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The map label for this gene is der

Identifier: 46447114

GI number: 46447114

Start: 1755590

End: 1757053

Strand: Direct

Name: der

Synonym: pc1480

Alternate gene names: 46447114

Gene position: 1755590-1757053 (Clockwise)

Preceding gene: 46447113

Following gene: 46447115

Centisome position: 72.71

GC content: 36.41

Gene sequence:

>1464_bases
ATGACCCATTTACCCAAACTCGCCATTGTTGGGCGACCAAATGTGGGAAAATCAGCACTATTTAATCGAATCTGCAAACA
AAAAATTGCAATCGTGGATGAAGCAGAAGGAATAACTCGGGATCGATTATATGCAGAAGGCGAACTATTTGGACTCCATT
TTCAAGTAATCGATACAGGCGGTATTAATGCTCGTTCAAAAGAAGTTTTTAATGAAGAAATCAAACGTCAAGCTGAAATC
GCGATTGAAGAAGCAGATACGATTGTTCAAGTTGTCGATGCTCATGTCGGTTTAACAGAATTGGATAAAGAAGTTGCGAG
AGTTTTGCTAAGAACAAAAAAGCCTGTTTGTTTGGCCGTCAATAAAATTGACAATTTATCGCAAACGTCTTTAATGCATC
AATTTCATTCTTTAGGAATCAAGCAAATGATTCCCGTTTCAGCAGCGCAAGGCTGGCAAATCGCAGAACTATTGGAAACA
GCTTTTGAAAAAATTTCGCGTGAAATTGAATCTCAAGAAACTTTTTCTTCCATTAAAGTGGCGATTGTGGGAAGAGCTAA
TGTAGGAAAATCTTCCCTGGTTAACTACTTATTAGATGAAGACCGTTGTATTGTTAGTCCTATACCTGGAACAACTCGTG
ATAGTGTAGATATTTCATTTACCCATAAAGATGAATGCTACACTCTTATTGATACAGCAGGAATAAGACGAAAACGAGCC
GAACATGAAGTTGTCGATAAATTTGCTGCAATTCGCACCGAAAGAGCTATTGAAAGGGCTGATTTATGCGTTTTGATGCT
AGATGTTCAAGAAGGAATTACAGCGCAGGATAAGAAAATAGCGAATACGATCGAAGAAGCTGGACAAGGCTGTATCATCT
TACTTAATAAATGGGATCTTGTTCAGGGTTTCCGTATGGAACATTGCCTGCAAAACTTGGAGGAAGAAGTTCCTTTTCTT
CGTCATTGTCCCAAGATTTTCACCTCTGCTAAAACGGGACGTAATATTGATAAATTGTTTCCTTTAATTCAAGAAGTCTA
TGCAAATTCGCAAAAAAGAATCACAACACATCAATTGAATAAATTCATCGGAGAAGCACTCCAAAAAAATCACCCTCCTA
TGATTCAAGGTAAGCGTTTACGCATTTATTATATGGCACAGGTTGCCGTTAAACCCCCCAAATTTATTTTATTCGTTAAC
TATCCGAATTTGATGACCGATACTTATAAAAAGTATCTTTATAATCAATTTAGGGAAGCTTATGCCTTTACTGGCGTCCC
TATCCTTATTCATTTGAAAGGAAAAACAAAAAAAGACAAACCAGTTTCTTCATTGTCTCTAACTCGAAAACAAACAAAAT
CAACAGATCAAGAAAATAATGAATATGATGAATTGTATCAGGAGCAGAGGGTAAGTGATGAAGACTATTATTTTGAAAAT
GAAGAAGATTTAACAGAAAAATAA

Upstream 100 bases:

>100_bases
GACCACTTATCAAAAAGATTAGAGCTAAAAATATTAAACTATTTGATTCAGAACTTTTCATTCTAAATTGTTCGTCAATT
GTAATCAACCGAGGATCATC

Downstream 100 bases:

>100_bases
GAGGAAACTAAGATGGAAGCTCCGCTTCATTTAAACTTAAATCTTTCGTCCGGTCATTTACCTTCTCAGATAAATACCGT
TAAAGAAATAGATCGTAAAA

Product: hypothetical protein

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTHLPKLAIVGRPNVGKSALFNRICKQKIAIVDEAEGITRDRLYAEGELFGLHFQVIDTGGINARSKEVFNEEIKRQAEI
AIEEADTIVQVVDAHVGLTELDKEVARVLLRTKKPVCLAVNKIDNLSQTSLMHQFHSLGIKQMIPVSAAQGWQIAELLET
AFEKISREIESQETFSSIKVAIVGRANVGKSSLVNYLLDEDRCIVSPIPGTTRDSVDISFTHKDECYTLIDTAGIRRKRA
EHEVVDKFAAIRTERAIERADLCVLMLDVQEGITAQDKKIANTIEEAGQGCIILLNKWDLVQGFRMEHCLQNLEEEVPFL
RHCPKIFTSAKTGRNIDKLFPLIQEVYANSQKRITTHQLNKFIGEALQKNHPPMIQGKRLRIYYMAQVAVKPPKFILFVN
YPNLMTDTYKKYLYNQFREAYAFTGVPILIHLKGKTKKDKPVSSLSLTRKQTKSTDQENNEYDELYQEQRVSDEDYYFEN
EEDLTEK

Sequences:

>Translated_487_residues
MTHLPKLAIVGRPNVGKSALFNRICKQKIAIVDEAEGITRDRLYAEGELFGLHFQVIDTGGINARSKEVFNEEIKRQAEI
AIEEADTIVQVVDAHVGLTELDKEVARVLLRTKKPVCLAVNKIDNLSQTSLMHQFHSLGIKQMIPVSAAQGWQIAELLET
AFEKISREIESQETFSSIKVAIVGRANVGKSSLVNYLLDEDRCIVSPIPGTTRDSVDISFTHKDECYTLIDTAGIRRKRA
EHEVVDKFAAIRTERAIERADLCVLMLDVQEGITAQDKKIANTIEEAGQGCIILLNKWDLVQGFRMEHCLQNLEEEVPFL
RHCPKIFTSAKTGRNIDKLFPLIQEVYANSQKRITTHQLNKFIGEALQKNHPPMIQGKRLRIYYMAQVAVKPPKFILFVN
YPNLMTDTYKKYLYNQFREAYAFTGVPILIHLKGKTKKDKPVSSLSLTRKQTKSTDQENNEYDELYQEQRVSDEDYYFEN
EEDLTEK
>Mature_486_residues
THLPKLAIVGRPNVGKSALFNRICKQKIAIVDEAEGITRDRLYAEGELFGLHFQVIDTGGINARSKEVFNEEIKRQAEIA
IEEADTIVQVVDAHVGLTELDKEVARVLLRTKKPVCLAVNKIDNLSQTSLMHQFHSLGIKQMIPVSAAQGWQIAELLETA
FEKISREIESQETFSSIKVAIVGRANVGKSSLVNYLLDEDRCIVSPIPGTTRDSVDISFTHKDECYTLIDTAGIRRKRAE
HEVVDKFAAIRTERAIERADLCVLMLDVQEGITAQDKKIANTIEEAGQGCIILLNKWDLVQGFRMEHCLQNLEEEVPFLR
HCPKIFTSAKTGRNIDKLFPLIQEVYANSQKRITTHQLNKFIGEALQKNHPPMIQGKRLRIYYMAQVAVKPPKFILFVNY
PNLMTDTYKKYLYNQFREAYAFTGVPILIHLKGKTKKDKPVSSLSLTRKQTKSTDQENNEYDELYQEQRVSDEDYYFENE
EDLTEK

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=458, Percent_Identity=35.1528384279476, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788919, Length=156, Percent_Identity=33.974358974359, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367268, Length=151, Percent_Identity=34.4370860927152, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=165, Percent_Identity=33.9393939393939, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_PARUW (Q6MB45)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008479.1
- HSSP:   Q9X1F8
- ProteinModelPortal:   Q6MB45
- SMR:   Q6MB45
- STRING:   Q6MB45
- GeneID:   2780865
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1480
- NMPDR:   fig|264201.1.peg.1480
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- PhylomeDB:   Q6MB45
- ProtClustDB:   CLSK2762407
- BioCyc:   CPRO264201:PC1480-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR011619
- InterPro:   IPR016484
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR001806
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00449
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF02421 FeoB_N; PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 55550; Mature: 55419

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLPKLAIVGRPNVGKSALFNRICKQKIAIVDEAEGITRDRLYAEGELFGLHFQVIDTG
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCEEEEEEEEEEECC
GINARSKEVFNEEIKRQAEIAIEEADTIVQVVDAHVGLTELDKEVARVLLRTKKPVCLAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEE
NKIDNLSQTSLMHQFHSLGIKQMIPVSAAQGWQIAELLETAFEKISREIESQETFSSIKV
CCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
AIVGRANVGKSSLVNYLLDEDRCIVSPIPGTTRDSVDISFTHKDECYTLIDTAGIRRKRA
EEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHH
EHEVVDKFAAIRTERAIERADLCVLMLDVQEGITAQDKKIANTIEEAGQGCIILLNKWDL
HHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCH
VQGFRMEHCLQNLEEEVPFLRHCPKIFTSAKTGRNIDKLFPLIQEVYANSQKRITTHQLN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KFIGEALQKNHPPMIQGKRLRIYYMAQVAVKPPKFILFVNYPNLMTDTYKKYLYNQFREA
HHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHH
YAFTGVPILIHLKGKTKKDKPVSSLSLTRKQTKSTDQENNEYDELYQEQRVSDEDYYFEN
HHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEECC
EEDLTEK
CHHCCCC
>Mature Secondary Structure 
THLPKLAIVGRPNVGKSALFNRICKQKIAIVDEAEGITRDRLYAEGELFGLHFQVIDTG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCEEEEEEEEEEECC
GINARSKEVFNEEIKRQAEIAIEEADTIVQVVDAHVGLTELDKEVARVLLRTKKPVCLAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEE
NKIDNLSQTSLMHQFHSLGIKQMIPVSAAQGWQIAELLETAFEKISREIESQETFSSIKV
CCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
AIVGRANVGKSSLVNYLLDEDRCIVSPIPGTTRDSVDISFTHKDECYTLIDTAGIRRKRA
EEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHH
EHEVVDKFAAIRTERAIERADLCVLMLDVQEGITAQDKKIANTIEEAGQGCIILLNKWDL
HHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCH
VQGFRMEHCLQNLEEEVPFLRHCPKIFTSAKTGRNIDKLFPLIQEVYANSQKRITTHQLN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
KFIGEALQKNHPPMIQGKRLRIYYMAQVAVKPPKFILFVNYPNLMTDTYKKYLYNQFREA
HHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHH
YAFTGVPILIHLKGKTKKDKPVSSLSLTRKQTKSTDQENNEYDELYQEQRVSDEDYYFEN
HHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEECC
EEDLTEK
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA