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The map label for this gene is dnaA

Identifier: 46446716

GI number: 46446716

Start: 1295440

End: 1296795

Strand: Direct

Name: dnaA

Synonym: pc1082

Alternate gene names: 46446716

Gene position: 1295440-1296795 (Clockwise)

Preceding gene: 46446715

Following gene: 46446717

Centisome position: 53.65

GC content: 37.09

Gene sequence:

>1356_bases
ATGCAAGCATGGGAAGAATTTCTAAAGGCACAAGAAGTTGAACTTGGTTTAGAAACGGTTCAAAAATGGCTCAGAACGTT
GAAAATACAACGATTTGATGCTTGTAATCTTTATTTAGAAGCCAAAGATTCCTTTCAAGCACTCTGGTTTGAGGAACATA
TTCGCAATAAAGCTCAACAAAAATTTATTAATGGAAATAATAAACGAATTAAAATTCATCTTTCCGTTGCTAATACCCCC
CAAAGAGCAAAAAAAACTAAAACGGCTAATAAAGAAAAAGATTTTAAAGCTCCTTTTGAATTAACCTTCGATGAATTAGA
CCCACTTTGTTTATTTCCCTATTTCATTTCAACGGAAGAAAATCTCCTCTCTCATCAATTACTTCTAGAAATTGCCGGTC
TTTCTCCGCAAATTCATTCAACCCAACTTGGCACGTTTAACCCCATTTATTTGTATGGGAGCGGAGGGTCGGGTAAAACT
CACTTATTGATGAGCTTAGCTCATGCTTTAAAAGCACAGGGGCTAAAGGTTATTTATGTTCGAGCAGAAACATTTACTGA
TCACGTCGTTACCGCCATCCGTGCAGGAGAAATGAGTGTATTTAGACAAGCATATCGCAATATCGATGTCTTGCTAGTGG
ACGATGTTCACGTTTTTTCTAGAAAAGGCGCCACGCAAGAAGAATTTTTCCATACTTTTAATACATTGCATTTAGAAGGT
AAGCAAATTATTTTAGCTTCTGAATGTTCCCCTCAAGATCTACAGCTCATTGAACCGCGCTTGGTTAGTCGTTTTGAATG
GGGAATTGTTCTTCCTTTAAAACCGTTAAGGCCTGGGGAAATGCGCAATCTTCTTATAGCTAAAGCTAAAGCTTTACATT
TTGAACTTCCCTTAAAGATTGCCGATTATCTTATCGAAACATTCAAAAGCAATGCCAAAGCATTAATAAAAGGTTTGGAA
GCCCTCGTTCTCCGACTGCATCTGGACGCAAAACATTCCATAACAGCCCTATCTGTAACAGCAACTAAAGCACTATTAAT
CGATTTAATCGAAGAAGAACAGAAAACTGCGATTACCCCTCAAAAAATTATTCAAGCAGTTGCTGAACAATACGGCATTC
GTACAGAAGATATTTTAGGTAAGGCTCAAACAAGAGAATGCGCACTTCCTCGTCAACTAGCTATGCATTTATGTCGTGAA
CAACTAAAAATGCCTTTCATGAAAATTGGAGATCTTTTTTCTCGAGATCATTCCACCGTGATGTCAAGTGTGAAGAGTAT
ACAAAAATCATTAGAGCAAGATGATCGAGAAATCTCAGGAATTTGTCATATCATTTTGAAAAAACTACAAGGATAG

Upstream 100 bases:

>100_bases
TGAAAACTGTTCCTAAAAAAGCTCGGTCTCGTTAGAACAATTTTAGAGGAAGAATTTTCTTCCTCTAATTAATTTTGAGA
GATTGACAAGAGTAAAAACT

Downstream 100 bases:

>100_bases
TTTTCTTTCTAAAAAAAAACATAAATTCGCTAAAAAAAATTTTACTTTTATGTAAAAAGATTCTTAAAAAAATACAATTT
CGTTTGTCAAAAAATTCAAT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MQAWEEFLKAQEVELGLETVQKWLRTLKIQRFDACNLYLEAKDSFQALWFEEHIRNKAQQKFINGNNKRIKIHLSVANTP
QRAKKTKTANKEKDFKAPFELTFDELDPLCLFPYFISTEENLLSHQLLLEIAGLSPQIHSTQLGTFNPIYLYGSGGSGKT
HLLMSLAHALKAQGLKVIYVRAETFTDHVVTAIRAGEMSVFRQAYRNIDVLLVDDVHVFSRKGATQEEFFHTFNTLHLEG
KQIILASECSPQDLQLIEPRLVSRFEWGIVLPLKPLRPGEMRNLLIAKAKALHFELPLKIADYLIETFKSNAKALIKGLE
ALVLRLHLDAKHSITALSVTATKALLIDLIEEEQKTAITPQKIIQAVAEQYGIRTEDILGKAQTRECALPRQLAMHLCRE
QLKMPFMKIGDLFSRDHSTVMSSVKSIQKSLEQDDREISGICHIILKKLQG

Sequences:

