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The map label for this gene is dfp [H]

Identifier: 49474864

GI number: 49474864

Start: 49481

End: 50893

Strand: Reverse

Name: dfp [H]

Synonym: BH00380

Alternate gene names: 49474864

Gene position: 50893-49481 (Counterclockwise)

Preceding gene: 49474865

Following gene: 49474863

Centisome position: 2.64

GC content: 43.45

Gene sequence:

>1413_bases
ATGGCCAGTCTTACCATCCGCAATCTTCCAGCTAAAGTTAAAGAAATTTTGCGTATACGCGCTGCGCAAAATGGTGTTTC
TATGGAAGAAGAAGCGCGCCGTCTTTTAAGTAATTTCACAACCCCAACGATATCATCATCTCAAGCAAGCCCCGTAGAAA
TGCAATCACTGCAATCAAAATCCATCCTCCTTATTATTGGTGGGAGTATTGCTGCCTATAAAGCGCTTGATTTGATTCGC
CGTTTGCAAGAACGGGGAGCACGCTTAAATATTATTATGACAAAAGCAGCACAAAAATTTATTACCCCTTTAGCAGCTGA
AGCGCTGAGTGGTCGTACTGTGTATAGCGATTTATTTTCACGCGAAGAAGAACATGATATTGGACATATCCGACTAGCAC
GGGATGCTGATTTGATTATTTTAGCACCAGCCACTGCCAATCGTATTGCAAAAATAGCAACCGGTAGAGGAGAAGATCTA
GCTGATTGTGTACTGTTAGCGGCACGTTGTCCACTCTTGATTGCACCGGCTATGAATCCAGCCATGTGGACACATCCAAC
AACTGTTCGCAATGTCGCACAACTATGCGCAGATGGCGTTCATATAGTCGGACCAGAAATCGGCAAAATGGCTGAGCGCA
ATGAATCAGGTCTAGGGCGCCTGAGCGAACCCTTAACCATTATAGCTGCAGCAGAAGCCCTTTTGAATATAACAGAAAGA
CCACTTTCTGGTCGCCATTTCATTGTTACCTCTGGCCCTACTCATGAACCCATTGATCCCGTGCGTTATCTTGCTAATCG
CTCTTCGGGTAAACAAGGCCACGCTATTGCAAAGGCTTTAGCTAACTTGGGCGCCAAAATAACGCTTATTTGTGGACCAG
TAGATCTTGCAGATCCACCACAAGTGAAAACTATTCATGTTGAAACAGCATGTCAGATGTTACAAACTGTGCAAGCAACA
TTGCCCGCTGATGGAGCAATTTTTGTTGCCGCCGTTTGTGACTGGCGCAGCCAAACACCATCTCTCCAAAAAATCAAAAA
GAGTGCTCATAAAACCCCCCCATCCTTACAGATGGTCAAAAACCCTGATATTTTAGCAACAATTGGTCATGCTTCAAACC
GCCCTCCACTTGTCATTGGTTTCGCGGCTGAAACCTGTGATCTCATTGCTAATGCGCAAAAGAAATGTGTTGAAAAAGGA
GCCAATTTTATTCTTGCGAATAACATTACTCTCCCTGATGGTAAAAATGTTATGGGAGCAGACACAAATCAAGTTTACCT
TGTTAGCAGAGAAAACATCGAACAGTGGCCGCATATGAGTAAACAACAAATAGCACAAAAATTAGCAAGCCTTGTTGTCT
CATTTTTCTGTCCTTCTTCTGCTGCTCATTCAAATGAACAAAGAACTCTTTAA

Upstream 100 bases:

>100_bases
CTGACTTTTTACCTTTTTCATTTTTTTTAATCTGTTGAATATACTCAAAAAATATTTATAATGAAATCATTGCAATCATT
TTGTTTTTTGAGTGTATTTT

Downstream 100 bases:

>100_bases
TCTTAAAAGTTTTTCAGATAACTTGATATTACTCACAAAACACAACAAAAAATGAGACGTAATTTTATTTCATAAAATTA
CATGGGAAATATCTGCATTA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MASLTIRNLPAKVKEILRIRAAQNGVSMEEEARRLLSNFTTPTISSSQASPVEMQSLQSKSILLIIGGSIAAYKALDLIR
RLQERGARLNIIMTKAAQKFITPLAAEALSGRTVYSDLFSREEEHDIGHIRLARDADLIILAPATANRIAKIATGRGEDL
ADCVLLAARCPLLIAPAMNPAMWTHPTTVRNVAQLCADGVHIVGPEIGKMAERNESGLGRLSEPLTIIAAAEALLNITER
PLSGRHFIVTSGPTHEPIDPVRYLANRSSGKQGHAIAKALANLGAKITLICGPVDLADPPQVKTIHVETACQMLQTVQAT
LPADGAIFVAAVCDWRSQTPSLQKIKKSAHKTPPSLQMVKNPDILATIGHASNRPPLVIGFAAETCDLIANAQKKCVEKG
ANFILANNITLPDGKNVMGADTNQVYLVSRENIEQWPHMSKQQIAQKLASLVVSFFCPSSAAHSNEQRTL

Sequences:

>Translated_470_residues
MASLTIRNLPAKVKEILRIRAAQNGVSMEEEARRLLSNFTTPTISSSQASPVEMQSLQSKSILLIIGGSIAAYKALDLIR
RLQERGARLNIIMTKAAQKFITPLAAEALSGRTVYSDLFSREEEHDIGHIRLARDADLIILAPATANRIAKIATGRGEDL
ADCVLLAARCPLLIAPAMNPAMWTHPTTVRNVAQLCADGVHIVGPEIGKMAERNESGLGRLSEPLTIIAAAEALLNITER
PLSGRHFIVTSGPTHEPIDPVRYLANRSSGKQGHAIAKALANLGAKITLICGPVDLADPPQVKTIHVETACQMLQTVQAT
LPADGAIFVAAVCDWRSQTPSLQKIKKSAHKTPPSLQMVKNPDILATIGHASNRPPLVIGFAAETCDLIANAQKKCVEKG
ANFILANNITLPDGKNVMGADTNQVYLVSRENIEQWPHMSKQQIAQKLASLVVSFFCPSSAAHSNEQRTL
>Mature_469_residues
ASLTIRNLPAKVKEILRIRAAQNGVSMEEEARRLLSNFTTPTISSSQASPVEMQSLQSKSILLIIGGSIAAYKALDLIRR
LQERGARLNIIMTKAAQKFITPLAAEALSGRTVYSDLFSREEEHDIGHIRLARDADLIILAPATANRIAKIATGRGEDLA
DCVLLAARCPLLIAPAMNPAMWTHPTTVRNVAQLCADGVHIVGPEIGKMAERNESGLGRLSEPLTIIAAAEALLNITERP
LSGRHFIVTSGPTHEPIDPVRYLANRSSGKQGHAIAKALANLGAKITLICGPVDLADPPQVKTIHVETACQMLQTVQATL
PADGAIFVAAVCDWRSQTPSLQKIKKSAHKTPPSLQMVKNPDILATIGHASNRPPLVIGFAAETCDLIANAQKKCVEKGA
NFILANNITLPDGKNVMGADTNQVYLVSRENIEQWPHMSKQQIAQKLASLVVSFFCPSSAAHSNEQRTL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=201, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=40.9876543209877, Blast_Score=260, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560194, Length=143, Percent_Identity=34.965034965035, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 50613; Mature: 50482

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLTIRNLPAKVKEILRIRAAQNGVSMEEEARRLLSNFTTPTISSSQASPVEMQSLQSK
CCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCC
SILLIIGGSIAAYKALDLIRRLQERGARLNIIMTKAAQKFITPLAAEALSGRTVYSDLFS
CEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHC
REEEHDIGHIRLARDADLIILAPATANRIAKIATGRGEDLADCVLLAARCPLLIAPAMNP
CCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCC
AMWTHPTTVRNVAQLCADGVHIVGPEIGKMAERNESGLGRLSEPLTIIAAAEALLNITER
CCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PLSGRHFIVTSGPTHEPIDPVRYLANRSSGKQGHAIAKALANLGAKITLICGPVDLADPP
CCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
QVKTIHVETACQMLQTVQATLPADGAIFVAAVCDWRSQTPSLQKIKKSAHKTPPSLQMVK
CEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEC
NPDILATIGHASNRPPLVIGFAAETCDLIANAQKKCVEKGANFILANNITLPDGKNVMGA
CCCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCCCCCCC
DTNQVYLVSRENIEQWPHMSKQQIAQKLASLVVSFFCPSSAAHSNEQRTL
CCCEEEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASLTIRNLPAKVKEILRIRAAQNGVSMEEEARRLLSNFTTPTISSSQASPVEMQSLQSK
CCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCC
SILLIIGGSIAAYKALDLIRRLQERGARLNIIMTKAAQKFITPLAAEALSGRTVYSDLFS
CEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHC
REEEHDIGHIRLARDADLIILAPATANRIAKIATGRGEDLADCVLLAARCPLLIAPAMNP
CCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCC
AMWTHPTTVRNVAQLCADGVHIVGPEIGKMAERNESGLGRLSEPLTIIAAAEALLNITER
CCCCCCHHHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PLSGRHFIVTSGPTHEPIDPVRYLANRSSGKQGHAIAKALANLGAKITLICGPVDLADPP
CCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
QVKTIHVETACQMLQTVQATLPADGAIFVAAVCDWRSQTPSLQKIKKSAHKTPPSLQMVK
CEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEC
NPDILATIGHASNRPPLVIGFAAETCDLIANAQKKCVEKGANFILANNITLPDGKNVMGA
CCCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEECCEECCCCCCCCCC
DTNQVYLVSRENIEQWPHMSKQQIAQKLASLVVSFFCPSSAAHSNEQRTL
CCCEEEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA