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The map label for this gene is glmU

Identifier: 49475738

GI number: 49475738

Start: 1095814

End: 1097160

Strand: Reverse

Name: glmU

Synonym: BH09930

Alternate gene names: 49475738

Gene position: 1097160-1095814 (Counterclockwise)

Preceding gene: 49475739

Following gene: 49475737

Centisome position: 56.82

GC content: 39.35

Gene sequence:

>1347_bases
ATGAGAAGTTGTCTTTCTATTGTTCTTGCAGCAGGTGAGGGGACGCGCATGAAGTCGTCGCTTCCTAAAGTGCTTCATAA
AATTGCTGGATTGCCTCTTATATGCCACGTTATAAAACAAATAGAATTAGCCGGTGTTTCACAATTAGCAGTCGTTGTGG
GTTTTGGGGCTAAAGATGTCGTGCATGTTGTTGAATCATTTGTAAAAAATGCAATGATTTTTGAACAAAAAGAACGTTTA
GGAACAGCACATGCTGTTTTATCTGCTCGCTTAGCTTTGCAAAAAGGGGTGGATGATGTTCTCATTGTTTTTGGTGATAC
CCCTTTGATTGAGCAAGATTCATTGTTACAACTTCGTGCGCAACTTGCTGGTGGAGCAGATGTTGTTGTTGCTGGTTTTC
GTGCTTTTAATCCAACAGGTTATGGGCGTCTTCTTGAGAAAAATGGTAAACTTATCGCGATTATAGAAGAAAAGGATGCT
AGCGACGAAGAAAAAAAGCTCTCTTTTTGTAATGGTGGGATATTGGCCCTTAATGGAAAGTATGCACTTTCTCTGTTAGA
GAAGATTGGTAACAATAATTCAAAGCGAGAATATTATCTCACAGATATTGTCTCTATTGCATCGCAAGAAGGATTAGATG
TTCGTGTTGTTGAAGTTCCTTTTGACAATATTATAGGAGTTAATAATTGTTTTGAGCTTTTTGAAGCTGATTCTTTATGG
CAAAAACGTAAAGCACGCGATTTAATGTTGTCTGGTGTGACAATCCTTAAACCAGAAACTGTTTATTTTTCTTATGATAC
GCAGATTAAACCAGGGGTGATGATTGAGCCAAATGTTTATTTTGGGCTGGGCGTAAAAGTACATTCTGGTGCAGTTATTC
ATGCATTTAGCTATCTAGAGGGTGCTGTGGTTGGTACAGATGCACGGATTGGACCCTATGCGCGTCTGCGACCTGGAACA
GAGTTGGCAGGATCGGTAAAGATTGGAAACTTTTGTGAAGTCAAAAAAGCTAAAATAGGAAAAGCCTCCAAGATTAATCA
TTTGAGTTATATTGGCGATGCCGAAATTGGAGCACAGGTCAACATTGGAGCTGGGACTATTACTTGCAATTATGACGGAT
TTCATAAACATAAAATTATGATTGGTGATCATGCTTTCATCGGATCTAATTCCGCACTTGTTTCTCCATTGATGATAGGG
GACGGTTCTTATATCGCCTCAGGCAGTGTAATTACTGAAGATGTTCCTATGAATAGTATAGCTTTGGGCCGTGCACGACA
AGTGACGAAAAAGGATTATGCAATGAAATTGCGTGCGCGTTTATCAGCCAATCAACAAAAAAAGTGA

Upstream 100 bases:

>100_bases
CTTTTGGAACATTACCCTTTGTTGAATCAAATTGAAACTATCCATTGGCATGATATTGTGAATTTTTTAGGTTTTTCTCG
TTAGTTTGATGAGTTTTATG

Downstream 100 bases:

>100_bases
TCATTTTTACTCTATTTTCTTTGTTTTATGGTGATCTATAATTTTGTAAGAGGCTTTTTAGATATCGCCTACATATATAT
GTGATTTATTTGATACCTGA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRSCLSIVLAAGEGTRMKSSLPKVLHKIAGLPLICHVIKQIELAGVSQLAVVVGFGAKDVVHVVESFVKNAMIFEQKERL
GTAHAVLSARLALQKGVDDVLIVFGDTPLIEQDSLLQLRAQLAGGADVVVAGFRAFNPTGYGRLLEKNGKLIAIIEEKDA
SDEEKKLSFCNGGILALNGKYALSLLEKIGNNNSKREYYLTDIVSIASQEGLDVRVVEVPFDNIIGVNNCFELFEADSLW
QKRKARDLMLSGVTILKPETVYFSYDTQIKPGVMIEPNVYFGLGVKVHSGAVIHAFSYLEGAVVGTDARIGPYARLRPGT
ELAGSVKIGNFCEVKKAKIGKASKINHLSYIGDAEIGAQVNIGAGTITCNYDGFHKHKIMIGDHAFIGSNSALVSPLMIG
DGSYIASGSVITEDVPMNSIALGRARQVTKKDYAMKLRARLSANQQKK

Sequences:

>Translated_448_residues
MRSCLSIVLAAGEGTRMKSSLPKVLHKIAGLPLICHVIKQIELAGVSQLAVVVGFGAKDVVHVVESFVKNAMIFEQKERL
GTAHAVLSARLALQKGVDDVLIVFGDTPLIEQDSLLQLRAQLAGGADVVVAGFRAFNPTGYGRLLEKNGKLIAIIEEKDA
SDEEKKLSFCNGGILALNGKYALSLLEKIGNNNSKREYYLTDIVSIASQEGLDVRVVEVPFDNIIGVNNCFELFEADSLW
QKRKARDLMLSGVTILKPETVYFSYDTQIKPGVMIEPNVYFGLGVKVHSGAVIHAFSYLEGAVVGTDARIGPYARLRPGT
ELAGSVKIGNFCEVKKAKIGKASKINHLSYIGDAEIGAQVNIGAGTITCNYDGFHKHKIMIGDHAFIGSNSALVSPLMIG
DGSYIASGSVITEDVPMNSIALGRARQVTKKDYAMKLRARLSANQQKK
>Mature_448_residues
MRSCLSIVLAAGEGTRMKSSLPKVLHKIAGLPLICHVIKQIELAGVSQLAVVVGFGAKDVVHVVESFVKNAMIFEQKERL
GTAHAVLSARLALQKGVDDVLIVFGDTPLIEQDSLLQLRAQLAGGADVVVAGFRAFNPTGYGRLLEKNGKLIAIIEEKDA
SDEEKKLSFCNGGILALNGKYALSLLEKIGNNNSKREYYLTDIVSIASQEGLDVRVVEVPFDNIIGVNNCFELFEADSLW
QKRKARDLMLSGVTILKPETVYFSYDTQIKPGVMIEPNVYFGLGVKVHSGAVIHAFSYLEGAVVGTDARIGPYARLRPGT
ELAGSVKIGNFCEVKKAKIGKASKINHLSYIGDAEIGAQVNIGAGTITCNYDGFHKHKIMIGDHAFIGSNSALVSPLMIG
DGSYIASGSVITEDVPMNSIALGRARQVTKKDYAMKLRARLSANQQKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=453, Percent_Identity=39.7350993377483, Blast_Score=323, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_BARHE (Q6G321)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033779.1
- ProteinModelPortal:   Q6G321
- SMR:   Q6G321
- GeneID:   2864741
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH09930
- NMPDR:   fig|283166.1.peg.907
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q6G321
- ProtClustDB:   PRK14353
- BioCyc:   BHEN283166:BH09930-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48305; Mature: 48305

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 347-347 BINDING 76-76 BINDING 142-142 BINDING 156-156 BINDING 171-171 BINDING 371-371 BINDING 389-389 BINDING 424-424

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSCLSIVLAAGEGTRMKSSLPKVLHKIAGLPLICHVIKQIELAGVSQLAVVVGFGAKDV
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCHHHH
VHVVESFVKNAMIFEQKERLGTAHAVLSARLALQKGVDDVLIVFGDTPLIEQDSLLQLRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
QLAGGADVVVAGFRAFNPTGYGRLLEKNGKLIAIIEEKDASDEEKKLSFCNGGILALNGK
HHCCCCEEEEEEEEECCCCCCCHHEECCCCEEEEEECCCCCCHHHHHHHCCCCEEEECCH
YALSLLEKIGNNNSKREYYLTDIVSIASQEGLDVRVVEVPFDNIIGVNNCFELFEADSLW
HHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
QKRKARDLMLSGVTILKPETVYFSYDTQIKPGVMIEPNVYFGLGVKVHSGAVIHAFSYLE
HHHHHHHHHHCCEEEECCCEEEEEECCCCCCCEEECCCEEEEEEEEEECCEEEEEHHHHC
GAVVGTDARIGPYARLRPGTELAGSVKIGNFCEVKKAKIGKASKINHLSYIGDAEIGAQV
CEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCEEECCCCCCCCEE
NIGAGTITCNYDGFHKHKIMIGDHAFIGSNSALVSPLMIGDGSYIASGSVITEDVPMNSI
EECCEEEEECCCCEEEEEEEEECEEEECCCCCEECEEEECCCCEEECCCEEECCCCCCCE
ALGRARQVTKKDYAMKLRARLSANQQKK
ECCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRSCLSIVLAAGEGTRMKSSLPKVLHKIAGLPLICHVIKQIELAGVSQLAVVVGFGAKDV
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCHHHH
VHVVESFVKNAMIFEQKERLGTAHAVLSARLALQKGVDDVLIVFGDTPLIEQDSLLQLRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
QLAGGADVVVAGFRAFNPTGYGRLLEKNGKLIAIIEEKDASDEEKKLSFCNGGILALNGK
HHCCCCEEEEEEEEECCCCCCCHHEECCCCEEEEEECCCCCCHHHHHHHCCCCEEEECCH
YALSLLEKIGNNNSKREYYLTDIVSIASQEGLDVRVVEVPFDNIIGVNNCFELFEADSLW
HHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
QKRKARDLMLSGVTILKPETVYFSYDTQIKPGVMIEPNVYFGLGVKVHSGAVIHAFSYLE
HHHHHHHHHHCCEEEECCCEEEEEECCCCCCCEEECCCEEEEEEEEEECCEEEEEHHHHC
GAVVGTDARIGPYARLRPGTELAGSVKIGNFCEVKKAKIGKASKINHLSYIGDAEIGAQV
CEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCEEECCCCCCCCEE
NIGAGTITCNYDGFHKHKIMIGDHAFIGSNSALVSPLMIGDGSYIASGSVITEDVPMNSI
EECCEEEEECCCCEEEEEEEEECEEEECCCCCEECEEEECCCCEEECCCEEECCCCCCCE
ALGRARQVTKKDYAMKLRARLSANQQKK
ECCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA