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The map label for this gene is treR [H]

Identifier: 49183622

GI number: 49183622

Start: 646062

End: 646772

Strand: Direct

Name: treR [H]

Synonym: BAS0597

Alternate gene names: 49183622

Gene position: 646062-646772 (Clockwise)

Preceding gene: 49183620

Following gene: 49183623

Centisome position: 12.36

GC content: 33.76

Gene sequence:

>711_bases
ATGATGAGTAAGTATGAACAAATTTATACAGCAATCAGCAAGTCTATTGATAATAAACAATTAAAAGAGGGATGCAAAAT
CCCATCAGAAACTGAATTAATGAAACAGTATGAAGCGAGCCGTGGTACTGTAAGAAAAGCAGTGGATTTATTACAAGAGC
GAGGATATGTTCAAAAAATACACGGAAAAGGTGTTTTTGTTTTAAAGCGTAAAAACATTGAATTCAACTTTGGTGGCATT
GTAAGTTTCCAAGAAGAAAATGAACGTTTAGGGCGCCATTGTATTACAGAAGTCGTGGAAATAGAGAAAATAAAAGCGAC
AAAAGAGATTGCAAAGCTATTAAATGTGAAAGAGAAAACAGAAATAGATCATATTAAACGCGTACGAAATATTGATGGAG
AAAAAGTAATTTTGGATATTAATCATTTTGTATCGGAACATATCCCTGGATTAACGAGTGAAATTGCAGCGGGGTCCATT
TATAAATACATAGAGAAAGAATTAGGTCTTCATATTAGTTACTCACAGAGGGTAATTGAGGTGCAGTCATGTACAGAGGA
CGATAGAAAGTATTTAGATTTAAATGGAACAGATTATGTTGTCGTTGTGAAAAACTTTACGCATTTTTATGATGGAAGTC
AGTTCGAATATACAGAATCACGTCACCGCTTAGATATTTTTCATTTTTCGGATGTGGCGCGGAGAAAATAA

Upstream 100 bases:

>100_bases
CTGTATTTTTCCTATACTGGAAAATAAGTGAGAGATTGGCAGAAGAGTGTAGCATGGTATAATACATATAGAATTAGAAG
GTGACAAGGGGCTATTGTAG

Downstream 100 bases:

>100_bases
GGAGATGGAACGAAATGTTTCATCTCTTTTTTTATAAAAAAGTTACAAACTCGTATATACGAGTGTTGACTAACTTATAT
ATACGAGTTAATATGTAATT

Product: trehalose operon transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MMSKYEQIYTAISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKIHGKGVFVLKRKNIEFNFGGI
VSFQEENERLGRHCITEVVEIEKIKATKEIAKLLNVKEKTEIDHIKRVRNIDGEKVILDINHFVSEHIPGLTSEIAAGSI
YKYIEKELGLHISYSQRVIEVQSCTEDDRKYLDLNGTDYVVVVKNFTHFYDGSQFEYTESRHRLDIFHFSDVARRK

Sequences:

>Translated_236_residues
MMSKYEQIYTAISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKIHGKGVFVLKRKNIEFNFGGI
VSFQEENERLGRHCITEVVEIEKIKATKEIAKLLNVKEKTEIDHIKRVRNIDGEKVILDINHFVSEHIPGLTSEIAAGSI
YKYIEKELGLHISYSQRVIEVQSCTEDDRKYLDLNGTDYVVVVKNFTHFYDGSQFEYTESRHRLDIFHFSDVARRK
>Mature_236_residues
MMSKYEQIYTAISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKIHGKGVFVLKRKNIEFNFGGI
VSFQEENERLGRHCITEVVEIEKIKATKEIAKLLNVKEKTEIDHIKRVRNIDGEKVILDINHFVSEHIPGLTSEIAAGSI
YKYIEKELGLHISYSQRVIEVQSCTEDDRKYLDLNGTDYVVVVKNFTHFYDGSQFEYTESRHRLDIFHFSDVARRK

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=235, Percent_Identity=28.5106382978723, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1790540, Length=230, Percent_Identity=23.4782608695652, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790118, Length=146, Percent_Identity=30.1369863013699, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082252, Length=172, Percent_Identity=27.3255813953488, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27438; Mature: 27438

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSKYEQIYTAISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKI
CCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
HGKGVFVLKRKNIEFNFGGIVSFQEENERLGRHCITEVVEIEKIKATKEIAKLLNVKEKT
CCCCEEEEEECCEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EIDHIKRVRNIDGEKVILDINHFVSEHIPGLTSEIAAGSIYKYIEKELGLHISYSQRVIE
HHHHHHHHHCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEECCHHEEE
VQSCTEDDRKYLDLNGTDYVVVVKNFTHFYDGSQFEYTESRHRLDIFHFSDVARRK
HHHCCCCCCEEECCCCCEEEEEEECCHHHCCCCCEEECCCCCEEEEEEHHHHHHCC
>Mature Secondary Structure
MMSKYEQIYTAISKSIDNKQLKEGCKIPSETELMKQYEASRGTVRKAVDLLQERGYVQKI
CCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEE
HGKGVFVLKRKNIEFNFGGIVSFQEENERLGRHCITEVVEIEKIKATKEIAKLLNVKEKT
CCCCEEEEEECCEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EIDHIKRVRNIDGEKVILDINHFVSEHIPGLTSEIAAGSIYKYIEKELGLHISYSQRVIE
HHHHHHHHHCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEECCHHEEE
VQSCTEDDRKYLDLNGTDYVVVVKNFTHFYDGSQFEYTESRHRLDIFHFSDVARRK
HHHCCCCCCEEECCCCCEEEEEEECCHHHCCCCCEEECCCCCEEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]