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The map label for this gene is hflK [H]

Identifier: 49475830

GI number: 49475830

Start: 1207198

End: 1208343

Strand: Reverse

Name: hflK [H]

Synonym: BH10960

Alternate gene names: 49475830

Gene position: 1208343-1207198 (Counterclockwise)

Preceding gene: 49475831

Following gene: 49475829

Centisome position: 62.57

GC content: 41.27

Gene sequence:

>1146_bases
ATGCCCTGGACAAATCAAAATGGTGGTGGCCCGTGGAGCGGCGATAAAAATAAGCTTAGTGGTGATAAAAAAACACCCTC
TAAGAATCTTTTCGGTTCTGGTGGCAATAATGGTGGTGACAATAGTCCCAATATTGATGATATTTTGCGTAAAGGGCAGG
ATCAGTTTAAACAATTTGGCAAAAATGGACTTTTTGTTTTGTTATTTCTATTTGCTGTGTTGTTTTGGCTCTATCAGTCC
CTTTATATTGTTCAGCAAAATGAACAAGCGGTAGAGTTGCGTTTTGGTGTGCCTAAGACAGAAACTATCGGTGATGGTTT
GCATTTTCACTTTTGGCCAATTGAGACCTATATGAAAGTGCCTTTAACGGAAAAAACAATTGCGATTGGTGGTCAGCCGG
GGCAGAGACAACAAAGTGAAGGCTTGATGCTTTCCAGTGACCAGAATATTGTTAATGTCAATTTTTCCATTTACTATCGC
ATTTCACATCCAGGTCAATTTTTATTTAATGTGAATGATCAAGAAGGGACGGTTCGTCAGGTTGCTGAGAGTGCAATGCG
TGAAGTCATTGGTTCAAGGCCTGTTGATGATGTTTTACGTGATAAAAAAGAAGAAGTTGCAAGTGACGTTAGAAAAATTA
TTCAATTGACTGTAGATAAATATCAACTTGGTGTTGAAATAAGCCGTGTGTCGATCAGTGAAGCTGCTCCTCCTACCAAG
GTTGCTGCTGCGTTTAATTCTGTCCAGCAAGCAGAACAGGAGCGTGGGCGAATGATTGAAGAGGGAAATCGTGTGCGTTT
TAATAAGATTGGTTTAGCCAATGGTGAGGCTTCACGAACGCGGGAGATTGCAAAAGGTGAAAAAGCACGAATGGTTGAGG
AGGCAACAGGGCGTGCTGAGCGTTTTCAGGCTATAGCTCGTGAATCTGCAATTTCACCAGAGGCCGTTCGTTATCGTCTT
TATATGGAGACGATGGGGCGTATTTTTTCTTCACCAAATAAGTTAATTCTTGATCAAACGAATTCTCCAGCGGTGCCTTA
TCTTCCTTTGAATGAATTGTTGCGTAGCAATTCATCAGAAAAAGTGAAAACAAGATCAGCGCATTCTGCATCGTTGTTGG
ATAATCACATTTCTGGAGGACGCTAA

Upstream 100 bases:

>100_bases
AAAAGAGGCTATCAGTTGCCTTGTAATGAGATGAGAGGCACCCTATAGATCAAGTGAATGGTTGGTATTTTAGGAATGGT
AGTCAGTTAAAGAGGTGATG

Downstream 100 bases:

>100_bases
TGATGCAGCAGTCTCGTTTTTTGTTTATGTTGAGTGCTATAGTGCTTATTTTCATGGTTTTGTGGATGTCCGTTTTTATT
GTCTATCCTCGTCAGCAAGT

Product: protease subunit hflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MPWTNQNGGGPWSGDKNKLSGDKKTPSKNLFGSGGNNGGDNSPNIDDILRKGQDQFKQFGKNGLFVLLFLFAVLFWLYQS
LYIVQQNEQAVELRFGVPKTETIGDGLHFHFWPIETYMKVPLTEKTIAIGGQPGQRQQSEGLMLSSDQNIVNVNFSIYYR
ISHPGQFLFNVNDQEGTVRQVAESAMREVIGSRPVDDVLRDKKEEVASDVRKIIQLTVDKYQLGVEISRVSISEAAPPTK
VAAAFNSVQQAEQERGRMIEEGNRVRFNKIGLANGEASRTREIAKGEKARMVEEATGRAERFQAIARESAISPEAVRYRL
YMETMGRIFSSPNKLILDQTNSPAVPYLPLNELLRSNSSEKVKTRSAHSASLLDNHISGGR

Sequences:

>Translated_381_residues
MPWTNQNGGGPWSGDKNKLSGDKKTPSKNLFGSGGNNGGDNSPNIDDILRKGQDQFKQFGKNGLFVLLFLFAVLFWLYQS
LYIVQQNEQAVELRFGVPKTETIGDGLHFHFWPIETYMKVPLTEKTIAIGGQPGQRQQSEGLMLSSDQNIVNVNFSIYYR
ISHPGQFLFNVNDQEGTVRQVAESAMREVIGSRPVDDVLRDKKEEVASDVRKIIQLTVDKYQLGVEISRVSISEAAPPTK
VAAAFNSVQQAEQERGRMIEEGNRVRFNKIGLANGEASRTREIAKGEKARMVEEATGRAERFQAIARESAISPEAVRYRL
YMETMGRIFSSPNKLILDQTNSPAVPYLPLNELLRSNSSEKVKTRSAHSASLLDNHISGGR
>Mature_380_residues
PWTNQNGGGPWSGDKNKLSGDKKTPSKNLFGSGGNNGGDNSPNIDDILRKGQDQFKQFGKNGLFVLLFLFAVLFWLYQSL
YIVQQNEQAVELRFGVPKTETIGDGLHFHFWPIETYMKVPLTEKTIAIGGQPGQRQQSEGLMLSSDQNIVNVNFSIYYRI
SHPGQFLFNVNDQEGTVRQVAESAMREVIGSRPVDDVLRDKKEEVASDVRKIIQLTVDKYQLGVEISRVSISEAAPPTKV
AAAFNSVQQAEQERGRMIEEGNRVRFNKIGLANGEASRTREIAKGEKARMVEEATGRAERFQAIARESAISPEAVRYRLY
METMGRIFSSPNKLILDQTNSPAVPYLPLNELLRSNSSEKVKTRSAHSASLLDNHISGGR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=199, Percent_Identity=23.6180904522613, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790616, Length=292, Percent_Identity=27.3972602739726, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32566490, Length=166, Percent_Identity=27.1084337349398, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 42481; Mature: 42349

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWTNQNGGGPWSGDKNKLSGDKKTPSKNLFGSGGNNGGDNSPNIDDILRKGQDQFKQFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHC
KNGLFVLLFLFAVLFWLYQSLYIVQQNEQAVELRFGVPKTETIGDGLHFHFWPIETYMKV
CCCHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEEHHHHEEC
PLTEKTIAIGGQPGQRQQSEGLMLSSDQNIVNVNFSIYYRISHPGQFLFNVNDQEGTVRQ
CCCCCEEEECCCCCCCHHHCCEEEECCCCEEEEEEEEEEEECCCCEEEEEECCCCCHHHH
VAESAMREVIGSRPVDDVLRDKKEEVASDVRKIIQLTVDKYQLGVEISRVSISEAAPPTK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHH
VAAAFNSVQQAEQERGRMIEEGNRVRFNKIGLANGEASRTREIAKGEKARMVEEATGRAE
HHHHHHHHHHHHHHHCCHHHCCCEEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCHHH
RFQAIARESAISPEAVRYRLYMETMGRIFSSPNKLILDQTNSPAVPYLPLNELLRSNSSE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCCCH
KVKTRSAHSASLLDNHISGGR
HHHHHCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PWTNQNGGGPWSGDKNKLSGDKKTPSKNLFGSGGNNGGDNSPNIDDILRKGQDQFKQFG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHC
KNGLFVLLFLFAVLFWLYQSLYIVQQNEQAVELRFGVPKTETIGDGLHFHFWPIETYMKV
CCCHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEEHHHHEEC
PLTEKTIAIGGQPGQRQQSEGLMLSSDQNIVNVNFSIYYRISHPGQFLFNVNDQEGTVRQ
CCCCCEEEECCCCCCCHHHCCEEEECCCCEEEEEEEEEEEECCCCEEEEEECCCCCHHHH
VAESAMREVIGSRPVDDVLRDKKEEVASDVRKIIQLTVDKYQLGVEISRVSISEAAPPTK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHH
VAAAFNSVQQAEQERGRMIEEGNRVRFNKIGLANGEASRTREIAKGEKARMVEEATGRAE
HHHHHHHHHHHHHHHCCHHHCCCEEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCHHH
RFQAIARESAISPEAVRYRLYMETMGRIFSSPNKLILDQTNSPAVPYLPLNELLRSNSSE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCCCH
KVKTRSAHSASLLDNHISGGR
HHHHHCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]