| Definition | Bartonella henselae str. Houston-1, complete genome. |
|---|---|
| Accession | NC_005956 |
| Length | 1,931,047 |
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The map label for this gene is murE [H]
Identifier: 49475860
GI number: 49475860
Start: 1245948
End: 1247399
Strand: Reverse
Name: murE [H]
Synonym: BH11290
Alternate gene names: 49475860
Gene position: 1247399-1245948 (Counterclockwise)
Preceding gene: 49475861
Following gene: 49475859
Centisome position: 64.6
GC content: 40.15
Gene sequence:
>1452_bases ATGTTGTTTGGAACAATTTTTACAGAATGTCTTGAAGATGAGAATCTTTCTTCAATGGAAATAACAGGAATCAGTGCAGA TTCTCGGCAAATCTTGCCAGGCTATATTTTTGTAGCTCTTCAAGGTCATCAAGACGATGGGAAACACTATATCAATGATG CACTAAAACGTGGTGCACAAGCAATCGTTACAGATTGTAATGTTGTTTTGGAGAATTTATCTGTTCCCCTTTTGCGTGTT TTGGATGCTCGTCATAGCTTAGCGGTAGCAGCTGCTCGTTTTTATGGTTCTCAACCTGAAACTGTCGTTGCTGTGACTGG GACAAGTGGAAAAACATCAGTTGTCTCTTTTCTTCGGCAAATTTGGACAAAGGTTGGATTATGTGCTGCGAGTATAGGAA CGCTAGGTGTTGTTTCTCCTAAACGAAATGATTATGGTTCTCTTACAACACCTGACCCGGTCTTCTTGCAGCGTCTTCTT TCTGAAATTGCTAATGAAGGTGTTACACATGCAGCTCTTGAAGCATCTTCGCATGGGCTTGATCAGTGCCGACTTGACGG AGTACGTCTTACTGCTGCTGCCTTTACCAATTTAGGACGTGATCATATGGATTATCACACCAGCGTAGAGGATTATTTGC GTGCTAAAATGAGGTTATTTGATACACTTTTACCTCGAGATGCTTCTGCTTTGATTTTTGCGGATGATATTTATTCGCAA AAGGTTATTGATACCCTCACACAAGCACGTCGTCATGTTTTAACAATTGGGCGTAAAGGGCAATTTATCACTATTAATCG TATTGAACATCAACGTTCGAAACAGTGTGTTGAATGTCGTTTGGAAAACAATATCTACACATTTAATTTACCTTTAGCGG GAGATTTTCAAGTGAATAATGCACTTATGGCGGCGGGACTTGCGATTTCAACAGGTATATCACCTGATAAGGTATTTCGT TCTCTTGAAACTTTGCAGGGAGCACCTGGTCGTTTAGAGTTGGTTGGAAAGACAGAAAATAATGCTTCTGTTTATATTGA TTATGCACATAAACCGGAAGCTTTGGAACAAGTGCTGCTTTCTGTTCGTCCCTTCACGCAAGGGCGTTTAATCCTTGTTT TTGGTTGTGGAGGTGATCGCGATCAAGGAAAAAGACCTTTAATGGGAAAAATTGCAGAAAATAAAGCTGATATTGTTATT ATAACGGATGATAACCCTCGCACGGAAATGCCAGCGAAAATACGCAAGGATATTTTACAAGCAGCGCCAAAAGCCATCGA AATAGCAGATCGTGGTGAAGCTATTACTTATGCAGTTGGGCTTTTAAAAGCAGGGGATACATTAATCATTGCTGGAAAAG GTCATGAGAATGGTCAAATTATAGGGCAAAAAACATATCCTTTTTCAGATCGTTTGAAAGCGATTGAAGCTTTACAGGAA CGGATTAGATGA
Upstream 100 bases:
>100_bases TAAAACCAGATTTTCAGAAAGAATATGAGCCTATTTTAACCACAGAGAACAGTTTAAGTTTTGTTAAAAAACGGTGAAAT TCATATAAAGGTGTGTTGTC
Downstream 100 bases:
>100_bases AAGCTTTATGGGATAAACAAGCACTTATTACAGCAATTGATGGTTATGCAATTGGGGAAATACCGGAAACTTTTTCCGGT ATTTCTATTGATAGTCGTAC
Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 483; Mature: 483
Protein sequence:
>483_residues MLFGTIFTECLEDENLSSMEITGISADSRQILPGYIFVALQGHQDDGKHYINDALKRGAQAIVTDCNVVLENLSVPLLRV LDARHSLAVAAARFYGSQPETVVAVTGTSGKTSVVSFLRQIWTKVGLCAASIGTLGVVSPKRNDYGSLTTPDPVFLQRLL SEIANEGVTHAALEASSHGLDQCRLDGVRLTAAAFTNLGRDHMDYHTSVEDYLRAKMRLFDTLLPRDASALIFADDIYSQ KVIDTLTQARRHVLTIGRKGQFITINRIEHQRSKQCVECRLENNIYTFNLPLAGDFQVNNALMAAGLAISTGISPDKVFR SLETLQGAPGRLELVGKTENNASVYIDYAHKPEALEQVLLSVRPFTQGRLILVFGCGGDRDQGKRPLMGKIAENKADIVI ITDDNPRTEMPAKIRKDILQAAPKAIEIADRGEAITYAVGLLKAGDTLIIAGKGHENGQIIGQKTYPFSDRLKAIEALQE RIR
Sequences:
>Translated_483_residues MLFGTIFTECLEDENLSSMEITGISADSRQILPGYIFVALQGHQDDGKHYINDALKRGAQAIVTDCNVVLENLSVPLLRV LDARHSLAVAAARFYGSQPETVVAVTGTSGKTSVVSFLRQIWTKVGLCAASIGTLGVVSPKRNDYGSLTTPDPVFLQRLL SEIANEGVTHAALEASSHGLDQCRLDGVRLTAAAFTNLGRDHMDYHTSVEDYLRAKMRLFDTLLPRDASALIFADDIYSQ KVIDTLTQARRHVLTIGRKGQFITINRIEHQRSKQCVECRLENNIYTFNLPLAGDFQVNNALMAAGLAISTGISPDKVFR SLETLQGAPGRLELVGKTENNASVYIDYAHKPEALEQVLLSVRPFTQGRLILVFGCGGDRDQGKRPLMGKIAENKADIVI ITDDNPRTEMPAKIRKDILQAAPKAIEIADRGEAITYAVGLLKAGDTLIIAGKGHENGQIIGQKTYPFSDRLKAIEALQE RIR >Mature_483_residues MLFGTIFTECLEDENLSSMEITGISADSRQILPGYIFVALQGHQDDGKHYINDALKRGAQAIVTDCNVVLENLSVPLLRV LDARHSLAVAAARFYGSQPETVVAVTGTSGKTSVVSFLRQIWTKVGLCAASIGTLGVVSPKRNDYGSLTTPDPVFLQRLL SEIANEGVTHAALEASSHGLDQCRLDGVRLTAAAFTNLGRDHMDYHTSVEDYLRAKMRLFDTLLPRDASALIFADDIYSQ KVIDTLTQARRHVLTIGRKGQFITINRIEHQRSKQCVECRLENNIYTFNLPLAGDFQVNNALMAAGLAISTGISPDKVFR SLETLQGAPGRLELVGKTENNASVYIDYAHKPEALEQVLLSVRPFTQGRLILVFGCGGDRDQGKRPLMGKIAENKADIVI ITDDNPRTEMPAKIRKDILQAAPKAIEIADRGEAITYAVGLLKAGDTLIIAGKGHENGQIIGQKTYPFSDRLKAIEALQE RIR
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family. MurE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=469, Percent_Identity=36.0341151385927, Blast_Score=237, Evalue=1e-63, Organism=Escherichia coli, GI1786274, Length=343, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=5e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 52855; Mature: 52855
Theoretical pI: Translated: 7.09; Mature: 7.09
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLFGTIFTECLEDENLSSMEITGISADSRQILPGYIFVALQGHQDDGKHYINDALKRGAQ CCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCHH AIVTDCNVVLENLSVPLLRVLDARHSLAVAAARFYGSQPETVVAVTGTSGKTSVVSFLRQ HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHH IWTKVGLCAASIGTLGVVSPKRNDYGSLTTPDPVFLQRLLSEIANEGVTHAALEASSHGL HHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCC DQCRLDGVRLTAAAFTNLGRDHMDYHTSVEDYLRAKMRLFDTLLPRDASALIFADDIYSQ CHHHCCCEEEHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHH KVIDTLTQARRHVLTIGRKGQFITINRIEHQRSKQCVECRLENNIYTFNLPLAGDFQVNN HHHHHHHHHHHHEEEECCCCCEEEEECHHHHHHHHHHHHEECCCEEEEECCCCCCCEECC ALMAAGLAISTGISPDKVFRSLETLQGAPGRLELVGKTENNASVYIDYAHKPEALEQVLL HHHHHCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHH SVRPFTQGRLILVFGCGGDRDQGKRPLMGKIAENKADIVIITDDNPRTEMPAKIRKDILQ HCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHH AAPKAIEIADRGEAITYAVGLLKAGDTLIIAGKGHENGQIIGQKTYPFSDRLKAIEALQE HCCCEEEECCCCCEEEEEHHHEECCCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHH RIR HCC >Mature Secondary Structure MLFGTIFTECLEDENLSSMEITGISADSRQILPGYIFVALQGHQDDGKHYINDALKRGAQ CCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCHH AIVTDCNVVLENLSVPLLRVLDARHSLAVAAARFYGSQPETVVAVTGTSGKTSVVSFLRQ HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHH IWTKVGLCAASIGTLGVVSPKRNDYGSLTTPDPVFLQRLLSEIANEGVTHAALEASSHGL HHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCC DQCRLDGVRLTAAAFTNLGRDHMDYHTSVEDYLRAKMRLFDTLLPRDASALIFADDIYSQ CHHHCCCEEEHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHH KVIDTLTQARRHVLTIGRKGQFITINRIEHQRSKQCVECRLENNIYTFNLPLAGDFQVNN HHHHHHHHHHHHEEEECCCCCEEEEECHHHHHHHHHHHHEECCCEEEEECCCCCCCEECC ALMAAGLAISTGISPDKVFRSLETLQGAPGRLELVGKTENNASVYIDYAHKPEALEQVLL HHHHHCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHH SVRPFTQGRLILVFGCGGDRDQGKRPLMGKIAENKADIVIITDDNPRTEMPAKIRKDILQ HCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHH AAPKAIEIADRGEAITYAVGLLKAGDTLIIAGKGHENGQIIGQKTYPFSDRLKAIEALQE HCCCEEEECCCCCEEEEEHHHEECCCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHH RIR HCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11756688 [H]