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The map label for this gene is hflC [H]

Identifier: 49475829

GI number: 49475829

Start: 1206248

End: 1207195

Strand: Reverse

Name: hflC [H]

Synonym: BH10950

Alternate gene names: 49475829

Gene position: 1207195-1206248 (Counterclockwise)

Preceding gene: 49475830

Following gene: 49475828

Centisome position: 62.52

GC content: 41.46

Gene sequence:

>948_bases
ATGCAGCAGTCTCGTTTTTTGTTTATGTTGAGTGCTATAGTGCTTATTTTCATGGTTTTGTGGATGTCCGTTTTTATTGT
CTATCCTCGTCAGCAAGTGGCAATTAAACGTTTTGGGCAAATTGTTAAAGTGGAGTCTGATCCAGGAATTTATTTGAAAG
TGCCCTTTGTGGATAAGAGGATCGTTGTTGATAACCGCTTGTTGCGTTACGATGTTCCTACGCAATCTGTACAGGTTCGT
GGTGGTGCCTATTATGAAGTGGATGCATTTTTTATTTATCGTATTACAGATCCTAAGTTGTTTTTACAGCGTATCGCTTC
TGGGCGTCCGCAAATTGCTGCACGTGAAAATCTTGCTCCGCGTTTTATTGATGCTTTACGTGCTGTTTATGGTAAACGGG
AATTTAAAGCCGCTTTATCAGATGAACGCGGAGCTATGATGGCTGAAGTACAACGCCAGTTTTCTGTAGATGCCGGTTCG
TTAGGTATTACTATTGTTGATGTGCGTATTCGCAAAACCGATTTGACCGATGCAGTTTCAGAAGATGTCTATCGACAAAT
GGCAGCTGAACGGGAGGCTGTAGCAGAAAATATTCGTGCTCGTGGTCAGCAAGAGCGAGATCGTATTGTGGCGGAAGCTA
ATCGTGAATATGAAGAAATCGTAGCGGCTGCAAAGCGTGATGCCGAAATTACTCGTGGTGAAGGTCAGGCTGAAAGTATT
CGCCTTTTATTGAAAGCGAGGGAGGCTAATCCATCCTTTTACGATTTTTGGTTGGCGATGGAGCAATATAAGAATTTAGA
GCATACTCCGATGGTGATTTCACCAAATGAGGATTTCTTTTTCTATTTTCGTAATTTACTACAGGCAAGGGAGAAACTTT
CATCGACAATGAACACTAATGGGAATACTGGACTTAATAAAACTGTTTCAAAATTTGGAGGAGAATAG

Upstream 100 bases:

>100_bases
TGAATGAATTGTTGCGTAGCAATTCATCAGAAAAAGTGAAAACAAGATCAGCGCATTCTGCATCGTTGTTGGATAATCAC
ATTTCTGGAGGACGCTAATG

Downstream 100 bases:

>100_bases
ATGAAACACTTGATTGCGAACACAAGATTTCGCGTGATAAGTGTAATATTTGATTGCTTTCTTTTAGGATGAAAATGGGT
ATTGAGCCATACTGATTTTG

Product: ftsH protease activity modulator hflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MQQSRFLFMLSAIVLIFMVLWMSVFIVYPRQQVAIKRFGQIVKVESDPGIYLKVPFVDKRIVVDNRLLRYDVPTQSVQVR
GGAYYEVDAFFIYRITDPKLFLQRIASGRPQIAARENLAPRFIDALRAVYGKREFKAALSDERGAMMAEVQRQFSVDAGS
LGITIVDVRIRKTDLTDAVSEDVYRQMAAEREAVAENIRARGQQERDRIVAEANREYEEIVAAAKRDAEITRGEGQAESI
RLLLKAREANPSFYDFWLAMEQYKNLEHTPMVISPNEDFFFYFRNLLQAREKLSSTMNTNGNTGLNKTVSKFGGE

Sequences:

>Translated_315_residues
MQQSRFLFMLSAIVLIFMVLWMSVFIVYPRQQVAIKRFGQIVKVESDPGIYLKVPFVDKRIVVDNRLLRYDVPTQSVQVR
GGAYYEVDAFFIYRITDPKLFLQRIASGRPQIAARENLAPRFIDALRAVYGKREFKAALSDERGAMMAEVQRQFSVDAGS
LGITIVDVRIRKTDLTDAVSEDVYRQMAAEREAVAENIRARGQQERDRIVAEANREYEEIVAAAKRDAEITRGEGQAESI
RLLLKAREANPSFYDFWLAMEQYKNLEHTPMVISPNEDFFFYFRNLLQAREKLSSTMNTNGNTGLNKTVSKFGGE
>Mature_315_residues
MQQSRFLFMLSAIVLIFMVLWMSVFIVYPRQQVAIKRFGQIVKVESDPGIYLKVPFVDKRIVVDNRLLRYDVPTQSVQVR
GGAYYEVDAFFIYRITDPKLFLQRIASGRPQIAARENLAPRFIDALRAVYGKREFKAALSDERGAMMAEVQRQFSVDAGS
LGITIVDVRIRKTDLTDAVSEDVYRQMAAEREAVAENIRARGQQERDRIVAEANREYEEIVAAAKRDAEITRGEGQAESI
RLLLKAREANPSFYDFWLAMEQYKNLEHTPMVISPNEDFFFYFRNLLQAREKLSSTMNTNGNTGLNKTVSKFGGE

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=318, Percent_Identity=30.188679245283, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17569497, Length=245, Percent_Identity=30.2040816326531, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 36153; Mature: 36153

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSRFLFMLSAIVLIFMVLWMSVFIVYPRQQVAIKRFGQIVKVESDPGIYLKVPFVDKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCEEEEECCCCCE
IVVDNRLLRYDVPTQSVQVRGGAYYEVDAFFIYRITDPKLFLQRIASGRPQIAARENLAP
EEECCEEEEECCCCCCEEECCCEEEEEEEEEEEEECCHHHHHHHHHCCCCCCCHHCCCCH
RFIDALRAVYGKREFKAALSDERGAMMAEVQRQFSVDAGSLGITIVDVRIRKTDLTDAVS
HHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEECCCHHHHHH
EDVYRQMAAEREAVAENIRARGQQERDRIVAEANREYEEIVAAAKRDAEITRGEGQAESI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHCCCCCHHHHH
RLLLKAREANPSFYDFWLAMEQYKNLEHTPMVISPNEDFFFYFRNLLQAREKLSSTMNTN
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
GNTGLNKTVSKFGGE
CCCCHHHHHHHHCCC
>Mature Secondary Structure
MQQSRFLFMLSAIVLIFMVLWMSVFIVYPRQQVAIKRFGQIVKVESDPGIYLKVPFVDKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCEEEEECCCCCE
IVVDNRLLRYDVPTQSVQVRGGAYYEVDAFFIYRITDPKLFLQRIASGRPQIAARENLAP
EEECCEEEEECCCCCCEEECCCEEEEEEEEEEEEECCHHHHHHHHHCCCCCCCHHCCCCH
RFIDALRAVYGKREFKAALSDERGAMMAEVQRQFSVDAGSLGITIVDVRIRKTDLTDAVS
HHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEECCCHHHHHH
EDVYRQMAAEREAVAENIRARGQQERDRIVAEANREYEEIVAAAKRDAEITRGEGQAESI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHCCCCCHHHHH
RLLLKAREANPSFYDFWLAMEQYKNLEHTPMVISPNEDFFFYFRNLLQAREKLSSTMNTN
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
GNTGLNKTVSKFGGE
CCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]