>Translated_451_residues
MQAWEEFLKAQEVELGLETVQKWLRTLKIQRFDACNLYLEAKDSFQALWFEEHIRNKAQQKFINGNNKRIKIHLSVANTP
QRAKKTKTANKEKDFKAPFELTFDELDPLCLFPYFISTEENLLSHQLLLEIAGLSPQIHSTQLGTFNPIYLYGSGGSGKT
HLLMSLAHALKAQGLKVIYVRAETFTDHVVTAIRAGEMSVFRQAYRNIDVLLVDDVHVFSRKGATQEEFFHTFNTLHLEG
KQIILASECSPQDLQLIEPRLVSRFEWGIVLPLKPLRPGEMRNLLIAKAKALHFELPLKIADYLIETFKSNAKALIKGLE
ALVLRLHLDAKHSITALSVTATKALLIDLIEEEQKTAITPQKIIQAVAEQYGIRTEDILGKAQTRECALPRQLAMHLCRE
QLKMPFMKIGDLFSRDHSTVMSSVKSIQKSLEQDDREISGICHIILKKLQG
>Mature_451_residues
MQAWEEFLKAQEVELGLETVQKWLRTLKIQRFDACNLYLEAKDSFQALWFEEHIRNKAQQKFINGNNKRIKIHLSVANTP
QRAKKTKTANKEKDFKAPFELTFDELDPLCLFPYFISTEENLLSHQLLLEIAGLSPQIHSTQLGTFNPIYLYGSGGSGKT
HLLMSLAHALKAQGLKVIYVRAETFTDHVVTAIRAGEMSVFRQAYRNIDVLLVDDVHVFSRKGATQEEFFHTFNTLHLEG
KQIILASECSPQDLQLIEPRLVSRFEWGIVLPLKPLRPGEMRNLLIAKAKALHFELPLKIADYLIETFKSNAKALIKGLE
ALVLRLHLDAKHSITALSVTATKALLIDLIEEEQKTAITPQKIIQAVAEQYGIRTEDILGKAQTRECALPRQLAMHLCRE
QLKMPFMKIGDLFSRDHSTVMSSVKSIQKSLEQDDREISGICHIILKKLQG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=458, Percent_Identity=29.0393013100437, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI226510964, Length=205, Percent_Identity=23.9024390243902, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA1_PARUW (Q6MC93)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008081.1
- ProteinModelPortal:   Q6MC93
- SMR:   Q6MC93
- STRING:   Q6MC93
- GeneID:   2780108
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1082
- NMPDR:   fig|264201.1.peg.1082
- eggNOG:   COG0593
- HOGENOM:   HBG414010
- OMA:   ENDLPFR
- PhylomeDB:   Q6MC93
- ProtClustDB:   PRK12422
- BioCyc:   CPRO264201:PC1082-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51317; Mature: 51317

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAWEEFLKAQEVELGLETVQKWLRTLKIQRFDACNLYLEAKDSFQALWFEEHIRNKAQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KFINGNNKRIKIHLSVANTPQRAKKTKTANKEKDFKAPFELTFDELDPLCLFPYFISTEE
HHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEHHHCCCCEEEHHHHCCHH
NLLSHQLLLEIAGLSPQIHSTQLGTFNPIYLYGSGGSGKTHLLMSLAHALKAQGLKVIYV
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEE
RAETFTDHVVTAIRAGEMSVFRQAYRNIDVLLVDDVHVFSRKGATQEEFFHTFNTLHLEG
EECHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCHHHHHCCCCCHHHHHHHHHHEEECC
KQIILASECSPQDLQLIEPRLVSRFEWGIVLPLKPLRPGEMRNLLIAKAKALHFELPLKI
CEEEEECCCCCCCHHHHCHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHEEECCHHH
ADYLIETFKSNAKALIKGLEALVLRLHLDAKHSITALSVTATKALLIDLIEEEQKTAITP
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCH
QKIIQAVAEQYGIRTEDILGKAQTRECALPRQLAMHLCREQLKMPFMKIGDLFSRDHSTV
HHHHHHHHHHHCCCCHHHHCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
MSSVKSIQKSLEQDDREISGICHIILKKLQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAWEEFLKAQEVELGLETVQKWLRTLKIQRFDACNLYLEAKDSFQALWFEEHIRNKAQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
KFINGNNKRIKIHLSVANTPQRAKKTKTANKEKDFKAPFELTFDELDPLCLFPYFISTEE
HHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEHHHCCCCEEEHHHHCCHH
NLLSHQLLLEIAGLSPQIHSTQLGTFNPIYLYGSGGSGKTHLLMSLAHALKAQGLKVIYV
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEE
RAETFTDHVVTAIRAGEMSVFRQAYRNIDVLLVDDVHVFSRKGATQEEFFHTFNTLHLEG
EECHHHHHHHHHHHHCHHHHHHHHHCCCCEEEECCHHHHHCCCCCHHHHHHHHHHEEECC
KQIILASECSPQDLQLIEPRLVSRFEWGIVLPLKPLRPGEMRNLLIAKAKALHFELPLKI
CEEEEECCCCCCCHHHHCHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHEEECCHHH
ADYLIETFKSNAKALIKGLEALVLRLHLDAKHSITALSVTATKALLIDLIEEEQKTAITP
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCH
QKIIQAVAEQYGIRTEDILGKAQTRECALPRQLAMHLCREQLKMPFMKIGDLFSRDHSTV
HHHHHHHHHHHCCCCHHHHCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
MSSVKSIQKSLEQDDREISGICHIILKKLQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA