGVACVKVGKEGLLSTPAVSHLIRKYHAYGGIILSASHNPGGRE
CHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
GDCGIKYNIANGGPAPASLCDAVFAASKRLSSYRIMEVPDIDLEREGTTFLGPMQIDIID
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEECCEEEEEEH
PVADYVALMQEIFDFDCIAKAVAEGLTLRFDALHAVTGPYAHEIFEKCLGFSEGTVVNGV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHHCCCCCCCEECCC
PLPDFGGKPPDPNLLHAKALYDLVMSDQGPDLGAASDGDGDRNLIMGRGQFVTPSDSLAI
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCEEE
MVDHAHLIKGYRQGIVGIARSMPTGRAADLVAEKKGLNFFETPTGWKFFGTLLDAGYVTF
EECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEE
CGEESFGTGSNHIREKDGLWAVLFWLNLLAVTGKTVAQIVQQHWRTYGRFYTLRYDYEEV
ECCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEECHHHH
ETCKASAIINALRAYLPKPGSEIAGLSVEKADDFTYHDPVDQSISTGQGVRIFFKNGARL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEE
VVRLSGTGTVGATLRLYFEQFEGDPRKHNQDPQKVLQPVQQAAFQLLNIKQHLRRTQPDV
EEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7959036; 2307661 [H]