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The map label for this gene is ubiG

Identifier: 49475201

GI number: 49475201

Start: 459992

End: 460735

Strand: Reverse

Name: ubiG

Synonym: BH04020

Alternate gene names: 49475201

Gene position: 460735-459992 (Counterclockwise)

Preceding gene: 49475203

Following gene: 49475198

Centisome position: 23.86

GC content: 40.59

Gene sequence:

>744_bases
ATGATAAATGAAACACGCACCACACTTGATCAAAGTGAAGTTGACCATTTTTCGCGTATTGCCGCTGAATGGTGGAATCC
ACACGGAAAATTTCGGCCACTTCATCAATTCAATCCAACACGCCTTGCTTACATTAGAGAAAAAATCTGTCTAGAACTTC
ATCGTGATCCTGTTTCACTTAAGCCCTTCGAAAATTTAAAAATCCTTGATATTGGCTGTGGAGGTGGTTTATTATGCGAA
CCAATGGCACGTCTTGGCGCTATGGTTGTAGGAGCTGATGCTTCCCAAACAAATATTGAAGTCGCAAAAATCCACGCAGC
CCAAAATGGCCTTTCAATTGACTACCGCACCACTACTGCGGAAGCACTTGCTACTGAAGGAGAGCAATTTGATATCATCC
TTAATATGGAAGTTGTTGAACATGTGGCTGATGTTAATCTCTTCATAGAGGCTACAGCAAAAATGCTCAAGCCACAAGGA
TTGATGTTTATCTCAACACTCAACCGTACATGGAAAGCATGGGGACTCGCTATTATAGGCGCTGAATATATTTTACGTTG
GCTTCCGAAAGGAACCCACAACTATAAAAAGTTTCTCAAACCTCGAGAACTGAAGAATCTCTTATTACAAAACGCTCTCA
CTGTCGTTGATGAGATCGGTGTTACTTATAATCCATTAAACGACAGCTGGAATCGCTCAAAAGATATGAACGTTAATTAT
CTGCTTCTGGCAAAAAAATCTTAA

Upstream 100 bases:

>100_bases
TATCTATCATTTGTGCAAGTGCACTCTATGTATGTTAATTTCCCTTGACTTTGGATACAATCAACTTGACTTAATTATGA
AAAAATAAAAAATGAGCAAT

Downstream 100 bases:

>100_bases
GCAAACATAATCTCCAATTAATTTAATGTACGTCCTGCAACAAAGAATCGAGCTTCCCTTTATTTTCTAAAGCGTAAAGA
TCATCACAACCGCCAACATG

Product: 3-demethylubiquinone-9 3-methyltransferase

Products: NA

Alternate protein names: 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; DHHB methyltransferase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MINETRTTLDQSEVDHFSRIAAEWWNPHGKFRPLHQFNPTRLAYIREKICLELHRDPVSLKPFENLKILDIGCGGGLLCE
PMARLGAMVVGADASQTNIEVAKIHAAQNGLSIDYRTTTAEALATEGEQFDIILNMEVVEHVADVNLFIEATAKMLKPQG
LMFISTLNRTWKAWGLAIIGAEYILRWLPKGTHNYKKFLKPRELKNLLLQNALTVVDEIGVTYNPLNDSWNRSKDMNVNY
LLLAKKS

Sequences:

>Translated_247_residues
MINETRTTLDQSEVDHFSRIAAEWWNPHGKFRPLHQFNPTRLAYIREKICLELHRDPVSLKPFENLKILDIGCGGGLLCE
PMARLGAMVVGADASQTNIEVAKIHAAQNGLSIDYRTTTAEALATEGEQFDIILNMEVVEHVADVNLFIEATAKMLKPQG
LMFISTLNRTWKAWGLAIIGAEYILRWLPKGTHNYKKFLKPRELKNLLLQNALTVVDEIGVTYNPLNDSWNRSKDMNVNY
LLLAKKS
>Mature_247_residues
MINETRTTLDQSEVDHFSRIAAEWWNPHGKFRPLHQFNPTRLAYIREKICLELHRDPVSLKPFENLKILDIGCGGGLLCE
PMARLGAMVVGADASQTNIEVAKIHAAQNGLSIDYRTTTAEALATEGEQFDIILNMEVVEHVADVNLFIEATAKMLKPQG
LMFISTLNRTWKAWGLAIIGAEYILRWLPKGTHNYKKFLKPRELKNLLLQNALTVVDEIGVTYNPLNDSWNRSKDMNVNY
LLLAKKS

Specific function: Ubiquinone biosynthesis. [C]

COG id: COG2227

COG function: function code H; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiG/COQ3 family

Homologues:

Organism=Homo sapiens, GI118600965, Length=251, Percent_Identity=38.6454183266932, Blast_Score=194, Evalue=5e-50,
Organism=Escherichia coli, GI1788564, Length=235, Percent_Identity=41.7021276595745, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI115533050, Length=249, Percent_Identity=31.3253012048193, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324476, Length=232, Percent_Identity=31.0344827586207, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI281365311, Length=255, Percent_Identity=33.7254901960784, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24585589, Length=217, Percent_Identity=35.4838709677419, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIG_BARHE (Q6G5K3)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033242.1
- ProteinModelPortal:   Q6G5K3
- SMR:   Q6G5K3
- GeneID:   2864849
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH04020
- NMPDR:   fig|283166.1.peg.370
- HOGENOM:   HBG738842
- OMA:   KFITPDE
- PhylomeDB:   Q6G5K3
- ProtClustDB:   PRK05134
- BioCyc:   BHEN283166:BH04020-MONOMER
- BRENDA:   2.1.1.64
- HAMAP:   MF_00472
- InterPro:   IPR013216
- InterPro:   IPR010233
- TIGRFAMs:   TIGR01983

Pfam domain/function: PF08241 Methyltransf_11

EC number: =2.1.1.64

Molecular weight: Translated: 27986; Mature: 27986

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINETRTTLDQSEVDHFSRIAAEWWNPHGKFRPLHQFNPTRLAYIREKICLELHRDPVSL
CCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
KPFENLKILDIGCGGGLLCEPMARLGAMVVGADASQTNIEVAKIHAAQNGLSIDYRTTTA
CCCCCEEEEEECCCCCHHHHHHHHHCEEEEECCCCCCCEEEEEEEECCCCCEEEEECCHH
EALATEGEQFDIILNMEVVEHVADVNLFIEATAKMLKPQGLMFISTLNRTWKAWGLAIIG
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHH
AEYILRWLPKGTHNYKKFLKPRELKNLLLQNALTVVDEIGVTYNPLNDSWNRSKDMNVNY
HHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCEE
LLLAKKS
EEEEECC
>Mature Secondary Structure
MINETRTTLDQSEVDHFSRIAAEWWNPHGKFRPLHQFNPTRLAYIREKICLELHRDPVSL
CCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
KPFENLKILDIGCGGGLLCEPMARLGAMVVGADASQTNIEVAKIHAAQNGLSIDYRTTTA
CCCCCEEEEEECCCCCHHHHHHHHHCEEEEECCCCCCCEEEEEEEECCCCCEEEEECCHH
EALATEGEQFDIILNMEVVEHVADVNLFIEATAKMLKPQGLMFISTLNRTWKAWGLAIIG
HHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHH
AEYILRWLPKGTHNYKKFLKPRELKNLLLQNALTVVDEIGVTYNPLNDSWNRSKDMNVNY
HHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCEE
LLLAKKS
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA