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The map label for this gene is htrA3 [H]

Identifier: 49475828

GI number: 49475828

Start: 1204580

End: 1206097

Strand: Reverse

Name: htrA3 [H]

Synonym: BH10940

Alternate gene names: 49475828

Gene position: 1206097-1204580 (Counterclockwise)

Preceding gene: 49475829

Following gene: 49475827

Centisome position: 62.46

GC content: 39.0

Gene sequence:

>1518_bases
ATGGGTAGAAATGTCATAGGTAAAAATACGTCTATGAAGTGCTTTCTTATAAGAGCTTTTGTTTGCGTGCTTTTATTTTT
ATTAGGATCAATGAATTCTTCTTGGGCGGTGGAGACAAAAAATAGATCGCTTTCCGTTCCTGATCTCGCTGCTCAGCTTT
TGGAGACAGTTGTAAATATTTCTACAGCACAGACAGTTGATGGGACCGAACAGGATGAACATACTTCGGTACCCGTTATT
CCAGAAGATTCATTGTTACAAGAATATTTTACTGATTTTTTCTCTCCTAAAGATGGTCAAAAAGAGAGTCAGTTTCAAAA
AGTACGTTCTTTGGGGTCTGGTTTTGTAATTGATGCCCAAAAAGGGCTTATCGTTACAAATTATCATGTTATCGTTGATG
CTGATGATATTGAAGTGAATTTTACCGATGGTACAAAGCTAAAGGCAAAATTACTTGGAAAGGATAGCAAGACTGATTTG
GCACTGCTTCAAGTGGATGCAGGAAGTAAAAAATTAAAGGCTGTACGTTTTGGTGACTCAGAAAAGGCCCGTATTGGTGA
TTGGGTGATGGCTATTGGTAATCCTTATGGTTTTGGTGGAAGTGTAACGGTTGGTATTATTTCTGCACGTAATCGTGATC
TCAATGCTGGTCCTTATGATAATTTTATTCAGACAGATGCAGCGATTAACCGAGGTAATTCTGGTGGTCCGTTATTTGAT
AGAAATGGTGAGGTTATTGGAATTAATACAGCAATTGTTTCGCCTTCTGGAGGGTCTATTGGTATTGGTTTTGCTATACC
ATCGGATATGGCGCTTTCTGTTATCAATCAATTGCGTGATTTTGGAGAAATAAGGCGTGGTTGGTTGGCTATTCGTATTC
AGCCGGTGACAGAGGATATTGCAAAAAGTTTAAAATTAGAAAGTCCTGTAGGGGCGTTGGTTGCAGGTAAAATGGAACAA
ACAGATGTAGATAATAGTCAGTTGCAGATTGGCGATATCATTCTTTCCTTTGGCAACGCTAAAATTAAACATGCACGTGA
CTTGCCTCGTTTGGTGGCGGAAAGTCTGGAAGGAAAGGTAGTGGATATTACTGTTTTGCGCAATGGGCAAGAAAAAACAG
TAAAAGTTAAGCTTGGACGTTTAATTGAGACAGATACAAATGAGAATATGGTAGAAGAATCTGATAATGAAAGAAGCGGT
CCTATATCGAAAAGCGGGACAATGCAATTTATGGGAATGACATTATCTGAGCTTACAGCGGATTTACGTCAACATTATTC
TATTACGGATAAACTTCAGGGATTGGTCGTGATATCTGTTGCCAAAAATAGTGCGGCGGATAAAAAGCGTATTCGCACTG
GTGAAGTGATTGTTGATATCAATCAAAGTACTGTCACGACAATTGGTGAGGCTAAAAAACGTATTCATAAATTACGTGAA
GCCGGACGCAAAAATGCTCTCTTCATCATTGCTAGGCCTGATGGAGAATTACGATTCGTAACGATTCCAATGGATTGA

Upstream 100 bases:

