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The map label for this gene is fabF2 [H]

Identifier: 49475515

GI number: 49475515

Start: 851138

End: 852412

Strand: Reverse

Name: fabF2 [H]

Synonym: BH07440

Alternate gene names: 49475515

Gene position: 852412-851138 (Counterclockwise)

Preceding gene: 49475516

Following gene: 49475514

Centisome position: 44.14

GC content: 40.55

Gene sequence:

>1275_bases
ATGCAATATAACGATCATTTTGGACGTCCAATTGTAGCAATAACTGGAGCAGGAATTGTAACATCACTGGGGAAAGGTAA
ACACGAAAATTGGCAAAAATTAACAAGTGGTGTTAGCGGTATCCATAAAATAACGCGCTTTCCTGTTGATGAATTAAAAA
CACGTATTGCTGGAACAGTCGATTTTCTTAAAGAAAGCACGTATGGTGCTTCTGCTCTTTCTGAAAAACTTGCTAATCTT
GCAGCAGAGGAAGCTTTAGAGCAAGCAGATCTTGGTAAAACGAATTTTAATGGACCACTCTTTTTAGCAGCTCCTCCTGT
TGAGCTTGAATGGAAAGCGCGTCTTACTCTTGATCAAGAAGGAGAATTAAATAGTGCGCCTTCCTATGTGCATCTTCTTG
AAATCTGCAGCCATAAACTCCACGAGACGCTGTTTGAAACCACACAATTTGGTGCAATTGCAGAAAATCTTCAGAAAAAA
TTTGGCACAAAAGGACTTCCTATTACACTTTCCACTGCTTGTGCATCTGGTGCAACAGCCATTCAATTAGGTGTTGAAGC
TATTCGACGGGGAGAAACAAATCGTGCACTCACAATTGCTACAGATGGTTCAGTTTCAGCAGAATCCCTTATACGCTTTT
CATTATTATCTGCTCTTTCAACCCAAAATGATCCTGCAGAAAAAGCAGCAAAACCCTTTAGCCGTGACCGAGATGGTTTT
GTTATGGCAGAAGGATCAGGTGCTCTTGTTCTTGAATCCCTCAAAAGCGCACTAGATCGTAATGCGATAATTTTAGGAAT
TTTAGCTGGCTGTGGAGAAACAGCAGATGATTTTCACCGTACGCGTTCAAAACCTGATGCATCTCCAGCAATTGAAGCCG
TTCGCAAAGCTTTAGAGGATGCGAATATAACCATCAATGAAATTGATTATATTAATGCACATGGCACCTCAACACCCGAA
AATGAAAAGATGGAGTATCTCGCATTATCAACAGTCTTCGGTGATAGACTAGAACATATTCCTGTTTCTTCTAATAAATC
AATGATTGGCCACACATTAACTGCTGCCGGTGCAATAGAGGCTGTTTTTTCGCTTTTAACGATTCAATCGGGAATACTTC
CTCCTACAATCAATTATGATGATCCTGATCCTGCTATCCCTTTAGATGTTGTTCCTAACCATAGCCGTAAGGCCTGTGTC
AATGCGGTTTTGTCCAACTCATTTGGATTCGGCGGTCAAAATATGAGTCTTGTTATCACAGCCTATAAAGGATAA

Upstream 100 bases:

>100_bases
CCTTTTCCTAAAGAAATACGTGAAGCATTTGTTACAACCATTGGTATCAAAAGAGCTGAAGGTATAGCACAGCTAACTGC
TGTATAAGGGGATTTCTACA

Downstream 100 bases:

>100_bases
TCCTTTTAATACTGATCAAATTTTGTCATACTTAATCTAAAAGTCATATATTTGAGGGGGAATAATAATGCGTGCACTGC
AACTATTCAATGAACGCCAA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MQYNDHFGRPIVAITGAGIVTSLGKGKHENWQKLTSGVSGIHKITRFPVDELKTRIAGTVDFLKESTYGASALSEKLANL
AAEEALEQADLGKTNFNGPLFLAAPPVELEWKARLTLDQEGELNSAPSYVHLLEICSHKLHETLFETTQFGAIAENLQKK
FGTKGLPITLSTACASGATAIQLGVEAIRRGETNRALTIATDGSVSAESLIRFSLLSALSTQNDPAEKAAKPFSRDRDGF
VMAEGSGALVLESLKSALDRNAIILGILAGCGETADDFHRTRSKPDASPAIEAVRKALEDANITINEIDYINAHGTSTPE
NEKMEYLALSTVFGDRLEHIPVSSNKSMIGHTLTAAGAIEAVFSLLTIQSGILPPTINYDDPDPAIPLDVVPNHSRKACV
NAVLSNSFGFGGQNMSLVITAYKG

Sequences:

>Translated_424_residues
MQYNDHFGRPIVAITGAGIVTSLGKGKHENWQKLTSGVSGIHKITRFPVDELKTRIAGTVDFLKESTYGASALSEKLANL
AAEEALEQADLGKTNFNGPLFLAAPPVELEWKARLTLDQEGELNSAPSYVHLLEICSHKLHETLFETTQFGAIAENLQKK
FGTKGLPITLSTACASGATAIQLGVEAIRRGETNRALTIATDGSVSAESLIRFSLLSALSTQNDPAEKAAKPFSRDRDGF
VMAEGSGALVLESLKSALDRNAIILGILAGCGETADDFHRTRSKPDASPAIEAVRKALEDANITINEIDYINAHGTSTPE
NEKMEYLALSTVFGDRLEHIPVSSNKSMIGHTLTAAGAIEAVFSLLTIQSGILPPTINYDDPDPAIPLDVVPNHSRKACV
NAVLSNSFGFGGQNMSLVITAYKG
>Mature_424_residues
MQYNDHFGRPIVAITGAGIVTSLGKGKHENWQKLTSGVSGIHKITRFPVDELKTRIAGTVDFLKESTYGASALSEKLANL
AAEEALEQADLGKTNFNGPLFLAAPPVELEWKARLTLDQEGELNSAPSYVHLLEICSHKLHETLFETTQFGAIAENLQKK
FGTKGLPITLSTACASGATAIQLGVEAIRRGETNRALTIATDGSVSAESLIRFSLLSALSTQNDPAEKAAKPFSRDRDGF
VMAEGSGALVLESLKSALDRNAIILGILAGCGETADDFHRTRSKPDASPAIEAVRKALEDANITINEIDYINAHGTSTPE
NEKMEYLALSTVFGDRLEHIPVSSNKSMIGHTLTAAGAIEAVFSLLTIQSGILPPTINYDDPDPAIPLDVVPNHSRKACV
NAVLSNSFGFGGQNMSLVITAYKG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=429, Percent_Identity=32.4009324009324, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=40.8163265306122, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI41872631, Length=282, Percent_Identity=27.3049645390071, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=33.0120481927711, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=31.0588235294118, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71983541, Length=268, Percent_Identity=33.2089552238806, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=33.5907335907336, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=271, Percent_Identity=26.5682656826568, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=262, Percent_Identity=29.7709923664122, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=283, Percent_Identity=35.6890459363958, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24644341, Length=441, Percent_Identity=31.7460317460317, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=24.7311827956989, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=24.7311827956989, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581345, Length=278, Percent_Identity=24.4604316546763, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45242; Mature: 45242

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYNDHFGRPIVAITGAGIVTSLGKGKHENWQKLTSGVSGIHKITRFPVDELKTRIAGTV
CCCCCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DFLKESTYGASALSEKLANLAAEEALEQADLGKTNFNGPLFLAAPPVELEWKARLTLDQE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEEECCC
GELNSAPSYVHLLEICSHKLHETLFETTQFGAIAENLQKKFGTKGLPITLSTACASGATA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCHH
IQLGVEAIRRGETNRALTIATDGSVSAESLIRFSLLSALSTQNDPAEKAAKPFSRDRDGF
HHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCE
VMAEGSGALVLESLKSALDRNAIILGILAGCGETADDFHRTRSKPDASPAIEAVRKALED
EEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHC
ANITINEIDYINAHGTSTPENEKMEYLALSTVFGDRLEHIPVSSNKSMIGHTLTAAGAIE
CCCEEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AVFSLLTIQSGILPPTINYDDPDPAIPLDVVPNHSRKACVNAVLSNSFGFGGQNMSLVIT
HHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
AYKG
EECC
>Mature Secondary Structure
MQYNDHFGRPIVAITGAGIVTSLGKGKHENWQKLTSGVSGIHKITRFPVDELKTRIAGTV
CCCCCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DFLKESTYGASALSEKLANLAAEEALEQADLGKTNFNGPLFLAAPPVELEWKARLTLDQE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEEECCC
GELNSAPSYVHLLEICSHKLHETLFETTQFGAIAENLQKKFGTKGLPITLSTACASGATA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCHH
IQLGVEAIRRGETNRALTIATDGSVSAESLIRFSLLSALSTQNDPAEKAAKPFSRDRDGF
HHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCE
VMAEGSGALVLESLKSALDRNAIILGILAGCGETADDFHRTRSKPDASPAIEAVRKALED
EEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHC
ANITINEIDYINAHGTSTPENEKMEYLALSTVFGDRLEHIPVSSNKSMIGHTLTAAGAIE
CCCEEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AVFSLLTIQSGILPPTINYDDPDPAIPLDVVPNHSRKACVNAVLSNSFGFGGQNMSLVIT
HHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
AYKG
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]