| Definition | Bartonella henselae str. Houston-1, complete genome. |
|---|---|
| Accession | NC_005956 |
| Length | 1,931,047 |
Click here to switch to the map view.
The map label for this gene is parC [H]
Identifier: 49475728
GI number: 49475728
Start: 1071815
End: 1074064
Strand: Reverse
Name: parC [H]
Synonym: BH09780
Alternate gene names: 49475728
Gene position: 1074064-1071815 (Counterclockwise)
Preceding gene: 49475729
Following gene: 49475717
Centisome position: 55.62
GC content: 38.93
Gene sequence:
>2250_bases ATGTCTGATAAAATGAATTTACCTTTTGATAAAGAACATATTGAGTCAATAGAATTACGTTCTGCTTTACAAGAGCGTTA TTTGGCTTATGCGCTTTCTACTATTACGCACCGTGCGTTGCCTGATGTGCGTGATGGTTTGAAACCTGTGCATAGGCGTA TTGTTCACGCTATGCGTTTACTCAAACTTAATCCAGGACATTCTTATGCGAAATGCGCAAGGATTGTTGGGGATGTCATG GGAAAATTTCATCCACATGGTGATGCATCTATTTATGATGCATTAGTGCGCTTGGCTCAGAATTTTGCTGTCCGTTATCC ATTGGTTGATGGACAAGGCAATTTTGGGAATATTGATGGTGATAATGCTGCTGCTATGCGTTATACGGAAGCACGCATGA CTGAAGTAGCTGCATTGCTGCTTGAAGGAATTAATGAAAACGCTATTGATTTTCGTTTAACCTATAATGAGGAAGATGAA GAACCGATCGTTTTACCTGGAGCTTTTCCTAATCTTTTAGCAAATGGTTCATCAGGTATTGCTGTTGGTATGGCAACATC TATTCCACCCCATAATGTTTCTGAACTTTGTGATGCGGCGCTTCATTTGATTGCGCATCCCAATGCCCGTGATGAGGAAT TAAATCACTTTGTGCTTGGACCTGATTTTCCAACAGGTGGCATTTTAGTTGAACCTAAAAAGAGTATTGAGGAATCTTAT CGTGTTGGGCGTGGTTTTTTTCGGTTGCGTTCGCGTTGGCATCAGGAAACCGGTAACCGTGGTTCTTATGTGCTTGTTGT GACTGAAATTCCCTATCAAGTTCAAAAGTCACGACTTATTGAAAAAACAGCAGAATTATTGCTTGCACGGCGGTTACCAA TGCTTGAAGATATTCGTGATGAGTCAGCAGAAGATATTCGCATTGTACTTATTCCTAAAAATCGTACCGTCGATCCTGAG ATTCTTATGGAGTCTCTTTTTAAATTGACTGATTTTGAAATAAGATTTCCTCTCAATCTTAATGTTTTGTCTTTTGGAAA AGTACCGAATGTTCTTTCTTTGCGGGAAAGTTTAAAACAATGGCTTGAACATCGTCAAGAGGTGCTTATTCGCCGTTCTC GTTATCAGCTTGACGAAATTGAACGACGGTTGGAAATCCTCCATGGATATCTTATCACATATTTGAATCTTGATGAGGTG ATCCAGATTATTCGGGAAGAGGATGAACCAAAAAAAAAGCTTATCGATCGTTTTGAATTAACAGAAAATCAAGCTGAAGC TATTCTTAATATGCGCTTGCGTTCTTTACGTAAACTTGAGGAATTTGAAATTCGTAAAGAATTTGAAACCTTGAGGGCTG AAAAAGAAAAACTGCAAAATTTGTTAGATTCTCGGACAAAGCAATGGAAAATAATTTCAGAGGAAATCATAAAAGTTCGT AAAGTTTTTGGTCCTCATACTCTCTTAGGGAAAAGGCGTACAACATTTGAAGAAGCACCAAGACATGATTTTGATGATAT TTATCAGGCAATGATTGAAAAAGAACCAGTTACTATTGTTATTTCTGAAAAGGGTTGGATGCGTGCTTTGAAGGGGCATT TGAGTGATTACAATGCACTTTCTTTCAAAGAAGGGGATTGTTTGAAATTAGCATTTCCAGCGTTTACTACAGATAAAATT GTGGTGATAAGTACTGGCGGAAAGTTTTTTGCTATTGCTGCAAATAGTTTGCCGGGAGGACGGGGGCATGGGGAACCCAT TCGTATTTTAGTTGATATGGATGACGAGCATGATCTCCTGACAGCTTTTGTGCATCATACACAGGAAAAACTTCTCTTAG TTTCATCTCATGGAAATGGTTTTATTGTACCTGCAACTGAAGTGATTGCTAATACACGAAAAGGCAAGCAAGTTATGAAT GTGAAATTTCCTGATAAGGTAAAACTTTGTGTTCCAGTAAAAGGTGATCATGTTGCAGTGGTTGGTGAAAACCGTAAAAT GCTCATTTTTGCCATTGAACAAATACCAGAAATGAGTCGTGGTAAAGGTGTTCGTTTACAACGTTACAAACAAGGGGGAG TTGTTGATGTCAAAACTTTTAATTTATCAGAAGGTTTAAGTTGGCAAGATACAGCTGAACGTTGCTTTAACCGCCAAGCG AGTGATCTCATTGAGTGGATGGGAGTACGTTCTGGGGTAGGGCGTGTGGTTCCGAAAGGCTTTCCAAAATCAGGGAAATT TACCAATTAA
Upstream 100 bases:
>100_bases AGTCAGTTTTTAATAAAAATAGTTGATTTACAAAAGGTCGCACTGAAAAAAATCTTATAAAATAATTGCTCATTATTTTG GGAATTGTTGTCCTAATACT
Downstream 100 bases:
>100_bases ACTGTGTTCCATATTTAATTCTTAAGTTTTGTGTTTTAAGTCAAGATTTGAAAAAAGGTGGAGTGCTGGTAATATTCCAT TTGTAAAGAACAGGAATTTT
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: Topoisomerase IV subunit A [H]
Number of amino acids: Translated: 749; Mature: 748
Protein sequence:
>749_residues MSDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRLLKLNPGHSYAKCARIVGDVM GKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDE EPIVLPGAFPNLLANGSSGIAVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRDESAEDIRIVLIPKNRTVDPE ILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQWLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEV IQIIREEDEPKKKLIDRFELTENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNALSFKEGDCLKLAFPAFTTDKI VVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLLTAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMN VKFPDKVKLCVPVKGDHVAVVGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA SDLIEWMGVRSGVGRVVPKGFPKSGKFTN
Sequences:
>Translated_749_residues MSDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRLLKLNPGHSYAKCARIVGDVM GKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDE EPIVLPGAFPNLLANGSSGIAVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRDESAEDIRIVLIPKNRTVDPE ILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQWLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEV IQIIREEDEPKKKLIDRFELTENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNALSFKEGDCLKLAFPAFTTDKI VVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLLTAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMN VKFPDKVKLCVPVKGDHVAVVGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA SDLIEWMGVRSGVGRVVPKGFPKSGKFTN >Mature_748_residues SDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRLLKLNPGHSYAKCARIVGDVMG KFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDEE PIVLPGAFPNLLANGSSGIAVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESYR VGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRDESAEDIRIVLIPKNRTVDPEI LMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQWLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEVI QIIREEDEPKKKLIDRFELTENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVRK VFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNALSFKEGDCLKLAFPAFTTDKIV VISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLLTAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMNV KFPDKVKLCVPVKGDHVAVVGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQAS DLIEWMGVRSGVGRVVPKGFPKSGKFTN
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=7e-12, Organism=Escherichia coli, GI1789396, Length=680, Percent_Identity=38.9705882352941, Blast_Score=498, Evalue=1e-142, Organism=Escherichia coli, GI1788562, Length=661, Percent_Identity=35.8547655068079, Blast_Score=393, Evalue=1e-110, Organism=Saccharomyces cerevisiae, GI6324241, Length=371, Percent_Identity=27.7628032345013, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI17136538, Length=227, Percent_Identity=28.6343612334802, Blast_Score=70, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013760 - InterPro: IPR005742 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: 5.99.1.-
Molecular weight: Translated: 85236; Mature: 85105
Theoretical pI: Translated: 7.60; Mature: 7.60
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRL CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH LKLNPGHSYAKCARIVGDVMGKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDG HCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCC DNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDEEPIVLPGAFPNLLANGSSGI CCCHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCHHHHCCCCCCE AVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY EEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHH RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRD HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHC ESAEDIRIVLIPKNRTVDPEILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQ CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECEECCEEECCCCCCHHHHHHHHHH WLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEVIQIIREEDEPKKKLIDRFEL HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHC TENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNAL HHCCCHHHHCCCCCCHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCC SFKEGDCLKLAFPAFTTDKIVVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLL CCCCCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHH TAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMNVKFPDKVKLCVPVKGDHVAV HHHHHHCCCEEEEEEECCCEEEEEHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCEEEE VGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA EECCCEEEEEEEHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHCCCH SDLIEWMGVRSGVGRVVPKGFPKSGKFTN HHHHHHHHHHCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure SDKMNLPFDKEHIESIELRSALQERYLAYALSTITHRALPDVRDGLKPVHRRIVHAMRL CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH LKLNPGHSYAKCARIVGDVMGKFHPHGDASIYDALVRLAQNFAVRYPLVDGQGNFGNIDG HCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCC DNAAAMRYTEARMTEVAALLLEGINENAIDFRLTYNEEDEEPIVLPGAFPNLLANGSSGI CCCHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCHHHHCCCCCCE AVGMATSIPPHNVSELCDAALHLIAHPNARDEELNHFVLGPDFPTGGILVEPKKSIEESY EEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHH RVGRGFFRLRSRWHQETGNRGSYVLVVTEIPYQVQKSRLIEKTAELLLARRLPMLEDIRD HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHC ESAEDIRIVLIPKNRTVDPEILMESLFKLTDFEIRFPLNLNVLSFGKVPNVLSLRESLKQ CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECEECCEEECCCCCCHHHHHHHHHH WLEHRQEVLIRRSRYQLDEIERRLEILHGYLITYLNLDEVIQIIREEDEPKKKLIDRFEL HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHC TENQAEAILNMRLRSLRKLEEFEIRKEFETLRAEKEKLQNLLDSRTKQWKIISEEIIKVR CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KVFGPHTLLGKRRTTFEEAPRHDFDDIYQAMIEKEPVTIVISEKGWMRALKGHLSDYNAL HHCCCHHHHCCCCCCHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCC SFKEGDCLKLAFPAFTTDKIVVISTGGKFFAIAANSLPGGRGHGEPIRILVDMDDEHDLL CCCCCCEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHHH TAFVHHTQEKLLLVSSHGNGFIVPATEVIANTRKGKQVMNVKFPDKVKLCVPVKGDHVAV HHHHHHCCCEEEEEEECCCEEEEEHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCEEEE VGENRKMLIFAIEQIPEMSRGKGVRLQRYKQGGVVDVKTFNLSEGLSWQDTAERCFNRQA EECCCEEEEEEEHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHCCCH SDLIEWMGVRSGVGRVVPKGFPKSGKFTN HHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11481430 [H]