>100_bases
TGATTGCTTTCTTTTAGGATGAAAATGGGTATTGAGCCATACTGATTTTGCAGAGATAAATTTGGTGTGGCTCTTTTCAG
TATTTAGTTAGAGGCGTGTT

Downstream 100 bases:

>100_bases
TACTTTGAAGATTGATGTTTTAGTAATTCATTTTTTTGAATATGTATTTAATCATCTGTGTTTTTGTTGTCACTATAAAG
ATATGGGACAGGTGAGAGTT

Product: Serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MGRNVIGKNTSMKCFLIRAFVCVLLFLLGSMNSSWAVETKNRSLSVPDLAAQLLETVVNISTAQTVDGTEQDEHTSVPVI
PEDSLLQEYFTDFFSPKDGQKESQFQKVRSLGSGFVIDAQKGLIVTNYHVIVDADDIEVNFTDGTKLKAKLLGKDSKTDL
ALLQVDAGSKKLKAVRFGDSEKARIGDWVMAIGNPYGFGGSVTVGIISARNRDLNAGPYDNFIQTDAAINRGNSGGPLFD
RNGEVIGINTAIVSPSGGSIGIGFAIPSDMALSVINQLRDFGEIRRGWLAIRIQPVTEDIAKSLKLESPVGALVAGKMEQ
TDVDNSQLQIGDIILSFGNAKIKHARDLPRLVAESLEGKVVDITVLRNGQEKTVKVKLGRLIETDTNENMVEESDNERSG
PISKSGTMQFMGMTLSELTADLRQHYSITDKLQGLVVISVAKNSAADKKRIRTGEVIVDINQSTVTTIGEAKKRIHKLRE
AGRKNALFIIARPDGELRFVTIPMD

Sequences:

>Translated_505_residues
MGRNVIGKNTSMKCFLIRAFVCVLLFLLGSMNSSWAVETKNRSLSVPDLAAQLLETVVNISTAQTVDGTEQDEHTSVPVI
PEDSLLQEYFTDFFSPKDGQKESQFQKVRSLGSGFVIDAQKGLIVTNYHVIVDADDIEVNFTDGTKLKAKLLGKDSKTDL
ALLQVDAGSKKLKAVRFGDSEKARIGDWVMAIGNPYGFGGSVTVGIISARNRDLNAGPYDNFIQTDAAINRGNSGGPLFD
RNGEVIGINTAIVSPSGGSIGIGFAIPSDMALSVINQLRDFGEIRRGWLAIRIQPVTEDIAKSLKLESPVGALVAGKMEQ
TDVDNSQLQIGDIILSFGNAKIKHARDLPRLVAESLEGKVVDITVLRNGQEKTVKVKLGRLIETDTNENMVEESDNERSG
PISKSGTMQFMGMTLSELTADLRQHYSITDKLQGLVVISVAKNSAADKKRIRTGEVIVDINQSTVTTIGEAKKRIHKLRE
AGRKNALFIIARPDGELRFVTIPMD
>Mature_504_residues
GRNVIGKNTSMKCFLIRAFVCVLLFLLGSMNSSWAVETKNRSLSVPDLAAQLLETVVNISTAQTVDGTEQDEHTSVPVIP
EDSLLQEYFTDFFSPKDGQKESQFQKVRSLGSGFVIDAQKGLIVTNYHVIVDADDIEVNFTDGTKLKAKLLGKDSKTDLA
LLQVDAGSKKLKAVRFGDSEKARIGDWVMAIGNPYGFGGSVTVGIISARNRDLNAGPYDNFIQTDAAINRGNSGGPLFDR
NGEVIGINTAIVSPSGGSIGIGFAIPSDMALSVINQLRDFGEIRRGWLAIRIQPVTEDIAKSLKLESPVGALVAGKMEQT
DVDNSQLQIGDIILSFGNAKIKHARDLPRLVAESLEGKVVDITVLRNGQEKTVKVKLGRLIETDTNENMVEESDNERSGP
ISKSGTMQFMGMTLSELTADLRQHYSITDKLQGLVVISVAKNSAADKKRIRTGEVIVDINQSTVTTIGEAKKRIHKLREA
GRKNALFIIARPDGELRFVTIPMD

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=258, Percent_Identity=35.2713178294574, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI22129776, Length=244, Percent_Identity=35.2459016393443, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI24308541, Length=271, Percent_Identity=30.9963099630996, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI7019477, Length=261, Percent_Identity=34.4827586206897, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786356, Length=462, Percent_Identity=36.1471861471861, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1789629, Length=429, Percent_Identity=37.5291375291375, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=38.4057971014493, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646839, Length=295, Percent_Identity=32.5423728813559, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 54893; Mature: 54762

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNVIGKNTSMKCFLIRAFVCVLLFLLGSMNSSWAVETKNRSLSVPDLAAQLLETVVNI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCC
STAQTVDGTEQDEHTSVPVIPEDSLLQEYFTDFFSPKDGQKESQFQKVRSLGSGFVIDAQ
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEECC
KGLIVTNYHVIVDADDIEVNFTDGTKLKAKLLGKDSKTDLALLQVDAGSKKLKAVRFGDS
CCEEEEEEEEEEECCCEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEECCCC
EKARIGDWVMAIGNPYGFGGSVTVGIISARNRDLNAGPYDNFIQTDAAINRGNSGGPLFD
CCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHCCHHHCCCCCCCCCCC
RNGEVIGINTAIVSPSGGSIGIGFAIPSDMALSVINQLRDFGEIRRGWLAIRIQPVTEDI
CCCCEEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHH
AKSLKLESPVGALVAGKMEQTDVDNSQLQIGDIILSFGNAKIKHARDLPRLVAESLEGKV
HHHCCCCCCCCHHHCCCCHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEE
VDITVLRNGQEKTVKVKLGRLIETDTNENMVEESDNERSGPISKSGTMQFMGMTLSELTA
EEEEEEECCCCEEEEEEECEEEECCCCCCHHHCCCCCCCCCCCCCCCEEEECCCHHHHHH
DLRQHYSITDKLQGLVVISVAKNSAADKKRIRTGEVIVDINQSTVTTIGEAKKRIHKLRE
HHHHHCCHHHHCCCEEEEEEECCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
AGRKNALFIIARPDGELRFVTIPMD
CCCCCEEEEEECCCCCEEEEEECCC
>Mature Secondary Structure 
GRNVIGKNTSMKCFLIRAFVCVLLFLLGSMNSSWAVETKNRSLSVPDLAAQLLETVVNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCC
STAQTVDGTEQDEHTSVPVIPEDSLLQEYFTDFFSPKDGQKESQFQKVRSLGSGFVIDAQ
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEECC
KGLIVTNYHVIVDADDIEVNFTDGTKLKAKLLGKDSKTDLALLQVDAGSKKLKAVRFGDS
CCEEEEEEEEEEECCCEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEECCCC
EKARIGDWVMAIGNPYGFGGSVTVGIISARNRDLNAGPYDNFIQTDAAINRGNSGGPLFD
CCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHCCHHHCCCCCCCCCCC
RNGEVIGINTAIVSPSGGSIGIGFAIPSDMALSVINQLRDFGEIRRGWLAIRIQPVTEDI
CCCCEEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHH
AKSLKLESPVGALVAGKMEQTDVDNSQLQIGDIILSFGNAKIKHARDLPRLVAESLEGKV
HHHCCCCCCCCHHHCCCCHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEE
VDITVLRNGQEKTVKVKLGRLIETDTNENMVEESDNERSGPISKSGTMQFMGMTLSELTA
EEEEEEECCCCEEEEEEECEEEECCCCCCHHHCCCCCCCCCCCCCCCEEEECCCHHHHHH
DLRQHYSITDKLQGLVVISVAKNSAADKKRIRTGEVIVDINQSTVTTIGEAKKRIHKLRE
HHHHHCCHHHHCCCEEEEEEECCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
AGRKNALFIIARPDGELRFVTIPMD
CCCCCEEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]