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The map label for this gene is crtE [H]

Identifier: 46447330

GI number: 46447330

Start: 2034915

End: 2035799

Strand: Direct

Name: crtE [H]

Synonym: pc1696

Alternate gene names: 46447330

Gene position: 2034915-2035799 (Clockwise)

Preceding gene: 46447329

Following gene: 46447331

Centisome position: 84.28

GC content: 37.06

Gene sequence:

>885_bases
ATGATGGATGTTGCCAATTATTTACAAACACAAAGTCAGCTTATTGAAAAACGCCTGGATCAACTTGTCTCCAAACGTCA
CGGCCCTCACCAAAATTTAATTGAAGCTGCTCGTTATGCTCTTTTAAGTGGAGGAAAAAGGCTACGTCCAATTTTAGCTT
TGACAACTGTTCAGACACTTCATGGAGATATTCAAGAAGCTTTATCTCCTGCTTGCACATTAGAACTTATCCATACTTAT
TCTCTTATTCATGATGACTTACCTTGCATGGATAATGATGATTATCGAAGAGGAAAACTGACTGTTCATCGCCAATATTC
AGAAGGCCACGCCGTTTTAACGGGAGACTTCCTTTTAACATACGCATTTGAACTTTTAGCGACCGATAAATATTTGACAT
CTGAAAAAAAAGTTAAACTTATTACTATTTTATCCAGACAAAGCGGATACGATGGAATGATTGGCGGGCAAGCCTTGGAT
TTAGCCAGCGAGGGACAAAAAATTAATCTTGAAACCCTTCGATTACTTCATCGTAATAAAACAGCTGCTTTGATTACAGC
ATCTGTTGAATTCGGAGGAATTTTAGCAAATGCAACAGAAGAACAGCTCGCTCATATCCGGGAGTTTGGTGAAAATATTG
GGCTGGCTTTTCAAATCACTGATGATATCCTTGATATCACATCAAGCGAAGCCAAACATGGGCGAAAAATTGGGTCTGAC
ATCCTAAAAGATAAATCGACTTATGTATCCTTACTTGGAATAGAACAAGCCAAAGCATACGCTTTAAATTTTTATCAAAA
GGCCATTAATGCTTTAAAACTCCTTCCCTATGATAATTCTTTTCTAATACATTTAGCTGACTTTATTATTCATCGTCATT
ATTGA

Upstream 100 bases:

>100_bases
AGGAAATGGCACGTAAAGGTTTCGATTATTTTAGTATTGGACGATCTGCAGCGTACGCAGAAGATCTCTCACTTCAAGTT
GGAAATATAGGTGGCGATGT

Downstream 100 bases:

>100_bases
CTGATTTTAATCAAGTTTTTAAGTGATTTGGTATTTTTTCTGAATTTTTATAAATTGACGATTATTTTAAAACTGATACT
ATTATAGACCAATGAAAAAT

Product: farnesyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MMDVANYLQTQSQLIEKRLDQLVSKRHGPHQNLIEAARYALLSGGKRLRPILALTTVQTLHGDIQEALSPACTLELIHTY
SLIHDDLPCMDNDDYRRGKLTVHRQYSEGHAVLTGDFLLTYAFELLATDKYLTSEKKVKLITILSRQSGYDGMIGGQALD
LASEGQKINLETLRLLHRNKTAALITASVEFGGILANATEEQLAHIREFGENIGLAFQITDDILDITSSEAKHGRKIGSD
ILKDKSTYVSLLGIEQAKAYALNFYQKAINALKLLPYDNSFLIHLADFIIHRHY

Sequences:

>Translated_294_residues
MMDVANYLQTQSQLIEKRLDQLVSKRHGPHQNLIEAARYALLSGGKRLRPILALTTVQTLHGDIQEALSPACTLELIHTY
SLIHDDLPCMDNDDYRRGKLTVHRQYSEGHAVLTGDFLLTYAFELLATDKYLTSEKKVKLITILSRQSGYDGMIGGQALD
LASEGQKINLETLRLLHRNKTAALITASVEFGGILANATEEQLAHIREFGENIGLAFQITDDILDITSSEAKHGRKIGSD
ILKDKSTYVSLLGIEQAKAYALNFYQKAINALKLLPYDNSFLIHLADFIIHRHY
>Mature_294_residues
MMDVANYLQTQSQLIEKRLDQLVSKRHGPHQNLIEAARYALLSGGKRLRPILALTTVQTLHGDIQEALSPACTLELIHTY
SLIHDDLPCMDNDDYRRGKLTVHRQYSEGHAVLTGDFLLTYAFELLATDKYLTSEKKVKLITILSRQSGYDGMIGGQALD
LASEGQKINLETLRLLHRNKTAALITASVEFGGILANATEEQLAHIREFGENIGLAFQITDDILDITSSEAKHGRKIGSD
ILKDKSTYVSLLGIEQAKAYALNFYQKAINALKLLPYDNSFLIHLADFIIHRHY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=240, Percent_Identity=31.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786623, Length=300, Percent_Identity=40.6666666666667, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789578, Length=220, Percent_Identity=30, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=260, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24651612, Length=233, Percent_Identity=28.3261802575107, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32932; Mature: 32932

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDVANYLQTQSQLIEKRLDQLVSKRHGPHQNLIEAARYALLSGGKRLRPILALTTVQTL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HGDIQEALSPACTLELIHTYSLIHDDLPCMDNDDYRRGKLTVHRQYSEGHAVLTGDFLLT
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHH
YAFELLATDKYLTSEKKVKLITILSRQSGYDGMIGGQALDLASEGQKINLETLRLLHRNK
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHCCC
TAALITASVEFGGILANATEEQLAHIREFGENIGLAFQITDDILDITSSEAKHGRKIGSD
CEEEEEEEEHHCCEECCCHHHHHHHHHHHHHCCCEEEEECHHHHHHCCHHHHHHHHHHHH
ILKDKSTYVSLLGIEQAKAYALNFYQKAINALKLLPYDNSFLIHLADFIIHRHY
HHHCHHHHEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MMDVANYLQTQSQLIEKRLDQLVSKRHGPHQNLIEAARYALLSGGKRLRPILALTTVQTL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HGDIQEALSPACTLELIHTYSLIHDDLPCMDNDDYRRGKLTVHRQYSEGHAVLTGDFLLT
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHH
YAFELLATDKYLTSEKKVKLITILSRQSGYDGMIGGQALDLASEGQKINLETLRLLHRNK
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHCCC
TAALITASVEFGGILANATEEQLAHIREFGENIGLAFQITDDILDITSSEAKHGRKIGSD
CEEEEEEEEHHCCEECCCHHHHHHHHHHHHHCCCEEEEECHHHHHHCCHHHHHHHHHHHH
ILKDKSTYVSLLGIEQAKAYALNFYQKAINALKLLPYDNSFLIHLADFIIHRHY
HHHCHHHHEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]