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The map label for this gene is thiD1 [H]

Identifier: 49475281

GI number: 49475281

Start: 566032

End: 566790

Strand: Reverse

Name: thiD1 [H]

Synonym: BH04860

Alternate gene names: 49475281

Gene position: 566790-566032 (Counterclockwise)

Preceding gene: 49475282

Following gene: 49475280

Centisome position: 29.35

GC content: 39.13

Gene sequence:

>759_bases
ATGGCGTTGATGCCTTCTATTCTTATTGTTGCAGGCACCGATCCAACAGGAGGTGCTGGTATTGTTCGTGATATAGAAAC
AGCTGCACATTTTCAAATAAAAGCAAATTTAGCAATTACTTGCATTAACGTACAAGATGATAACCATGTTGCTGAAATTG
TTCCAATGTGCGAAAAACTCATAGCTGCGCAAATGCGCGCAGCCTTAGAGGCCAATCCAATAAGCGCAATAAAAATTGGG
ATGACAGGAAATCAAGCAATTATCGCAGCAATCTGTAATGTCATAGAAGACTATCCTCATATTCCGGTTATTCTTGACCC
GGTACTTTTTGCCTCATCAGGAGGAAAACTAACAACGGAACCAATCATAGAAATTATGATCAATAAACTTCTCCCTTACG
TTGATCTTTTAACACCCAATAGGGAAGAGCTCGCCCTTCTCAGCCAAACCCCATTGGCATCTTGTCATAAGCAAGCAATA
CAACAAGCAAAAAAACTTCTGTCATTTGGTCCACGTTCTATCTTGATAAAAGGTGGACATGCAGATGGTCCCCTTGCAAC
TGATAGCTTCATTGATAAAACTGAAATCATCGATATTTCCACTGTGCGCTTAACGAGAACAATGCGTGGAACAGGTTGCA
TCCTCTCCAGCGCTATTGCAGCACATTTGGCATTAAATGAATCTATGATACAAGCTATAAAAAATGCAAAAGAATATATT
TACAGATTACTGTTAAATCACAATCAAAAAGGTGATTAA

Upstream 100 bases:

>100_bases
TTTTGAAAGCAGGAGCCAATAGTGCCGCTGTTGTAACCGATATTCTCCTCCATAAAAAACCTGAAAAACGTGTAAGACAG
TGGATCAAAGTGACACAAGC

Downstream 100 bases:

>100_bases
TTAATATTATATCACAATCTTATTAAATATTCTTGCTCACTTTTACAGTTTATATGCTTATTATTTCCTAAAATAAATTT
ATATCTATATCTTTAGAATT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MALMPSILIVAGTDPTGGAGIVRDIETAAHFQIKANLAITCINVQDDNHVAEIVPMCEKLIAAQMRAALEANPISAIKIG
MTGNQAIIAAICNVIEDYPHIPVILDPVLFASSGGKLTTEPIIEIMINKLLPYVDLLTPNREELALLSQTPLASCHKQAI
QQAKKLLSFGPRSILIKGGHADGPLATDSFIDKTEIIDISTVRLTRTMRGTGCILSSAIAAHLALNESMIQAIKNAKEYI
YRLLLNHNQKGD

Sequences:

>Translated_252_residues
MALMPSILIVAGTDPTGGAGIVRDIETAAHFQIKANLAITCINVQDDNHVAEIVPMCEKLIAAQMRAALEANPISAIKIG
MTGNQAIIAAICNVIEDYPHIPVILDPVLFASSGGKLTTEPIIEIMINKLLPYVDLLTPNREELALLSQTPLASCHKQAI
QQAKKLLSFGPRSILIKGGHADGPLATDSFIDKTEIIDISTVRLTRTMRGTGCILSSAIAAHLALNESMIQAIKNAKEYI
YRLLLNHNQKGD
>Mature_251_residues
ALMPSILIVAGTDPTGGAGIVRDIETAAHFQIKANLAITCINVQDDNHVAEIVPMCEKLIAAQMRAALEANPISAIKIGM
TGNQAIIAAICNVIEDYPHIPVILDPVLFASSGGKLTTEPIIEIMINKLLPYVDLLTPNREELALLSQTPLASCHKQAIQ
QAKKLLSFGPRSILIKGGHADGPLATDSFIDKTEIIDISTVRLTRTMRGTGCILSSAIAAHLALNESMIQAIKNAKEYIY
RLLLNHNQKGD

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=234, Percent_Identity=31.1965811965812, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324997, Length=252, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324517, Length=252, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325378, Length=251, Percent_Identity=31.0756972111554, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27075; Mature: 26944

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALMPSILIVAGTDPTGGAGIVRDIETAAHFQIKANLAITCINVQDDNHVAEIVPMCEKL
CCCCCCEEEEECCCCCCCCHHHHHHHHHHEEEEEECEEEEEEEECCCCHHHHHHHHHHHH
IAAQMRAALEANPISAIKIGMTGNQAIIAAICNVIEDYPHIPVILDPVLFASSGGKLTTE
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEECHHHEECCCCCCCHH
PIIEIMINKLLPYVDLLTPNREELALLSQTPLASCHKQAIQQAKKLLSFGPRSILIKGGH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCC
ADGPLATDSFIDKTEIIDISTVRLTRTMRGTGCILSSAIAAHLALNESMIQAIKNAKEYI
CCCCCCCCHHCCCHHEEEEEHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRLLLNHNQKGD
HHHHHCCCCCCC
>Mature Secondary Structure 
ALMPSILIVAGTDPTGGAGIVRDIETAAHFQIKANLAITCINVQDDNHVAEIVPMCEKL
CCCCCEEEEECCCCCCCCHHHHHHHHHHEEEEEECEEEEEEEECCCCHHHHHHHHHHHH
IAAQMRAALEANPISAIKIGMTGNQAIIAAICNVIEDYPHIPVILDPVLFASSGGKLTTE
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEECHHHEECCCCCCCHH
PIIEIMINKLLPYVDLLTPNREELALLSQTPLASCHKQAIQQAKKLLSFGPRSILIKGGH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCC
ADGPLATDSFIDKTEIIDISTVRLTRTMRGTGCILSSAIAAHLALNESMIQAIKNAKEYI
CCCCCCCCHHCCCHHEEEEEHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRLLLNHNQKGD
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]