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The map label for this gene is hemN [H]

Identifier: 46446730

GI number: 46446730

Start: 1314343

End: 1315500

Strand: Direct

Name: hemN [H]

Synonym: pc1096

Alternate gene names: 46446730

Gene position: 1314343-1315500 (Clockwise)

Preceding gene: 46446729

Following gene: 46446731

Centisome position: 54.44

GC content: 37.48

Gene sequence:

>1158_bases
ATGCTAACGATTGGTAACCCCACTTCATCGGAAATCAGTCTTTATTTTCATATCCCTTTTTGTACAAAAAAGTGTAATTA
CTGCCACTTTTATGTCCTTCCTGATCAAGAGCCTTTAAAAAATCAATTACTGATTGCTTTAAAATTAGAGTGGAAGCGTA
TGCTTCCTCTCTTAATAAATAAATGTATTATCTCTATTTATTTTGGTGGGGGAACTCCTTCCTTATTCAGCCCAGATCGC
ATTCAGGCTGTACTAGAAACGATACATCAAGATCTCCCCTTTGACTACTCAACAACTGAAATTACTTTGGAGGTAAATCC
TGAAAATGGTTATTTCTCCCTTATGCGAGCTTACGCTCAGGCGGGAATTAATCGAGTCAGCATCGGCATTCAAACTCTAG
ATCAAGAACTTCTTCATCTATTAGGCCGCTTGCATAGTCCTTCCTTAGCAAAACGATCCGTTTTAGAAACATATGAAGCA
GGCATCACCAATCTTTCTATCGACCTCATGTACGATTTACCGCGTCAGTCCCTCAAACATTGGGAAATGACTTTACAAGA
GATTGGTACCCTTCCTCTATCTCATCTTTCTTTATACAATCTCACAATCGAACCTTTTACAGTCTTTTTTAAAAAACAAA
ATTTTGTACGTCCCCTATTACCCGATGAAGAGACCAGTTTAGCCATGTATAATGCTGCCATCGAGCACTTAACTAGTTTT
GGATTAGAACAATATGAAATCTCCGCTTTTGCAAAGCCAGGATTCTATTCTAAACACAATACAGGCTACTGGTTAGCACG
CCCCTTCATAGGATTTGGTCCCTCTGCATTTAGTTATTGGGAAGGAAAACGTTTTCGCAATGTCGCTAACTTAAAAAAAT
ATCATCAATCATTAACTCTTAATCAATCCCCGATTGATTTTAATGAGCAATTAGATCCCATTGCCCATTTAAAGGAATTG
TTTGTCATTCAAATTCGGCTCTGCCAAGGAATTTCTATCGCAGATTTCGAGCAAAGGCACGGGAAACTATCACAAGAAAC
GTTAGAAACAATAGAACAATTCATTTTGGATGGTTTTCTCACCCAATCGAATCAAATTTTAAGCTTAACAAAAAAAGGTG
TTCTTTTTTATGACACAGTGGCTTCTGAATTGATTTAG

Upstream 100 bases:

>100_bases
GATGATGAAGATGGCGAAAATGAGGAAGAGGATGATGAAGATGACGAATCCTATTTCAGTGATCGCAATCGATGGCGGCG
TGGAGGAATCGTAGACCCAG

Downstream 100 bases:

>100_bases
GATTTATGAAAATTTGCTGTTTTACTTAAGCACAATTTACCAATTCAGAACTCAATAAAGAGCGTCTAAATCATTTTCAC
TAGCTTCAATTCAATCGATT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MLTIGNPTSSEISLYFHIPFCTKKCNYCHFYVLPDQEPLKNQLLIALKLEWKRMLPLLINKCIISIYFGGGTPSLFSPDR
IQAVLETIHQDLPFDYSTTEITLEVNPENGYFSLMRAYAQAGINRVSIGIQTLDQELLHLLGRLHSPSLAKRSVLETYEA
GITNLSIDLMYDLPRQSLKHWEMTLQEIGTLPLSHLSLYNLTIEPFTVFFKKQNFVRPLLPDEETSLAMYNAAIEHLTSF
GLEQYEISAFAKPGFYSKHNTGYWLARPFIGFGPSAFSYWEGKRFRNVANLKKYHQSLTLNQSPIDFNEQLDPIAHLKEL
FVIQIRLCQGISIADFEQRHGKLSQETLETIEQFILDGFLTQSNQILSLTKKGVLFYDTVASELI

Sequences:

>Translated_385_residues
MLTIGNPTSSEISLYFHIPFCTKKCNYCHFYVLPDQEPLKNQLLIALKLEWKRMLPLLINKCIISIYFGGGTPSLFSPDR
IQAVLETIHQDLPFDYSTTEITLEVNPENGYFSLMRAYAQAGINRVSIGIQTLDQELLHLLGRLHSPSLAKRSVLETYEA
GITNLSIDLMYDLPRQSLKHWEMTLQEIGTLPLSHLSLYNLTIEPFTVFFKKQNFVRPLLPDEETSLAMYNAAIEHLTSF
GLEQYEISAFAKPGFYSKHNTGYWLARPFIGFGPSAFSYWEGKRFRNVANLKKYHQSLTLNQSPIDFNEQLDPIAHLKEL
FVIQIRLCQGISIADFEQRHGKLSQETLETIEQFILDGFLTQSNQILSLTKKGVLFYDTVASELI
>Mature_385_residues
MLTIGNPTSSEISLYFHIPFCTKKCNYCHFYVLPDQEPLKNQLLIALKLEWKRMLPLLINKCIISIYFGGGTPSLFSPDR
IQAVLETIHQDLPFDYSTTEITLEVNPENGYFSLMRAYAQAGINRVSIGIQTLDQELLHLLGRLHSPSLAKRSVLETYEA
GITNLSIDLMYDLPRQSLKHWEMTLQEIGTLPLSHLSLYNLTIEPFTVFFKKQNFVRPLLPDEETSLAMYNAAIEHLTSF
GLEQYEISAFAKPGFYSKHNTGYWLARPFIGFGPSAFSYWEGKRFRNVANLKKYHQSLTLNQSPIDFNEQLDPIAHLKEL
FVIQIRLCQGISIADFEQRHGKLSQETLETIEQFILDGFLTQSNQILSLTKKGVLFYDTVASELI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=272, Percent_Identity=38.2352941176471, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1789325, Length=371, Percent_Identity=31.266846361186, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082341, Length=300, Percent_Identity=27.3333333333333, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44104; Mature: 44104

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIGNPTSSEISLYFHIPFCTKKCNYCHFYVLPDQEPLKNQLLIALKLEWKRMLPLLIN
CEECCCCCCCEEEEEEEECHHCCCCCEEEEEEECCCCCCCCCEEEEEEECHHHHHHHHHH
KCIISIYFGGGTPSLFSPDRIQAVLETIHQDLPFDYSTTEITLEVNPENGYFSLMRAYAQ
HHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHH
AGINRVSIGIQTLDQELLHLLGRLHSPSLAKRSVLETYEAGITNLSIDLMYDLPRQSLKH
CCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
WEMTLQEIGTLPLSHLSLYNLTIEPFTVFFKKQNFVRPLLPDEETSLAMYNAAIEHLTSF
HHHHHHHHCCCCHHHEEEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GLEQYEISAFAKPGFYSKHNTGYWLARPFIGFGPSAFSYWEGKRFRNVANLKKYHQSLTL
CCCCEEHHEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
NQSPIDFNEQLDPIAHLKELFVIQIRLCQGISIADFEQRHGKLSQETLETIEQFILDGFL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHH
TQSNQILSLTKKGVLFYDTVASELI
CCCCCEEEHHHCCEEEEEHHHHHCC
>Mature Secondary Structure
MLTIGNPTSSEISLYFHIPFCTKKCNYCHFYVLPDQEPLKNQLLIALKLEWKRMLPLLIN
CEECCCCCCCEEEEEEEECHHCCCCCEEEEEEECCCCCCCCCEEEEEEECHHHHHHHHHH
KCIISIYFGGGTPSLFSPDRIQAVLETIHQDLPFDYSTTEITLEVNPENGYFSLMRAYAQ
HHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHH
AGINRVSIGIQTLDQELLHLLGRLHSPSLAKRSVLETYEAGITNLSIDLMYDLPRQSLKH
CCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
WEMTLQEIGTLPLSHLSLYNLTIEPFTVFFKKQNFVRPLLPDEETSLAMYNAAIEHLTSF
HHHHHHHHCCCCHHHEEEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GLEQYEISAFAKPGFYSKHNTGYWLARPFIGFGPSAFSYWEGKRFRNVANLKKYHQSLTL
CCCCEEHHEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
NQSPIDFNEQLDPIAHLKELFVIQIRLCQGISIADFEQRHGKLSQETLETIEQFILDGFL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHH
TQSNQILSLTKKGVLFYDTVASELI
CCCCCEEEHHHCCEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]