Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 46446675

GI number: 46446675

Start: 1239407

End: 1240102

Strand: Reverse

Name: adk [H]

Synonym: pc1041

Alternate gene names: 46446675

Gene position: 1240102-1239407 (Counterclockwise)

Preceding gene: 46446677

Following gene: 46446673

Centisome position: 51.36

GC content: 36.93

Gene sequence:

>696_bases
ATGATTATGATAAAAAGCACAAAACCTCTAGTCAGTACTCAAGCAGCCGTTGCTTTAATTTTACTTGGCCCTCCAGGCTC
GGGAAAAGGAACTCAAGCAAAAAGACTTGCGCATGAATATCAAATTCCTCACATCTCTAGCGGCGATCTTTTTAGAGAGC
ATATGTCAAAAGAAACGATTATCGGTTTGAAGGCAAAAGAATTTATTCAAGCAGGAAAATTAGTGCCCGACGAATTTGTA
ATGGATATGCTGTTTGATCGACTTGCCCATCCAGATTGTGCTAGAGGATATTTACTAGATGGTTTTCCTCGTACTGTCGC
ACAAGCAGAAGCTTTAGCTGGTAAACGGGATATAAAAATCCCTCTGATTGTTTTATATTTAGAAGTTCCCGATGCAGTGA
TTGTTAAGCGAGCAGAAGGTCGGCTTGTTTGTAAGAATTGCGGAATGGTTTATAATCTTTATTCTTCTTCTCCTCGTCTT
CCTGGAGTTTGTGATAAATGTGGGGGAGAGATTTATCGTCGTCCAGATGATGATGCCAACATAGTTTTAAAAAGATTAGA
AGTTTATCATGAGTTGACAAGCCCTCTTATTCAATATTATACTGATCAAGGAATTCTGTTAAAATTTGATGGAAATCAAA
ATTCTGATACGGTTTATTACCAGTTGAAAAAATCTATTAATGAAAAGTACTTATAA

Upstream 100 bases:

>100_bases
AAGAAATATTAAATCAAATTGAAAATATCACTACTTTGAGTATAGTCCTTGATTAAGATTTTTATTTTGTCTATTCTATT
TTTTTTTATTTAACTTTCCA

Downstream 100 bases:

>100_bases
CTTCTATTAGATTTTTTAATTCTGATGCAATGTCTGTCAGTGAAAAGAATTCACACTCGAGTTAAAAGAAAAATTTATTG
TGGTTTCACATTAAAATTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MIMIKSTKPLVSTQAAVALILLGPPGSGKGTQAKRLAHEYQIPHISSGDLFREHMSKETIIGLKAKEFIQAGKLVPDEFV
MDMLFDRLAHPDCARGYLLDGFPRTVAQAEALAGKRDIKIPLIVLYLEVPDAVIVKRAEGRLVCKNCGMVYNLYSSSPRL
PGVCDKCGGEIYRRPDDDANIVLKRLEVYHELTSPLIQYYTDQGILLKFDGNQNSDTVYYQLKKSINEKYL

Sequences:

>Translated_231_residues
MIMIKSTKPLVSTQAAVALILLGPPGSGKGTQAKRLAHEYQIPHISSGDLFREHMSKETIIGLKAKEFIQAGKLVPDEFV
MDMLFDRLAHPDCARGYLLDGFPRTVAQAEALAGKRDIKIPLIVLYLEVPDAVIVKRAEGRLVCKNCGMVYNLYSSSPRL
PGVCDKCGGEIYRRPDDDANIVLKRLEVYHELTSPLIQYYTDQGILLKFDGNQNSDTVYYQLKKSINEKYL
>Mature_231_residues
MIMIKSTKPLVSTQAAVALILLGPPGSGKGTQAKRLAHEYQIPHISSGDLFREHMSKETIIGLKAKEFIQAGKLVPDEFV
MDMLFDRLAHPDCARGYLLDGFPRTVAQAEALAGKRDIKIPLIVLYLEVPDAVIVKRAEGRLVCKNCGMVYNLYSSSPRL
PGVCDKCGGEIYRRPDDDANIVLKRLEVYHELTSPLIQYYTDQGILLKFDGNQNSDTVYYQLKKSINEKYL

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=39.8058252427184, Blast_Score=157, Evalue=6e-39,
Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=39.8058252427184, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI19923437, Length=201, Percent_Identity=38.3084577114428, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI310110345, Length=203, Percent_Identity=34.9753694581281, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI53832003, Length=203, Percent_Identity=34.9753694581281, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI8051579, Length=203, Percent_Identity=34.9753694581281, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI53832001, Length=203, Percent_Identity=34.9753694581281, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4502011, Length=205, Percent_Identity=32.6829268292683, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI28144899, Length=214, Percent_Identity=28.9719626168224, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI28144897, Length=214, Percent_Identity=28.9719626168224, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI22749187, Length=210, Percent_Identity=29.5238095238095, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7706497, Length=221, Percent_Identity=26.6968325791855, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI237858799, Length=137, Percent_Identity=33.5766423357664, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786680, Length=185, Percent_Identity=44.3243243243243, Blast_Score=157, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=37.914691943128, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=28.0788177339901, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=207, Percent_Identity=29.4685990338164, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=208, Percent_Identity=27.4038461538462, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=35.8139534883721, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6321018, Length=204, Percent_Identity=39.7058823529412, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=233, Percent_Identity=25.3218884120172, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI22026816, Length=217, Percent_Identity=39.1705069124424, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=40.6091370558376, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=40.6091370558376, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI221459597, Length=231, Percent_Identity=26.8398268398268, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21356893, Length=231, Percent_Identity=26.8398268398268, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24663208, Length=210, Percent_Identity=22.8571428571429, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647141, Length=210, Percent_Identity=22.8571428571429, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 25832; Mature: 25832

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMIKSTKPLVSTQAAVALILLGPPGSGKGTQAKRLAHEYQIPHISSGDLFREHMSKETI
CEEECCCCCCHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCHHE
IGLKAKEFIQAGKLVPDEFVMDMLFDRLAHPDCARGYLLDGFPRTVAQAEALAGKRDIKI
ECCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCC
PLIVLYLEVPDAVIVKRAEGRLVCKNCGMVYNLYSSSPRLPGVCDKCGGEIYRRPDDDAN
EEEEEEEECCCCEEEEECCCCEEEECCCEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHH
IVLKRLEVYHELTSPLIQYYTDQGILLKFDGNQNSDTVYYQLKKSINEKYL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEHHHHHCCCC
>Mature Secondary Structure
MIMIKSTKPLVSTQAAVALILLGPPGSGKGTQAKRLAHEYQIPHISSGDLFREHMSKETI
CEEECCCCCCHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCHHE
IGLKAKEFIQAGKLVPDEFVMDMLFDRLAHPDCARGYLLDGFPRTVAQAEALAGKRDIKI
ECCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCC
PLIVLYLEVPDAVIVKRAEGRLVCKNCGMVYNLYSSSPRLPGVCDKCGGEIYRRPDDDAN
EEEEEEEECCCCEEEEECCCCEEEECCCEEEEECCCCCCCCCHHHHCCCCCCCCCCCHHH
IVLKRLEVYHELTSPLIQYYTDQGILLKFDGNQNSDTVYYQLKKSINEKYL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA