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The map label for this gene is nhaA

Identifier: 49475203

GI number: 49475203

Start: 463108

End: 464469

Strand: Reverse

Name: nhaA

Synonym: BH04040

Alternate gene names: 49475203

Gene position: 464469-463108 (Counterclockwise)

Preceding gene: 49475204

Following gene: 49475201

Centisome position: 24.05

GC content: 38.84

Gene sequence:

>1362_bases
ATGTCTGATTTATCTTCAAATCGCCTGCCTAATCGCGCTTCTCGTGTTACGAATCAAGCGCTTTCAGCTATTGAGCGTTT
TCTCCATATCGAAGCCCTCAGCGGTGTTGTCCTTTTATTAGCCGCTGCTGCTGCACTCATGTTTGCCAATTCTGAATATG
CTTCTCTTTACGAATCCTTCTGGCATACACCTCTTGGCTTTAACTTTGGCCATTTTACCCTTTCATGGGATTTACATTTC
TGGGTTAACGATGCTCTCATGGCTGTTTTCTTTCTCGTAGCTGGAATGGAAATCCGACGTGAAATTCATGAAGGTGCTCT
AGCCGATTTTAAACAAGCAATTTTACCAATTGTTGCAGCAATAGGTGGAGTTTGTCTTCCTGCAATTATTTATTTCAGCT
TCAACTTTAACAGTGGACAGATACATGGTTGGGCTGTGCCAACAGCAACAGATATTGCCTTTGCGCTAGGTATTCTTGCT
CTTCTTGGAAAAAAAATTCCTTCTAACCTTCATATCATTCTCTTATCCTTAGCAATTATTGATGATATTATAGCTGTTCT
TATTATTGCTTTTTTCTATTCAACGAACATTGATCCTAGTGGTCTCGTTATTGCTATAGCAGGTATTGCTTTAGTATTAT
TTTTTCAATGGATTGGATTCGCATCAGCATGGCTTTACATTCTACCTGGTGCAATCATTTGGTGGGGCTTAATGGTAACG
GGCATTCATCCATCACTTGCAGGTGTGATTTTAGGTATGATGACTCCAGTTCTTCCGACTCGTACGCTTATAGCTCCGCT
TACAATACTGAGCAACGCTATGCAAATTCTTCAAGAAAAAAATACAAAAACAGACCTGCATCATATCTCAACTGCACTGA
AAAAAATGCGTAAAGGACAACGTGATATAATTGCGCCAGTAACACGTATTCAAAAAGCATTGCATCCATGGGTCGCATAT
GGTGTGATGCCAATTTTCGCTTTTGCAAATGCTGGTGTTAGTTTTGCAAATTTTGATCTTTCTTCTGATAAATCTTTCTT
GATTGTTCTTGGTGTTGTAATTGGTCTCTTTATTGGTAAACCTCTTGGTATTATAACTGCAAGTTATCTAGCAGTAAAAT
CAGGGCTGTGTCGATTGCCTCCTCAAATGACATGGGCAGGAATTTTGTTGATTGGGTTTTTAGCAGGAATTGGCTTTACA
ATGTCTATCTTTGTTTCAATGCTTGCTTTTAAAGATATTGTTCTGCTTGATTCTGCAAAAATTGGTGTTCTTTGTGGATC
TGGTTTATCTGCTCTTATCGGGCTTGGATATGGCCTCATTTATATCAAACGCAATAAAAAAGCGTCTCATAGTTCTCAAT
AA

Upstream 100 bases:

>100_bases
TATCCTTCTTTTTTCTTTTGTATGGTACAAGAGAATACCATACAAAAGAGTTCATGTAGAAAATATATATTCGTAAAATT
GTCGATAGTTGGAGTTGTTT

Downstream 100 bases:

>100_bases
AAACAAACGAAAACCTACTTTCTTATGCTCATCTTTTACAAAACAGTTTGATTGAGTTGTTACATTATGGCTGTATCATA
ATTACAAAAATGAATAAGAA

Product: Na+/H antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSDLSSNRLPNRASRVTNQALSAIERFLHIEALSGVVLLLAAAAALMFANSEYASLYESFWHTPLGFNFGHFTLSWDLHF
WVNDALMAVFFLVAGMEIRREIHEGALADFKQAILPIVAAIGGVCLPAIIYFSFNFNSGQIHGWAVPTATDIAFALGILA
LLGKKIPSNLHIILLSLAIIDDIIAVLIIAFFYSTNIDPSGLVIAIAGIALVLFFQWIGFASAWLYILPGAIIWWGLMVT
GIHPSLAGVILGMMTPVLPTRTLIAPLTILSNAMQILQEKNTKTDLHHISTALKKMRKGQRDIIAPVTRIQKALHPWVAY
GVMPIFAFANAGVSFANFDLSSDKSFLIVLGVVIGLFIGKPLGIITASYLAVKSGLCRLPPQMTWAGILLIGFLAGIGFT
MSIFVSMLAFKDIVLLDSAKIGVLCGSGLSALIGLGYGLIYIKRNKKASHSSQ

Sequences:

>Translated_453_residues
MSDLSSNRLPNRASRVTNQALSAIERFLHIEALSGVVLLLAAAAALMFANSEYASLYESFWHTPLGFNFGHFTLSWDLHF
WVNDALMAVFFLVAGMEIRREIHEGALADFKQAILPIVAAIGGVCLPAIIYFSFNFNSGQIHGWAVPTATDIAFALGILA
LLGKKIPSNLHIILLSLAIIDDIIAVLIIAFFYSTNIDPSGLVIAIAGIALVLFFQWIGFASAWLYILPGAIIWWGLMVT
GIHPSLAGVILGMMTPVLPTRTLIAPLTILSNAMQILQEKNTKTDLHHISTALKKMRKGQRDIIAPVTRIQKALHPWVAY
GVMPIFAFANAGVSFANFDLSSDKSFLIVLGVVIGLFIGKPLGIITASYLAVKSGLCRLPPQMTWAGILLIGFLAGIGFT
MSIFVSMLAFKDIVLLDSAKIGVLCGSGLSALIGLGYGLIYIKRNKKASHSSQ
>Mature_452_residues
SDLSSNRLPNRASRVTNQALSAIERFLHIEALSGVVLLLAAAAALMFANSEYASLYESFWHTPLGFNFGHFTLSWDLHFW
VNDALMAVFFLVAGMEIRREIHEGALADFKQAILPIVAAIGGVCLPAIIYFSFNFNSGQIHGWAVPTATDIAFALGILAL
LGKKIPSNLHIILLSLAIIDDIIAVLIIAFFYSTNIDPSGLVIAIAGIALVLFFQWIGFASAWLYILPGAIIWWGLMVTG
IHPSLAGVILGMMTPVLPTRTLIAPLTILSNAMQILQEKNTKTDLHHISTALKKMRKGQRDIIAPVTRIQKALHPWVAYG
VMPIFAFANAGVSFANFDLSSDKSFLIVLGVVIGLFIGKPLGIITASYLAVKSGLCRLPPQMTWAGILLIGFLAGIGFTM
SIFVSMLAFKDIVLLDSAKIGVLCGSGLSALIGLGYGLIYIKRNKKASHSSQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=415, Percent_Identity=40.9638554216867, Blast_Score=272, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_BARHE (Q6G5K1)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033244.1
- HSSP:   P13738
- ProteinModelPortal:   Q6G5K1
- SMR:   Q6G5K1
- GeneID:   2865378
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH04040
- NMPDR:   fig|283166.1.peg.372
- HOGENOM:   HBG665619
- OMA:   VLGLMTP
- PhylomeDB:   Q6G5K1
- ProtClustDB:   CLSK927010
- BioCyc:   BHEN283166:BH04040-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 48966; Mature: 48835

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x23a2839c)-; HASH(0x236ef27c)-; HASH(0x23ce8328)-; HASH(0x234583c0)-; HASH(0x23a285d0)-; HASH(0x235a7cc4)-; HASH(0x233dbae8)-; HASH(0x23aa3684)-; HASH(0x237c880c)-; HASH(0x2401444c)-; HASH(0x2354d6e8)-; HASH(0x23d5d8b0)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLSSNRLPNRASRVTNQALSAIERFLHIEALSGVVLLLAAAAALMFANSEYASLYESF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
WHTPLGFNFGHFTLSWDLHFWVNDALMAVFFLVAGMEIRREIHEGALADFKQAILPIVAA
CCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGVCLPAIIYFSFNFNSGQIHGWAVPTATDIAFALGILALLGKKIPSNLHIILLSLAII
HHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
DDIIAVLIIAFFYSTNIDPSGLVIAIAGIALVLFFQWIGFASAWLYILPGAIIWWGLMVT
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIHPSLAGVILGMMTPVLPTRTLIAPLTILSNAMQILQEKNTKTDLHHISTALKKMRKGQ
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
RDIIAPVTRIQKALHPWVAYGVMPIFAFANAGVSFANFDLSSDKSFLIVLGVVIGLFIGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
PLGIITASYLAVKSGLCRLPPQMTWAGILLIGFLAGIGFTMSIFVSMLAFKDIVLLDSAK
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
IGVLCGSGLSALIGLGYGLIYIKRNKKASHSSQ
EEEEECCHHHHHHHCCCEEEEEECCCCCCCCCH
>Mature Secondary Structure 
SDLSSNRLPNRASRVTNQALSAIERFLHIEALSGVVLLLAAAAALMFANSEYASLYESF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
WHTPLGFNFGHFTLSWDLHFWVNDALMAVFFLVAGMEIRREIHEGALADFKQAILPIVAA
CCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGVCLPAIIYFSFNFNSGQIHGWAVPTATDIAFALGILALLGKKIPSNLHIILLSLAII
HHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
DDIIAVLIIAFFYSTNIDPSGLVIAIAGIALVLFFQWIGFASAWLYILPGAIIWWGLMVT
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIHPSLAGVILGMMTPVLPTRTLIAPLTILSNAMQILQEKNTKTDLHHISTALKKMRKGQ
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
RDIIAPVTRIQKALHPWVAYGVMPIFAFANAGVSFANFDLSSDKSFLIVLGVVIGLFIGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
PLGIITASYLAVKSGLCRLPPQMTWAGILLIGFLAGIGFTMSIFVSMLAFKDIVLLDSAK
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
IGVLCGSGLSALIGLGYGLIYIKRNKKASHSSQ
EEEEECCHHHHHHHCCCEEEEEECCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA