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The map label for this gene is hemH

Identifier: 49184021

GI number: 49184021

Start: 1052128

End: 1053063

Strand: Direct

Name: hemH

Synonym: BAS1000

Alternate gene names: 49184021

Gene position: 1052128-1053063 (Clockwise)

Preceding gene: 49184020

Following gene: 49184022

Centisome position: 20.12

GC content: 38.46

Gene sequence:

>936_bases
ATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAACGTTACTATACACA
TATTCGCAGAGGAAGAAAGCCAAGTCCTGAAATGCTGGAAGATTTAACAGAGCGTTACCGTGCAATTGGTGGTATTTCTC
CTTTAGCTACTATTACATTAGAGCAAGCTAAGAAGTTAGAGAAGCGTTTAAATGAAGTGCAAGATGAAGTCGAGTACCAT
ATGTATCTTGGCTTAAAACATATTGAACCGTTCATTGAAGATGCAGTGAAAGAGATGCATAACGACGGTATACAAGATGC
AATTGCACTTGTTCTTGCGCCGCACTATTCTACATTTAGCGTGAAATCATATGTAGGACGAGCACAAGAAGAAGCTGAGA
AACTTGGAAACTTAACTATTCATGGCATTGATAGCTGGTATAAAGAACCGAAATTTATCCAGTACTGGGTTGATGCAGTA
AAAAGTATATATAGCGGTATGTCAGATGCAGAACGTGAAAAAGCAGTATTGATTGTATCTGCTCACAGTTTACCAGAGAA
AATTATTGCAATGGGCGATCCATATCCAGATCAGTTAAATGAAACAGCGGACTATATCGCGCGCGGAGCTGAAGTAGCAA
ACTATGCAGTAGGCTGGCAAAGTGCAGGAAACACACCAGATCCTTGGATTGGTCCAGATGTACAAGATTTAACGAGAGAA
CTAAATGAAAAGTACGGTTATACTTCATTCGTATACGCGCCAGTTGGATTTGTTGCGGAACATTTAGAAGTTTTATATGA
CAACGACTTTGAGTGTAAAGTGGTAACAGATGAAATTGGCGCGAAATATTATCGTCCAGAAATGCCAAATGCATCGGACG
CATTTATTGACTGTTTAACAGATGTTGTAGTAAAGAAAAAAGAATCTGTAATGTAA

Upstream 100 bases:

>100_bases
GTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAGTTAGCG
AAGTAAAGGAGCATTGCTGT

Downstream 100 bases:

>100_bases
GAAGAAAGGGGGAGCCTGCTTGAGGAAAAAAGTTGTAATCATCGGCGGTGGCATCACAGGATTAACAACAATGTATCACT
TACAAAAAGATATTCGTGAC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KSIYSGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVM

Sequences:

>Translated_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KSIYSGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVM
>Mature_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KSIYSGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLTDVVVKKKESVM

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=30.8550185873606, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=30.8550185873606, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6324750, Length=282, Percent_Identity=27.3049645390071, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17864156, Length=328, Percent_Identity=25.609756097561, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=31.1764705882353, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=22.9249011857708, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH1_BACAN (Q81U22)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843565.1
- RefSeq:   YP_017696.1
- RefSeq:   YP_027273.1
- PDB:   2C8J
- PDBsum:   2C8J
- ProteinModelPortal:   Q81U22
- SMR:   Q81U22
- IntAct:   Q81U22
- EnsemblBacteria:   EBBACT00000011608
- EnsemblBacteria:   EBBACT00000014266
- EnsemblBacteria:   EBBACT00000019853
- GeneID:   1089001
- GeneID:   2815434
- GeneID:   2849644
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1071
- KEGG:   bar:GBAA_1071
- KEGG:   bat:BAS1000
- TIGR:   BA_1071
- TIGR:   GBAA_1071
- GeneTree:   EBGT00050000002085
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK12435
- BioCyc:   BANT260799:BAS1000-MONOMER
- BioCyc:   BANT261594:GBAA1071-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35349; Mature: 35349

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKSIYSGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLT
HHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCCHHHHHHHHH
DVVVKKKESVM
HHHHHHHHCCC
>Mature Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKSIYSGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDCLT
HHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCCHHHHHHHHH
DVVVKKKESVM
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629