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The map label for this gene is uvrC

Identifier: 49475349

GI number: 49475349

Start: 651275

End: 653260

Strand: Reverse

Name: uvrC

Synonym: BH05550

Alternate gene names: 49475349

Gene position: 653260-651275 (Counterclockwise)

Preceding gene: 49475350

Following gene: 49475348

Centisome position: 33.83

GC content: 38.22

Gene sequence:

>1986_bases
ATGATCTTGAAAAATAACATCGCTTATGCCGAAAATGAGCAAGAAAAGCTCTCTTTTCTCTCTCATATTACATGGGATGA
TGCGCATCAAAGAAATGATAAAAATCAATTTAAAGGTGCCAAACTCATACAAGAATTTGTCAAACATCTTCCGCATAAGC
CAGGAGTTTATCGGATGGTTGATGAAAATGGTAAGGTTCTCTATGTTGGCAAAGCACGTAATCTTAAAAAACGTGTCTCA
AACTATACACGTGAACAAGGACACAATAACCGTATCACCCGAATGATTCGTGCAACATCTCATATGGAATTTGTCGTTAC
TCACACAGAAATAGAAGCGCTCCTTTTAGAGGCTAATCTGATCAAAAGGTTGCATCCACGTTTTAATGTATTACTGCGTG
ATGATAAAAGCTTTCCTTACATCATTATTACTGATGATCATCGAGCACCCGCACTTTACAAACATCGTGGCGCTCGAACA
CGAAAAGCCCATTATTTTGGTCCTTTTGCTTCTTCGAGCGCTGTTACACAAACAATCAATGTTTTACAACGCGCTTTTTT
ATTACGCACCTGTACGGATTCAGTTCTTGAAAACCGTACACGTCCTTGTTTGCTTTATCAAATCAAGCGATGTTCTGCGC
CCTGTACGCATGAAATTAGTGACCGTGATTACAGAGAACTCGTTAAAGGAGCAAAATCTTTTCTTTCGGGGAAAAGCCAA
TCCATTAAAAATGATATGGTTCAAGCTATGCATAAAGCTGCAAAAAATTTTGATTTTGAACAAGCTGCCGCCTACCGTGA
TCGTTTATCGGCACTCTCTCACATACAAAGTCATCAAGGCATTAATCCCCAAACAATAGAAGAAGCAGATGTCTTTGCAA
TTGCGCAAAAGGAAGGAATAAGCTGCATTCAAGTGTTCTTTTTCCGCATGGGACAAAATTGGGGAAACAGAGCATATTTT
CCTAAAGCAGACCCATCTTTCTCCAGTAGCGAAATTTTAGCGAGTTTCCTTTCCCAATTTTACGATGATAAACCACTTCC
CAAACTCATTCTTTTATCTGAATCGATTGAAGACAAAACACTTCTTGCAGAAGCATTCAGTCTAAAAGCAAATCGTAAAA
TATCCCTTTCTTTACCCAAACAAGGTGAACGCAAAACTCTGGTTAATTATGCCTATATCAATGCCCATGAAACACTTGGG
CACAAGCTTGCTGAAACAGCTACACATACAAAATTGTTTCAGGGTATTGCAGAAATATTTCAACTGCCTCATACCCCATG
CCGTATAGAAATCTATGACAATTCCCACATTATGGGGACAAATGCAGTAGGTGCAATGATTGTTGCAGGTAAAAACGGAT
TTATTAAAAATCAATATCGCAAATTCAACATTCGCTCAACCGATATCACACCTGGCGATGACTTTGGTATGATGAAAGAA
GTCATTAAACGAAGATTTTCACGCCTTATCAAAGAGCATGGTCTGCCTCATGAAAGCAAAAACATACAAAGTAAAGACGA
TGCTTCTTTTCCCATTTGGCCTGATCTTATCTTAATCGATGGAGGTAAAGGACAAATAAACAGTGTGCATACAATATTAT
CTGAATTAGGATTAGATAATTTCATGACAGTAGTAGGAATAGCGAAAGGCGCTGACCGTAGAGCGGGACGTGAACGTTTT
TTTATAAAAGGAAAAACACCTTTTACGCTTCCCCCGTGTGACCCTATTTTGTATTTTTTGCAACGTCTACGTGATGAAGC
ACATCGTTTTGCAATTGGGACTCACAGAGCAAAACGAAAAAAAGAAACATTGAAAAATCCGCTTGATGAAATCGAAAATA
TTGGTCCGACAAGAAAGCGTGCGTTGCTTCATCATTTTGGAAGTGCTAAAGCCATTGCAAGCGCTTCACTAGAAGATTTA
ACAAAAGTTATAGGAATTTCTACCACAATTGCACAAAAAATTTATAACCATTTTAATGAAAAATAG

Upstream 100 bases:

>100_bases
CATTATTTATAGGAAAAAAACTATAAATACATAAACAATAAGGCTTAATGGAACAGAATATTTCATATAAAAAAATACAA
AACATCCCTTGGTAAACTGA

Downstream 100 bases:

>100_bases
GCTTGTTGCATAATCTTTGCCTTATTACGTTTATAAAGTATATTGTAATTTCAAAAAAAATTGAAAATAATTTTATGAAA
AATCATACTTTTTCTTTTCC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MILKNNIAYAENEQEKLSFLSHITWDDAHQRNDKNQFKGAKLIQEFVKHLPHKPGVYRMVDENGKVLYVGKARNLKKRVS
NYTREQGHNNRITRMIRATSHMEFVVTHTEIEALLLEANLIKRLHPRFNVLLRDDKSFPYIIITDDHRAPALYKHRGART
RKAHYFGPFASSSAVTQTINVLQRAFLLRTCTDSVLENRTRPCLLYQIKRCSAPCTHEISDRDYRELVKGAKSFLSGKSQ
SIKNDMVQAMHKAAKNFDFEQAAAYRDRLSALSHIQSHQGINPQTIEEADVFAIAQKEGISCIQVFFFRMGQNWGNRAYF
PKADPSFSSSEILASFLSQFYDDKPLPKLILLSESIEDKTLLAEAFSLKANRKISLSLPKQGERKTLVNYAYINAHETLG
HKLAETATHTKLFQGIAEIFQLPHTPCRIEIYDNSHIMGTNAVGAMIVAGKNGFIKNQYRKFNIRSTDITPGDDFGMMKE
VIKRRFSRLIKEHGLPHESKNIQSKDDASFPIWPDLILIDGGKGQINSVHTILSELGLDNFMTVVGIAKGADRRAGRERF
FIKGKTPFTLPPCDPILYFLQRLRDEAHRFAIGTHRAKRKKETLKNPLDEIENIGPTRKRALLHHFGSAKAIASASLEDL
TKVIGISTTIAQKIYNHFNEK

Sequences:

>Translated_661_residues
MILKNNIAYAENEQEKLSFLSHITWDDAHQRNDKNQFKGAKLIQEFVKHLPHKPGVYRMVDENGKVLYVGKARNLKKRVS
NYTREQGHNNRITRMIRATSHMEFVVTHTEIEALLLEANLIKRLHPRFNVLLRDDKSFPYIIITDDHRAPALYKHRGART
RKAHYFGPFASSSAVTQTINVLQRAFLLRTCTDSVLENRTRPCLLYQIKRCSAPCTHEISDRDYRELVKGAKSFLSGKSQ
SIKNDMVQAMHKAAKNFDFEQAAAYRDRLSALSHIQSHQGINPQTIEEADVFAIAQKEGISCIQVFFFRMGQNWGNRAYF
PKADPSFSSSEILASFLSQFYDDKPLPKLILLSESIEDKTLLAEAFSLKANRKISLSLPKQGERKTLVNYAYINAHETLG
HKLAETATHTKLFQGIAEIFQLPHTPCRIEIYDNSHIMGTNAVGAMIVAGKNGFIKNQYRKFNIRSTDITPGDDFGMMKE
VIKRRFSRLIKEHGLPHESKNIQSKDDASFPIWPDLILIDGGKGQINSVHTILSELGLDNFMTVVGIAKGADRRAGRERF
FIKGKTPFTLPPCDPILYFLQRLRDEAHRFAIGTHRAKRKKETLKNPLDEIENIGPTRKRALLHHFGSAKAIASASLEDL
TKVIGISTTIAQKIYNHFNEK
>Mature_661_residues
MILKNNIAYAENEQEKLSFLSHITWDDAHQRNDKNQFKGAKLIQEFVKHLPHKPGVYRMVDENGKVLYVGKARNLKKRVS
NYTREQGHNNRITRMIRATSHMEFVVTHTEIEALLLEANLIKRLHPRFNVLLRDDKSFPYIIITDDHRAPALYKHRGART
RKAHYFGPFASSSAVTQTINVLQRAFLLRTCTDSVLENRTRPCLLYQIKRCSAPCTHEISDRDYRELVKGAKSFLSGKSQ
SIKNDMVQAMHKAAKNFDFEQAAAYRDRLSALSHIQSHQGINPQTIEEADVFAIAQKEGISCIQVFFFRMGQNWGNRAYF
PKADPSFSSSEILASFLSQFYDDKPLPKLILLSESIEDKTLLAEAFSLKANRKISLSLPKQGERKTLVNYAYINAHETLG
HKLAETATHTKLFQGIAEIFQLPHTPCRIEIYDNSHIMGTNAVGAMIVAGKNGFIKNQYRKFNIRSTDITPGDDFGMMKE
VIKRRFSRLIKEHGLPHESKNIQSKDDASFPIWPDLILIDGGKGQINSVHTILSELGLDNFMTVVGIAKGADRRAGRERF
FIKGKTPFTLPPCDPILYFLQRLRDEAHRFAIGTHRAKRKKETLKNPLDEIENIGPTRKRALLHHFGSAKAIASASLEDL
TKVIGISTTIAQKIYNHFNEK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=619, Percent_Identity=40.064620355412, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1788037, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_BARHE (Q6G424)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033390.1
- HSSP:   P0A8G0
- ProteinModelPortal:   Q6G424
- GeneID:   2865811
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH05550
- NMPDR:   fig|283166.1.peg.518
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q6G424
- ProtClustDB:   PRK00558
- BioCyc:   BHEN283166:BH05550-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 75294; Mature: 75294

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKNNIAYAENEQEKLSFLSHITWDDAHQRNDKNQFKGAKLIQEFVKHLPHKPGVYRMV
CEECCCCCCCCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
DENGKVLYVGKARNLKKRVSNYTREQGHNNRITRMIRATSHMEFVVTHTEIEALLLEANL
CCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
IKRLHPRFNVLLRDDKSFPYIIITDDHRAPALYKHRGARTRKAHYFGPFASSSAVTQTIN
HHHHCCCCEEEEECCCCCCEEEEECCCCCCHHHHHCCCCCCCCEECCCCCCCHHHHHHHH
VLQRAFLLRTCTDSVLENRTRPCLLYQIKRCSAPCTHEISDRDYRELVKGAKSFLSGKSQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHH
SIKNDMVQAMHKAAKNFDFEQAAAYRDRLSALSHIQSHQGINPQTIEEADVFAIAQKEGI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEHHHCCH
SCIQVFFFRMGQNWGNRAYFPKADPSFSSSEILASFLSQFYDDKPLPKLILLSESIEDKT
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHH
LLAEAFSLKANRKISLSLPKQGERKTLVNYAYINAHETLGHKLAETATHTKLFQGIAEIF
HHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
QLPHTPCRIEIYDNSHIMGTNAVGAMIVAGKNGFIKNQYRKFNIRSTDITPGDDFGMMKE
HCCCCCEEEEEECCCEEEECCCCCEEEEECCCCCCCCCCEEEECEECCCCCCCCHHHHHH
VIKRRFSRLIKEHGLPHESKNIQSKDDASFPIWPDLILIDGGKGQINSVHTILSELGLDN
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCHH
FMTVVGIAKGADRRAGRERFFIKGKTPFTLPPCDPILYFLQRLRDEAHRFAIGTHRAKRK
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KETLKNPLDEIENIGPTRKRALLHHFGSAKAIASASLEDLTKVIGISTTIAQKIYNHFNE
HHHHHCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MILKNNIAYAENEQEKLSFLSHITWDDAHQRNDKNQFKGAKLIQEFVKHLPHKPGVYRMV
CEECCCCCCCCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
DENGKVLYVGKARNLKKRVSNYTREQGHNNRITRMIRATSHMEFVVTHTEIEALLLEANL
CCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
IKRLHPRFNVLLRDDKSFPYIIITDDHRAPALYKHRGARTRKAHYFGPFASSSAVTQTIN
HHHHCCCCEEEEECCCCCCEEEEECCCCCCHHHHHCCCCCCCCEECCCCCCCHHHHHHHH
VLQRAFLLRTCTDSVLENRTRPCLLYQIKRCSAPCTHEISDRDYRELVKGAKSFLSGKSQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHH
SIKNDMVQAMHKAAKNFDFEQAAAYRDRLSALSHIQSHQGINPQTIEEADVFAIAQKEGI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEHHHCCH
SCIQVFFFRMGQNWGNRAYFPKADPSFSSSEILASFLSQFYDDKPLPKLILLSESIEDKT
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHH
LLAEAFSLKANRKISLSLPKQGERKTLVNYAYINAHETLGHKLAETATHTKLFQGIAEIF
HHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
QLPHTPCRIEIYDNSHIMGTNAVGAMIVAGKNGFIKNQYRKFNIRSTDITPGDDFGMMKE
HCCCCCEEEEEECCCEEEECCCCCEEEEECCCCCCCCCCEEEECEECCCCCCCCHHHHHH
VIKRRFSRLIKEHGLPHESKNIQSKDDASFPIWPDLILIDGGKGQINSVHTILSELGLDN
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCHH
FMTVVGIAKGADRRAGRERFFIKGKTPFTLPPCDPILYFLQRLRDEAHRFAIGTHRAKRK
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KETLKNPLDEIENIGPTRKRALLHHFGSAKAIASASLEDLTKVIGISTTIAQKIYNHFNE
HHHHHCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA