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The map label for this gene is nuoH

Identifier: 49475651

GI number: 49475651

Start: 1002981

End: 1004030

Strand: Reverse

Name: nuoH

Synonym: BH08880

Alternate gene names: 49475651

Gene position: 1004030-1002981 (Counterclockwise)

Preceding gene: 49475652

Following gene: 49475650

Centisome position: 51.99

GC content: 38.95

Gene sequence:

>1050_bases
ATGATATATGATTTCTTCATGACCTGGTTATTCCCATTACTTATTATAGTTGGAAAAACGCTTCTTCTTTTGGTTATTCT
CCTGCTTCTTGTTGCTTATCTCCTTTACGCAGATAGAAAGATTTGGGCGGCGGTACAGTTACGGCGTGGTCCAAACGTTG
TTGGACCATGGGGATTGTTACAGTCTTTCGCGGATTTAATTAAATTTGTTGTTAAGGAGCCTATTATTCCTGCTGGCGCT
AATAAAGGTGTTTTTCTTTTGGCACCTTTTGTTTCTGCGACTCTTGCTTTATCAACGTGGGCTGTTATCCCTGTCAATGA
AGGTTGGGCAGTTGCAAATATTAATGTTGGTTTGCTCTATATCTTAGCTATTTCATCTCTTGAGGTTTACGGCGTAATTA
TGGGAGGATGGGCGTCAAATTCAAAATATCCTTTCTTAGGAGCTCTTCGTTCTGCGGCTCAGATGGTTTCTTATGAGGTT
TCCATTGGCTTTGTGCTTGTAACCGTCATTTTAGTAAGTGGCTCATTGGATCTTACAACAATTGTTCAGAAGCAAAGTCA
TGGAATGGGCACAGCTCTTGGCCTTCCTTTTAACAGTTTTCTTGATTGGAATTGGCTCGTTCTTTTCCCAATGTTTATTA
TATTTTTTATTTCTGCACTCGCAGAGACAAATCGCCCGCCTTTTGATTTAGTTGAAGCAGAATCTGAACTTGTTGCTGGT
CACATGGTTGAGTATTCTTCAACACCTTATATGCTTTTTTTTCTTGGTGAGTATGTTGCTATTGTTTTGATGTGTGCATT
AACAACTATTTTATTTTTAGGTGGTTGGTTGCCTCCCTTAGATGTTTGGTGGCTGAATTGGGTTCCTGGTATCATTTGGT
TTGTTTTAAAAGTTTGTTTTGTATTTTTTTGGTTTGCTATGGTCAAAGCATTTGTTCCGCGTTATCGCTATGATCAACTT
ATGCGGCTTGGTTGGAAGGTGTTCCTTCCTCTCTCGTTAGCAATGGTTGTAATAACTGCTGCTTTTTTAAAATATACTGG
TTTCGCTTAA

Upstream 100 bases:

>100_bases
AATCCGATAGCACGTGCTTCTGCAGTTATGGCTGAATGTTCTTCTCTTGCAAAGAATCGTGCTATGCAAGCTGTAGAGTA
AGGGTAGAGGAAAAGAAATA

Downstream 100 bases:

>100_bases
AAGGAGATTTCACGATGTTAGGTCTTATTCAGGCGGCAAAATCACTCCTTTTATTGGAATTTATGAGTGCTTTTTTCTTG
GCAATGCGTCAGTTTTTTTC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MIYDFFMTWLFPLLIIVGKTLLLLVILLLLVAYLLYADRKIWAAVQLRRGPNVVGPWGLLQSFADLIKFVVKEPIIPAGA
NKGVFLLAPFVSATLALSTWAVIPVNEGWAVANINVGLLYILAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEV
SIGFVLVTVILVSGSLDLTTIVQKQSHGMGTALGLPFNSFLDWNWLVLFPMFIIFFISALAETNRPPFDLVEAESELVAG
HMVEYSSTPYMLFFLGEYVAIVLMCALTTILFLGGWLPPLDVWWLNWVPGIIWFVLKVCFVFFWFAMVKAFVPRYRYDQL
MRLGWKVFLPLSLAMVVITAAFLKYTGFA

Sequences:

>Translated_349_residues
MIYDFFMTWLFPLLIIVGKTLLLLVILLLLVAYLLYADRKIWAAVQLRRGPNVVGPWGLLQSFADLIKFVVKEPIIPAGA
NKGVFLLAPFVSATLALSTWAVIPVNEGWAVANINVGLLYILAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEV
SIGFVLVTVILVSGSLDLTTIVQKQSHGMGTALGLPFNSFLDWNWLVLFPMFIIFFISALAETNRPPFDLVEAESELVAG
HMVEYSSTPYMLFFLGEYVAIVLMCALTTILFLGGWLPPLDVWWLNWVPGIIWFVLKVCFVFFWFAMVKAFVPRYRYDQL
MRLGWKVFLPLSLAMVVITAAFLKYTGFA
>Mature_349_residues
MIYDFFMTWLFPLLIIVGKTLLLLVILLLLVAYLLYADRKIWAAVQLRRGPNVVGPWGLLQSFADLIKFVVKEPIIPAGA
NKGVFLLAPFVSATLALSTWAVIPVNEGWAVANINVGLLYILAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEV
SIGFVLVTVILVSGSLDLTTIVQKQSHGMGTALGLPFNSFLDWNWLVLFPMFIIFFISALAETNRPPFDLVEAESELVAG
HMVEYSSTPYMLFFLGEYVAIVLMCALTTILFLGGWLPPLDVWWLNWVPGIIWFVLKVCFVFFWFAMVKAFVPRYRYDQL
MRLGWKVFLPLSLAMVVITAAFLKYTGFA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=309, Percent_Identity=43.3656957928803, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI1788618, Length=339, Percent_Identity=41.8879056047198, Blast_Score=254, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_BARHE (Q6G395)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033692.1
- GeneID:   2864981
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH08880
- NMPDR:   fig|283166.1.peg.820
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q6G395
- ProtClustDB:   PRK06076
- BioCyc:   BHEN283166:BH08880-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39086; Mature: 39086

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x24a12da4)-; HASH(0x24804ea4)-; HASH(0x24b831ec)-; HASH(0x246f20d4)-; HASH(0x23cde344)-; HASH(0x24696328)-; HASH(0x24b8321c)-; HASH(0x24b815d8)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYDFFMTWLFPLLIIVGKTLLLLVILLLLVAYLLYADRKIWAAVQLRRGPNVVGPWGLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHH
QSFADLIKFVVKEPIIPAGANKGVFLLAPFVSATLALSTWAVIPVNEGWAVANINVGLLY
HHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHEEEEECCCCEEEEECCHHHHH
ILAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVLVTVILVSGSLDLTT
HHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IVQKQSHGMGTALGLPFNSFLDWNWLVLFPMFIIFFISALAETNRPPFDLVEAESELVAG
HHHHHCCCCCCEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
HMVEYSSTPYMLFFLGEYVAIVLMCALTTILFLGGWLPPLDVWWLNWVPGIIWFVLKVCF
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VFFWFAMVKAFVPRYRYDQLMRLGWKVFLPLSLAMVVITAAFLKYTGFA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MIYDFFMTWLFPLLIIVGKTLLLLVILLLLVAYLLYADRKIWAAVQLRRGPNVVGPWGLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHH
QSFADLIKFVVKEPIIPAGANKGVFLLAPFVSATLALSTWAVIPVNEGWAVANINVGLLY
HHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHEEEEECCCCEEEEECCHHHHH
ILAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVLVTVILVSGSLDLTT
HHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IVQKQSHGMGTALGLPFNSFLDWNWLVLFPMFIIFFISALAETNRPPFDLVEAESELVAG
HHHHHCCCCCCEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
HMVEYSSTPYMLFFLGEYVAIVLMCALTTILFLGGWLPPLDVWWLNWVPGIIWFVLKVCF
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VFFWFAMVKAFVPRYRYDQLMRLGWKVFLPLSLAMVVITAAFLKYTGFA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA