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The map label for this gene is lpxC [H]

Identifier: 49475848

GI number: 49475848

Start: 1231013

End: 1231888

Strand: Reverse

Name: lpxC [H]

Synonym: BH11170

Alternate gene names: 49475848

Gene position: 1231888-1231013 (Counterclockwise)

Preceding gene: 49475849

Following gene: 49475847

Centisome position: 63.79

GC content: 39.84

Gene sequence:

>876_bases
ATGATAAAGCTGGTACAAAAATATCAGTCCACTCTTAAAAAAGTAGTGACATTTAAGGGCATTGGTGTTCACAGTGGGTG
TTTATCTGTGGTGAAAGTTTGTCCAGCTGATGTTGGGTGTGGTATTGTTTTTAAGCGTTTTGCAGTGGATGGGACAGAGC
AAATATTTCAAGCACATGCATCACAAACGGGGGCGACTGAATTATCAACAGCGCTTGGACATGGAGGGTTCAGAGTTGAA
ACAATTGAGCATCTGATGGCTGCGATTGCTGCTTATAATTTGGATAATCTTATTATTGAAGTGTCGAGTCATGAGATTCC
GATTTTGGATGGTTCTTCATGGCAGTATTGTCAAGCTTTTGATGAAGTTGGTGTTATACGGCAGAATGTGTTGCGTTCCT
ATTTCGTTATAAAAAAGCCGCTGCGGGTCGAAAGCACCAATGGTGTTGCAGAGTTTTTACCCTTTGATGGGCGCCGTTTT
GATATAACAATCTCTTTTCCTTCTTCTGCTATTGGTAAACAACATTTAACTTTTGATCTTACCCCACAAAGCTTTCGCGA
TGACTTGTCGCGTGCACGCACTTTTGGTTTTGTCAAAGACGTGGAAAAATTATGGGTTTCTGGAAAAGGGATAGGCGCTT
CTTTAGAAAATTCTCTCATTATCGGTCTTAATGACAAAATCATAAATCCAGATGGACCTTATTGGAAGAATGAATATGTT
CGGCACAAAACGCTTGATGCAATTGGTGATACTGCTTTGCTTGGAGCCCCTTTTATTGGATTATTTCGCTCTTATTGTAG
TGGTCATAGAATGAATTCGCAATTGGTGAAAGCTGTTTTGGCGGATGAATCATGTTATGAAAAAAGTCATTTATAG

Upstream 100 bases:

>100_bases
AACCCGCTTGTAATAAGCGGGTTTATTATTTGCTATGAATATAATCTTTATCGTTTTATAAATATTTTTAAAGGCCGTAA
AAATTATTCAATGAAGTGAC

Downstream 100 bases:

>100_bases
GAAGAGTGAAAGAAAAATTGAAAAGATTTTGTTGTAGTTTATTTGATTTTTAAGGGGATGATTAATCTTAAGCTATTAAA
TTGGTTAGTGGCTTTTGACA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MIKLVQKYQSTLKKVVTFKGIGVHSGCLSVVKVCPADVGCGIVFKRFAVDGTEQIFQAHASQTGATELSTALGHGGFRVE
TIEHLMAAIAAYNLDNLIIEVSSHEIPILDGSSWQYCQAFDEVGVIRQNVLRSYFVIKKPLRVESTNGVAEFLPFDGRRF
DITISFPSSAIGKQHLTFDLTPQSFRDDLSRARTFGFVKDVEKLWVSGKGIGASLENSLIIGLNDKIINPDGPYWKNEYV
RHKTLDAIGDTALLGAPFIGLFRSYCSGHRMNSQLVKAVLADESCYEKSHL

Sequences:

>Translated_291_residues
MIKLVQKYQSTLKKVVTFKGIGVHSGCLSVVKVCPADVGCGIVFKRFAVDGTEQIFQAHASQTGATELSTALGHGGFRVE
TIEHLMAAIAAYNLDNLIIEVSSHEIPILDGSSWQYCQAFDEVGVIRQNVLRSYFVIKKPLRVESTNGVAEFLPFDGRRF
DITISFPSSAIGKQHLTFDLTPQSFRDDLSRARTFGFVKDVEKLWVSGKGIGASLENSLIIGLNDKIINPDGPYWKNEYV
RHKTLDAIGDTALLGAPFIGLFRSYCSGHRMNSQLVKAVLADESCYEKSHL
>Mature_291_residues
MIKLVQKYQSTLKKVVTFKGIGVHSGCLSVVKVCPADVGCGIVFKRFAVDGTEQIFQAHASQTGATELSTALGHGGFRVE
TIEHLMAAIAAYNLDNLIIEVSSHEIPILDGSSWQYCQAFDEVGVIRQNVLRSYFVIKKPLRVESTNGVAEFLPFDGRRF
DITISFPSSAIGKQHLTFDLTPQSFRDDLSRARTFGFVKDVEKLWVSGKGIGASLENSLIIGLNDKIINPDGPYWKNEYV
RHKTLDAIGDTALLGAPFIGLFRSYCSGHRMNSQLVKAVLADESCYEKSHL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=282, Percent_Identity=36.5248226950355, Blast_Score=190, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32092; Mature: 32092

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLVQKYQSTLKKVVTFKGIGVHSGCLSVVKVCPADVGCGIVFKRFAVDGTEQIFQAHA
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHH
SQTGATELSTALGHGGFRVETIEHLMAAIAAYNLDNLIIEVSSHEIPILDGSSWQYCQAF
CCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCHHHHHH
DEVGVIRQNVLRSYFVIKKPLRVESTNGVAEFLPFDGRRFDITISFPSSAIGKQHLTFDL
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCCEEEEEEECCCHHCCCCCEEEEC
TPQSFRDDLSRARTFGFVKDVEKLWVSGKGIGASLENSLIIGLNDKIINPDGPYWKNEYV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEECCCCCCCCCHHH
RHKTLDAIGDTALLGAPFIGLFRSYCSGHRMNSQLVKAVLADESCYEKSHL
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCC
>Mature Secondary Structure
MIKLVQKYQSTLKKVVTFKGIGVHSGCLSVVKVCPADVGCGIVFKRFAVDGTEQIFQAHA
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHH
SQTGATELSTALGHGGFRVETIEHLMAAIAAYNLDNLIIEVSSHEIPILDGSSWQYCQAF
CCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCHHHHHH
DEVGVIRQNVLRSYFVIKKPLRVESTNGVAEFLPFDGRRFDITISFPSSAIGKQHLTFDL
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCCCCEEEEEEECCCHHCCCCCEEEEC
TPQSFRDDLSRARTFGFVKDVEKLWVSGKGIGASLENSLIIGLNDKIINPDGPYWKNEYV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEECCCCCCCCCHHH
RHKTLDAIGDTALLGAPFIGLFRSYCSGHRMNSQLVKAVLADESCYEKSHL
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA