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The map label for this gene is adh [C]

Identifier: 49475514

GI number: 49475514

Start: 850042

End: 851070

Strand: Reverse

Name: adh [C]

Synonym: BH07430

Alternate gene names: 49475514

Gene position: 851070-850042 (Counterclockwise)

Preceding gene: 49475515

Following gene: 49475513

Centisome position: 44.07

GC content: 41.69

Gene sequence:

>1029_bases
ATGCGTGCACTGCAACTATTCAATGAACGCCAACTTGAAATCACCACTATTGCCCCACCACCACCACCTAACCCCGATGA
AGTAACAGTACGTATAAAAGCTGTTGCTCTTAATCATCTTGATGTATGGGGCTGGCGTGGTATGGCCTTTGCTAAAAGAA
AAATGCCCCTTGTCATTGGCGCAGAAGCTTCCGGTGAAGTTACTCAGCTGGGAAGTAACGTTAAAAATTTACAACTTGGA
CAAATTGTCTCAATTTATGGTGCACAAACCTGCGGAATATGCCAAGCTTGCCGTGAAGGACGTGATAATCTTTGCAATGA
TGTAAAGGGCGTCTACGGTTTTCATCTTGACGGTTTTGCCCGCGAACTTGTTAATTTGCCAGTACGTCTATTGGTCTCCG
CCCCTGCAAAATGTGATGAACTGCAAGCAGCTGTTGCTCCAATCACTTTTGGTACTGTAGAACATATGCTTTTCGATAAT
GCAAAACTACAAACAGGCGAAACAATCCTGATACAGGCAGGTGGTTCCGGTATTGGCTCAGCAGCCATTCAACTCGCAAA
ACAAAAAGGGTGTACAGTTATCACGACTGTCGGTTCAGATGAAAAAATTGCAAAAGCACAATCTCTTGGTGCGGATCATG
TTATTAATTACCGTAAAGATCGTTTTGAAGGTGTTGTGCGCAAATTAACCAAAAAAAAAGGTGTCGATGTTGTTTTTGAA
CACGTAGGTGCAGAGACATGGAGCGGTTCTCTGTTGTGTATGAAACCAGGAGCACGCTTGGTAACTTGTGGTTCTACCTC
TGGTATTTCAACATCATTCAATCTCATGCAATTGTTTCAGCAACAACTTAAGATATTCGGTTCATTTGGCTGCCGTATAG
AAAATATGCAAAACGCCATGCAGAAAATGGCACAAGGCGTTGTACACCCTGTCATTGATACAATTGTTCAATTTAATGAA
ATTGATACAGCTTTAAAGCGAATGGAAAGTCGTGACGTTTTTGGTAAAATTATTCTTAAAATCGATTAA

Upstream 100 bases:

>100_bases
ATGAGTCTTGTTATCACAGCCTATAAAGGATAATCCTTTTAATACTGATCAAATTTTGTCATACTTAATCTAAAAGTCAT
ATATTTGAGGGGGAATAATA

Downstream 100 bases:

>100_bases
ATTATGATGAAATTCTATATTAAAAATTTTGTATATCATATTAAAATTATAGCAAAAAAATCATTTCACTTTTTATGGGG
ATATCTGCTCATTAGTTCTT

Product: alcohol dehydrogenase (quinone oxidoreductase)

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MRALQLFNERQLEITTIAPPPPPNPDEVTVRIKAVALNHLDVWGWRGMAFAKRKMPLVIGAEASGEVTQLGSNVKNLQLG
QIVSIYGAQTCGICQACREGRDNLCNDVKGVYGFHLDGFARELVNLPVRLLVSAPAKCDELQAAVAPITFGTVEHMLFDN
AKLQTGETILIQAGGSGIGSAAIQLAKQKGCTVITTVGSDEKIAKAQSLGADHVINYRKDRFEGVVRKLTKKKGVDVVFE
HVGAETWSGSLLCMKPGARLVTCGSTSGISTSFNLMQLFQQQLKIFGSFGCRIENMQNAMQKMAQGVVHPVIDTIVQFNE
IDTALKRMESRDVFGKIILKID

Sequences:

>Translated_342_residues
MRALQLFNERQLEITTIAPPPPPNPDEVTVRIKAVALNHLDVWGWRGMAFAKRKMPLVIGAEASGEVTQLGSNVKNLQLG
QIVSIYGAQTCGICQACREGRDNLCNDVKGVYGFHLDGFARELVNLPVRLLVSAPAKCDELQAAVAPITFGTVEHMLFDN
AKLQTGETILIQAGGSGIGSAAIQLAKQKGCTVITTVGSDEKIAKAQSLGADHVINYRKDRFEGVVRKLTKKKGVDVVFE
HVGAETWSGSLLCMKPGARLVTCGSTSGISTSFNLMQLFQQQLKIFGSFGCRIENMQNAMQKMAQGVVHPVIDTIVQFNE
IDTALKRMESRDVFGKIILKID
>Mature_342_residues
MRALQLFNERQLEITTIAPPPPPNPDEVTVRIKAVALNHLDVWGWRGMAFAKRKMPLVIGAEASGEVTQLGSNVKNLQLG
QIVSIYGAQTCGICQACREGRDNLCNDVKGVYGFHLDGFARELVNLPVRLLVSAPAKCDELQAAVAPITFGTVEHMLFDN
AKLQTGETILIQAGGSGIGSAAIQLAKQKGCTVITTVGSDEKIAKAQSLGADHVINYRKDRFEGVVRKLTKKKGVDVVFE
HVGAETWSGSLLCMKPGARLVTCGSTSGISTSFNLMQLFQQQLKIFGSFGCRIENMQNAMQKMAQGVVHPVIDTIVQFNE
IDTALKRMESRDVFGKIILKID

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=338, Percent_Identity=28.4023668639053, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI22538444, Length=338, Percent_Identity=28.4023668639053, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI24308257, Length=351, Percent_Identity=25.0712250712251, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI41872631, Length=226, Percent_Identity=28.3185840707965, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI18379349, Length=337, Percent_Identity=21.6617210682493, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI28557745, Length=260, Percent_Identity=29.6153846153846, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI194239674, Length=349, Percent_Identity=22.9226361031519, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI13236495, Length=349, Percent_Identity=22.9226361031519, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226059159, Length=231, Percent_Identity=29.004329004329, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI226059133, Length=231, Percent_Identity=29.004329004329, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI226056130, Length=112, Percent_Identity=37.5, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI156627571, Length=286, Percent_Identity=28.6713286713287, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790485, Length=262, Percent_Identity=29.3893129770992, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=351, Percent_Identity=27.3504273504274, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=26.7267267267267, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI226510992, Length=160, Percent_Identity=33.125, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790718, Length=281, Percent_Identity=26.3345195729537, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=24.0331491712707, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=24.1071428571429, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081918, Length=289, Percent_Identity=25.9515570934256, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082125, Length=306, Percent_Identity=24.8366013071895, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=211, Percent_Identity=30.3317535545024, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=228, Percent_Identity=30.7017543859649, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=261, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=321, Percent_Identity=26.4797507788162, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=323, Percent_Identity=24.4582043343653, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=345, Percent_Identity=25.2173913043478, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=323, Percent_Identity=25.077399380805, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=324, Percent_Identity=25.3086419753086, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=332, Percent_Identity=25, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319520, Length=336, Percent_Identity=24.4047619047619, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=314, Percent_Identity=25.796178343949, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=314, Percent_Identity=25.4777070063694, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=273, Percent_Identity=26.7399267399267, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581345, Length=225, Percent_Identity=29.3333333333333, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI221330659, Length=226, Percent_Identity=28.7610619469027, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19920632, Length=226, Percent_Identity=28.7610619469027, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 37170; Mature: 37170

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALQLFNERQLEITTIAPPPPPNPDEVTVRIKAVALNHLDVWGWRGMAFAKRKMPLVIG
CCCHHHCCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHCCCCEEEE
AEASGEVTQLGSNVKNLQLGQIVSIYGAQTCGICQACREGRDNLCNDVKGVYGFHLDGFA
CCCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHH
RELVNLPVRLLVSAPAKCDELQAAVAPITFGTVEHMLFDNAKLQTGETILIQAGGSGIGS
HHHHCCCHHEEECCCCCHHHHHHHHCCEEHHHHHHHHHCCCEEECCCEEEEEECCCCCCH
AAIQLAKQKGCTVITTVGSDEKIAKAQSLGADHVINYRKDRFEGVVRKLTKKKGVDVVFE
HHHHHHHHCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HVGAETWSGSLLCMKPGARLVTCGSTSGISTSFNLMQLFQQQLKIFGSFGCRIENMQNAM
HCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHH
QKMAQGVVHPVIDTIVQFNEIDTALKRMESRDVFGKIILKID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MRALQLFNERQLEITTIAPPPPPNPDEVTVRIKAVALNHLDVWGWRGMAFAKRKMPLVIG
CCCHHHCCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHCCCCEEEE
AEASGEVTQLGSNVKNLQLGQIVSIYGAQTCGICQACREGRDNLCNDVKGVYGFHLDGFA
CCCCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHH
RELVNLPVRLLVSAPAKCDELQAAVAPITFGTVEHMLFDNAKLQTGETILIQAGGSGIGS
HHHHCCCHHEEECCCCCHHHHHHHHCCEEHHHHHHHHHCCCEEECCCEEEEEECCCCCCH
AAIQLAKQKGCTVITTVGSDEKIAKAQSLGADHVINYRKDRFEGVVRKLTKKKGVDVVFE
HHHHHHHHCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HVGAETWSGSLLCMKPGARLVTCGSTSGISTSFNLMQLFQQQLKIFGSFGCRIENMQNAM
HCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHH
QKMAQGVVHPVIDTIVQFNEIDTALKRMESRDVFGKIILKID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA