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The map label for this gene is nprM [H]

Identifier: 49185400

GI number: 49185400

Start: 2388844

End: 2389920

Strand: Direct

Name: nprM [H]

Synonym: BAS2392

Alternate gene names: 49185400

Gene position: 2388844-2389920 (Clockwise)

Preceding gene: 49185399

Following gene: 49185401

Centisome position: 45.69

GC content: 33.52

Gene sequence:

>1077_bases
ATGAAAAATAAAAAAGAAATAGCTATAGTTGCATTAACAACAGGATTGGTTTTAACAAGCATAGTACCATACGGGATAGG
TTATGCAGAGGAAACGGGTCAAATGCAAGTTGATATTCAAGAGGATTCGTTCCGTACAGGTGAACTTACAAAACCATCAA
AAAAAACGCCAGAGAGTGTAGTGAAAGATGCACTTAAGGAAAAAACGGAGCATGTTTTGTCTCCAAAACAAGTTAGTGGA
GACAAAGGGGTAGATTACAAGGTCCTTCAAAAACGTGGTTCATATGATGGGACTACACTTGTGCGTTTGCAACAAATATA
TGAAGGAAAAGAAGTATATGGACACCAATTGACTGCTCATGTAGATAAAAAGGGTATTATTAAAAGTGTTTCAGGGGAAA
GCGCACAAAATTTAGAAAAAGAAGATTTAAAGAATCCTATTAATTTATCAAAAGAAGAAGCAAAACAATATATTTATAAA
AAGTACGGAAATGATATTAAATTTATTTCTGAGCCAGAAGTTAAGGAAGTTATTTTTGTTGATGAAAATAATGGACAGGC
TAGCAATGCATATCAAGTTACATTTGCGGCTGCCACACCAAACTATGTATCTGGAACTTATTTAGTGGATGCCCATAATG
GTGTTATGTTGAAAAATACGTTACAAGAATCCGATTTAAAAGTAAGTGAAGAGCAAGTTGAATCTTTAAAGGAGAATAAA
AAAAGCAATTCCATATCATTAACTGGAACAGGAAAAGATGATTTAGGGATAACTCGCATATTTGGTATTTCTGAACAGAG
TAACGGAAAATATGCGCTTGCTGATTATACAAGAGGGCAAGGAATTGAAACGTACGATGTAAATTATAGAGATATTAATT
TTGAAGAAAGATATTATCCTGGTATATTAGCAACTAGCACTTCAACAACCTTTGATGATCCAAAGGCGGTCAGTGCTCAT
TTCTTAGCAACAAAGGTATATGATTTTTATAAAGACAAATATAAGCGTAATAGTTTTGATAATAAGGGAAAAAATAGTAT
CAGTTGTACATGCATGGCATTCAGGAGAAACAGATGA

Upstream 100 bases:

>100_bases
GTGACTTTTGTTGATTACAGAAGTCATCTTTTTACATTAGAAATAGATTGTATAAATTTCAGTCATTTCATATTTTAGGA
AATCATAAGAGGGAAATAAC

Downstream 100 bases:

>100_bases
CCCTAAAAATTGGGGGAATGCATTTAGTGCTAATATTAACAATGTGAGTATGCTTATATATGGTGATCCAATGGTTAGAG
CGTTTGACATAGCGGGCCAT

Product: thermolysin metallopeptidase catalytic subunit

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKNKKEIAIVALTTGLVLTSIVPYGIGYAEETGQMQVDIQEDSFRTGELTKPSKKTPESVVKDALKEKTEHVLSPKQVSG
DKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYK
KYGNDIKFISEPEVKEVIFVDENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENK
KSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAH
FLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRRNR

Sequences:

>Translated_358_residues
MKNKKEIAIVALTTGLVLTSIVPYGIGYAEETGQMQVDIQEDSFRTGELTKPSKKTPESVVKDALKEKTEHVLSPKQVSG
DKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYK
KYGNDIKFISEPEVKEVIFVDENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENK
KSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAH
FLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRRNR
>Mature_358_residues
MKNKKEIAIVALTTGLVLTSIVPYGIGYAEETGQMQVDIQEDSFRTGELTKPSKKTPESVVKDALKEKTEHVLSPKQVSG
DKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYK
KYGNDIKFISEPEVKEVIFVDENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENK
KSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAH
FLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRRNR

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 40079; Mature: 40079

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKKEIAIVALTTGLVLTSIVPYGIGYAEETGQMQVDIQEDSFRTGELTKPSKKTPESV
CCCCCEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHH
VKDALKEKTEHVLSPKQVSGDKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAH
HHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHCCEEEEE
VDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKEVIFV
CCCCCCCCCCCCCCHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEEE
DENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENK
ECCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHCC
KSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYP
CCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEECCEEECCCCCCCCC
GILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRRNR
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MKNKKEIAIVALTTGLVLTSIVPYGIGYAEETGQMQVDIQEDSFRTGELTKPSKKTPESV
CCCCCEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHH
VKDALKEKTEHVLSPKQVSGDKGVDYKVLQKRGSYDGTTLVRLQQIYEGKEVYGHQLTAH
HHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHCCEEEEE
VDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKEVIFV
CCCCCCCCCCCCCCHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEEE
DENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENK
ECCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHCC
KSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEERYYP
CCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEECCEEECCCCCCCCC
GILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRRNR
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]