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The map label for this gene is trxA [H]

Identifier: 46446581

GI number: 46446581

Start: 1144309

End: 1144743

Strand: Reverse

Name: trxA [H]

Synonym: pc0947

Alternate gene names: 46446581

Gene position: 1144743-1144309 (Counterclockwise)

Preceding gene: 46446582

Following gene: 46446580

Centisome position: 47.41

GC content: 30.8

Gene sequence:

>435_bases
ATGAAAGTTTTAAATTATCTTCTTTGCCTTTTTATTTGCCTGACAGCCTTGGTCTATAGCGAGATAAAATCTGTTAAAGA
TAAAATCTGTTGCGATCTTAATGCTTCTTCGATTGTTGAAGTCACTCAAGATAACTTTAAACAGCTGATATTTCCAGAAA
AACCTGTTATTTTGATGATTTATGCAGAATGGTGTGGGTGTTGCTGTCGCTTTCAACCTATTTTGGAAACGTTTAGCGAA
AGTTTTAAAGAATCTATCCGTTTTGCTAAATTAAATTATGATGAAGAAACTGATTTAGCTGATTCTTTCGATATCAACTA
TTTTCCTACATTTATATTTATTGATTCAGGGATCGTTATGGATAAAACTGATGAAATAGATACTCAAGAAGAGTTGGAAT
CTCAAATTTTTGCATGGATAAATCAATTAAACTAA

Upstream 100 bases:

>100_bases
ATATTTTACATTTTTTTGGTGGGTATTTAAATTATCATAAATTTTCTATGATTTTTTAAAATAGGTGCTATACCGTAACT
TTTAATCCTGAGATGAAAAA

Downstream 100 bases:

>100_bases
CCTAAATATGAATAGGTTTATCAAATTAGAATATTTAATTTAACTTCTTTTTTTAATAGATCTTTCTTCTCCCTGTGAAT
ACTTTTTGAAAAATTTTAAT

Product: putative thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKVLNYLLCLFICLTALVYSEIKSVKDKICCDLNASSIVEVTQDNFKQLIFPEKPVILMIYAEWCGCCCRFQPILETFSE
SFKESIRFAKLNYDEETDLADSFDINYFPTFIFIDSGIVMDKTDEIDTQEELESQIFAWINQLN

Sequences:

>Translated_144_residues
MKVLNYLLCLFICLTALVYSEIKSVKDKICCDLNASSIVEVTQDNFKQLIFPEKPVILMIYAEWCGCCCRFQPILETFSE
SFKESIRFAKLNYDEETDLADSFDINYFPTFIFIDSGIVMDKTDEIDTQEELESQIFAWINQLN
>Mature_144_residues
MKVLNYLLCLFICLTALVYSEIKSVKDKICCDLNASSIVEVTQDNFKQLIFPEKPVILMIYAEWCGCCCRFQPILETFSE
SFKESIRFAKLNYDEETDLADSFDINYFPTFIFIDSGIVMDKTDEIDTQEELESQIFAWINQLN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=111, Percent_Identity=27.9279279279279, Blast_Score=63, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=110, Percent_Identity=32.7272727272727, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 16765; Mature: 16765

Theoretical pI: Translated: 3.96; Mature: 3.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
5.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLNYLLCLFICLTALVYSEIKSVKDKICCDLNASSIVEVTQDNFKQLIFPEKPVILMI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
YAEWCGCCCRFQPILETFSESFKESIRFAKLNYDEETDLADSFDINYFPTFIFIDSGIVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEE
DKTDEIDTQEELESQIFAWINQLN
CCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVLNYLLCLFICLTALVYSEIKSVKDKICCDLNASSIVEVTQDNFKQLIFPEKPVILMI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
YAEWCGCCCRFQPILETFSESFKESIRFAKLNYDEETDLADSFDINYFPTFIFIDSGIVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEE
DKTDEIDTQEELESQIFAWINQLN
CCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9359865; 10632710 [H]