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The map label for this gene is xseA

Identifier: 49475937

GI number: 49475937

Start: 1361589

End: 1363016

Strand: Reverse

Name: xseA

Synonym: BH12220

Alternate gene names: 49475937

Gene position: 1363016-1361589 (Counterclockwise)

Preceding gene: 49475938

Following gene: 49475936

Centisome position: 70.58

GC content: 42.65

Gene sequence:

>1428_bases
ATGAATTTGTTTTTTGAAAAAACAGGAGCAACAAATGTAGCAGAATTTAGTGTTTCTGAAATAGCGGGTGCTTTAAAACG
CGTTGTTGAAGAAAAGTTTGGTTATGTACGGGTGCGTGGGGAAATATCAGGTTATCGTGGTGCTCATGCTTCAGGTCATG
CTTATTTTGCCTTAAAAGATGATAAGGCGCGGTTGGAAGCTGTTATTTGGCGCGGAATTATGGAAAAGCTTAAATTTCCT
CCTGAAGAAGGGATGGAAGTGATCGCTGTTGGCAAGCTTACCACGTATCCTGGGTCATCAAAATATCAAATTGTCATTGA
AGCTCTTGAGCCAACAGGTGTTGGCGCTTTGATGACTCTTCTAGAAAATCGCAAGAAGAAGTTTGCAGAGGAAGGCTTAT
TTGACGAAGAAAAAAAGAAGCCTTTGCCTTATATGCCTAAAATTATAGGCGTTGTGACATCGCCAACAGGTGCTGTCATT
CGTGATATCATTCATCGTATCTCGGATCGTTTTCCGTTGCATATCTTGGTGTGGCCTGTACGGGTTCAGGGGGAGACAAG
TGGTCGTGAAGTGGCCGCTGCTGTTAAAGGTTTTAATGTGTTGCCTTTAGAAGGGCTTATTCCAAAACCTGATCTCCTTA
TTGTTGCACGGGGAGGAGGAAGTTTAGAAGATTTGTGGGGATTTAATGATGAGGTCGTTGTTCGTGCTGTTTATGAATCT
TCCCTTCCGGTTATTTCTGCTGTTGGGCATGAAACGGATTGGACCTTGATTGATTATGTCGCTGATTGGCGCGCTCCGAC
TCCCACAGCAGCAGCAGAGAAGGCTGTGCCCGTCAAGATTGATCTCGAAGTATATGTGGTATCGCTTGGTGCACGTTTGC
GCACCGGACTTGCACGTTATTTTGATTTTCATCAACAAAAATTGCGGGCTATTATACGTGCGCTTCCCACTGCCGACCAA
CTTTTTGCTCTACCACGGCGTGGTTTCGATGAAATTTCAAGTCGATTAGAGCGTGCTCTTTGTGTAAGCTGCGATAAAAA
ACGTCTTTATTTTCATACACTTGCTATCCGTTTTACTCCGCGTTTACTGAATACTGAAAAAGCTCAACACAGTGCAAAGG
AATATACTGCACGTCTTCATCGTGCTTTTGTGCACATTGTGGAAAAACAACGCGCTCAATTAGAGATCGCGTTTAGGCTT
TTAAAAAGCACTTCTTACCAGAATATTTTAGAACGTGGCTTTGTTTTGGCTTTGGGGCAAAACAATAAACCCATTAAACG
GTTGGCGCAGATTCCTGAAAAAGAGCAGATAAATTTACGCTTTTTTGATGGTGAGATCAGCGTTATAACACAGGAGTCTT
TTTTCAATCGATCTTCAAAATCTAAACGGATCAAGTCGAAACAAGATGATCAAGGAACGCTCTTTTGA

Upstream 100 bases:

>100_bases
TTTGAGCCATCCTGTTTTAGAGAGACTATTCATTCCGATAAAGATGTGTTTGTGTGGCTGTGAGGATTGAATGTTTCAAC
GTCTGTGAATGAAAAAAATG

Downstream 100 bases:

>100_bases
TACGGTAAATATACCGCTTGCTGAAGGACTTCTCATGGGAACAGATGGGAAAGTTCGTTGTTCATGGGCTGGTACAGATC
CACTTTATTGTGCTTATCAT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MNLFFEKTGATNVAEFSVSEIAGALKRVVEEKFGYVRVRGEISGYRGAHASGHAYFALKDDKARLEAVIWRGIMEKLKFP
PEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTLLENRKKKFAEEGLFDEEKKKPLPYMPKIIGVVTSPTGAVI
RDIIHRISDRFPLHILVWPVRVQGETSGREVAAAVKGFNVLPLEGLIPKPDLLIVARGGGSLEDLWGFNDEVVVRAVYES
SLPVISAVGHETDWTLIDYVADWRAPTPTAAAEKAVPVKIDLEVYVVSLGARLRTGLARYFDFHQQKLRAIIRALPTADQ
LFALPRRGFDEISSRLERALCVSCDKKRLYFHTLAIRFTPRLLNTEKAQHSAKEYTARLHRAFVHIVEKQRAQLEIAFRL
LKSTSYQNILERGFVLALGQNNKPIKRLAQIPEKEQINLRFFDGEISVITQESFFNRSSKSKRIKSKQDDQGTLF

Sequences:

>Translated_475_residues
MNLFFEKTGATNVAEFSVSEIAGALKRVVEEKFGYVRVRGEISGYRGAHASGHAYFALKDDKARLEAVIWRGIMEKLKFP
PEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTLLENRKKKFAEEGLFDEEKKKPLPYMPKIIGVVTSPTGAVI
RDIIHRISDRFPLHILVWPVRVQGETSGREVAAAVKGFNVLPLEGLIPKPDLLIVARGGGSLEDLWGFNDEVVVRAVYES
SLPVISAVGHETDWTLIDYVADWRAPTPTAAAEKAVPVKIDLEVYVVSLGARLRTGLARYFDFHQQKLRAIIRALPTADQ
LFALPRRGFDEISSRLERALCVSCDKKRLYFHTLAIRFTPRLLNTEKAQHSAKEYTARLHRAFVHIVEKQRAQLEIAFRL
LKSTSYQNILERGFVLALGQNNKPIKRLAQIPEKEQINLRFFDGEISVITQESFFNRSSKSKRIKSKQDDQGTLF
>Mature_475_residues
MNLFFEKTGATNVAEFSVSEIAGALKRVVEEKFGYVRVRGEISGYRGAHASGHAYFALKDDKARLEAVIWRGIMEKLKFP
PEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTLLENRKKKFAEEGLFDEEKKKPLPYMPKIIGVVTSPTGAVI
RDIIHRISDRFPLHILVWPVRVQGETSGREVAAAVKGFNVLPLEGLIPKPDLLIVARGGGSLEDLWGFNDEVVVRAVYES
SLPVISAVGHETDWTLIDYVADWRAPTPTAAAEKAVPVKIDLEVYVVSLGARLRTGLARYFDFHQQKLRAIIRALPTADQ
LFALPRRGFDEISSRLERALCVSCDKKRLYFHTLAIRFTPRLLNTEKAQHSAKEYTARLHRAFVHIVEKQRAQLEIAFRL
LKSTSYQNILERGFVLALGQNNKPIKRLAQIPEKEQINLRFFDGEISVITQESFFNRSSKSKRIKSKQDDQGTLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=441, Percent_Identity=34.0136054421769, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_BARHE (Q6G2I3)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033978.1
- GeneID:   2865833
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH12220
- NMPDR:   fig|283166.1.peg.1106
- HOGENOM:   HBG634411
- OMA:   ILERGFV
- PhylomeDB:   Q6G2I3
- ProtClustDB:   PRK00286
- BioCyc:   BHEN283166:BH12220-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 53449; Mature: 53449

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFFEKTGATNVAEFSVSEIAGALKRVVEEKFGYVRVRGEISGYRGAHASGHAYFALKD
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEEEEEEC
DKARLEAVIWRGIMEKLKFPPEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTL
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCHHHHHHH
LENRKKKFAEEGLFDEEKKKPLPYMPKIIGVVTSPTGAVIRDIIHRISDRFPLHILVWPV
HHHHHHHHHHCCCCCCHHCCCCCCCCHHHEEEECCCHHHHHHHHHHHCCCCCEEEEEEEE
RVQGETSGREVAAAVKGFNVLPLEGLIPKPDLLIVARGGGSLEDLWGFNDEVVVRAVYES
EEECCCCCHHHHHHHCCCCEECCCCCCCCCCEEEEECCCCCHHHHCCCCCHHEEEEEHHC
SLPVISAVGHETDWTLIDYVADWRAPTPTAAAEKAVPVKIDLEVYVVSLGARLRTGLARY
CCCEEEECCCCCCCHHHHHHHHCCCCCCCCHHCCCCEEEEEEEEEEEEHHHHHHHHHHHH
FDFHQQKLRAIIRALPTADQLFALPRRGFDEISSRLERALCVSCDKKRLYFHTLAIRFTP
HHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECH
RLLNTEKAQHSAKEYTARLHRAFVHIVEKQRAQLEIAFRLLKSTSYQNILERGFVLALGQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEECC
NNKPIKRLAQIPEKEQINLRFFDGEISVITQESFFNRSSKSKRIKSKQDDQGTLF
CCCHHHHHHCCCCCCCEEEEEECCEEEEEECHHHHCCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNLFFEKTGATNVAEFSVSEIAGALKRVVEEKFGYVRVRGEISGYRGAHASGHAYFALKD
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEEEEEEC
DKARLEAVIWRGIMEKLKFPPEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTL
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCHHHHHHH
LENRKKKFAEEGLFDEEKKKPLPYMPKIIGVVTSPTGAVIRDIIHRISDRFPLHILVWPV
HHHHHHHHHHCCCCCCHHCCCCCCCCHHHEEEECCCHHHHHHHHHHHCCCCCEEEEEEEE
RVQGETSGREVAAAVKGFNVLPLEGLIPKPDLLIVARGGGSLEDLWGFNDEVVVRAVYES
EEECCCCCHHHHHHHCCCCEECCCCCCCCCCEEEEECCCCCHHHHCCCCCHHEEEEEHHC
SLPVISAVGHETDWTLIDYVADWRAPTPTAAAEKAVPVKIDLEVYVVSLGARLRTGLARY
CCCEEEECCCCCCCHHHHHHHHCCCCCCCCHHCCCCEEEEEEEEEEEEHHHHHHHHHHHH
FDFHQQKLRAIIRALPTADQLFALPRRGFDEISSRLERALCVSCDKKRLYFHTLAIRFTP
HHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECH
RLLNTEKAQHSAKEYTARLHRAFVHIVEKQRAQLEIAFRLLKSTSYQNILERGFVLALGQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEECC
NNKPIKRLAQIPEKEQINLRFFDGEISVITQESFFNRSSKSKRIKSKQDDQGTLF
CCCHHHHHHCCCCCCCEEEEEECCEEEEEECHHHHCCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA