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The map label for this gene is hemE [H]

Identifier: 49184020

GI number: 49184020

Start: 1051067

End: 1052113

Strand: Direct

Name: hemE [H]

Synonym: BAS0999

Alternate gene names: 49184020

Gene position: 1051067-1052113 (Clockwise)

Preceding gene: 49184019

Following gene: 49184021

Centisome position: 20.1

GC content: 39.26

Gene sequence:

>1047_bases
TTGGTAAGAACTATAAATGAGACATTTTTAAAAGCATGTAGGGGGGAACGTACTGATTATGTGCCAGCATGGTATATGCG
TCAAGCAGGTCGTTCGCAGCCGGAATATAGAAAGATAAAAGAAAAGTATTCTTTATTTGAAATTACACATAATCCAGAGT
TATGTGCTTACGTTACAAAACTACCAGTTGATCAATATAACGTAGACGCAGCAATTCTTTATAAAGATATTATGTCACCA
CTACCTGCAATTGGTGTGGATGTAGAAATTAAATCAGGTATTGGCCCAGTTATTGATAATCCAATCCGTTCTTTACAAGA
CGTAGAAAAACTAGGGGAAATCAATCCAGAAGATGACGTACCGTACATATTAGATACAATTCGTTTATTAACGACTGAAA
TGCTAGACGTACCGTTAATCGGTTTTTCAGGAGCTCCATTTACGTTAGCGAGCTATATGATTGAAGGCGGTCCATCTCGT
AACTACCATAATACGAAAGCGTTTATGTATGCAGAGCCGAAAGCTTGGTTTGCTTTAATCGATAAGCTAGCAGATATGGT
TATTACATATTTGAAAGCGCAAATTAACGCAGGAGCAAAAGCAGTTCAAATTTTCGATTCTTGGGTTGGAACAGTAAACG
TAGCAGATTACCGCGTATTTATTAAACCAGCAATGGAGCGTATTTTTGCAGAAGTTCGCACAATGGGTGTACCGATGATT
ATGCACGGCGTAGGAGCTGCACACTTAGTGAATGAGTGGCACGACTTACCGCTTGATGTAGTCGGTTTAGACTGGCGTTT
ACCAATTGAAGAAGCACGTGCACGCGGCGTTCACAAGGCGGTACAAGGGAATATGGATCCGTCATTCTTACTTGCACCAT
GGTCTGTTATTGAAGAACATGTAAAAGGTATTTTAGATCAAGGGATGAAGCAGCCAGGTTATATCTTTAACTTAGGTCAC
GGTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCATGAATACTCTAAAGGGCAGTTAGC
GAAGTAA

Upstream 100 bases:

>100_bases
GTACATAATATTATGCATTTTGTTTTTACAAGCTGTATAGTAAAAAAAGATAAATATCGAACGTATTCGAAGCATTGTGG
TAAGGAAGGGAGCTAGGGTC

Downstream 100 bases:

>100_bases
AGGAGCATTGCTGTATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAA
CGTTACTATACACATATTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALIDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK

Sequences:

>Translated_348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALIDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK
>Mature_348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALIDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=36.2857142857143, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=40, Blast_Score=247, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=32.4786324786325, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=33.4302325581395, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=33.4302325581395, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39195; Mature: 39195

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTK
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHH
LPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDV
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCC
PYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALI
CHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHH
DKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEH
HHHCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
VKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTK
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHH
LPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDV
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCC
PYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALI
CHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHH
DKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEH
HHHCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
VKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA