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The map label for this gene is gppA [H]

Identifier: 49475731

GI number: 49475731

Start: 1078686

End: 1080197

Strand: Reverse

Name: gppA [H]

Synonym: BH09810

Alternate gene names: 49475731

Gene position: 1080197-1078686 (Counterclockwise)

Preceding gene: 49475732

Following gene: 49475729

Centisome position: 55.94

GC content: 40.28

Gene sequence:

>1512_bases
ATGACATATATCAATGCTCAGGGTCGGCTAAAGGGTTGTAAACCTATCGCTGTTATCGATATTGGTTCAAATTCTGTTCG
GCTTGTTATTTATGAGGGTCTTGTTCGTTCACCAACAGTTTTATTTAATGAAAAAATTCTCTGTGGTCTTGGTCAAGGCG
TTGCAAAGACTGGACTTTTAGAAGAAAATTCGATGAATATGGCCCTACGAACACTCAAGCGGTTTCGTGCGCTTTGTCTG
CAGATTGGAGCAGATGAGATCTATATTTTAGCAACAGCAGCAGCGCGAGAAGCAAAAAACGGGTTAGCTTTTATTCAAAA
TGCTGAAAATATTTTACAAAATAAAATATACCTTCTTTCAGGAAGTGAAGAGGCTGTTTATTCGGCATATGGTGTTATTT
CGACTTTTTATCAACCAAAGGGTATTTCTGGTGATCTTGGGGGCGGCAGTCTTGAACTTATTGATATTGATAACTCTGAG
GTAGGTGAGGGGATAACTCTACCATTAGGTGGTTTACGTCTACAGTATATGTCGAATAATGATATTGCTGTTGCTGCAAA
AATTGCTCAGGAGCAGTTTGGCAAATCTGCTGTTGTTCATAAAAGCATGGCACGTTGTTTTTATGCAGTAGGAGGAACTT
GGCGTAATTTGGCAAAACTCCATATGGCAACCAAACATTATCGGCTACCTGTTATGCATGGCTATGAAGTTGATGCAGTT
GAAATGGAAGATTTCTTACGTTTTGTCGTGAATGGCAGTATTGAGAATATGAAAGGGATTTCAGCTGTTTCAAAAAATCG
CCGTCAACTTTTGTCTTACGGAGCGATCATTCTTATCGAGCTTATTCGGTGTGTGGGCTTTGAAAAAATAATCTTTTCGG
GGGCTGGAGTCCGTGAAGGCTTTCTTTATTCAAGATTGCCACAAGAAGTTCGGGTTTCAGATCCTCTCATTGCAGCATGT
ACCGAAATGGCTATTCTAAGGGCACGTTCACCAAAGCAGGCAGAGGAACTCATTGACTTCACAACAAATGCATTTGAAGT
TTTTGGAATTTTGGAAACTGAAAATGAATGTCGTTATCGTAAAGCAGCTTGTCTTCTTGCGGATATTGGTTGGCGCATTC
ATCCAGATTATCGAGGTAACGAGGCGGCCAATCAGATAGCGTTGGGATCTTATCCAGGAATTTCTCATGAGGGGCGTGCT
TATGCTGCTCTCGCTGTTTTTTTTCGCAATACTGGTTCACTCATTGGTGAAGAATCTCTTCCCATTTTCCAATTAGCAAG
CAAAGATGTAATTGAGAAAGCACGTATTCTTGGTGAGATTATGCGTATTGCTCATCTTTTTAGCGCTTCTACTACAGGGG
TTCTACCACACTTATCGTGGCATAAAAAAATAGATCATGTTGTGTTACACATTCCGGCGCGTTATGCTGATTTATTAGGA
GAACGTCCTCTTTCTCGGTTGAAGAAATTGTCAAAAATAATAGAATTGCCTCTCGCTTTTGAAATTTTCTGA

Upstream 100 bases:

>100_bases
TGCGGGTCTTTCAAGGATGGAAAGGTCTTTTGACTCTTCTGTTTCGCATTTGGTTGCGTTGTATCAGCAGAAGGTCAAAC
TATATAAAGACTGAAATTCA

Downstream 100 bases:

>100_bases
TTCTTTTCCTATTATATTATGATGTGCTTCTCTTGTACTCTCTTTTTGTTTTTATACTGCATCATATTGGTTTATAAGGC
TAATTTAGCATTATTCAACT

Product: exopolyphosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTYINAQGRLKGCKPIAVIDIGSNSVRLVIYEGLVRSPTVLFNEKILCGLGQGVAKTGLLEENSMNMALRTLKRFRALCL
QIGADEIYILATAAAREAKNGLAFIQNAENILQNKIYLLSGSEEAVYSAYGVISTFYQPKGISGDLGGGSLELIDIDNSE
VGEGITLPLGGLRLQYMSNNDIAVAAKIAQEQFGKSAVVHKSMARCFYAVGGTWRNLAKLHMATKHYRLPVMHGYEVDAV
EMEDFLRFVVNGSIENMKGISAVSKNRRQLLSYGAIILIELIRCVGFEKIIFSGAGVREGFLYSRLPQEVRVSDPLIAAC
TEMAILRARSPKQAEELIDFTTNAFEVFGILETENECRYRKAACLLADIGWRIHPDYRGNEAANQIALGSYPGISHEGRA
YAALAVFFRNTGSLIGEESLPIFQLASKDVIEKARILGEIMRIAHLFSASTTGVLPHLSWHKKIDHVVLHIPARYADLLG
ERPLSRLKKLSKIIELPLAFEIF

Sequences:

>Translated_503_residues
MTYINAQGRLKGCKPIAVIDIGSNSVRLVIYEGLVRSPTVLFNEKILCGLGQGVAKTGLLEENSMNMALRTLKRFRALCL
QIGADEIYILATAAAREAKNGLAFIQNAENILQNKIYLLSGSEEAVYSAYGVISTFYQPKGISGDLGGGSLELIDIDNSE
VGEGITLPLGGLRLQYMSNNDIAVAAKIAQEQFGKSAVVHKSMARCFYAVGGTWRNLAKLHMATKHYRLPVMHGYEVDAV
EMEDFLRFVVNGSIENMKGISAVSKNRRQLLSYGAIILIELIRCVGFEKIIFSGAGVREGFLYSRLPQEVRVSDPLIAAC
TEMAILRARSPKQAEELIDFTTNAFEVFGILETENECRYRKAACLLADIGWRIHPDYRGNEAANQIALGSYPGISHEGRA
YAALAVFFRNTGSLIGEESLPIFQLASKDVIEKARILGEIMRIAHLFSASTTGVLPHLSWHKKIDHVVLHIPARYADLLG
ERPLSRLKKLSKIIELPLAFEIF
>Mature_502_residues
TYINAQGRLKGCKPIAVIDIGSNSVRLVIYEGLVRSPTVLFNEKILCGLGQGVAKTGLLEENSMNMALRTLKRFRALCLQ
IGADEIYILATAAAREAKNGLAFIQNAENILQNKIYLLSGSEEAVYSAYGVISTFYQPKGISGDLGGGSLELIDIDNSEV
GEGITLPLGGLRLQYMSNNDIAVAAKIAQEQFGKSAVVHKSMARCFYAVGGTWRNLAKLHMATKHYRLPVMHGYEVDAVE
MEDFLRFVVNGSIENMKGISAVSKNRRQLLSYGAIILIELIRCVGFEKIIFSGAGVREGFLYSRLPQEVRVSDPLIAACT
EMAILRARSPKQAEELIDFTTNAFEVFGILETENECRYRKAACLLADIGWRIHPDYRGNEAANQIALGSYPGISHEGRAY
AALAVFFRNTGSLIGEESLPIFQLASKDVIEKARILGEIMRIAHLFSASTTGVLPHLSWHKKIDHVVLHIPARYADLLGE
RPLSRLKKLSKIIELPLAFEIF

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=450, Percent_Identity=22.4444444444444, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321185, Length=435, Percent_Identity=25.7471264367816, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 55444; Mature: 55313

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00310 LAMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYINAQGRLKGCKPIAVIDIGSNSVRLVIYEGLVRSPTVLFNEKILCGLGQGVAKTGLL
CCEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEEECCCCHHHCCCC
EENSMNMALRTLKRFRALCLQIGADEIYILATAAAREAKNGLAFIQNAENILQNKIYLLS
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCHHHHHHHHHHHHCEEEEEE
GSEEAVYSAYGVISTFYQPKGISGDLGGGSLELIDIDNSEVGEGITLPLGGLRLQYMSNN
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEEECCC
DIAVAAKIAQEQFGKSAVVHKSMARCFYAVGGTWRNLAKLHMATKHYRLPVMHGYEVDAV
CEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCEECCCCCCCC
EMEDFLRFVVNGSIENMKGISAVSKNRRQLLSYGAIILIELIRCVGFEKIIFSGAGVREG
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
FLYSRLPQEVRVSDPLIAACTEMAILRARSPKQAEELIDFTTNAFEVFGILETENECRYR
HHHHHCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHH
KAACLLADIGWRIHPDYRGNEAANQIALGSYPGISHEGRAYAALAVFFRNTGSLIGEESL
HHHHHHHHCCCEECCCCCCCHHHCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
PIFQLASKDVIEKARILGEIMRIAHLFSASTTGVLPHLSWHKKIDHVVLHIPARYADLLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECHHHHHHHC
ERPLSRLKKLSKIIELPLAFEIF
CCHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure 
TYINAQGRLKGCKPIAVIDIGSNSVRLVIYEGLVRSPTVLFNEKILCGLGQGVAKTGLL
CEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEEECCCCHHHCCCC
EENSMNMALRTLKRFRALCLQIGADEIYILATAAAREAKNGLAFIQNAENILQNKIYLLS
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCHHHHHHHHHHHHCEEEEEE
GSEEAVYSAYGVISTFYQPKGISGDLGGGSLELIDIDNSEVGEGITLPLGGLRLQYMSNN
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEEECCC
DIAVAAKIAQEQFGKSAVVHKSMARCFYAVGGTWRNLAKLHMATKHYRLPVMHGYEVDAV
CEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCEECCCCCCCC
EMEDFLRFVVNGSIENMKGISAVSKNRRQLLSYGAIILIELIRCVGFEKIIFSGAGVREG
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
FLYSRLPQEVRVSDPLIAACTEMAILRARSPKQAEELIDFTTNAFEVFGILETENECRYR
HHHHHCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHH
KAACLLADIGWRIHPDYRGNEAANQIALGSYPGISHEGRAYAALAVFFRNTGSLIGEESL
HHHHHHHHCCCEECCCCCCCHHHCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
PIFQLASKDVIEKARILGEIMRIAHLFSASTTGVLPHLSWHKKIDHVVLHIPARYADLLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECHHHHHHHC
ERPLSRLKKLSKIIELPLAFEIF
CCHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA