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The map label for this gene is lpxD

Identifier: 46447362

GI number: 46447362

Start: 2066322

End: 2067371

Strand: Direct

Name: lpxD

Synonym: pc1728

Alternate gene names: 46447362

Gene position: 2066322-2067371 (Clockwise)

Preceding gene: 46447361

Following gene: 46447376

Centisome position: 85.58

GC content: 37.71

Gene sequence:

>1050_bases
ATGAACGAGAAAAAACATTTTACCTTACAAGAACTCGCTCTTTTAACGGACTGTAAACTTGTTGGTAACCCATCACAAAT
CATCAAGAGCGTAGCAGATCTAGAAAATGCCTCAGAAGAAGATGCTTCATTTTTTGCTAATAATCGTTATCTACAATCCT
TAAAAGAGTCTCAGGCAGGGGTTGTTTTTGTCGACTTACAAACTCCGTTAATAGAAGGGAAAAACTATCTTTTATCTGAA
AATCCTTCCCGCTCATTTCAACATTTAATTGATACATTATATCCTCAAAAAAAACACCCCTCGGGATTTACGGGTATTCA
CACTTCTGCTGTTATACATCCGACGGCAGAAATTGGAAATAAAGTCACGATTTGCCCGCAAGCAGTCATTGATGAAGGAG
TAAAGATTGGTTCAGGCTCATTTATTGGTGCTGGAGTCTATATAGGATCATACTCTGAAATTGGAGAAGATTGTACCATT
CATCCGCGTGTCGTTATTAGAGAAAAATGCTATTTAGGTAATCGAGTCATCTTACAACCAGGTGTTGTTATTGGCTCTTG
CGGATTTGGCTATACAACTAACCAACAAGGACAACACATCAAACTGAATCAAGTTGGCAATGTGTGGGTTGAAAATGATG
TAGAAATTGGTGCTAATACAACAATAGATCGAGCACGTTTTAAAAGTACCCGTATTGGTCAAGGAACAAAAATTGACAAC
CTTGTCCAAATTGCTCATGGCGTGACAATTGGATCATATAATATCATTGTTTCCCAAACAGGAATTGCGGGTTCCACTAC
AACAGGTAAATATGTTGTTATTGCTGGGCAAGCTGCTATCGCAGGACATCTACACTTAAAAGATCATGTGGTGGTAGCAG
GCAAAAGTGGGGTTACGAAGTCTTTAAATACCGGTAAATATAGTGGTATTCCCGCTATGCCAATAAAAGACTATAACCGC
AACCAAGTTTTTTTAAGAAAAATTGAAATTTACATCAACCAAATCAAAAACCTTGAAAAAAGGGTGCTAGAATTGGAATC
TCAAAACTGA

Upstream 100 bases:

>100_bases
TTTCGACTAATACCAAATTGAAAAAATAAATGTTATTTTTTCGATTTGGTAAAATTGTTAATTTGAGTGAAAATTTTTAT
TGGTTAAAAACTAGTGGGAT

Downstream 100 bases:

>100_bases
ATTAGCTCTTAAGAAATGAGGAAGATCTTATTCAATCGGATAATTAGATAAAGTTAAAAGATTCTCGATTCATTCATCTA
AAATGTTAATCAATTCTTAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNEKKHFTLQELALLTDCKLVGNPSQIIKSVADLENASEEDASFFANNRYLQSLKESQAGVVFVDLQTPLIEGKNYLLSE
NPSRSFQHLIDTLYPQKKHPSGFTGIHTSAVIHPTAEIGNKVTICPQAVIDEGVKIGSGSFIGAGVYIGSYSEIGEDCTI
HPRVVIREKCYLGNRVILQPGVVIGSCGFGYTTNQQGQHIKLNQVGNVWVENDVEIGANTTIDRARFKSTRIGQGTKIDN
LVQIAHGVTIGSYNIIVSQTGIAGSTTTGKYVVIAGQAAIAGHLHLKDHVVVAGKSGVTKSLNTGKYSGIPAMPIKDYNR
NQVFLRKIEIYINQIKNLEKRVLELESQN

Sequences:

>Translated_349_residues
MNEKKHFTLQELALLTDCKLVGNPSQIIKSVADLENASEEDASFFANNRYLQSLKESQAGVVFVDLQTPLIEGKNYLLSE
NPSRSFQHLIDTLYPQKKHPSGFTGIHTSAVIHPTAEIGNKVTICPQAVIDEGVKIGSGSFIGAGVYIGSYSEIGEDCTI
HPRVVIREKCYLGNRVILQPGVVIGSCGFGYTTNQQGQHIKLNQVGNVWVENDVEIGANTTIDRARFKSTRIGQGTKIDN
LVQIAHGVTIGSYNIIVSQTGIAGSTTTGKYVVIAGQAAIAGHLHLKDHVVVAGKSGVTKSLNTGKYSGIPAMPIKDYNR
NQVFLRKIEIYINQIKNLEKRVLELESQN
>Mature_349_residues
MNEKKHFTLQELALLTDCKLVGNPSQIIKSVADLENASEEDASFFANNRYLQSLKESQAGVVFVDLQTPLIEGKNYLLSE
NPSRSFQHLIDTLYPQKKHPSGFTGIHTSAVIHPTAEIGNKVTICPQAVIDEGVKIGSGSFIGAGVYIGSYSEIGEDCTI
HPRVVIREKCYLGNRVILQPGVVIGSCGFGYTTNQQGQHIKLNQVGNVWVENDVEIGANTTIDRARFKSTRIGQGTKIDN
LVQIAHGVTIGSYNIIVSQTGIAGSTTTGKYVVIAGQAAIAGHLHLKDHVVVAGKSGVTKSLNTGKYSGIPAMPIKDYNR
NQVFLRKIEIYINQIKNLEKRVLELESQN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=34.5238095238095, Blast_Score=181, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PARUW (Q6MAE7)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008727.1
- ProteinModelPortal:   Q6MAE7
- SMR:   Q6MAE7
- STRING:   Q6MAE7
- GeneID:   2780009
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1728
- NMPDR:   fig|264201.1.peg.1728
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   TIHASTV
- PhylomeDB:   Q6MAE7
- ProtClustDB:   PRK00892
- BioCyc:   CPRO264201:PC1728-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 38002; Mature: 38002

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKKHFTLQELALLTDCKLVGNPSQIIKSVADLENASEEDASFFANNRYLQSLKESQAG
CCCCCCCHHHHHHHHHCCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
VVFVDLQTPLIEGKNYLLSENPSRSFQHLIDTLYPQKKHPSGFTGIHTSAVIHPTAEIGN
EEEEEECCCEECCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECHHHHCC
KVTICPQAVIDEGVKIGSGSFIGAGVYIGSYSEIGEDCTIHPRVVIREKCYLGNRVILQP
EEEECCHHHHHCCCEECCCCEEEEEEEECCHHHHCCCCEECCEEEEEEECCCCCEEEEEC
GVVIGSCGFGYTTNQQGQHIKLNQVGNVWVENDVEIGANTTIDRARFKSTRIGQGTKIDN
CEEEECCCCCCCCCCCCCEEEEECCCCEEEECCEEECCCCCHHHHHHCCCCCCCCCCHHH
LVQIAHGVTIGSYNIIVSQTGIAGSTTTGKYVVIAGQAAIAGHLHLKDHVVVAGKSGVTK
HHHHHHCEEECCEEEEEEECCCCCCCCCCCEEEEECCEEEEEEEEEECEEEEECCCCCCC
SLNTGKYSGIPAMPIKDYNRNQVFLRKIEIYINQIKNLEKRVLELESQN
CCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNEKKHFTLQELALLTDCKLVGNPSQIIKSVADLENASEEDASFFANNRYLQSLKESQAG
CCCCCCCHHHHHHHHHCCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
VVFVDLQTPLIEGKNYLLSENPSRSFQHLIDTLYPQKKHPSGFTGIHTSAVIHPTAEIGN
EEEEEECCCEECCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECHHHHCC
KVTICPQAVIDEGVKIGSGSFIGAGVYIGSYSEIGEDCTIHPRVVIREKCYLGNRVILQP
EEEECCHHHHHCCCEECCCCEEEEEEEECCHHHHCCCCEECCEEEEEEECCCCCEEEEEC
GVVIGSCGFGYTTNQQGQHIKLNQVGNVWVENDVEIGANTTIDRARFKSTRIGQGTKIDN
CEEEECCCCCCCCCCCCCEEEEECCCCEEEECCEEECCCCCHHHHHHCCCCCCCCCCHHH
LVQIAHGVTIGSYNIIVSQTGIAGSTTTGKYVVIAGQAAIAGHLHLKDHVVVAGKSGVTK
HHHHHHCEEECCEEEEEEECCCCCCCCCCCEEEEECCEEEEEEEEEECEEEEECCCCCCC
SLNTGKYSGIPAMPIKDYNRNQVFLRKIEIYINQIKNLEKRVLELESQN
CCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA